Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASF8_LEIMU

TriTrypDb:

LmxM.36.0410

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASF8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	20	22	PF00675	0.605
CLV_NRD_NRD_1	6	8	PF00675	0.571
CLV_PCSK_KEX2_1	164	166	PF00082	0.698
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.704
CLV_PCSK_SKI1_1	35	39	PF00082	0.654
CLV_PCSK_SKI1_1	62	66	PF00082	0.588
DEG_Nend_Nbox_1	1	3	PF02207	0.628
DOC_CDC14_PxL_1	78	86	PF14671	0.625
DOC_MAPK_gen_1	60	70	PF00069	0.629
DOC_MAPK_MEF2A_6	60	68	PF00069	0.664
DOC_PP1_RVXF_1	127	133	PF00149	0.654
DOC_PP2B_LxvP_1	166	169	PF13499	0.590
DOC_USP7_UBL2_3	36	40	PF12436	0.622
DOC_WW_Pin1_4	121	126	PF00397	0.502
DOC_WW_Pin1_4	154	159	PF00397	0.620
DOC_WW_Pin1_4	167	172	PF00397	0.370
LIG_14-3-3_CanoR_1	100	109	PF00244	0.653
LIG_14-3-3_CanoR_1	139	147	PF00244	0.504
LIG_14-3-3_CanoR_1	179	184	PF00244	0.617
LIG_14-3-3_CanoR_1	7	11	PF00244	0.574
LIG_Actin_WH2_2	106	124	PF00022	0.481
LIG_DLG_GKlike_1	179	187	PF00625	0.617
LIG_FHA_2	18	24	PF00498	0.667
LIG_FHA_2	56	62	PF00498	0.577
LIG_FHA_2	7	13	PF00498	0.549
LIG_Integrin_isoDGR_2	92	94	PF01839	0.679
LIG_IRF3_LxIS_1	130	136	PF10401	0.556
LIG_LIR_Gen_1	111	121	PF02991	0.669
LIG_LIR_Gen_1	131	140	PF02991	0.355
LIG_LIR_Gen_1	157	166	PF02991	0.586
LIG_LIR_Nem_3	111	117	PF02991	0.665
LIG_LIR_Nem_3	131	135	PF02991	0.354
LIG_LIR_Nem_3	157	162	PF02991	0.578
LIG_LIR_Nem_3	46	52	PF02991	0.582
LIG_LIR_Nem_3	79	83	PF02991	0.652
LIG_NRBOX	64	70	PF00104	0.706
LIG_PCNA_PIPBox_1	42	51	PF02747	0.653
LIG_PCNA_yPIPBox_3	35	49	PF02747	0.570
LIG_REV1ctd_RIR_1	49	58	PF16727	0.670
LIG_SH2_CRK	180	184	PF00017	0.594
LIG_SH2_PTP2	80	83	PF00017	0.395
LIG_SH2_SRC	80	83	PF00017	0.395
LIG_SH2_STAP1	180	184	PF00017	0.618
LIG_SH2_STAT5	80	83	PF00017	0.395
LIG_SH3_3	67	73	PF00018	0.635
LIG_SH3_3	79	85	PF00018	0.502
LIG_TYR_ITIM	78	83	PF00017	0.398
LIG_UBA3_1	183	191	PF00899	0.634
MOD_CK1_1	167	173	PF00069	0.682
MOD_CK1_1	182	188	PF00069	0.607
MOD_CK2_1	17	23	PF00069	0.657
MOD_CK2_1	55	61	PF00069	0.584
MOD_CK2_1	6	12	PF00069	0.553
MOD_GlcNHglycan	134	138	PF01048	0.577
MOD_GlcNHglycan	184	187	PF01048	0.594
MOD_GSK3_1	117	124	PF00069	0.519
MOD_N-GLC_2	97	99	PF02516	0.557
MOD_NEK2_1	109	114	PF00069	0.661
MOD_NEK2_1	117	122	PF00069	0.648
MOD_NEK2_1	133	138	PF00069	0.456
MOD_NEK2_1	68	73	PF00069	0.685
MOD_PIKK_1	38	44	PF00454	0.635
MOD_PK_1	164	170	PF00069	0.640
MOD_PKA_1	164	170	PF00069	0.640
MOD_PKA_1	35	41	PF00069	0.665
MOD_PKA_2	138	144	PF00069	0.543
MOD_PKA_2	164	170	PF00069	0.727
MOD_PKA_2	6	12	PF00069	0.569
MOD_PKA_2	93	99	PF00069	0.666
MOD_PKB_1	177	185	PF00069	0.634
MOD_Plk_1	109	115	PF00069	0.591
MOD_Plk_2-3	55	61	PF00069	0.660
MOD_Plk_2-3	6	12	PF00069	0.588
MOD_Plk_4	109	115	PF00069	0.501
MOD_Plk_4	179	185	PF00069	0.578
MOD_ProDKin_1	121	127	PF00069	0.500
MOD_ProDKin_1	154	160	PF00069	0.624
MOD_ProDKin_1	167	173	PF00069	0.364
MOD_SUMO_rev_2	3	10	PF00179	0.620
MOD_SUMO_rev_2	55	65	PF00179	0.666
TRG_DiLeu_BaEn_1	61	66	PF01217	0.642
TRG_DiLeu_BaEn_4	26	32	PF01217	0.608
TRG_ENDOCYTIC_2	180	183	PF00928	0.594
TRG_ENDOCYTIC_2	80	83	PF00928	0.395
TRG_ER_diArg_1	176	179	PF00400	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I786	Leptomonas seymouri	85%	100%
A0A0S4JIF8	Bodo saltans	27%	96%
A0A1X0P8L2	Trypanosomatidae	46%	100%
A0A3S7XA94	Leishmania donovani	93%	100%
A0A422P2B0	Trypanosoma rangeli	43%	99%
A4HNP9	Leishmania braziliensis	87%	100%
A4ICU6	Leishmania infantum	93%	100%
D0A2K9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	99%
Q4Q237	Leishmania major	94%	100%
V5BA10	Trypanosoma cruzi	47%	100%