Cytochrome c oxidase subunit Vb

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASG5_LEIMU

TriTrypDb:

LmxM.36.0480

Length:

225

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005751	mitochondrial respiratory chain complex IV	4	11
GO:0032991	protein-containing complex	1	11
GO:0045277	respiratory chain complex IV	4	11
GO:0070069	cytochrome complex	3	11
GO:0098796	membrane protein complex	2	11
GO:0098798	mitochondrial protein-containing complex	2	11
GO:0098800	inner mitochondrial membrane protein complex	3	11
GO:0098803	respiratory chain complex	3	11
GO:1902494	catalytic complex	2	11
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASG5

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	11
GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	7	11
GO:0008152	metabolic process	1	11
GO:0009060	aerobic respiration	6	11
GO:0009987	cellular process	1	11
GO:0015980	energy derivation by oxidation of organic compounds	4	11
GO:0019646	aerobic electron transport chain	6	11
GO:0022900	electron transport chain	4	11
GO:0022904	respiratory electron transport chain	5	11
GO:0044237	cellular metabolic process	2	11
GO:0045333	cellular respiration	5	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016491	oxidoreductase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.519
CLV_NRD_NRD_1	50	52	PF00675	0.586
DEG_Nend_Nbox_1	1	3	PF02207	0.519
DOC_MAPK_gen_1	3	9	PF00069	0.522
DOC_PP1_RVXF_1	74	80	PF00149	0.516
DOC_USP7_MATH_1	120	124	PF00917	0.537
DOC_USP7_MATH_1	15	19	PF00917	0.553
DOC_USP7_MATH_1	54	58	PF00917	0.560
DOC_USP7_UBL2_3	162	166	PF12436	0.512
DOC_WW_Pin1_4	50	55	PF00397	0.558
LIG_APCC_ABBA_1	184	189	PF00400	0.533
LIG_APCC_ABBA_1	64	69	PF00400	0.546
LIG_FHA_1	92	98	PF00498	0.545
LIG_FHA_2	201	207	PF00498	0.535
LIG_LIR_Gen_1	107	117	PF02991	0.552
LIG_LIR_Gen_1	155	164	PF02991	0.516
LIG_LIR_Gen_1	203	211	PF02991	0.534
LIG_LIR_Gen_1	212	222	PF02991	0.606
LIG_LIR_Nem_3	107	113	PF02991	0.553
LIG_LIR_Nem_3	203	207	PF02991	0.559
LIG_LIR_Nem_3	212	218	PF02991	0.576
LIG_Pex14_2	211	215	PF04695	0.499
LIG_SH2_GRB2like	221	224	PF00017	0.494
LIG_SH2_PTP2	110	113	PF00017	0.557
LIG_SH2_SRC	117	120	PF00017	0.541
LIG_SH2_SRC	221	224	PF00017	0.494
LIG_SH2_SRC	67	70	PF00017	0.530
LIG_SH2_STAP1	67	71	PF00017	0.530
LIG_SH2_STAT3	33	36	PF00017	0.572
LIG_SH2_STAT5	110	113	PF00017	0.557
LIG_SH2_STAT5	177	180	PF00017	0.552
LIG_SH2_STAT5	202	205	PF00017	0.539
LIG_SH2_STAT5	221	224	PF00017	0.494
LIG_SH3_3	147	153	PF00018	0.609
LIG_SH3_3	182	188	PF00018	0.539
LIG_SUMO_SIM_par_1	92	99	PF11976	0.547
MOD_CK1_1	18	24	PF00069	0.606
MOD_CK2_1	200	206	PF00069	0.537
MOD_GlcNHglycan	17	20	PF01048	0.553
MOD_GSK3_1	15	22	PF00069	0.571
MOD_GSK3_1	46	53	PF00069	0.581
MOD_NEK2_1	10	15	PF00069	0.510
MOD_NEK2_1	2	7	PF00069	0.535
MOD_NEK2_1	60	65	PF00069	0.595
MOD_PK_1	31	37	PF00069	0.453
MOD_PKA_2	2	8	PF00069	0.526
MOD_Plk_1	60	66	PF00069	0.568
MOD_Plk_1	91	97	PF00069	0.544
MOD_Plk_4	91	97	PF00069	0.544
MOD_ProDKin_1	50	56	PF00069	0.558
TRG_ENDOCYTIC_2	110	113	PF00928	0.557
TRG_ENDOCYTIC_2	157	160	PF00928	0.518
TRG_ENDOCYTIC_2	67	70	PF00928	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILG0	Leptomonas seymouri	94%	100%
A0A0S4JMS0	Bodo saltans	76%	100%
A0A1X0P8B6	Trypanosomatidae	88%	100%
A0A3S7XAI6	Leishmania donovani	99%	100%
A0A422P2A1	Trypanosoma rangeli	88%	100%
A4HNQ6	Leishmania braziliensis	97%	100%
A4ICT9	Leishmania infantum	99%	100%
D0A2L4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	87%	100%
Q4Q230	Leishmania major	99%	100%
V5BA06	Trypanosoma cruzi	86%	76%