Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASD4_LEIMU

TriTrypDb:

LmxM.36.0160

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASD4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.480
CLV_NRD_NRD_1	137	139	PF00675	0.680
CLV_NRD_NRD_1	234	236	PF00675	0.557
CLV_PCSK_KEX2_1	137	139	PF00082	0.714
CLV_PCSK_SKI1_1	199	203	PF00082	0.602
CLV_PCSK_SKI1_1	230	234	PF00082	0.469
DEG_Kelch_Keap1_1	147	152	PF01344	0.352
DEG_Nend_UBRbox_3	1	3	PF02207	0.631
DOC_CKS1_1	154	159	PF01111	0.526
DOC_CYCLIN_yCln2_LP_2	154	160	PF00134	0.519
DOC_MAPK_MEF2A_6	94	103	PF00069	0.518
DOC_USP7_MATH_1	200	204	PF00917	0.518
DOC_USP7_UBL2_3	266	270	PF12436	0.509
DOC_USP7_UBL2_3	56	60	PF12436	0.429
DOC_WW_Pin1_4	119	124	PF00397	0.446
DOC_WW_Pin1_4	153	158	PF00397	0.468
DOC_WW_Pin1_4	250	255	PF00397	0.768
LIG_14-3-3_CanoR_1	94	100	PF00244	0.492
LIG_Actin_WH2_2	88	104	PF00022	0.517
LIG_FHA_1	174	180	PF00498	0.508
LIG_FHA_1	29	35	PF00498	0.502
LIG_FHA_1	98	104	PF00498	0.459
LIG_FHA_2	56	62	PF00498	0.564
LIG_LIR_Apic_2	118	123	PF02991	0.448
LIG_LIR_Nem_3	195	201	PF02991	0.504
LIG_NRBOX	11	17	PF00104	0.549
LIG_PDZ_Class_1	280	285	PF00595	0.765
LIG_Rb_pABgroove_1	65	73	PF01858	0.506
LIG_SH2_CRK	198	202	PF00017	0.540
LIG_SH2_CRK	82	86	PF00017	0.481
LIG_SH2_STAP1	48	52	PF00017	0.530
LIG_SH2_STAT5	164	167	PF00017	0.442
LIG_SH3_1	138	144	PF00018	0.519
LIG_SH3_3	138	144	PF00018	0.461
LIG_Sin3_3	217	224	PF02671	0.246
LIG_SUMO_SIM_par_1	171	176	PF11976	0.418
LIG_TYR_ITIM	196	201	PF00017	0.495
LIG_TYR_ITIM	80	85	PF00017	0.602
LIG_UBA3_1	267	272	PF00899	0.462
LIG_WRC_WIRS_1	126	131	PF05994	0.663
LIG_WW_1	45	48	PF00397	0.688
MOD_CDK_SPxK_1	153	159	PF00069	0.667
MOD_CDK_SPxxK_3	250	257	PF00069	0.715
MOD_CK1_1	207	213	PF00069	0.620
MOD_CK1_1	97	103	PF00069	0.666
MOD_CK2_1	55	61	PF00069	0.706
MOD_GlcNHglycan	146	149	PF01048	0.677
MOD_GlcNHglycan	183	186	PF01048	0.515
MOD_GlcNHglycan	202	205	PF01048	0.647
MOD_GlcNHglycan	23	26	PF01048	0.479
MOD_GlcNHglycan	6	9	PF01048	0.604
MOD_GSK3_1	115	122	PF00069	0.647
MOD_GSK3_1	17	24	PF00069	0.578
MOD_GSK3_1	200	207	PF00069	0.604
MOD_GSK3_1	208	215	PF00069	0.382
MOD_GSK3_1	28	35	PF00069	0.469
MOD_N-GLC_1	250	255	PF02516	0.508
MOD_NEK2_1	16	21	PF00069	0.572
MOD_NEK2_1	173	178	PF00069	0.555
MOD_NEK2_1	4	9	PF00069	0.578
MOD_NEK2_2	17	22	PF00069	0.649
MOD_NEK2_2	55	60	PF00069	0.652
MOD_PIKK_1	183	189	PF00454	0.632
MOD_PKA_2	21	27	PF00069	0.622
MOD_PKB_1	197	205	PF00069	0.517
MOD_Plk_1	32	38	PF00069	0.593
MOD_Plk_1	48	54	PF00069	0.678
MOD_Plk_4	115	121	PF00069	0.668
MOD_Plk_4	209	215	PF00069	0.494
MOD_Plk_4	33	39	PF00069	0.615
MOD_ProDKin_1	119	125	PF00069	0.548
MOD_ProDKin_1	153	159	PF00069	0.578
MOD_ProDKin_1	250	256	PF00069	0.718
MOD_SUMO_for_1	271	274	PF00179	0.551
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.385
TRG_DiLeu_BaLyEn_6	223	228	PF01217	0.513
TRG_ENDOCYTIC_2	198	201	PF00928	0.580
TRG_ENDOCYTIC_2	82	85	PF00928	0.591
TRG_ER_diArg_1	137	139	PF00400	0.641
TRG_ER_diArg_1	158	161	PF00400	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3B3	Leptomonas seymouri	44%	99%
A0A3Q8IN72	Leishmania donovani	87%	100%
A4HNM3	Leishmania braziliensis	79%	100%
A4ICX1	Leishmania infantum	87%	100%
Q4Q262	Leishmania major	87%	100%