Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASF2_LEIMU

TriTrypDb:

LmxM.36.0350

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASF2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.664
CLV_NRD_NRD_1	131	133	PF00675	0.506
CLV_NRD_NRD_1	161	163	PF00675	0.564
CLV_NRD_NRD_1	248	250	PF00675	0.573
CLV_NRD_NRD_1	251	253	PF00675	0.548
CLV_NRD_NRD_1	304	306	PF00675	0.347
CLV_NRD_NRD_1	308	310	PF00675	0.318
CLV_NRD_NRD_1	429	431	PF00675	0.417
CLV_NRD_NRD_1	47	49	PF00675	0.665
CLV_NRD_NRD_1	486	488	PF00675	0.485
CLV_NRD_NRD_1	5	7	PF00675	0.582
CLV_NRD_NRD_1	92	94	PF00675	0.595
CLV_PCSK_FUR_1	249	253	PF00082	0.537
CLV_PCSK_FUR_1	427	431	PF00082	0.588
CLV_PCSK_FUR_1	45	49	PF00082	0.658
CLV_PCSK_KEX2_1	161	163	PF00082	0.603
CLV_PCSK_KEX2_1	248	250	PF00082	0.573
CLV_PCSK_KEX2_1	251	253	PF00082	0.548
CLV_PCSK_KEX2_1	308	310	PF00082	0.324
CLV_PCSK_KEX2_1	429	431	PF00082	0.417
CLV_PCSK_KEX2_1	47	49	PF00082	0.665
CLV_PCSK_KEX2_1	5	7	PF00082	0.579
CLV_PCSK_SKI1_1	214	218	PF00082	0.520
CLV_PCSK_SKI1_1	239	243	PF00082	0.511
CLV_PCSK_SKI1_1	342	346	PF00082	0.627
CLV_PCSK_SKI1_1	59	63	PF00082	0.696
DEG_COP1_1	371	380	PF00400	0.443
DEG_Nend_UBRbox_3	1	3	PF02207	0.744
DEG_SCF_FBW7_1	442	447	PF00400	0.512
DEG_SPOP_SBC_1	7	11	PF00917	0.520
DOC_MAPK_gen_1	287	296	PF00069	0.417
DOC_MAPK_gen_1	494	502	PF00069	0.397
DOC_PP1_RVXF_1	212	218	PF00149	0.521
DOC_PP1_RVXF_1	242	248	PF00149	0.521
DOC_PP2B_LxvP_1	216	219	PF13499	0.515
DOC_PP2B_LxvP_1	264	267	PF13499	0.576
DOC_PP2B_LxvP_1	51	54	PF13499	0.693
DOC_PP4_FxxP_1	62	65	PF00568	0.692
DOC_USP7_MATH_1	106	110	PF00917	0.687
DOC_USP7_MATH_1	368	372	PF00917	0.654
DOC_USP7_MATH_1	376	380	PF00917	0.530
DOC_WW_Pin1_4	154	159	PF00397	0.654
DOC_WW_Pin1_4	332	337	PF00397	0.669
DOC_WW_Pin1_4	440	445	PF00397	0.514
LIG_14-3-3_CanoR_1	161	171	PF00244	0.597
LIG_14-3-3_CanoR_1	255	263	PF00244	0.579
LIG_14-3-3_CanoR_1	354	364	PF00244	0.513
LIG_14-3-3_CanoR_1	47	52	PF00244	0.672
LIG_14-3-3_CanoR_1	5	15	PF00244	0.711
LIG_14-3-3_CanoR_1	88	93	PF00244	0.628
LIG_Actin_WH2_2	256	274	PF00022	0.525
LIG_Actin_WH2_2	77	95	PF00022	0.517
LIG_BRCT_BRCA1_1	403	407	PF00533	0.473
LIG_CaM_IQ_9	282	297	PF13499	0.504
LIG_Clathr_ClatBox_1	397	401	PF01394	0.467
LIG_eIF4E_1	210	216	PF01652	0.531
LIG_FHA_1	176	182	PF00498	0.547
LIG_FHA_1	210	216	PF00498	0.415
LIG_FHA_1	232	238	PF00498	0.536
LIG_FHA_1	401	407	PF00498	0.465
LIG_FHA_1	468	474	PF00498	0.354
LIG_FHA_2	129	135	PF00498	0.643
