LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9ASF5_LEIMU
TriTrypDb:
LmxM.36.0380
Length:
153

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 10
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9ASF5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASF5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 101 103 PF00675 0.491
CLV_NRD_NRD_1 147 149 PF00675 0.619
CLV_NRD_NRD_1 30 32 PF00675 0.491
CLV_PCSK_KEX2_1 29 31 PF00082 0.505
CLV_PCSK_KEX2_1 99 101 PF00082 0.499
CLV_PCSK_PC1ET2_1 99 101 PF00082 0.499
CLV_PCSK_PC7_1 26 32 PF00082 0.509
CLV_PCSK_SKI1_1 31 35 PF00082 0.516
DOC_USP7_MATH_1 112 116 PF00917 0.708
DOC_USP7_MATH_1 121 125 PF00917 0.639
DOC_USP7_MATH_1 132 136 PF00917 0.549
DOC_USP7_MATH_1 62 66 PF00917 0.722
DOC_USP7_MATH_1 70 74 PF00917 0.615
DOC_USP7_MATH_1 86 90 PF00917 0.593
DOC_USP7_UBL2_3 145 149 PF12436 0.581
DOC_WW_Pin1_4 113 118 PF00397 0.757
DOC_WW_Pin1_4 44 49 PF00397 0.707
DOC_WW_Pin1_4 60 65 PF00397 0.664
LIG_BIR_II_1 1 5 PF00653 0.613
LIG_SH2_STAT3 75 78 PF00017 0.753
LIG_SH2_STAT3 90 93 PF00017 0.429
LIG_SH2_STAT5 53 56 PF00017 0.699
LIG_SH2_STAT5 90 93 PF00017 0.523
LIG_UBA3_1 91 99 PF00899 0.586
MOD_CK1_1 63 69 PF00069 0.704
MOD_CK1_1 71 77 PF00069 0.679
MOD_CK2_1 138 144 PF00069 0.588
MOD_GlcNHglycan 110 113 PF01048 0.689
MOD_GlcNHglycan 65 68 PF01048 0.661
MOD_GlcNHglycan 70 73 PF01048 0.631
MOD_GlcNHglycan 75 78 PF01048 0.605
MOD_GSK3_1 104 111 PF00069 0.656
MOD_GSK3_1 56 63 PF00069 0.672
MOD_N-GLC_1 108 113 PF02516 0.532
MOD_NEK2_2 138 143 PF00069 0.455
MOD_PIKK_1 123 129 PF00454 0.773
MOD_PIKK_1 132 138 PF00454 0.743
MOD_Plk_1 108 114 PF00069 0.512
MOD_Plk_1 138 144 PF00069 0.649
MOD_Plk_1 56 62 PF00069 0.753
MOD_Plk_4 86 92 PF00069 0.641
MOD_ProDKin_1 113 119 PF00069 0.758
MOD_ProDKin_1 44 50 PF00069 0.708
MOD_ProDKin_1 60 66 PF00069 0.663
TRG_ER_diArg_1 100 102 PF00400 0.505
TRG_ER_diArg_1 29 31 PF00400 0.520

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7D8 Leptomonas seymouri 47% 81%
A0A0S4JKZ0 Bodo saltans 37% 100%
A0A1X0P8A6 Trypanosomatidae 33% 100%
A0A3S7XA93 Leishmania donovani 90% 100%
A0A422P2F7 Trypanosoma rangeli 41% 100%
A4HNP6 Leishmania braziliensis 71% 96%
A4ICU9 Leishmania infantum 90% 100%
D0A2K4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
Q4Q240 Leishmania major 88% 100%
V5BV99 Trypanosoma cruzi 44% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS