GAF domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASG9_LEIMU

TriTrypDb:

LmxM.36.0520

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASG9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	431	435	PF00656	0.412
CLV_NRD_NRD_1	162	164	PF00675	0.518
CLV_NRD_NRD_1	199	201	PF00675	0.496
CLV_NRD_NRD_1	229	231	PF00675	0.581
CLV_NRD_NRD_1	322	324	PF00675	0.502
CLV_NRD_NRD_1	334	336	PF00675	0.553
CLV_NRD_NRD_1	402	404	PF00675	0.504
CLV_NRD_NRD_1	93	95	PF00675	0.739
CLV_PCSK_KEX2_1	150	152	PF00082	0.460
CLV_PCSK_KEX2_1	229	231	PF00082	0.473
CLV_PCSK_KEX2_1	322	324	PF00082	0.450
CLV_PCSK_KEX2_1	334	336	PF00082	0.548
CLV_PCSK_KEX2_1	35	37	PF00082	0.436
CLV_PCSK_KEX2_1	402	404	PF00082	0.502
CLV_PCSK_KEX2_1	423	425	PF00082	0.392
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.460
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.396
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.392
CLV_PCSK_SKI1_1	372	376	PF00082	0.466
CLV_PCSK_SKI1_1	85	89	PF00082	0.669
DEG_APCC_DBOX_1	74	82	PF00400	0.471
DEG_Nend_UBRbox_2	1	3	PF02207	0.522
DOC_MAPK_gen_1	200	207	PF00069	0.402
DOC_MAPK_MEF2A_6	163	172	PF00069	0.338
DOC_PP1_RVXF_1	161	168	PF00149	0.455
DOC_PP2B_PxIxI_1	328	334	PF00149	0.582
DOC_PP4_FxxP_1	268	271	PF00568	0.438
DOC_USP7_MATH_1	159	163	PF00917	0.567
DOC_USP7_MATH_1	21	25	PF00917	0.515
DOC_USP7_MATH_1	428	432	PF00917	0.440
DOC_WW_Pin1_4	55	60	PF00397	0.680
LIG_14-3-3_CanoR_1	141	149	PF00244	0.371
LIG_14-3-3_CanoR_1	200	208	PF00244	0.357
LIG_14-3-3_CanoR_1	315	324	PF00244	0.491
LIG_Actin_WH2_2	125	143	PF00022	0.391
LIG_Actin_WH2_2	376	394	PF00022	0.472
LIG_APCC_ABBA_1	234	239	PF00400	0.426
LIG_BRCT_BRCA1_1	112	116	PF00533	0.423
LIG_Clathr_ClatBox_1	380	384	PF01394	0.483
LIG_EH1_1	206	214	PF00400	0.388
LIG_FHA_1	134	140	PF00498	0.437
LIG_FHA_1	222	228	PF00498	0.403
LIG_FHA_1	271	277	PF00498	0.473
LIG_FHA_1	319	325	PF00498	0.636
LIG_FHA_2	265	271	PF00498	0.459
LIG_FHA_2	385	391	PF00498	0.547
LIG_FHA_2	399	405	PF00498	0.422
LIG_GBD_Chelix_1	10	18	PF00786	0.445
LIG_LIR_Apic_2	266	271	PF02991	0.515
LIG_LIR_Gen_1	244	255	PF02991	0.392
LIG_LIR_Nem_3	231	237	PF02991	0.600
LIG_LIR_Nem_3	244	250	PF02991	0.336
LIG_LIR_Nem_3	281	286	PF02991	0.623
LIG_LIR_Nem_3	425	429	PF02991	0.278
LIG_MYND_1	55	59	PF01753	0.755
LIG_NRBOX	128	134	PF00104	0.406
LIG_Pex14_2	247	251	PF04695	0.468
LIG_Pex14_2	264	268	PF04695	0.359
LIG_Rb_LxCxE_1	249	267	PF01857	0.433
LIG_SH2_CRK	283	287	PF00017	0.580
LIG_SH2_CRK	426	430	PF00017	0.484
LIG_SH2_SRC	269	272	PF00017	0.483
LIG_SH2_STAP1	243	247	PF00017	0.348
LIG_SH2_STAP1	312	316	PF00017	0.557
LIG_SH2_STAT5	243	246	PF00017	0.448
LIG_SH2_STAT5	283	286	PF00017	0.483
LIG_SH2_STAT5	362	365	PF00017	0.465
LIG_SH3_3	276	282	PF00018	0.468
LIG_SH3_3	283	289	PF00018	0.500
LIG_SH3_3	342	348	PF00018	0.611
LIG_SH3_3	53	59	PF00018	0.553
LIG_SUMO_SIM_anti_2	376	382	PF11976	0.476