LIG_FHA_2	338	344	PF00498	0.436
LIG_FHA_2	429	435	PF00498	0.403
LIG_LIR_Gen_1	257	267	PF02991	0.539
LIG_LIR_Gen_1	313	321	PF02991	0.490
LIG_LIR_Gen_1	404	415	PF02991	0.427
LIG_LIR_Gen_1	466	473	PF02991	0.465
LIG_LIR_Gen_1	79	85	PF02991	0.510
LIG_LIR_Nem_3	205	210	PF02991	0.443
LIG_LIR_Nem_3	257	263	PF02991	0.547
LIG_LIR_Nem_3	301	307	PF02991	0.467
LIG_LIR_Nem_3	313	319	PF02991	0.360
LIG_LIR_Nem_3	333	337	PF02991	0.395
LIG_LIR_Nem_3	404	410	PF02991	0.409
LIG_LIR_Nem_3	466	472	PF02991	0.469
LIG_LIR_Nem_3	79	84	PF02991	0.558
LIG_Pex14_2	217	221	PF04695	0.515
LIG_PTB_Apo_2	472	479	PF02174	0.451
LIG_PTB_Phospho_1	472	478	PF10480	0.446
LIG_SH2_CRK	210	214	PF00017	0.534
LIG_SH2_CRK	304	308	PF00017	0.465
LIG_SH2_CRK	469	473	PF00017	0.395
LIG_SH2_CRK	81	85	PF00017	0.513
LIG_SH2_PTP2	240	243	PF00017	0.375
LIG_SH2_STAP1	373	377	PF00017	0.622
LIG_SH2_STAP1	380	384	PF00017	0.527
LIG_SH2_STAP1	469	473	PF00017	0.395
LIG_SH2_STAP1	81	85	PF00017	0.513
LIG_SH2_STAT5	240	243	PF00017	0.375
LIG_SH2_STAT5	469	472	PF00017	0.386
LIG_SH2_STAT5	478	481	PF00017	0.434
LIG_SH2_STAT5	60	63	PF00017	0.644
LIG_SH3_3	13	19	PF00018	0.690
LIG_SH3_3	65	71	PF00018	0.567
LIG_TYR_ITIM	302	307	PF00017	0.464
LIG_UBA3_1	216	222	PF00899	0.514
MOD_CDK_SPK_2	154	159	PF00069	0.654
MOD_CDK_SPxxK_3	154	161	PF00069	0.517
MOD_CDK_SPxxK_3	332	339	PF00069	0.670
MOD_CK1_1	149	155	PF00069	0.697
MOD_CK1_1	165	171	PF00069	0.517
MOD_CK1_1	188	194	PF00069	0.643
MOD_CK1_1	198	204	PF00069	0.534
MOD_CK1_1	467	473	PF00069	0.268
MOD_CK1_1	8	14	PF00069	0.582
MOD_CK1_1	96	102	PF00069	0.673
MOD_CK2_1	110	116	PF00069	0.561
MOD_CK2_1	337	343	PF00069	0.434
MOD_CK2_1	428	434	PF00069	0.508
MOD_Cter_Amidation	159	162	PF01082	0.556
MOD_DYRK1A_RPxSP_1	332	336	PF00069	0.556
MOD_GlcNHglycan	108	111	PF01048	0.695
MOD_GlcNHglycan	167	170	PF01048	0.503
MOD_GlcNHglycan	187	190	PF01048	0.568
MOD_GlcNHglycan	192	195	PF01048	0.559
MOD_GlcNHglycan	23	26	PF01048	0.564
MOD_GlcNHglycan	366	369	PF01048	0.614
MOD_GlcNHglycan	403	406	PF01048	0.464
MOD_GlcNHglycan	412	415	PF01048	0.423
MOD_GlcNHglycan	438	441	PF01048	0.463
MOD_GlcNHglycan	97	101	PF01048	0.630
MOD_GSK3_1	106	113	PF00069	0.566
MOD_GSK3_1	147	154	PF00069	0.640
MOD_GSK3_1	250	257	PF00069	0.534
MOD_GSK3_1	355	362	PF00069	0.615
MOD_GSK3_1	364	371	PF00069	0.576
MOD_GSK3_1	436	443	PF00069	0.492
MOD_GSK3_1	445	452	PF00069	0.496
MOD_GSK3_1	473	480	PF00069	0.453
MOD_GSK3_1	60	67	PF00069	0.691
MOD_GSK3_1	80	87	PF00069	0.487
MOD_GSK3_1	88	95	PF00069	0.606
