Vacuolar protein sorting-associated protein,putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vacuolar protein sorting-associated protein, putative

Species:

Leishmania mexicana

UniProt:

E9ASG3_LEIMU

TriTrypDb:

LmxM.36.0460

Length:

617

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	2
GO:0016020	membrane	2	2
GO:0031090	organelle membrane	3	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ASG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASG3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	18
GO:0016192	vesicle-mediated transport	4	18
GO:0051179	localization	1	18
GO:0051234	establishment of localization	2	18
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.293
CLV_NRD_NRD_1	13	15	PF00675	0.514
CLV_NRD_NRD_1	195	197	PF00675	0.277
CLV_NRD_NRD_1	240	242	PF00675	0.388
CLV_NRD_NRD_1	343	345	PF00675	0.274
CLV_NRD_NRD_1	495	497	PF00675	0.218
CLV_NRD_NRD_1	574	576	PF00675	0.265
CLV_PCSK_FUR_1	11	15	PF00082	0.556
CLV_PCSK_KEX2_1	13	15	PF00082	0.514
CLV_PCSK_KEX2_1	195	197	PF00082	0.289
CLV_PCSK_SKI1_1	35	39	PF00082	0.305
CLV_PCSK_SKI1_1	367	371	PF00082	0.307
CLV_PCSK_SKI1_1	390	394	PF00082	0.348
CLV_PCSK_SKI1_1	44	48	PF00082	0.316
DEG_APCC_DBOX_1	389	397	PF00400	0.389
DOC_CKS1_1	245	250	PF01111	0.321
DOC_CKS1_1	286	291	PF01111	0.351
DOC_CYCLIN_yCln2_LP_2	249	255	PF00134	0.289
DOC_MAPK_DCC_7	241	251	PF00069	0.389
DOC_MAPK_gen_1	322	330	PF00069	0.334
DOC_MAPK_gen_1	344	350	PF00069	0.275
DOC_MAPK_gen_1	531	540	PF00069	0.218
DOC_MAPK_MEF2A_6	206	215	PF00069	0.265
DOC_MAPK_MEF2A_6	230	239	PF00069	0.295
DOC_MAPK_MEF2A_6	531	540	PF00069	0.273
DOC_PP2B_LxvP_1	249	252	PF13499	0.298
DOC_PP4_FxxP_1	165	168	PF00568	0.369
DOC_USP7_MATH_1	231	235	PF00917	0.274
DOC_USP7_MATH_1	355	359	PF00917	0.363
DOC_USP7_MATH_1	596	600	PF00917	0.405
DOC_USP7_UBL2_3	206	210	PF12436	0.274
DOC_USP7_UBL2_3	318	322	PF12436	0.183
DOC_USP7_UBL2_3	471	475	PF12436	0.274
DOC_WW_Pin1_4	160	165	PF00397	0.366
DOC_WW_Pin1_4	244	249	PF00397	0.318
DOC_WW_Pin1_4	285	290	PF00397	0.350
LIG_14-3-3_CanoR_1	181	189	PF00244	0.275
LIG_14-3-3_CanoR_1	325	331	PF00244	0.285
LIG_14-3-3_CanoR_1	344	349	PF00244	0.285
LIG_14-3-3_CanoR_1	371	375	PF00244	0.298
LIG_14-3-3_CanoR_1	463	470	PF00244	0.317
LIG_Actin_WH2_2	141	156	PF00022	0.274
LIG_Actin_WH2_2	215	232	PF00022	0.360
LIG_BIR_III_2	277	281	PF00653	0.293
LIG_BRCT_BRCA1_1	607	611	PF00533	0.231
LIG_Clathr_ClatBox_1	236	240	PF01394	0.298
LIG_deltaCOP1_diTrp_1	18	28	PF00928	0.443
LIG_eIF4E_1	51	57	PF01652	0.256
LIG_FHA_1	109	115	PF00498	0.333
