MYND-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASF6_LEIMU

TriTrypDb:

LmxM.36.0390

Length:

656

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASF6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.681
CLV_C14_Caspase3-7	539	543	PF00656	0.614
CLV_C14_Caspase3-7	56	60	PF00656	0.684
CLV_NRD_NRD_1	16	18	PF00675	0.830
CLV_NRD_NRD_1	267	269	PF00675	0.401
CLV_NRD_NRD_1	450	452	PF00675	0.351
CLV_NRD_NRD_1	495	497	PF00675	0.549
CLV_NRD_NRD_1	548	550	PF00675	0.702
CLV_PCSK_KEX2_1	129	131	PF00082	0.454
CLV_PCSK_KEX2_1	16	18	PF00082	0.746
CLV_PCSK_KEX2_1	267	269	PF00082	0.401
CLV_PCSK_KEX2_1	4	6	PF00082	0.760
CLV_PCSK_KEX2_1	450	452	PF00082	0.336
CLV_PCSK_KEX2_1	495	497	PF00082	0.499
CLV_PCSK_KEX2_1	513	515	PF00082	0.483
CLV_PCSK_KEX2_1	546	548	PF00082	0.589
CLV_PCSK_KEX2_1	607	609	PF00082	0.511
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.494
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.641
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.593
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.587
CLV_PCSK_PC1ET2_1	607	609	PF00082	0.544
CLV_PCSK_SKI1_1	119	123	PF00082	0.529
CLV_PCSK_SKI1_1	267	271	PF00082	0.425
CLV_PCSK_SKI1_1	378	382	PF00082	0.564
CLV_PCSK_SKI1_1	527	531	PF00082	0.419
DEG_APCC_DBOX_1	618	626	PF00400	0.537
DEG_SPOP_SBC_1	288	292	PF00917	0.576
DEG_SPOP_SBC_1	430	434	PF00917	0.445
DOC_CDC14_PxL_1	105	113	PF14671	0.568
DOC_CDC14_PxL_1	403	411	PF14671	0.549
DOC_CYCLIN_RxL_1	116	127	PF00134	0.466
DOC_MAPK_DCC_7	569	577	PF00069	0.662
DOC_MAPK_gen_1	100	108	PF00069	0.620
DOC_MAPK_gen_1	493	503	PF00069	0.458
DOC_MAPK_gen_1	546	554	PF00069	0.689
DOC_MAPK_MEF2A_6	177	186	PF00069	0.362
DOC_MAPK_MEF2A_6	338	345	PF00069	0.806
DOC_MAPK_MEF2A_6	546	554	PF00069	0.533
DOC_MAPK_MEF2A_6	569	577	PF00069	0.662
DOC_MAPK_MEF2A_6	582	589	PF00069	0.636
DOC_PP1_RVXF_1	117	123	PF00149	0.475
DOC_PP1_RVXF_1	376	383	PF00149	0.468
DOC_PP1_RVXF_1	496	503	PF00149	0.516
DOC_PP2B_LxvP_1	587	590	PF13499	0.529
DOC_PP4_FxxP_1	530	533	PF00568	0.571
DOC_PP4_FxxP_1	98	101	PF00568	0.468
DOC_USP7_MATH_1	164	168	PF00917	0.442
DOC_USP7_MATH_1	296	300	PF00917	0.706
DOC_USP7_MATH_1	353	357	PF00917	0.684
DOC_USP7_MATH_1	36	40	PF00917	0.796
DOC_USP7_MATH_1	364	368	PF00917	0.692
DOC_USP7_MATH_1	430	434	PF00917	0.501
DOC_USP7_UBL2_3	342	346	PF12436	0.637
DOC_WW_Pin1_4	650	655	PF00397	0.633
LIG_14-3-3_CanoR_1	135	140	PF00244	0.498
LIG_14-3-3_CanoR_1	173	177	PF00244	0.458
LIG_14-3-3_CanoR_1	297	306	PF00244	0.600
LIG_14-3-3_CanoR_1	504	509	PF00244	0.551
LIG_14-3-3_CanoR_1	62	66	PF00244	0.588
LIG_14-3-3_CanoR_1	77	84	PF00244	0.825
LIG_BIR_II_1	1	5	PF00653	0.759
LIG_BRCT_BRCA1_1	394	398	PF00533	0.535
LIG_Clathr_ClatBox_1	521	525	PF01394	0.480
