TFIIS central domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASE5_LEIMU

TriTrypDb:

LmxM.36.0280

Length:

201

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASE5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006351	DNA-templated transcription	7	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009058	biosynthetic process	2	3
GO:0009059	macromolecule biosynthetic process	4	3
GO:0009987	cellular process	1	3
GO:0016070	RNA metabolic process	5	3
GO:0018130	heterocycle biosynthetic process	4	3
GO:0019438	aromatic compound biosynthetic process	4	3
GO:0032774	RNA biosynthetic process	5	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0034654	nucleobase-containing compound biosynthetic process	4	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044249	cellular biosynthetic process	3	3
GO:0044271	cellular nitrogen compound biosynthetic process	4	3
GO:0046483	heterocycle metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:0097659	nucleic acid-templated transcription	6	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:1901362	organic cyclic compound biosynthetic process	4	3
GO:1901576	organic substance biosynthetic process	3	3

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.669
CLV_C14_Caspase3-7	9	13	PF00656	0.618
CLV_NRD_NRD_1	112	114	PF00675	0.508
CLV_NRD_NRD_1	136	138	PF00675	0.506
CLV_NRD_NRD_1	81	83	PF00675	0.557
CLV_PCSK_KEX2_1	105	107	PF00082	0.473
CLV_PCSK_KEX2_1	114	116	PF00082	0.442
CLV_PCSK_KEX2_1	136	138	PF00082	0.506
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.493
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.428
DEG_SPOP_SBC_1	5	9	PF00917	0.601
DOC_CYCLIN_yClb5_NLxxxL_5	69	75	PF00134	0.461
DOC_MAPK_gen_1	136	142	PF00069	0.502
DOC_MAPK_MEF2A_6	14	23	PF00069	0.438
DOC_USP7_MATH_1	146	150	PF00917	0.517
DOC_USP7_MATH_1	193	197	PF00917	0.647
DOC_USP7_MATH_1	5	9	PF00917	0.607
DOC_USP7_MATH_1	98	102	PF00917	0.640
DOC_WW_Pin1_4	7	12	PF00397	0.575
LIG_14-3-3_CanoR_1	37	47	PF00244	0.578
LIG_BIR_II_1	1	5	PF00653	0.601
LIG_FHA_2	118	124	PF00498	0.555
LIG_FHA_2	192	198	PF00498	0.729
LIG_GBD_Chelix_1	15	23	PF00786	0.432
LIG_Pex14_2	156	160	PF04695	0.500
LIG_SH2_STAP1	39	43	PF00017	0.404
LIG_SH2_STAT3	39	42	PF00017	0.451
LIG_TRAF2_1	170	173	PF00917	0.625
LIG_TRAF2_1	53	56	PF00917	0.540
LIG_UBA3_1	61	69	PF00899	0.460
MOD_CDK_SPxxK_3	7	14	PF00069	0.414
MOD_CK1_1	149	155	PF00069	0.552
MOD_CK1_1	167	173	PF00069	0.570
MOD_CK1_1	188	194	PF00069	0.675
MOD_CK1_1	3	9	PF00069	0.704
MOD_CK2_1	166	172	PF00069	0.609
MOD_CK2_1	174	180	PF00069	0.680
MOD_CK2_1	48	54	PF00069	0.451
MOD_CK2_1	84	90	PF00069	0.519
MOD_GlcNHglycan	150	154	PF01048	0.603
MOD_GlcNHglycan	176	179	PF01048	0.755
MOD_GlcNHglycan	3	6	PF01048	0.719
MOD_GlcNHglycan	86	89	PF01048	0.573
MOD_GSK3_1	1	8	PF00069	0.714
MOD_GSK3_1	104	111	PF00069	0.572
MOD_GSK3_1	123	130	PF00069	0.416
MOD_GSK3_1	160	167	PF00069	0.623
MOD_GSK3_1	191	198	PF00069	0.613
MOD_N-GLC_2	162	164	PF02516	0.446
MOD_NEK2_1	1	6	PF00069	0.701
MOD_NEK2_1	108	113	PF00069	0.560
MOD_NEK2_1	127	132	PF00069	0.315
MOD_NEK2_1	160	165	PF00069	0.531
MOD_PIKK_1	38	44	PF00454	0.402
MOD_PIKK_1	76	82	PF00454	0.594
MOD_PKA_2	173	179	PF00069	0.709
MOD_PKB_1	115	123	PF00069	0.552
MOD_Plk_1	122	128	PF00069	0.474
MOD_Plk_1	182	188	PF00069	0.712
MOD_Plk_2-3	90	96	PF00069	0.582
MOD_ProDKin_1	7	13	PF00069	0.561
MOD_SUMO_rev_2	7	16	PF00179	0.585
MOD_SUMO_rev_2	79	84	PF00179	0.741
TRG_ER_diArg_1	112	115	PF00400	0.479
TRG_ER_diArg_1	135	137	PF00400	0.490
TRG_ER_diArg_1	99	102	PF00400	0.507
TRG_NLS_MonoExtC_3	112	117	PF00514	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7E0	Leptomonas seymouri	61%	100%
A0A0S4JM83	Bodo saltans	32%	100%
A0A1X0P8N4	Trypanosomatidae	44%	100%
A0A3Q8IVQ2	Leishmania donovani	93%	70%
A0A422P2F0	Trypanosoma rangeli	45%	100%
A4HNN6	Leishmania braziliensis	78%	100%
A4ICV9	Leishmania infantum	94%	100%
D0A2I9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4Q250	Leishmania major	93%	100%
V5DRU1	Trypanosoma cruzi	46%	100%