Putative DNAJ domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR-repeat-containing chaperone protein DNAJ, putative

Species:

Leishmania mexicana

UniProt:

E9ASG7_LEIMU

TriTrypDb:

LmxM.36.0500

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASG7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASG7

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.425
CLV_C14_Caspase3-7	389	393	PF00656	0.413
CLV_NRD_NRD_1	331	333	PF00675	0.295
CLV_NRD_NRD_1	374	376	PF00675	0.430
CLV_NRD_NRD_1	501	503	PF00675	0.655
CLV_PCSK_FUR_1	369	373	PF00082	0.460
CLV_PCSK_KEX2_1	249	251	PF00082	0.458
CLV_PCSK_KEX2_1	331	333	PF00082	0.295
CLV_PCSK_KEX2_1	371	373	PF00082	0.437
CLV_PCSK_KEX2_1	374	376	PF00082	0.427
CLV_PCSK_KEX2_1	395	397	PF00082	0.305
CLV_PCSK_KEX2_1	441	443	PF00082	0.321
CLV_PCSK_KEX2_1	500	502	PF00082	0.658
CLV_PCSK_KEX2_1	63	65	PF00082	0.427
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.458
CLV_PCSK_PC1ET2_1	371	373	PF00082	0.437
CLV_PCSK_PC1ET2_1	374	376	PF00082	0.427
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.305
CLV_PCSK_PC1ET2_1	441	443	PF00082	0.321
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.427
CLV_PCSK_PC7_1	245	251	PF00082	0.452
CLV_PCSK_SKI1_1	130	134	PF00082	0.519
CLV_PCSK_SKI1_1	245	249	PF00082	0.349
CLV_PCSK_SKI1_1	268	272	PF00082	0.390
CLV_PCSK_SKI1_1	309	313	PF00082	0.452
CLV_PCSK_SKI1_1	364	368	PF00082	0.441
CLV_PCSK_SKI1_1	371	375	PF00082	0.407
CLV_PCSK_SKI1_1	76	80	PF00082	0.508
DEG_APCC_DBOX_1	244	252	PF00400	0.390
DEG_SPOP_SBC_1	114	118	PF00917	0.577
DEG_SPOP_SBC_1	170	174	PF00917	0.519
DEG_SPOP_SBC_1	8	12	PF00917	0.659
DOC_CYCLIN_RxL_1	127	137	PF00134	0.474
DOC_CYCLIN_RxL_1	374	388	PF00134	0.323
DOC_MAPK_gen_1	266	274	PF00069	0.461
DOC_MAPK_gen_1	295	305	PF00069	0.504
DOC_PP2B_LxvP_1	382	385	PF13499	0.341
DOC_USP7_MATH_1	156	160	PF00917	0.429
DOC_USP7_MATH_1	170	174	PF00917	0.484
DOC_USP7_MATH_1	253	257	PF00917	0.398
DOC_USP7_MATH_1	27	31	PF00917	0.147
DOC_USP7_MATH_1	330	334	PF00917	0.362
DOC_USP7_MATH_1	411	415	PF00917	0.336
DOC_USP7_MATH_1	492	496	PF00917	0.603
DOC_USP7_MATH_1	7	11	PF00917	0.718
DOC_USP7_UBL2_3	109	113	PF12436	0.266
DOC_USP7_UBL2_3	367	371	PF12436	0.396
DOC_USP7_UBL2_3	376	380	PF12436	0.291
DOC_USP7_UBL2_3	395	399	PF12436	0.305
DOC_WW_Pin1_4	115	120	PF00397	0.546
DOC_WW_Pin1_4	184	189	PF00397	0.508
DOC_WW_Pin1_4	193	198	PF00397	0.525
LIG_14-3-3_CanoR_1	289	295	PF00244	0.416
LIG_14-3-3_CanoR_1	90	98	PF00244	0.504
LIG_BRCT_BRCA1_1	29	33	PF00533	0.452
LIG_FHA_1	276	282	PF00498	0.371
LIG_FHA_2	120	126	PF00498	0.556
LIG_FHA_2	17	23	PF00498	0.283
LIG_FXI_DFP_1	166	170	PF00024	0.544
LIG_Integrin_isoDGR_2	498	500	PF01839	0.768
LIG_LIR_Gen_1	205	216	PF02991	0.338
LIG_LIR_Nem_3	204	210	PF02991	0.354
LIG_LIR_Nem_3	377	382	PF02991	0.281
LIG_LIR_Nem_3	422	428	PF02991	0.305
LIG_LIR_Nem_3	430	435	PF02991	0.305
LIG_NRBOX	128	134	PF00104	0.528