LIG_CtBP_PxDLS_1	584	588	PF00389	0.627
LIG_eIF4E_1	643	649	PF01652	0.471
LIG_FHA_1	16	22	PF00498	0.508
LIG_FHA_1	254	260	PF00498	0.626
LIG_FHA_1	321	327	PF00498	0.600
LIG_FHA_1	495	501	PF00498	0.530
LIG_FHA_1	503	509	PF00498	0.453
LIG_FHA_2	29	35	PF00498	0.771
LIG_FHA_2	436	442	PF00498	0.433
LIG_FHA_2	537	543	PF00498	0.743
LIG_FHA_2	592	598	PF00498	0.643
LIG_FHA_2	615	621	PF00498	0.477
LIG_FHA_2	8	14	PF00498	0.598
LIG_LIR_Apic_2	95	101	PF02991	0.501
LIG_LIR_Gen_1	438	447	PF02991	0.474
LIG_LIR_Gen_1	644	654	PF02991	0.469
LIG_LIR_Nem_3	102	108	PF02991	0.445
LIG_LIR_Nem_3	138	144	PF02991	0.376
LIG_LIR_Nem_3	232	236	PF02991	0.447
LIG_LIR_Nem_3	438	443	PF02991	0.486
LIG_LIR_Nem_3	448	452	PF02991	0.460
LIG_LIR_Nem_3	644	649	PF02991	0.477
LIG_NRBOX	442	448	PF00104	0.491
LIG_PCNA_yPIPBox_3	564	574	PF02747	0.613
LIG_Pex14_1	642	646	PF04695	0.461
LIG_Pex14_2	452	456	PF04695	0.409
LIG_Rb_pABgroove_1	191	199	PF01858	0.351
LIG_RPA_C_Fungi	446	458	PF08784	0.477
LIG_SH2_CRK	197	201	PF00017	0.395
LIG_SH2_CRK	646	650	PF00017	0.534
LIG_SH2_PTP2	105	108	PF00017	0.622
LIG_SH2_STAP1	610	614	PF00017	0.524
LIG_SH2_STAT3	157	160	PF00017	0.408
LIG_SH2_STAT5	105	108	PF00017	0.570
LIG_SH2_STAT5	141	144	PF00017	0.336
LIG_SH2_STAT5	274	277	PF00017	0.383
LIG_SH2_STAT5	528	531	PF00017	0.410
LIG_SH3_2	107	112	PF14604	0.530
LIG_SH3_2	337	342	PF14604	0.679
LIG_SH3_3	104	110	PF00018	0.579
LIG_SH3_3	201	207	PF00018	0.473
LIG_SH3_3	256	262	PF00018	0.485
LIG_SH3_3	323	329	PF00018	0.617
LIG_SH3_3	334	340	PF00018	0.585
LIG_SH3_3	578	584	PF00018	0.529
LIG_SH3_3	627	633	PF00018	0.540
LIG_SH3_3	634	640	PF00018	0.481
LIG_SH3_3	648	654	PF00018	0.495
LIG_SUMO_SIM_anti_2	505	511	PF11976	0.266
LIG_SUMO_SIM_par_1	218	224	PF11976	0.483
LIG_SUMO_SIM_par_1	519	525	PF11976	0.460
LIG_SUMO_SIM_par_1	647	653	PF11976	0.601
LIG_TRAF2_1	11	14	PF00917	0.652
LIG_TYR_ITIM	139	144	PF00017	0.395
LIG_TYR_ITIM	195	200	PF00017	0.382
LIG_UBA3_1	121	129	PF00899	0.462
LIG_WRC_WIRS_1	230	235	PF05994	0.263
LIG_WRC_WIRS_1	446	451	PF05994	0.472
MOD_CK1_1	19	25	PF00069	0.644
MOD_CK1_1	232	238	PF00069	0.471
MOD_CK1_1	26	32	PF00069	0.642
MOD_CK1_1	3	9	PF00069	0.646
MOD_CK1_1	38	44	PF00069	0.619
MOD_CK1_1	46	52	PF00069	0.606
MOD_CK1_1	55	61	PF00069	0.657
MOD_CK1_1	650	656	PF00069	0.616
MOD_CK1_1	72	78	PF00069	0.554
MOD_CK2_1	435	441	PF00069	0.487
MOD_CK2_1	50	56	PF00069	0.689
MOD_CK2_1	591	597	PF00069	0.529
MOD_CK2_1	603	609	PF00069	0.492
MOD_CK2_1	614	620	PF00069	0.561
MOD_CK2_1	7	13	PF00069	0.511
MOD_Cter_Amidation	511	514	PF01082	0.498
MOD_GlcNHglycan	166	169	PF01048	0.557
MOD_GlcNHglycan	178	181	PF01048	0.466
MOD_GlcNHglycan	18	21	PF01048	0.713
MOD_GlcNHglycan	276	279	PF01048	0.489
