Dolichol-phosphate mannosyltransferase subunit 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dolichyl-phosphate beta-D-mannosyltransferase precursor, conserved

Species:

Leishmania mexicana

UniProt:

E9ASD9_LEIMU

TriTrypDb:

LmxM.36.0220

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	12
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0016020	membrane	2	10
GO:0031090	organelle membrane	3	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12

Previous1 2Next

Expansion

Sequence features

E9ASD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASD9

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	1
GO:0006486	protein glycosylation	4	12
GO:0006493	protein O-linked glycosylation	5	1
GO:0006497	protein lipidation	5	1
GO:0006505	GPI anchor metabolic process	6	1
GO:0006506	GPI anchor biosynthetic process	6	1
GO:0006629	lipid metabolic process	3	1
GO:0006643	membrane lipid metabolic process	4	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006650	glycerophospholipid metabolic process	5	1

Previous1 2 3 4 5 6Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0000030	mannosyltransferase activity	5	12
GO:0003824	catalytic activity	1	12
GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016757	glycosyltransferase activity	3	12
GO:0016758	hexosyltransferase activity	4	12

Previous1Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	139	141	PF00675	0.253
CLV_NRD_NRD_1	21	23	PF00675	0.339
CLV_PCSK_KEX2_1	139	141	PF00082	0.253
CLV_PCSK_KEX2_1	172	174	PF00082	0.368
CLV_PCSK_KEX2_1	21	23	PF00082	0.293
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.388
CLV_PCSK_SKI1_1	151	155	PF00082	0.253
CLV_PCSK_SKI1_1	21	25	PF00082	0.264
CLV_PCSK_SKI1_1	218	222	PF00082	0.388
DEG_Nend_UBRbox_3	1	3	PF02207	0.591

Previous1 2 3 4 5…8Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYX9	Leptomonas seymouri	82%	100%
A0A0S4KKX1	Bodo saltans	66%	100%
A0A1X0P8C1	Trypanosomatidae	67%	100%
A0A3Q8IGV1	Leishmania donovani	95%	100%
A0A422P2H6	Trypanosoma rangeli	64%	100%
A0QZ12	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	31%	99%
A1ADA6	Escherichia coli O1:K1 / APEC	27%	81%
A1JPP5	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	27%	80%
A4HNN0	Leishmania braziliensis	82%	100%
A4ICW5	Leishmania infantum	95%	100%

Previous1 2 3 4 5 6Next