Putative SET domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain protein, putative

Species:

Leishmania mexicana

UniProt:

E9ASD8_LEIMU

TriTrypDb:

LmxM.36.0210

Length:

473

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASD8

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016740	transferase activity	2	12
GO:0000166	nucleotide binding	3	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0008716	D-alanine-D-alanine ligase activity	5	2
GO:0016874	ligase activity	2	2
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	2
GO:0016881	acid-amino acid ligase activity	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2
GO:0008168	methyltransferase activity	4	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.495
CLV_C14_Caspase3-7	18	22	PF00656	0.509
CLV_NRD_NRD_1	130	132	PF00675	0.480
CLV_NRD_NRD_1	297	299	PF00675	0.515
CLV_NRD_NRD_1	314	316	PF00675	0.542
CLV_NRD_NRD_1	326	328	PF00675	0.407
CLV_NRD_NRD_1	461	463	PF00675	0.462
CLV_PCSK_KEX2_1	130	132	PF00082	0.352
CLV_PCSK_SKI1_1	233	237	PF00082	0.372
CLV_PCSK_SKI1_1	358	362	PF00082	0.425
CLV_PCSK_SKI1_1	469	473	PF00082	0.614
CLV_PCSK_SKI1_1	95	99	PF00082	0.388
DOC_CYCLIN_yCln2_LP_2	136	142	PF00134	0.306
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.353
DOC_MAPK_gen_1	135	142	PF00069	0.453
DOC_MAPK_gen_1	185	193	PF00069	0.413
DOC_MAPK_gen_1	324	333	PF00069	0.396
DOC_MAPK_MEF2A_6	185	193	PF00069	0.439
DOC_PP1_RVXF_1	173	180	PF00149	0.346
DOC_PP2B_LxvP_1	136	139	PF13499	0.408
DOC_PP4_FxxP_1	397	400	PF00568	0.540
DOC_USP7_MATH_1	206	210	PF00917	0.532
DOC_USP7_MATH_1	229	233	PF00917	0.393
DOC_USP7_MATH_1	297	301	PF00917	0.493
DOC_USP7_MATH_1	366	370	PF00917	0.476
DOC_USP7_UBL2_3	324	328	PF12436	0.506
DOC_WW_Pin1_4	13	18	PF00397	0.578
DOC_WW_Pin1_4	273	278	PF00397	0.400
LIG_14-3-3_CanoR_1	143	151	PF00244	0.413
LIG_14-3-3_CanoR_1	153	159	PF00244	0.297
LIG_14-3-3_CanoR_1	298	302	PF00244	0.305
LIG_14-3-3_CanoR_1	442	448	PF00244	0.523
LIG_14-3-3_CanoR_1	95	100	PF00244	0.413
LIG_APCC_ABBA_1	308	313	PF00400	0.537
LIG_BIR_II_1	1	5	PF00653	0.458
LIG_deltaCOP1_diTrp_1	254	258	PF00928	0.281
LIG_EH1_1	102	110	PF00400	0.456
LIG_eIF4E_1	101	107	PF01652	0.400
LIG_FHA_1	143	149	PF00498	0.498
LIG_FHA_1	274	280	PF00498	0.465
LIG_FHA_1	74	80	PF00498	0.493
LIG_FHA_2	155	161	PF00498	0.387
LIG_FHA_2	246	252	PF00498	0.503
LIG_FHA_2	283	289	PF00498	0.375
LIG_FHA_2	357	363	PF00498	0.434
LIG_FHA_2	421	427	PF00498	0.341
LIG_LIR_Apic_2	349	355	PF02991	0.470
LIG_LIR_Apic_2	361	366	PF02991	0.315
LIG_LIR_Gen_1	21	28	PF02991	0.236
LIG_LIR_Gen_1	339	348	PF02991	0.385
LIG_LIR_Gen_1	418	429	PF02991	0.488
LIG_LIR_Nem_3	21	26	PF02991	0.471
LIG_LIR_Nem_3	232	237	PF02991	0.422
LIG_LIR_Nem_3	30	36	PF02991	0.446
LIG_LIR_Nem_3	339	343	PF02991	0.397
LIG_LIR_Nem_3	359	363	PF02991	0.480