MOD_GlcNHglycan	291	294	PF01048	0.586
MOD_GlcNHglycan	299	302	PF01048	0.609
MOD_GlcNHglycan	433	436	PF01048	0.402
MOD_GlcNHglycan	46	49	PF01048	0.639
MOD_GlcNHglycan	52	55	PF01048	0.671
MOD_GlcNHglycan	578	581	PF01048	0.622
MOD_GlcNHglycan	626	629	PF01048	0.550
MOD_GlcNHglycan	71	74	PF01048	0.693
MOD_GSK3_1	15	22	PF00069	0.645
MOD_GSK3_1	172	179	PF00069	0.542
MOD_GSK3_1	23	30	PF00069	0.635
MOD_GSK3_1	270	277	PF00069	0.368
MOD_GSK3_1	3	10	PF00069	0.632
MOD_GSK3_1	34	41	PF00069	0.745
MOD_GSK3_1	42	49	PF00069	0.493
MOD_GSK3_1	431	438	PF00069	0.498
MOD_GSK3_1	50	57	PF00069	0.625
MOD_GSK3_1	71	78	PF00069	0.665
MOD_N-GLC_1	22	27	PF02516	0.811
MOD_N-GLC_1	481	486	PF02516	0.392
MOD_NEK2_1	196	201	PF00069	0.441
MOD_NEK2_1	365	370	PF00069	0.655
MOD_NEK2_1	381	386	PF00069	0.539
MOD_NEK2_1	429	434	PF00069	0.413
MOD_NEK2_1	603	608	PF00069	0.510
MOD_NEK2_2	322	327	PF00069	0.551
MOD_NEK2_2	366	371	PF00069	0.651
MOD_NEK2_2	435	440	PF00069	0.519
MOD_NEK2_2	445	450	PF00069	0.430
MOD_PIKK_1	392	398	PF00454	0.361
MOD_PIKK_1	481	487	PF00454	0.407
MOD_PIKK_1	78	84	PF00454	0.702
MOD_PK_1	260	266	PF00069	0.462
MOD_PKA_1	16	22	PF00069	0.643
MOD_PKA_2	15	21	PF00069	0.743
MOD_PKA_2	172	178	PF00069	0.461
MOD_PKA_2	296	302	PF00069	0.748
MOD_PKA_2	494	500	PF00069	0.566
MOD_PKA_2	61	67	PF00069	0.739
MOD_PKA_2	76	82	PF00069	0.791
MOD_Plk_1	597	603	PF00069	0.614
MOD_Plk_4	226	232	PF00069	0.431
MOD_Plk_4	270	276	PF00069	0.367
MOD_Plk_4	381	387	PF00069	0.508
MOD_Plk_4	435	441	PF00069	0.502
MOD_Plk_4	504	510	PF00069	0.373
MOD_ProDKin_1	650	656	PF00069	0.638
MOD_SUMO_for_1	269	272	PF00179	0.417
MOD_SUMO_rev_2	507	515	PF00179	0.420
TRG_DiLeu_BaEn_1	421	426	PF01217	0.482
TRG_ENDOCYTIC_2	105	108	PF00928	0.580
TRG_ENDOCYTIC_2	141	144	PF00928	0.353
TRG_ENDOCYTIC_2	197	200	PF00928	0.365
TRG_ENDOCYTIC_2	646	649	PF00928	0.466
TRG_ER_diArg_1	15	17	PF00400	0.805
TRG_ER_diArg_1	267	269	PF00400	0.445
TRG_ER_diArg_1	449	451	PF00400	0.349
TRG_ER_diArg_1	495	498	PF00400	0.552
TRG_ER_diArg_1	547	549	PF00400	0.672
TRG_NES_CRM1_1	113	127	PF08389	0.435
TRG_NES_CRM1_1	499	511	PF08389	0.402
TRG_NES_CRM1_1	556	568	PF08389	0.660
TRG_NLS_MonoCore_2	545	550	PF00514	0.666
TRG_NLS_MonoExtC_3	545	550	PF00514	0.641
TRG_NLS_MonoExtN_4	544	550	PF00514	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Z4	Leptomonas seymouri	69%	100%
A0A0S4JPG4	Bodo saltans	30%	100%
A0A1X0P8L9	Trypanosomatidae	40%	100%
A0A3S7XAH7	Leishmania donovani	90%	99%
A0A422P299	Trypanosoma rangeli	39%	100%
A4HNP7	Leishmania braziliensis	85%	100%
A4ICU8	Leishmania infantum	90%	99%
D0A2K5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	98%
Q4Q239	Leishmania major	90%	100%
V5BZZ1	Trypanosoma cruzi	41%	100%