LIG_FHA_1	143	149	PF00498	0.286
LIG_FHA_1	230	236	PF00498	0.334
LIG_FHA_1	245	251	PF00498	0.217
LIG_FHA_1	29	35	PF00498	0.370
LIG_FHA_1	325	331	PF00498	0.354
LIG_FHA_1	355	361	PF00498	0.423
LIG_FHA_1	41	47	PF00498	0.224
LIG_FHA_1	419	425	PF00498	0.454
LIG_FHA_1	487	493	PF00498	0.274
LIG_FHA_1	504	510	PF00498	0.274
LIG_FHA_1	577	583	PF00498	0.303
LIG_FHA_1	589	595	PF00498	0.259
LIG_FHA_1	601	607	PF00498	0.215
LIG_FHA_2	223	229	PF00498	0.389
LIG_FHA_2	399	405	PF00498	0.312
LIG_FHA_2	542	548	PF00498	0.285
LIG_Integrin_isoDGR_2	365	367	PF01839	0.274
LIG_KLC1_Yacidic_2	136	140	PF13176	0.162
LIG_LIR_Apic_2	163	168	PF02991	0.369
LIG_LIR_Gen_1	107	118	PF02991	0.340
LIG_LIR_Gen_1	145	155	PF02991	0.289
LIG_LIR_Gen_1	18	28	PF02991	0.308
LIG_LIR_Gen_1	254	263	PF02991	0.285
LIG_LIR_Nem_3	100	106	PF02991	0.325
LIG_LIR_Nem_3	107	112	PF02991	0.320
LIG_LIR_Nem_3	145	150	PF02991	0.289
LIG_LIR_Nem_3	18	24	PF02991	0.315
LIG_LIR_Nem_3	225	229	PF02991	0.274
LIG_LIR_Nem_3	301	306	PF02991	0.274
LIG_MYND_1	248	252	PF01753	0.389
LIG_NRBOX	33	39	PF00104	0.273
LIG_PCNA_yPIPBox_3	60	72	PF02747	0.274
LIG_Pex14_2	336	340	PF04695	0.256
LIG_PTB_Apo_2	22	29	PF02174	0.446
LIG_PTB_Apo_2	497	504	PF02174	0.256
LIG_PTB_Phospho_1	497	503	PF10480	0.256
LIG_SH2_GRB2like	23	26	PF00017	0.461
LIG_SH2_NCK_1	417	421	PF00017	0.320
LIG_SH2_SRC	138	141	PF00017	0.284
LIG_SH2_STAP1	106	110	PF00017	0.277
LIG_SH2_STAP1	255	259	PF00017	0.256
LIG_SH2_STAP1	590	594	PF00017	0.263
LIG_SH2_STAT3	451	454	PF00017	0.389
LIG_SH2_STAT3	512	515	PF00017	0.269
LIG_SH2_STAT5	109	112	PF00017	0.303
LIG_SH2_STAT5	138	141	PF00017	0.274
LIG_SH2_STAT5	23	26	PF00017	0.300
LIG_SH2_STAT5	539	542	PF00017	0.361
LIG_SH2_STAT5	543	546	PF00017	0.355
LIG_SH2_STAT5	590	593	PF00017	0.275
LIG_SH3_1	242	248	PF00018	0.389
LIG_SH3_3	242	248	PF00018	0.358
LIG_SH3_3	283	289	PF00018	0.338
LIG_SH3_3	393	399	PF00018	0.268
LIG_SH3_3	515	521	PF00018	0.284
LIG_SH3_3	579	585	PF00018	0.235
LIG_SH3_3	80	86	PF00018	0.389
LIG_SUMO_SIM_anti_2	232	240	PF11976	0.290
LIG_SUMO_SIM_anti_2	370	376	PF11976	0.299
LIG_SUMO_SIM_anti_2	534	539	PF11976	0.266
LIG_SUMO_SIM_par_1	232	240	PF11976	0.287
LIG_SUMO_SIM_par_1	326	332	PF11976	0.389
LIG_SUMO_SIM_par_1	505	510	PF11976	0.372
LIG_SUMO_SIM_par_1	60	65	PF11976	0.269
LIG_TRAF2_1	68	71	PF00917	0.265
LIG_TYR_ITIM	415	420	PF00017	0.275
LIG_UBA3_1	150	154	PF00899	0.265
LIG_UBA3_1	424	429	PF00899	0.315
MOD_CK1_1	156	162	PF00069	0.344
MOD_CK1_1	205	211	PF00069	0.420
MOD_CK1_1	3	9	PF00069	0.658
MOD_CK1_1	599	605	PF00069	0.391
MOD_CK1_1	87	93	PF00069	0.359
