PDZ domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASF7_LEIMU

TriTrypDb:

LmxM.36.0400

Length:

446

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASF7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	316	318	PF00675	0.507
CLV_NRD_NRD_1	43	45	PF00675	0.604
CLV_NRD_NRD_1	7	9	PF00675	0.402
CLV_NRD_NRD_1	88	90	PF00675	0.535
CLV_PCSK_KEX2_1	265	267	PF00082	0.495
CLV_PCSK_KEX2_1	316	318	PF00082	0.507
CLV_PCSK_KEX2_1	7	9	PF00082	0.463
CLV_PCSK_KEX2_1	88	90	PF00082	0.535
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.495
CLV_PCSK_SKI1_1	265	269	PF00082	0.364
CLV_PCSK_SKI1_1	310	314	PF00082	0.541
CLV_PCSK_SKI1_1	439	443	PF00082	0.461
DEG_SPOP_SBC_1	325	329	PF00917	0.551
DEG_SPOP_SBC_1	63	67	PF00917	0.647
DOC_CKS1_1	281	286	PF01111	0.452
DOC_CKS1_1	408	413	PF01111	0.498
DOC_MAPK_DCC_7	326	335	PF00069	0.537
DOC_MAPK_MEF2A_6	293	302	PF00069	0.452
DOC_MAPK_MEF2A_6	326	335	PF00069	0.537
DOC_MIT_MIM_1	261	270	PF04212	0.530
DOC_SPAK_OSR1_1	8	12	PF12202	0.455
DOC_USP7_MATH_1	118	122	PF00917	0.435
DOC_USP7_MATH_1	187	191	PF00917	0.460
DOC_USP7_MATH_1	255	259	PF00917	0.525
DOC_USP7_MATH_1	289	293	PF00917	0.491
DOC_WW_Pin1_4	16	21	PF00397	0.347
DOC_WW_Pin1_4	280	285	PF00397	0.567
DOC_WW_Pin1_4	321	326	PF00397	0.725
DOC_WW_Pin1_4	346	351	PF00397	0.711
DOC_WW_Pin1_4	353	358	PF00397	0.572
DOC_WW_Pin1_4	407	412	PF00397	0.431
LIG_14-3-3_CanoR_1	108	116	PF00244	0.467
LIG_14-3-3_CanoR_1	120	126	PF00244	0.326
LIG_14-3-3_CanoR_1	366	372	PF00244	0.389
LIG_14-3-3_CanoR_1	405	411	PF00244	0.339
LIG_14-3-3_CanoR_1	427	434	PF00244	0.279
LIG_14-3-3_CanoR_1	439	446	PF00244	0.503
LIG_14-3-3_CanoR_1	44	51	PF00244	0.483
LIG_14-3-3_CanoR_1	88	94	PF00244	0.575
LIG_Actin_WH2_2	233	250	PF00022	0.451
LIG_Actin_WH2_2	263	280	PF00022	0.351
LIG_AP2alpha_2	432	434	PF02296	0.439
LIG_BIR_II_1	1	5	PF00653	0.368
LIG_FHA_1	111	117	PF00498	0.614
LIG_FHA_1	124	130	PF00498	0.340
LIG_FHA_1	213	219	PF00498	0.474
LIG_FHA_1	281	287	PF00498	0.568
LIG_FHA_1	408	414	PF00498	0.545
LIG_FHA_2	122	128	PF00498	0.497
LIG_FHA_2	168	174	PF00498	0.444
LIG_FHA_2	254	260	PF00498	0.484
LIG_FHA_2	360	366	PF00498	0.564
LIG_FHA_2	427	433	PF00498	0.378
LIG_Integrin_isoDGR_2	435	437	PF01839	0.463
LIG_LIR_Gen_1	211	221	PF02991	0.462
LIG_LIR_Nem_3	211	217	PF02991	0.408
LIG_LIR_Nem_3	429	434	PF02991	0.426
LIG_PTB_Apo_2	3	10	PF02174	0.495
LIG_Rb_LxCxE_1	245	261	PF01857	0.470
LIG_SH2_STAP1	125	129	PF00017	0.419
LIG_SH2_STAP1	214	218	PF00017	0.498
LIG_SH2_STAT5	125	128	PF00017	0.518
LIG_SH2_STAT5	21	24	PF00017	0.372
LIG_SH2_STAT5	214	217	PF00017	0.447
LIG_SH2_STAT5	62	65	PF00017	0.457
LIG_SH3_1	278	284	PF00018	0.428
LIG_SH3_3	278	284	PF00018	0.535
LIG_SH3_3	297	303	PF00018	0.648
LIG_SH3_3	349	355	PF00018	0.596
LIG_SH3_3	405	411	PF00018	0.507
LIG_SH3_3	94	100	PF00018	0.532
LIG_SUMO_SIM_anti_2	172	180	PF11976	0.447
LIG_SUMO_SIM_anti_2	24	30	PF11976	0.405