LIG_Pex14_2	489	493	PF04695	0.763
LIG_PTB_Apo_2	473	480	PF02174	0.515
LIG_RPA_C_Fungi	52	64	PF08784	0.425
LIG_SH2_CRK	379	383	PF00017	0.339
LIG_SH2_CRK	88	92	PF00017	0.357
LIG_SH2_GRB2like	54	57	PF00017	0.425
LIG_SH2_SRC	179	182	PF00017	0.477
LIG_SH2_SRC	317	320	PF00017	0.443
LIG_SH2_SRC	67	70	PF00017	0.390
LIG_SH2_STAP1	277	281	PF00017	0.321
LIG_SH2_STAP1	40	44	PF00017	0.321
LIG_SH2_STAT3	218	221	PF00017	0.321
LIG_SH2_STAT5	200	203	PF00017	0.446
LIG_SH2_STAT5	208	211	PF00017	0.287
LIG_SH2_STAT5	277	280	PF00017	0.390
LIG_SH2_STAT5	61	64	PF00017	0.339
LIG_SH3_3	182	188	PF00018	0.430
LIG_SH3_3	191	197	PF00018	0.421
LIG_SH3_3	45	51	PF00018	0.425
LIG_SUMO_SIM_anti_2	469	476	PF11976	0.656
LIG_TRAF2_1	352	355	PF00917	0.452
LIG_TRAF2_1	413	416	PF00917	0.321
LIG_TRAF2_1	466	469	PF00917	0.669
MOD_CDK_SPK_2	115	120	PF00069	0.528
MOD_CK1_1	55	61	PF00069	0.321
MOD_CK2_1	16	22	PF00069	0.419
MOD_CK2_1	184	190	PF00069	0.498
MOD_CK2_1	411	417	PF00069	0.313
MOD_Cter_Amidation	498	501	PF01082	0.682
MOD_DYRK1A_RPxSP_1	193	197	PF00069	0.482
MOD_GlcNHglycan	11	14	PF01048	0.667
MOD_GlcNHglycan	225	228	PF01048	0.372
MOD_GlcNHglycan	324	327	PF01048	0.488
MOD_GlcNHglycan	40	43	PF01048	0.381
MOD_GlcNHglycan	445	448	PF01048	0.528
MOD_GlcNHglycan	459	462	PF01048	0.547
MOD_GlcNHglycan	494	497	PF01048	0.504
MOD_GlcNHglycan	57	60	PF01048	0.178
MOD_GlcNHglycan	92	95	PF01048	0.487
MOD_GSK3_1	115	122	PF00069	0.497
MOD_GSK3_1	189	196	PF00069	0.512
MOD_GSK3_1	317	324	PF00069	0.464
MOD_GSK3_1	416	423	PF00069	0.374
MOD_GSK3_1	76	83	PF00069	0.511
MOD_GSK3_1	86	93	PF00069	0.461
MOD_N-GLC_1	290	295	PF02516	0.521
MOD_N-GLC_1	55	60	PF02516	0.305
MOD_NEK2_1	149	154	PF00069	0.504
MOD_NEK2_1	198	203	PF00069	0.513
MOD_NEK2_1	231	236	PF00069	0.385
MOD_NEK2_1	290	295	PF00069	0.408
MOD_NEK2_1	443	448	PF00069	0.546
MOD_NEK2_1	80	85	PF00069	0.546
MOD_PIKK_1	275	281	PF00454	0.409
MOD_PIKK_1	420	426	PF00454	0.437
MOD_PIKK_1	464	470	PF00454	0.664
MOD_PKA_2	102	108	PF00069	0.497
MOD_PKA_2	231	237	PF00069	0.362
MOD_PKA_2	330	336	PF00069	0.362
MOD_Plk_1	189	195	PF00069	0.465
MOD_Plk_1	290	296	PF00069	0.536
MOD_Plk_1	80	86	PF00069	0.405
MOD_Plk_4	470	476	PF00069	0.649
MOD_ProDKin_1	115	121	PF00069	0.540
MOD_ProDKin_1	184	190	PF00069	0.510
MOD_ProDKin_1	193	199	PF00069	0.524
MOD_SUMO_rev_2	304	311	PF00179	0.435
MOD_SUMO_rev_2	414	419	PF00179	0.342
TRG_DiLeu_BaEn_3	354	360	PF01217	0.374
TRG_ENDOCYTIC_2	166	169	PF00928	0.479
TRG_ENDOCYTIC_2	208	211	PF00928	0.323
TRG_ENDOCYTIC_2	378	381	PF00928	0.305
TRG_ENDOCYTIC_2	88	91	PF00928	0.343
TRG_ER_diArg_1	144	147	PF00400	0.498
TRG_ER_diArg_1	331	334	PF00400	0.305
TRG_ER_diArg_1	500	502	PF00400	0.686
TRG_NLS_MonoCore_2	438	443	PF00514	0.390
TRG_NLS_MonoExtC_3	370	375	PF00514	0.426
TRG_NLS_MonoExtC_3	439	445	PF00514	0.321
TRG_NLS_MonoExtN_4	369	375	PF00514	0.483
TRG_NLS_MonoExtN_4	438	444	PF00514	0.306
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.209