MOD_CK2_1	326	332	PF00069	0.287
MOD_CK2_1	370	376	PF00069	0.310
MOD_CK2_1	541	547	PF00069	0.285
MOD_Cter_Amidation	11	14	PF01082	0.455
MOD_GlcNHglycan	28	31	PF01048	0.456
MOD_GlcNHglycan	86	89	PF01048	0.460
MOD_GSK3_1	114	121	PF00069	0.386
MOD_GSK3_1	138	145	PF00069	0.279
MOD_GSK3_1	156	163	PF00069	0.360
MOD_GSK3_1	185	192	PF00069	0.349
MOD_GSK3_1	344	351	PF00069	0.288
MOD_GSK3_1	45	52	PF00069	0.257
MOD_GSK3_1	567	574	PF00069	0.299
MOD_GSK3_1	576	583	PF00069	0.351
MOD_GSK3_1	584	591	PF00069	0.289
MOD_GSK3_1	596	603	PF00069	0.241
MOD_N-GLC_1	367	372	PF02516	0.285
MOD_N-GLC_1	383	388	PF02516	0.192
MOD_N-GLC_1	503	508	PF02516	0.256
MOD_N-GLC_1	567	572	PF02516	0.177
MOD_NEK2_1	113	118	PF00069	0.324
MOD_NEK2_1	189	194	PF00069	0.285
MOD_NEK2_1	28	33	PF00069	0.420
MOD_NEK2_1	462	467	PF00069	0.281
MOD_NEK2_1	469	474	PF00069	0.301
MOD_NEK2_1	567	572	PF00069	0.335
MOD_NEK2_1	600	605	PF00069	0.226
MOD_NEK2_1	611	616	PF00069	0.333
MOD_PIKK_1	169	175	PF00454	0.290
MOD_PIKK_1	486	492	PF00454	0.289
MOD_PIKK_1	49	55	PF00454	0.298
MOD_PK_1	344	350	PF00069	0.287
MOD_PKA_1	344	350	PF00069	0.256
MOD_PKA_2	180	186	PF00069	0.294
MOD_PKA_2	324	330	PF00069	0.316
MOD_PKA_2	370	376	PF00069	0.326
MOD_PKA_2	418	424	PF00069	0.273
MOD_PKA_2	462	468	PF00069	0.292
MOD_PKA_2	84	90	PF00069	0.350
MOD_PKB_1	200	208	PF00069	0.389
MOD_Plk_1	114	120	PF00069	0.436
MOD_Plk_1	367	373	PF00069	0.315
MOD_Plk_1	386	392	PF00069	0.465
MOD_Plk_2-3	175	181	PF00069	0.298
MOD_Plk_2-3	398	404	PF00069	0.274
MOD_Plk_4	114	120	PF00069	0.473
MOD_Plk_4	153	159	PF00069	0.419
MOD_Plk_4	231	237	PF00069	0.293
MOD_Plk_4	370	376	PF00069	0.260
MOD_Plk_4	562	568	PF00069	0.249
MOD_Plk_4	596	602	PF00069	0.268
MOD_ProDKin_1	160	166	PF00069	0.366
MOD_ProDKin_1	244	250	PF00069	0.318
MOD_ProDKin_1	285	291	PF00069	0.350
MOD_SUMO_for_1	278	281	PF00179	0.298
MOD_SUMO_for_1	428	431	PF00179	0.347
MOD_SUMO_for_1	592	595	PF00179	0.389
MOD_SUMO_rev_2	172	179	PF00179	0.369
MOD_SUMO_rev_2	274	280	PF00179	0.253
MOD_SUMO_rev_2	329	336	PF00179	0.303
MOD_SUMO_rev_2	394	401	PF00179	0.274
TRG_DiLeu_BaEn_1	146	151	PF01217	0.265
TRG_DiLeu_BaEn_1	387	392	PF01217	0.389
TRG_DiLeu_BaEn_1	440	445	PF01217	0.333
TRG_DiLeu_BaEn_2	331	337	PF01217	0.274
TRG_DiLeu_BaLyEn_6	245	250	PF01217	0.333
TRG_DiLeu_BaLyEn_6	444	449	PF01217	0.333
TRG_ENDOCYTIC_2	255	258	PF00928	0.285
TRG_ENDOCYTIC_2	317	320	PF00928	0.347
TRG_ENDOCYTIC_2	417	420	PF00928	0.275
TRG_ENDOCYTIC_2	95	98	PF00928	0.309
TRG_ER_diArg_1	11	14	PF00400	0.448
TRG_Pf-PMV_PEXEL_1	575	580	PF00026	0.265

