LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania mexicana
UniProt:
E9ASD2_LEIMU
TriTrypDb:
LmxM.36.0140
Length:
647

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASD2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASD2

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016310 phosphorylation 5 1
GO:0019538 protein metabolic process 3 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 1
GO:0003824 catalytic activity 1 1
GO:0004672 protein kinase activity 3 1
GO:0005488 binding 1 1
GO:0005524 ATP binding 5 1
GO:0016301 kinase activity 4 1
GO:0016740 transferase activity 2 1
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 1
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 1
GO:0017076 purine nucleotide binding 4 1
GO:0030554 adenyl nucleotide binding 5 1
GO:0032553 ribonucleotide binding 3 1
GO:0032555 purine ribonucleotide binding 4 1
GO:0032559 adenyl ribonucleotide binding 5 1
GO:0035639 purine ribonucleoside triphosphate binding 4 1
GO:0036094 small molecule binding 2 1
GO:0043167 ion binding 2 1
GO:0043168 anion binding 3 1
GO:0097159 organic cyclic compound binding 2 1
GO:0097367 carbohydrate derivative binding 2 1
GO:0140096 catalytic activity, acting on a protein 2 1
GO:1901265 nucleoside phosphate binding 3 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 354 358 PF00656 0.492
CLV_C14_Caspase3-7 483 487 PF00656 0.406
CLV_PCSK_FUR_1 57 61 PF00082 0.447
CLV_PCSK_KEX2_1 251 253 PF00082 0.488
CLV_PCSK_KEX2_1 413 415 PF00082 0.504
CLV_PCSK_KEX2_1 59 61 PF00082 0.508
CLV_PCSK_PC1ET2_1 251 253 PF00082 0.488
CLV_PCSK_PC1ET2_1 413 415 PF00082 0.488
CLV_PCSK_PC1ET2_1 59 61 PF00082 0.508
CLV_PCSK_SKI1_1 220 224 PF00082 0.680
CLV_PCSK_SKI1_1 251 255 PF00082 0.489
CLV_PCSK_SKI1_1 3 7 PF00082 0.606
CLV_PCSK_SKI1_1 305 309 PF00082 0.481
CLV_PCSK_SKI1_1 323 327 PF00082 0.288
CLV_PCSK_SKI1_1 361 365 PF00082 0.394
CLV_PCSK_SKI1_1 456 460 PF00082 0.501
CLV_PCSK_SKI1_1 497 501 PF00082 0.583
CLV_PCSK_SKI1_1 549 553 PF00082 0.517
CLV_PCSK_SKI1_1 59 63 PF00082 0.428
CLV_PCSK_SKI1_1 75 79 PF00082 0.361
DEG_APCC_DBOX_1 360 368 PF00400 0.381
DEG_Nend_Nbox_1 1 3 PF02207 0.569
DEG_ODPH_VHL_1 117 129 PF01847 0.471
DOC_CDC14_PxL_1 394 402 PF14671 0.486
DOC_CKS1_1 299 304 PF01111 0.541
DOC_CYCLIN_RxL_1 494 505 PF00134 0.571
DOC_CYCLIN_yCln2_LP_2 430 436 PF00134 0.437
DOC_CYCLIN_yCln2_LP_2 556 562 PF00134 0.500
DOC_MAPK_DCC_7 361 369 PF00069 0.435
DOC_MAPK_DCC_7 427 436 PF00069 0.425
DOC_MAPK_DCC_7 552 562 PF00069 0.576