MOD_LATS_1	86	92	PF00433	0.595
MOD_N-GLC_1	369	374	PF02516	0.577
MOD_N-GLC_1	445	450	PF02516	0.449
MOD_N-GLC_1	473	478	PF02516	0.448
MOD_N-GLC_2	475	477	PF02516	0.442
MOD_NEK2_1	148	153	PF00069	0.690
MOD_NEK2_1	185	190	PF00069	0.569
MOD_NEK2_1	23	28	PF00069	0.577
MOD_NEK2_1	355	360	PF00069	0.505
MOD_NEK2_1	400	405	PF00069	0.470
MOD_NEK2_1	410	415	PF00069	0.405
MOD_NEK2_1	423	428	PF00069	0.443
MOD_NEK2_1	449	454	PF00069	0.590
MOD_NEK2_1	473	478	PF00069	0.448
MOD_NEK2_2	209	214	PF00069	0.458
MOD_PIKK_1	135	141	PF00454	0.577
MOD_PIKK_1	163	169	PF00454	0.615
MOD_PIKK_1	188	194	PF00454	0.478
MOD_PIKK_1	355	361	PF00454	0.469
MOD_PIKK_1	98	104	PF00454	0.547
MOD_PKA_1	47	53	PF00069	0.656
MOD_PKA_1	5	11	PF00069	0.571
MOD_PKA_1	93	99	PF00069	0.594
MOD_PKA_2	163	169	PF00069	0.612
MOD_PKA_2	185	191	PF00069	0.454
MOD_PKA_2	250	256	PF00069	0.511
MOD_PKA_2	359	365	PF00069	0.635
MOD_PKA_2	428	434	PF00069	0.417
MOD_PKA_2	47	53	PF00069	0.656
MOD_PKA_2	5	11	PF00069	0.583
MOD_PKA_2	92	98	PF00069	0.543
MOD_PKB_1	45	53	PF00069	0.705
MOD_Plk_1	135	141	PF00069	0.627
MOD_Plk_1	369	375	PF00069	0.596
MOD_Plk_1	445	451	PF00069	0.450
MOD_Plk_1	473	479	PF00069	0.454
MOD_Plk_2-3	177	183	PF00069	0.416
MOD_Plk_4	256	262	PF00069	0.595
MOD_Plk_4	393	399	PF00069	0.474
MOD_Plk_4	445	451	PF00069	0.482
MOD_Plk_4	464	470	PF00069	0.457
MOD_Plk_4	478	484	PF00069	0.345
MOD_Plk_4	80	86	PF00069	0.540
MOD_ProDKin_1	154	160	PF00069	0.654
MOD_ProDKin_1	332	338	PF00069	0.667
MOD_ProDKin_1	440	446	PF00069	0.516
MOD_SUMO_rev_2	481	489	PF00179	0.469
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.527
TRG_ENDOCYTIC_2	210	213	PF00928	0.535
TRG_ENDOCYTIC_2	240	243	PF00928	0.375
TRG_ENDOCYTIC_2	304	307	PF00928	0.465
TRG_ENDOCYTIC_2	469	472	PF00928	0.448
TRG_ENDOCYTIC_2	81	84	PF00928	0.514
TRG_ER_diArg_1	161	164	PF00400	0.623
TRG_ER_diArg_1	247	249	PF00400	0.585
TRG_ER_diArg_1	293	296	PF00400	0.451
TRG_ER_diArg_1	307	309	PF00400	0.284
TRG_ER_diArg_1	352	355	PF00400	0.646
TRG_ER_diArg_1	4	6	PF00400	0.549
TRG_ER_diArg_1	427	430	PF00400	0.431
TRG_ER_diArg_1	45	48	PF00400	0.674
TRG_ER_diArg_1	450	453	PF00400	0.596
TRG_ER_diArg_1	493	496	PF00400	0.524
TRG_NLS_MonoExtC_3	304	309	PF00514	0.474
TRG_Pf-PMV_PEXEL_1	305	310	PF00026	0.295
TRG_Pf-PMV_PEXEL_1	462	466	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJS5	Leishmania donovani	84%	100%
A4HNP3	Leishmania braziliensis	60%	100%
A4ICV2	Leishmania infantum	83%	100%
Q4Q243	Leishmania major	83%	100%