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7D5	Leptomonas seymouri	84%	100%
A0A0N0P7P1	Leptomonas seymouri	31%	100%
A0A0S4JI94	Bodo saltans	50%	94%
A0A1X0P7Y3	Trypanosomatidae	27%	100%
A0A1X0P895	Trypanosomatidae	67%	100%
A0A3Q8IG36	Leishmania donovani	33%	100%
A0A3S7XAA1	Leishmania donovani	97%	100%
A0A422P2E3	Trypanosoma rangeli	66%	100%
A4HNQ4	Leishmania braziliensis	90%	100%
A4HP92	Leishmania braziliensis	32%	100%
A4ICU1	Leishmania infantum	97%	100%
A4IDJ7	Leishmania infantum	33%	100%
D0A395	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AT00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
O00186	Homo sapiens	21%	100%
O08599	Mus musculus	21%	100%
O08700	Rattus norvegicus	31%	100%
O49048	Arabidopsis thaliana	30%	100%
O74534	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	97%
P22213	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	93%
P34815	Caenorhabditis elegans	21%	92%
P38932	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P61763	Bos taurus	21%	100%
P61764	Homo sapiens	21%	100%
P61765	Rattus norvegicus	21%	100%
P97390	Mus musculus	31%	100%
Q09805	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
Q15833	Homo sapiens	20%	100%
Q24179	Drosophila melanogaster	21%	97%
Q28288	Canis lupus familiaris	20%	100%
Q4Q1J8	Leishmania major	32%	100%
Q4Q232	Leishmania major	96%	100%
Q54GE3	Dictyostelium discoideum	29%	100%
Q5R6D2	Pongo abelii	21%	100%
Q5VNU3	Oryza sativa subsp. japonica	21%	94%
Q60770	Mus musculus	22%	100%
Q62753	Rattus norvegicus	20%	100%
Q62991	Rattus norvegicus	20%	97%
Q64324	Mus musculus	20%	100%
Q6R748	Gallus gallus	21%	100%
Q851W1	Oryza sativa subsp. japonica	21%	99%
Q8BRF7	Mus musculus	20%	97%
Q9C5P7	Arabidopsis thaliana	21%	92%
Q9NRW7	Homo sapiens	30%	100%
Q9SZ77	Arabidopsis thaliana	22%	93%
V5BV59	Trypanosoma cruzi	66%	100%
V5DCK0	Trypanosoma cruzi	30%	100%