Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASE6_LEIMU

TriTrypDb:

LmxM.36.0290

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 6
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9ASE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASE6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.604
CLV_NRD_NRD_1	138	140	PF00675	0.622
CLV_NRD_NRD_1	3	5	PF00675	0.468
CLV_NRD_NRD_1	94	96	PF00675	0.688
CLV_PCSK_KEX2_1	102	104	PF00082	0.604
CLV_PCSK_KEX2_1	138	140	PF00082	0.622
CLV_PCSK_KEX2_1	2	4	PF00082	0.523
CLV_PCSK_KEX2_1	94	96	PF00082	0.688
CLV_PCSK_PC7_1	98	104	PF00082	0.684
CLV_PCSK_SKI1_1	236	240	PF00082	0.709
DEG_MDM2_SWIB_1	300	308	PF02201	0.412
DEG_Nend_UBRbox_1	1	4	PF02207	0.729
DOC_CYCLIN_yCln2_LP_2	251	254	PF00134	0.569
DOC_MAPK_MEF2A_6	166	173	PF00069	0.426
DOC_PP2B_LxvP_1	251	254	PF13499	0.533
DOC_PP4_FxxP_1	35	38	PF00568	0.545
DOC_USP7_MATH_1	142	146	PF00917	0.502
DOC_USP7_MATH_1	194	198	PF00917	0.487
DOC_USP7_MATH_1	306	310	PF00917	0.550
DOC_WW_Pin1_4	214	219	PF00397	0.497
LIG_14-3-3_CanoR_1	102	108	PF00244	0.408
LIG_14-3-3_CanoR_1	206	216	PF00244	0.482
LIG_AP2alpha_2	242	244	PF02296	0.474
LIG_APCC_ABBA_1	216	221	PF00400	0.584
LIG_BIR_III_4	71	75	PF00653	0.331
LIG_EH1_1	11	19	PF00400	0.429
LIG_eIF4E_1	13	19	PF01652	0.502
LIG_FHA_1	294	300	PF00498	0.420
LIG_FHA_2	158	164	PF00498	0.487
LIG_FHA_2	66	72	PF00498	0.543
LIG_LIR_Apic_2	135	140	PF02991	0.499
LIG_LIR_Gen_1	273	280	PF02991	0.466
LIG_LIR_Nem_3	241	247	PF02991	0.527
LIG_LIR_Nem_3	273	277	PF02991	0.437
LIG_LIR_Nem_3	309	313	PF02991	0.684
LIG_LIR_Nem_3	31	35	PF02991	0.460
LIG_MYND_1	249	253	PF01753	0.531
LIG_NRBOX	20	26	PF00104	0.469
LIG_Pex14_1	240	244	PF04695	0.436
LIG_Pex14_1	311	315	PF04695	0.635
LIG_Pex14_2	300	304	PF04695	0.376
LIG_PTB_Apo_2	258	265	PF02174	0.456
LIG_PTB_Phospho_1	258	264	PF10480	0.458
LIG_RPA_C_Fungi	193	205	PF08784	0.542
LIG_SH2_CRK	115	119	PF00017	0.331
LIG_SH2_CRK	274	278	PF00017	0.624
LIG_SH2_NCK_1	127	131	PF00017	0.589
LIG_SH2_SRC	113	116	PF00017	0.618
LIG_SH2_STAP1	155	159	PF00017	0.522
LIG_SH2_STAT5	174	177	PF00017	0.502
LIG_SH2_STAT5	264	267	PF00017	0.562
LIG_SH2_STAT5	274	277	PF00017	0.498
LIG_SH3_3	240	246	PF00018	0.628
LIG_TRAF2_1	145	148	PF00917	0.656
LIG_TYR_ITIM	272	277	PF00017	0.621
LIG_TYR_ITIM	308	313	PF00017	0.556
LIG_WW_3	252	256	PF00397	0.634
MOD_CDK_SPxK_1	214	220	PF00069	0.686
MOD_CK1_1	157	163	PF00069	0.546
MOD_CK1_1	62	68	PF00069	0.629
MOD_CK2_1	142	148	PF00069	0.633
MOD_CK2_1	157	163	PF00069	0.477
MOD_CK2_1	194	200	PF00069	0.571
MOD_GlcNHglycan	7	10	PF01048	0.660
MOD_GSK3_1	155	162	PF00069	0.540
MOD_GSK3_1	219	226	PF00069	0.687
MOD_GSK3_1	24	31	PF00069	0.368
MOD_N-GLC_1	65	70	PF02516	0.562
MOD_NEK2_1	24	29	PF00069	0.400
MOD_NEK2_1	272	277	PF00069	0.531
MOD_NEK2_1	280	285	PF00069	0.512
MOD_NEK2_1	300	305	PF00069	0.459
MOD_NEK2_1	59	64	PF00069	0.534
MOD_NEK2_2	231	236	PF00069	0.681
MOD_PIKK_1	207	213	PF00454	0.595
MOD_PKA_2	219	225	PF00069	0.658
MOD_PKB_1	190	198	PF00069	0.574
MOD_Plk_2-3	87	93	PF00069	0.658
MOD_Plk_4	264	270	PF00069	0.604
MOD_Plk_4	272	278	PF00069	0.606
MOD_Plk_4	282	288	PF00069	0.314
MOD_Plk_4	306	312	PF00069	0.597
MOD_Plk_4	59	65	PF00069	0.598
MOD_ProDKin_1	214	220	PF00069	0.634
TRG_DiLeu_BaEn_3	91	97	PF01217	0.628
TRG_ENDOCYTIC_2	115	118	PF00928	0.336
TRG_ENDOCYTIC_2	274	277	PF00928	0.554
TRG_ENDOCYTIC_2	310	313	PF00928	0.638
TRG_ER_diArg_1	1	4	PF00400	0.673
TRG_ER_diArg_1	102	104	PF00400	0.498
TRG_ER_diArg_1	137	139	PF00400	0.472
TRG_ER_diArg_1	203	206	PF00400	0.603
TRG_ER_diArg_1	94	96	PF00400	0.615
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Z7	Leptomonas seymouri	47%	99%
A0A3R7NUC0	Trypanosoma rangeli	25%	100%
A0A3S7XAG8	Leishmania donovani	93%	100%
A4HNN7	Leishmania braziliensis	77%	100%
A4ICV8	Leishmania infantum	92%	100%
Q4Q249	Leishmania major	91%	100%