LIG_SUMO_SIM_par_1	21	27	PF11976	0.405
LIG_TRAF2_1	170	173	PF00917	0.443
LIG_TYR_ITIM	92	97	PF00017	0.596
MOD_CDK_SPK_2	321	326	PF00069	0.654
MOD_CK1_1	110	116	PF00069	0.519
MOD_CK1_1	121	127	PF00069	0.385
MOD_CK1_1	200	206	PF00069	0.506
MOD_CK1_1	212	218	PF00069	0.518
MOD_CK1_1	272	278	PF00069	0.550
MOD_CK1_1	319	325	PF00069	0.706
MOD_CK2_1	121	127	PF00069	0.497
MOD_CK2_1	167	173	PF00069	0.484
MOD_CK2_1	255	261	PF00069	0.537
MOD_CK2_1	359	365	PF00069	0.582
MOD_Cter_Amidation	263	266	PF01082	0.337
MOD_DYRK1A_RPxSP_1	321	325	PF00069	0.616
MOD_GlcNHglycan	139	142	PF01048	0.464
MOD_GlcNHglycan	14	17	PF01048	0.424
MOD_GlcNHglycan	339	342	PF01048	0.793
MOD_GlcNHglycan	386	389	PF01048	0.470
MOD_GlcNHglycan	59	62	PF01048	0.658
MOD_GSK3_1	12	19	PF00069	0.342
MOD_GSK3_1	187	194	PF00069	0.410
MOD_GSK3_1	208	215	PF00069	0.496
MOD_GSK3_1	269	276	PF00069	0.476
MOD_GSK3_1	285	292	PF00069	0.482
MOD_GSK3_1	321	328	PF00069	0.686
MOD_GSK3_1	335	342	PF00069	0.623
MOD_GSK3_1	403	410	PF00069	0.607
MOD_GSK3_1	53	60	PF00069	0.717
MOD_GSK3_1	64	71	PF00069	0.664
MOD_N-GLC_1	319	324	PF02516	0.699
MOD_N-GLC_1	33	38	PF02516	0.425
MOD_NEK2_1	12	17	PF00069	0.392
MOD_NEK2_1	137	142	PF00069	0.384
MOD_NEK2_1	181	186	PF00069	0.498
MOD_NEK2_1	210	215	PF00069	0.461
MOD_NEK2_1	335	340	PF00069	0.536
MOD_OFUCOSY	13	18	PF10250	0.481
MOD_PIKK_1	148	154	PF00454	0.522
MOD_PIKK_1	200	206	PF00454	0.434
MOD_PIKK_1	304	310	PF00454	0.710
MOD_PIKK_1	319	325	PF00454	0.618
MOD_PIKK_1	87	93	PF00454	0.627
MOD_PK_1	339	345	PF00069	0.489
MOD_PKA_1	316	322	PF00069	0.508
MOD_PKA_2	107	113	PF00069	0.477
MOD_PKA_2	316	322	PF00069	0.645
MOD_PKA_2	426	432	PF00069	0.298
MOD_PKA_2	43	49	PF00069	0.535
MOD_PKA_2	87	93	PF00069	0.614
MOD_PKB_1	437	445	PF00069	0.502
MOD_Plk_1	118	124	PF00069	0.422
MOD_Plk_4	110	116	PF00069	0.519
MOD_Plk_4	162	168	PF00069	0.447
MOD_Plk_4	24	30	PF00069	0.405
MOD_Plk_4	269	275	PF00069	0.635
MOD_ProDKin_1	16	22	PF00069	0.347
MOD_ProDKin_1	280	286	PF00069	0.568
MOD_ProDKin_1	321	327	PF00069	0.726
MOD_ProDKin_1	346	352	PF00069	0.711
MOD_ProDKin_1	353	359	PF00069	0.568
MOD_ProDKin_1	407	413	PF00069	0.430
MOD_SUMO_for_1	343	346	PF00179	0.499
MOD_SUMO_for_1	39	42	PF00179	0.480
MOD_SUMO_rev_2	127	132	PF00179	0.546
TRG_DiLeu_BaLyEn_6	328	333	PF01217	0.476
TRG_ENDOCYTIC_2	214	217	PF00928	0.446
TRG_ENDOCYTIC_2	431	434	PF00928	0.440
TRG_ENDOCYTIC_2	94	97	PF00928	0.599
TRG_ER_diArg_1	437	440	PF00400	0.506
TRG_ER_diArg_1	7	9	PF00400	0.463
TRG_NES_CRM1_1	191	205	PF08389	0.342
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	439	444	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0I6	Leptomonas seymouri	56%	94%
A0A0S4JLZ1	Bodo saltans	24%	71%
A0A1X0P8C3	Trypanosomatidae	32%	100%
A0A3S5H814	Leishmania donovani	85%	100%
A4HNP8	Leishmania braziliensis	74%	100%
A4ICU7	Leishmania infantum	86%	100%
Q4Q238	Leishmania major	89%	100%
V5DRR0	Trypanosoma cruzi	33%	100%