DOC_MAPK_gen_1 381 390 PF00069 0.461
DOC_MAPK_gen_1 75 83 PF00069 0.505
DOC_MAPK_HePTP_8 424 436 PF00069 0.434
DOC_MAPK_MEF2A_6 361 369 PF00069 0.386
DOC_MAPK_MEF2A_6 427 436 PF00069 0.394
DOC_MAPK_MEF2A_6 507 514 PF00069 0.367
DOC_MAPK_RevD_3 90 104 PF00069 0.410
DOC_PP1_RVXF_1 102 109 PF00149 0.413
DOC_PP1_RVXF_1 495 502 PF00149 0.484
DOC_PP2B_LxvP_1 182 185 PF13499 0.554
DOC_PP2B_LxvP_1 283 286 PF13499 0.501
DOC_PP2B_LxvP_1 430 433 PF13499 0.437
DOC_PP2B_LxvP_1 467 470 PF13499 0.507
DOC_PP2B_LxvP_1 594 597 PF13499 0.495
DOC_PP4_FxxP_1 175 178 PF00568 0.471
DOC_PP4_FxxP_1 299 302 PF00568 0.555
DOC_PP4_FxxP_1 362 365 PF00568 0.436
DOC_USP7_MATH_1 12 16 PF00917 0.584
DOC_USP7_MATH_1 156 160 PF00917 0.422
DOC_USP7_MATH_1 191 195 PF00917 0.490
DOC_USP7_MATH_1 550 554 PF00917 0.503
DOC_USP7_MATH_1 572 576 PF00917 0.516
DOC_USP7_MATH_1 608 612 PF00917 0.728
DOC_WW_Pin1_4 298 303 PF00397 0.549
DOC_WW_Pin1_4 459 464 PF00397 0.496
LIG_14-3-3_CanoR_1 112 116 PF00244 0.413
LIG_14-3-3_CanoR_1 179 185 PF00244 0.522
LIG_14-3-3_CanoR_1 265 274 PF00244 0.478
LIG_14-3-3_CanoR_1 287 295 PF00244 0.490
LIG_14-3-3_CanoR_1 64 74 PF00244 0.450
LIG_APCC_ABBA_1 560 565 PF00400 0.281
LIG_BRCT_BRCA1_1 274 278 PF00533 0.473
LIG_BRCT_BRCA1_1 33 37 PF00533 0.545
LIG_BRCT_BRCA1_2 33 39 PF00533 0.462
LIG_deltaCOP1_diTrp_1 164 175 PF00928 0.456
LIG_EH1_1 570 578 PF00400 0.496
LIG_EVH1_1 285 289 PF00568 0.494
LIG_EVH1_1 594 598 PF00568 0.491
LIG_EVH1_2 186 190 PF00568 0.603
LIG_FAT_LD_1 530 538 PF03623 0.467
LIG_FHA_1 203 209 PF00498 0.455
LIG_FHA_1 242 248 PF00498 0.393
LIG_FHA_1 290 296 PF00498 0.515
LIG_FHA_1 390 396 PF00498 0.448
LIG_FHA_1 427 433 PF00498 0.398
LIG_FHA_1 460 466 PF00498 0.521
LIG_FHA_1 513 519 PF00498 0.575
LIG_FHA_1 53 59 PF00498 0.454
LIG_FHA_1 589 595 PF00498 0.550
LIG_FHA_2 210 216 PF00498 0.341
LIG_FHA_2 331 337 PF00498 0.539
LIG_FHA_2 380 386 PF00498 0.461
LIG_FHA_2 504 510 PF00498 0.559
LIG_FHA_2 64 70 PF00498 0.391
LIG_LIR_Apic_2 172 178 PF02991 0.458
LIG_LIR_Apic_2 296 302 PF02991 0.564
LIG_LIR_Gen_1 237 248 PF02991 0.379
LIG_LIR_Gen_1 385 395 PF02991 0.390
LIG_LIR_Gen_1 524 533 PF02991 0.521
LIG_LIR_Gen_1 639 646 PF02991 0.565
LIG_LIR_Nem_3 205 210 PF02991 0.472
LIG_LIR_Nem_3 235 241 PF02991 0.426
LIG_LIR_Nem_3 312 316 PF02991 0.446
LIG_LIR_Nem_3 319 325 PF02991 0.409
LIG_LIR_Nem_3 385 390 PF02991 0.394
LIG_LIR_Nem_3 453 458 PF02991 0.462
LIG_LIR_Nem_3 524 528 PF02991 0.547
LIG_LIR_Nem_3 639 645 PF02991 0.576