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0D1E2P6	Ustilago maydis (strain 521 / FGSC 9021)	24%	88%
A0A0D2XVZ5	Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936)	24%	98%
A0A0N1PF59	Leptomonas seymouri	78%	97%
A0A0S4JLZ7	Bodo saltans	53%	100%
A0A1X0P8B2	Trypanosomatidae	59%	100%
A0A1X0P9Z7	Trypanosomatidae	32%	74%
A0A3S7XAC9	Leishmania donovani	98%	100%
A0A422NFP3	Trypanosoma rangeli	27%	97%
A0A422P0G2	Trypanosoma rangeli	33%	73%
A0A422P289	Trypanosoma rangeli	52%	100%
A4H7V3	Leishmania braziliensis	27%	100%
A4HNQ8	Leishmania braziliensis	89%	100%
A4ICT7	Leishmania infantum	98%	100%
A6ZRW3	Saccharomyces cerevisiae (strain YJM789)	25%	83%
C9ZML0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	72%
C9ZST7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	97%
D0A2L6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
F4IXE4	Arabidopsis thaliana	28%	70%
J9VKM5	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	25%	98%
P07213	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	83%
Q13217	Homo sapiens	24%	100%
Q27968	Bos taurus	25%	100%
Q4Q228	Leishmania major	95%	100%
Q54IP0	Dictyostelium discoideum	36%	95%
Q54M21	Dictyostelium discoideum	24%	100%
Q5R8D8	Pongo abelii	34%	100%
Q5ZI13	Gallus gallus	26%	100%
Q84JR9	Arabidopsis thaliana	25%	75%
Q91YW3	Mus musculus	24%	100%
Q99615	Homo sapiens	34%	100%
Q9HGM9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q9LYW9	Arabidopsis thaliana	27%	100%
Q9MAH1	Arabidopsis thaliana	25%	73%
Q9QYI3	Mus musculus	34%	100%
Q9R0T3	Rattus norvegicus	24%	100%
Q9SIN1	Arabidopsis thaliana	24%	74%
V5BKG1	Trypanosoma cruzi	32%	73%
V5BZY4	Trypanosoma cruzi	53%	100%
V5DRP2	Trypanosoma cruzi	25%	69%