LIG_LIR_Nem_3	418	424	PF02991	0.443
LIG_REV1ctd_RIR_1	31	41	PF16727	0.231
LIG_SH2_CRK	57	61	PF00017	0.425
LIG_SH2_NCK_1	112	116	PF00017	0.398
LIG_SH2_SRC	112	115	PF00017	0.402
LIG_SH2_SRC	311	314	PF00017	0.378
LIG_SH2_STAP1	306	310	PF00017	0.272
LIG_SH2_STAT3	44	47	PF00017	0.231
LIG_SH2_STAT5	234	237	PF00017	0.379
LIG_SH2_STAT5	347	350	PF00017	0.441
LIG_SH2_STAT5	44	47	PF00017	0.329
LIG_SH2_STAT5	91	94	PF00017	0.414
LIG_SH3_3	112	118	PF00018	0.388
LIG_SH3_3	259	265	PF00018	0.438
LIG_SH3_3	340	346	PF00018	0.379
LIG_SH3_3	467	473	PF00018	0.530
LIG_SUMO_SIM_anti_2	104	109	PF11976	0.454
LIG_SUMO_SIM_par_1	443	448	PF11976	0.244
LIG_TRAF2_1	248	251	PF00917	0.292
LIG_TYR_ITIM	110	115	PF00017	0.473
LIG_UBA3_1	166	175	PF00899	0.288
LIG_Vh1_VBS_1	151	169	PF01044	0.220
LIG_WRC_WIRS_1	421	426	PF05994	0.344
LIG_WW_1	54	57	PF00397	0.249
MOD_CK1_1	154	160	PF00069	0.268
MOD_CK2_1	245	251	PF00069	0.491
MOD_CK2_1	282	288	PF00069	0.530
MOD_CK2_1	356	362	PF00069	0.439
MOD_GlcNHglycan	280	283	PF01048	0.558
MOD_GlcNHglycan	465	468	PF01048	0.659
MOD_GlcNHglycan	66	70	PF01048	0.613
MOD_GlcNHglycan	76	79	PF01048	0.473
MOD_GSK3_1	278	285	PF00069	0.495
MOD_GSK3_1	443	450	PF00069	0.529
MOD_GSK3_1	74	81	PF00069	0.486
MOD_GSK3_1	85	92	PF00069	0.490
MOD_N-GLC_1	181	186	PF02516	0.450
MOD_N-GLC_1	387	392	PF02516	0.238
MOD_N-GLC_2	144	146	PF02516	0.512
MOD_N-GLC_2	29	31	PF02516	0.310
MOD_N-GLC_2	62	64	PF02516	0.312
MOD_NEK2_1	1	6	PF00069	0.354
MOD_NEK2_1	151	156	PF00069	0.335
MOD_NEK2_1	162	167	PF00069	0.462
MOD_NEK2_1	289	294	PF00069	0.463
MOD_NEK2_1	356	361	PF00069	0.371
MOD_NEK2_1	89	94	PF00069	0.328
MOD_NEK2_2	425	430	PF00069	0.374
MOD_NEK2_2	78	83	PF00069	0.477
MOD_PIKK_1	1	7	PF00454	0.405
MOD_PKA_2	142	148	PF00069	0.488
MOD_PKA_2	297	303	PF00069	0.297
MOD_Plk_1	162	168	PF00069	0.472
MOD_Plk_1	415	421	PF00069	0.458
MOD_Plk_1	447	453	PF00069	0.399
MOD_Plk_1	456	462	PF00069	0.446
MOD_Plk_2-3	32	38	PF00069	0.225
MOD_Plk_2-3	415	421	PF00069	0.424
MOD_Plk_4	162	168	PF00069	0.399
MOD_Plk_4	289	295	PF00069	0.512
MOD_Plk_4	456	462	PF00069	0.543
MOD_Plk_4	78	84	PF00069	0.378
MOD_ProDKin_1	13	19	PF00069	0.574
MOD_ProDKin_1	273	279	PF00069	0.386
TRG_DiLeu_BaLyEn_6	467	472	PF01217	0.601
TRG_ENDOCYTIC_2	112	115	PF00928	0.375
TRG_ENDOCYTIC_2	421	424	PF00928	0.327
TRG_ENDOCYTIC_2	57	60	PF00928	0.441
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILG6	Leptomonas seymouri	65%	100%
A0A0S4KKY2	Bodo saltans	40%	100%
A0A1X0P8J8	Trypanosomatidae	40%	100%
A0A3Q8IJR2	Leishmania donovani	89%	100%
A0A3R7MWC4	Trypanosoma rangeli	28%	92%
A0A3R7P2U3	Trypanosoma rangeli	40%	100%
A4HNM9	Leishmania braziliensis	82%	100%
A4ICW6	Leishmania infantum	89%	100%
D0A2I3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4Q257	Leishmania major	89%	100%
V5BHW2	Trypanosoma cruzi	22%	100%
V5BQK1	Trypanosoma cruzi	38%	100%