LIG_MLH1_MIPbox_1 274 278 PF16413 0.545
LIG_MYND_1 398 402 PF01753 0.501
LIG_MYND_1 555 559 PF01753 0.505
LIG_PCNA_PIPBox_1 128 137 PF02747 0.209
LIG_PCNA_PIPBox_1 304 313 PF02747 0.456
LIG_PCNA_yPIPBox_3 128 142 PF02747 0.260
LIG_Pex14_2 488 492 PF04695 0.458
LIG_Pex14_2 642 646 PF04695 0.537
LIG_Rb_pABgroove_1 323 331 PF01858 0.460
LIG_SH2_CRK 238 242 PF00017 0.424
LIG_SH2_CRK 329 333 PF00017 0.402
LIG_SH2_CRK 579 583 PF00017 0.499
LIG_SH2_STAP1 406 410 PF00017 0.447
LIG_SH2_STAP1 579 583 PF00017 0.616
LIG_SH2_STAT3 406 409 PF00017 0.451
LIG_SH2_STAT5 161 164 PF00017 0.368
LIG_SH2_STAT5 202 205 PF00017 0.382
LIG_SH2_STAT5 207 210 PF00017 0.425
LIG_SH2_STAT5 277 280 PF00017 0.497
LIG_SH2_STAT5 386 389 PF00017 0.386
LIG_SH3_3 113 119 PF00018 0.527
LIG_SH3_3 182 188 PF00018 0.557
LIG_SH3_3 192 198 PF00018 0.450
LIG_SH3_3 283 289 PF00018 0.491
LIG_SH3_3 292 298 PF00018 0.495
LIG_SH3_3 590 596 PF00018 0.640
LIG_SH3_5 198 202 PF00018 0.387
LIG_SUMO_SIM_anti_2 244 249 PF11976 0.409
LIG_SUMO_SIM_anti_2 68 75 PF11976 0.513
LIG_SUMO_SIM_anti_2 79 85 PF11976 0.383
LIG_SUMO_SIM_par_1 241 246 PF11976 0.403
LIG_SUMO_SIM_par_1 291 296 PF11976 0.517
LIG_SUMO_SIM_par_1 347 354 PF11976 0.433
LIG_SUMO_SIM_par_1 558 565 PF11976 0.364
LIG_SUMO_SIM_par_1 91 96 PF11976 0.452
LIG_TYR_ITIM 577 582 PF00017 0.484
LIG_UBA3_1 1 6 PF00899 0.613
LIG_UBA3_1 430 437 PF00899 0.433
LIG_UBA3_1 53 59 PF00899 0.447
LIG_UBA3_1 536 543 PF00899 0.572
LIG_WRC_WIRS_1 310 315 PF05994 0.465
LIG_WRC_WIRS_1 498 503 PF05994 0.484
MOD_CDK_SPxxK_3 298 305 PF00069 0.546
MOD_CDK_SPxxK_3 459 466 PF00069 0.493
MOD_CK1_1 11 17 PF00069 0.515
MOD_CK1_1 26 32 PF00069 0.479
MOD_CK1_1 375 381 PF00069 0.525
MOD_CK1_1 389 395 PF00069 0.379
MOD_CK1_1 52 58 PF00069 0.364
MOD_CK1_1 524 530 PF00069 0.457
MOD_CK1_1 600 606 PF00069 0.680
MOD_CK2_1 265 271 PF00069 0.503
MOD_CK2_1 379 385 PF00069 0.458
MOD_CK2_1 499 505 PF00069 0.568
MOD_CK2_1 63 69 PF00069 0.413
MOD_Cter_Amidation 249 252 PF01082 0.465
MOD_Cter_Amidation 47 50 PF01082 0.494
MOD_GlcNHglycan 10 13 PF01048 0.579
MOD_GlcNHglycan 182 185 PF01048 0.447
MOD_GlcNHglycan 223 226 PF01048 0.551
MOD_GlcNHglycan 24 28 PF01048 0.275
MOD_GlcNHglycan 267 270 PF01048 0.448
MOD_GlcNHglycan 343 346 PF01048 0.277
MOD_GlcNHglycan 501 504 PF01048 0.408
MOD_GlcNHglycan 584 587 PF01048 0.702
MOD_GlcNHglycan 599 602 PF01048 0.765
MOD_GlcNHglycan 606 609 PF01048 0.699
MOD_GlcNHglycan 610 613 PF01048 0.658
MOD_GlcNHglycan 628 631 PF01048 0.692
MOD_GSK3_1 156 163 PF00069 0.403