LIG_SUMO_SIM_par_1	379	384	PF11976	0.481
LIG_UBA3_1	356	360	PF00899	0.481
LIG_WRC_WIRS_1	265	270	PF05994	0.575
MOD_CDK_SPxxK_3	55	62	PF00069	0.567
MOD_CK1_1	104	110	PF00069	0.719
MOD_CK1_1	119	125	PF00069	0.440
MOD_CK1_1	318	324	PF00069	0.513
MOD_CK1_1	337	343	PF00069	0.474
MOD_CK1_1	58	64	PF00069	0.766
MOD_CK1_1	86	92	PF00069	0.488
MOD_CK2_1	352	358	PF00069	0.463
MOD_CK2_1	398	404	PF00069	0.421
MOD_Cter_Amidation	198	201	PF01082	0.499
MOD_GlcNHglycan	103	106	PF01048	0.673
MOD_GlcNHglycan	178	181	PF01048	0.419
MOD_GlcNHglycan	201	204	PF01048	0.376
MOD_GlcNHglycan	324	327	PF01048	0.668
MOD_GlcNHglycan	52	55	PF01048	0.564
MOD_GSK3_1	115	122	PF00069	0.356
MOD_GSK3_1	237	244	PF00069	0.483
MOD_GSK3_1	318	325	PF00069	0.633
MOD_GSK3_1	81	88	PF00069	0.579
MOD_GSK3_1	99	106	PF00069	0.691
MOD_N-GLC_1	159	164	PF02516	0.503
MOD_N-GLC_1	21	26	PF02516	0.514
MOD_N-GLC_1	340	345	PF02516	0.452
MOD_NEK2_1	133	138	PF00069	0.436
MOD_NEK2_1	140	145	PF00069	0.503
MOD_NEK2_1	185	190	PF00069	0.516
MOD_NEK2_1	264	269	PF00069	0.610
MOD_NEK2_1	398	403	PF00069	0.491
MOD_NEK2_1	81	86	PF00069	0.711
MOD_NEK2_1	90	95	PF00069	0.743
MOD_NEK2_2	21	26	PF00069	0.514
MOD_NEK2_2	221	226	PF00069	0.391
MOD_PIKK_1	119	125	PF00454	0.467
MOD_PIKK_1	270	276	PF00454	0.456
MOD_PIKK_1	315	321	PF00454	0.542
MOD_PIKK_1	384	390	PF00454	0.533
MOD_PIKK_1	48	54	PF00454	0.508
MOD_PKA_1	322	328	PF00069	0.620
MOD_PKA_1	334	340	PF00069	0.567
MOD_PKA_2	140	146	PF00069	0.484
MOD_PKA_2	199	205	PF00069	0.407
MOD_PKA_2	322	328	PF00069	0.527
MOD_PKA_2	334	340	PF00069	0.610
MOD_PKA_2	384	390	PF00069	0.594
MOD_Plk_1	241	247	PF00069	0.385
MOD_Plk_1	42	48	PF00069	0.659
MOD_Plk_4	208	214	PF00069	0.308
MOD_Plk_4	246	252	PF00069	0.426
MOD_Plk_4	264	270	PF00069	0.574
MOD_Plk_4	352	358	PF00069	0.583
MOD_ProDKin_1	55	61	PF00069	0.682
MOD_SUMO_for_1	4	7	PF00179	0.438
MOD_SUMO_for_1	429	432	PF00179	0.405
MOD_SUMO_rev_2	107	116	PF00179	0.441
MOD_SUMO_rev_2	355	361	PF00179	0.473
MOD_SUMO_rev_2	384	394	PF00179	0.392
TRG_DiLeu_BaEn_1	6	11	PF01217	0.494
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.406
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.446
TRG_DiLeu_LyEn_5	29	34	PF01217	0.305
TRG_ENDOCYTIC_2	130	133	PF00928	0.363
TRG_ENDOCYTIC_2	283	286	PF00928	0.578
TRG_ENDOCYTIC_2	426	429	PF00928	0.529
TRG_ER_diArg_1	322	324	PF00400	0.529
TRG_ER_diArg_1	333	335	PF00400	0.615
TRG_ER_diArg_1	36	39	PF00400	0.412
TRG_NES_CRM1_1	28	43	PF08389	0.434
TRG_NLS_MonoExtN_4	32	39	PF00514	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JPJ4	Bodo saltans	34%	86%
A0A1X0P9M8	Trypanosomatidae	36%	100%
A0A3Q8IFS3	Leishmania donovani	89%	100%
A0A422P297	Trypanosoma rangeli	37%	99%
A4HNR0	Leishmania braziliensis	72%	100%
A4ICT5	Leishmania infantum	89%	100%
D0A2L8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4Q226	Leishmania major	90%	100%