eIF3-interacting protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 3 subunit l

Species:

Leishmania mexicana

UniProt:

E9ASE2_LEIMU

TriTrypDb:

LmxM.36.0250

Length:

544

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005852	eukaryotic translation initiation factor 3 complex	2	12
GO:0016020	membrane	2	2
GO:0016282	eukaryotic 43S preinitiation complex	4	5
GO:0032991	protein-containing complex	1	12
GO:0033290	eukaryotic 48S preinitiation complex	4	5
GO:0070993	translation preinitiation complex	3	5
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	5

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Expansion

Sequence features

E9ASE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASE2

Function

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Biological processes
Term	Name	Level	Count
GO:0001732	formation of cytoplasmic translation initiation complex	7	5
GO:0006413	translational initiation	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	5
GO:0016043	cellular component organization	3	5
GO:0022607	cellular component assembly	4	5
GO:0022618	ribonucleoprotein complex assembly	6	5
GO:0043933	protein-containing complex organization	4	5
GO:0044237	cellular metabolic process	2	1
GO:0065003	protein-containing complex assembly	5	5

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003743	translation initiation factor activity	4	12
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	162	166	PF00656	0.608
CLV_C14_Caspase3-7	27	31	PF00656	0.592
CLV_C14_Caspase3-7	302	306	PF00656	0.600
CLV_MEL_PAP_1	229	235	PF00089	0.408
CLV_NRD_NRD_1	262	264	PF00675	0.336
CLV_NRD_NRD_1	272	274	PF00675	0.390
CLV_NRD_NRD_1	28	30	PF00675	0.593
CLV_NRD_NRD_1	306	308	PF00675	0.315
CLV_NRD_NRD_1	363	365	PF00675	0.328
CLV_NRD_NRD_1	472	474	PF00675	0.583

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDA7	Leptomonas seymouri	78%	100%
A0A0S4KNQ8	Bodo saltans	35%	100%
A0A1X0P8D7	Trypanosomatidae	53%	100%
A0A3Q8IIN0	Leishmania donovani	98%	100%
A0A3R7KQY4	Trypanosoma rangeli	53%	100%
A1C690	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	23%	100%
A1DGW6	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	23%	100%
A2R7S7	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	23%	100%
A4HNN3	Leishmania braziliensis	97%	100%
A4ICW2	Leishmania infantum	98%	100%

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