MOD_GSK3_1 22 29 PF00069 0.339
MOD_GSK3_1 289 296 PF00069 0.483
MOD_GSK3_1 305 312 PF00069 0.469
MOD_GSK3_1 370 377 PF00069 0.389
MOD_GSK3_1 457 464 PF00069 0.465
MOD_GSK3_1 480 487 PF00069 0.488
MOD_GSK3_1 497 504 PF00069 0.413
MOD_GSK3_1 512 519 PF00069 0.350
MOD_GSK3_1 596 603 PF00069 0.590
MOD_GSK3_1 604 611 PF00069 0.639
MOD_GSK3_1 8 15 PF00069 0.571
MOD_N-GLC_1 512 517 PF02516 0.531
MOD_N-GLC_2 255 257 PF02516 0.299
MOD_NEK2_1 155 160 PF00069 0.422
MOD_NEK2_1 23 28 PF00069 0.499
MOD_NEK2_1 374 379 PF00069 0.410
MOD_NEK2_1 499 504 PF00069 0.548
MOD_NEK2_1 5 10 PF00069 0.584
MOD_NEK2_1 514 519 PF00069 0.408
MOD_NEK2_1 582 587 PF00069 0.688
MOD_NEK2_1 604 609 PF00069 0.634
MOD_NEK2_1 617 622 PF00069 0.686
MOD_NEK2_2 156 161 PF00069 0.422
MOD_PIKK_1 457 463 PF00454 0.485
MOD_PIKK_1 619 625 PF00454 0.771
MOD_PK_1 49 55 PF00069 0.366
MOD_PKA_1 49 55 PF00069 0.442
MOD_PKA_2 111 117 PF00069 0.398
MOD_PKA_2 63 69 PF00069 0.533
MOD_Plk_4 111 117 PF00069 0.402
MOD_Plk_4 156 162 PF00069 0.422
MOD_Plk_4 289 295 PF00069 0.443
MOD_Plk_4 386 392 PF00069 0.436
MOD_Plk_4 426 432 PF00069 0.396
MOD_Plk_4 49 55 PF00069 0.385
MOD_Plk_4 5 11 PF00069 0.536
MOD_Plk_4 572 578 PF00069 0.455
MOD_Plk_4 641 647 PF00069 0.552
MOD_ProDKin_1 298 304 PF00069 0.542
MOD_ProDKin_1 459 465 PF00069 0.507
MOD_SUMO_rev_2 423 429 PF00179 0.260
MOD_SUMO_rev_2 502 508 PF00179 0.413
MOD_SUMO_rev_2 96 106 PF00179 0.579
TRG_DiLeu_BaEn_1 146 151 PF01217 0.464
TRG_DiLeu_BaEn_1 69 74 PF01217 0.448
TRG_DiLeu_BaEn_1 79 84 PF01217 0.323
TRG_DiLeu_BaEn_2 138 144 PF01217 0.507
TRG_DiLeu_BaLyEn_6 195 200 PF01217 0.450
TRG_DiLeu_BaLyEn_6 320 325 PF01217 0.463
TRG_DiLeu_BaLyEn_6 430 435 PF01217 0.441
TRG_DiLeu_BaLyEn_6 473 478 PF01217 0.477
TRG_DiLeu_BaLyEn_6 552 557 PF01217 0.447
TRG_ENDOCYTIC_2 207 210 PF00928 0.496
TRG_ENDOCYTIC_2 238 241 PF00928 0.425
TRG_ENDOCYTIC_2 329 332 PF00928 0.435
TRG_ENDOCYTIC_2 579 582 PF00928 0.534
TRG_Pf-PMV_PEXEL_1 142 146 PF00026 0.454
TRG_Pf-PMV_PEXEL_1 3 7 PF00026 0.600
TRG_Pf-PMV_PEXEL_1 381 385 PF00026 0.478
TRG_Pf-PMV_PEXEL_1 538 542 PF00026 0.496

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P470 Leptomonas seymouri 65% 100%
A0A1X0P8C9 Trypanosomatidae 33% 100%
A0A3Q8IIL7 Leishmania donovani 92% 100%
A4HNM1 Leishmania braziliensis 78% 99%
A4ICX3 Leishmania infantum 92% 100%
F4I313 Arabidopsis thaliana 22% 71%
Q4Q264 Leishmania major 91% 100%
Q9C9H8 Arabidopsis thaliana 21% 71%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS