LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania mexicana
UniProt:
E9ASD2_LEIMU
TriTrypDb:
LmxM.36.0140
Length:
647

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASD2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASD2

Function

Biological processes
TermNameLevelCount
GO:0006468 protein phosphorylation 5 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016310 phosphorylation 5 1
GO:0019538 protein metabolic process 3 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
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Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 1
GO:0003824 catalytic activity 1 1
GO:0004672 protein kinase activity 3 1
GO:0005488 binding 1 1
GO:0005524 ATP binding 5 1
GO:0016301 kinase activity 4 1
GO:0016740 transferase activity 2 1
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 1
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 1
GO:0017076 purine nucleotide binding 4 1
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 354 358 PF00656 0.492
CLV_C14_Caspase3-7 483 487 PF00656 0.406
CLV_PCSK_FUR_1 57 61 PF00082 0.447
CLV_PCSK_KEX2_1 251 253 PF00082 0.488
CLV_PCSK_KEX2_1 413 415 PF00082 0.504
CLV_PCSK_KEX2_1 59 61 PF00082 0.508
CLV_PCSK_PC1ET2_1 251 253 PF00082 0.488
CLV_PCSK_PC1ET2_1 413 415 PF00082 0.488
CLV_PCSK_PC1ET2_1 59 61 PF00082 0.508
CLV_PCSK_SKI1_1 220 224 PF00082 0.680
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P470 Leptomonas seymouri 65% 100%
A0A1X0P8C9 Trypanosomatidae 33% 100%
A0A3Q8IIL7 Leishmania donovani 92% 100%
A4HNM1 Leishmania braziliensis 78% 99%
A4ICX3 Leishmania infantum 92% 100%
F4I313 Arabidopsis thaliana 22% 71%
Q4Q264 Leishmania major 91% 100%
Q9C9H8 Arabidopsis thaliana 21% 71%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS