PUB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PUB domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ASD1_LEIMU

TriTrypDb:

LmxM.36.0130

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASD1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.279
CLV_C14_Caspase3-7	31	35	PF00656	0.714
CLV_NRD_NRD_1	120	122	PF00675	0.588
CLV_NRD_NRD_1	141	143	PF00675	0.374
CLV_NRD_NRD_1	155	157	PF00675	0.493
CLV_NRD_NRD_1	164	166	PF00675	0.482
CLV_NRD_NRD_1	175	177	PF00675	0.399
CLV_NRD_NRD_1	188	190	PF00675	0.452
CLV_NRD_NRD_1	274	276	PF00675	0.507
CLV_NRD_NRD_1	355	357	PF00675	0.491
CLV_PCSK_FUR_1	118	122	PF00082	0.478
CLV_PCSK_KEX2_1	100	102	PF00082	0.501
CLV_PCSK_KEX2_1	120	122	PF00082	0.288
CLV_PCSK_KEX2_1	155	157	PF00082	0.515
CLV_PCSK_KEX2_1	164	166	PF00082	0.477
CLV_PCSK_KEX2_1	174	176	PF00082	0.514
CLV_PCSK_KEX2_1	188	190	PF00082	0.520
CLV_PCSK_KEX2_1	276	278	PF00082	0.580
CLV_PCSK_KEX2_1	306	308	PF00082	0.269
CLV_PCSK_KEX2_1	355	357	PF00082	0.520
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.501
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.524
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.269
CLV_PCSK_SKI1_1	100	104	PF00082	0.470
CLV_PCSK_SKI1_1	108	112	PF00082	0.423
CLV_PCSK_SKI1_1	142	146	PF00082	0.455
CLV_PCSK_SKI1_1	175	179	PF00082	0.486
CLV_PCSK_SKI1_1	291	295	PF00082	0.303
CLV_PCSK_SKI1_1	358	362	PF00082	0.386
DEG_APCC_DBOX_1	290	298	PF00400	0.362
DEG_APCC_DBOX_1	357	365	PF00400	0.381
DOC_MAPK_gen_1	120	130	PF00069	0.564
DOC_MAPK_gen_1	174	181	PF00069	0.414
DOC_MAPK_gen_1	305	311	PF00069	0.413
DOC_MAPK_gen_1	314	323	PF00069	0.413
DOC_MAPK_gen_1	355	363	PF00069	0.482
DOC_MAPK_HePTP_8	311	323	PF00069	0.167
DOC_MAPK_MEF2A_6	174	181	PF00069	0.391
DOC_MAPK_MEF2A_6	314	323	PF00069	0.167
DOC_PP1_RVXF_1	326	333	PF00149	0.347
DOC_USP7_UBL2_3	123	127	PF12436	0.449
DOC_WW_Pin1_4	231	236	PF00397	0.627
LIG_14-3-3_CanoR_1	101	109	PF00244	0.346
LIG_14-3-3_CanoR_1	146	154	PF00244	0.578
LIG_14-3-3_CanoR_1	310	316	PF00244	0.299
LIG_14-3-3_CanoR_1	51	58	PF00244	0.593
LIG_Actin_WH2_2	345	360	PF00022	0.309
LIG_AP2alpha_2	300	302	PF02296	0.413
LIG_BIR_II_1	1	5	PF00653	0.626
LIG_BRCT_BRCA1_1	298	302	PF00533	0.467
LIG_FHA_1	287	293	PF00498	0.413
LIG_FHA_1	306	312	PF00498	0.351
LIG_FHA_1	344	350	PF00498	0.355
LIG_FHA_1	35	41	PF00498	0.502
LIG_FHA_1	71	77	PF00498	0.395
LIG_FHA_2	102	108	PF00498	0.446
LIG_FHA_2	190	196	PF00498	0.520
LIG_FHA_2	41	47	PF00498	0.409
LIG_FHA_2	85	91	PF00498	0.504
LIG_GBD_Chelix_1	353	361	PF00786	0.361
LIG_LIR_Gen_1	43	53	PF02991	0.424
LIG_LIR_Gen_1	73	83	PF02991	0.455
LIG_LIR_Nem_3	313	319	PF02991	0.488
LIG_LIR_Nem_3	43	48	PF02991	0.411
LIG_PCNA_PIPBox_1	252	261	PF02747	0.476
LIG_RPA_C_Fungi	207	219	PF08784	0.469
LIG_SH2_NCK_1	204	208	PF00017	0.548
LIG_SH2_SRC	204	207	PF00017	0.421
LIG_SH2_STAP1	204	208	PF00017	0.417
LIG_SH2_STAT5	38	41	PF00017	0.474
LIG_SH3_3	17	23	PF00018	0.739
LIG_SH3_3	295	301	PF00018	0.431
LIG_SH3_3	316	322	PF00018	0.210
LIG_SUMO_SIM_anti_2	90	97	PF11976	0.445
MOD_CK1_1	24	30	PF00069	0.620
MOD_CK1_1	243	249	PF00069	0.579
MOD_CK2_1	101	107	PF00069	0.386
MOD_CK2_1	146	152	PF00069	0.427
MOD_CK2_1	189	195	PF00069	0.467
MOD_CK2_1	25	31	PF00069	0.626
MOD_CK2_1	84	90	PF00069	0.518
MOD_Cter_Amidation	140	143	PF01082	0.467
MOD_GlcNHglycan	242	245	PF01048	0.643
MOD_GlcNHglycan	249	252	PF01048	0.618
MOD_GSK3_1	21	28	PF00069	0.628
MOD_GSK3_1	243	250	PF00069	0.602
MOD_GSK3_1	30	37	PF00069	0.565
MOD_GSK3_1	301	308	PF00069	0.306
MOD_GSK3_1	343	350	PF00069	0.266
MOD_N-GLC_1	240	245	PF02516	0.662
MOD_N-GLC_1	25	30	PF02516	0.742
MOD_N-GLC_1	343	348	PF02516	0.307
MOD_NEK2_1	309	314	PF00069	0.285
MOD_NEK2_1	347	352	PF00069	0.358
MOD_NEK2_2	286	291	PF00069	0.362
MOD_OFUCOSY	66	72	PF10250	0.392
MOD_PIKK_1	38	44	PF00454	0.402
MOD_PIKK_1	70	76	PF00454	0.405
MOD_PKA_1	305	311	PF00069	0.328
MOD_PKA_2	309	315	PF00069	0.416
MOD_Plk_1	240	246	PF00069	0.626
MOD_Plk_1	343	349	PF00069	0.338
MOD_Plk_4	251	257	PF00069	0.570
MOD_Plk_4	266	272	PF00069	0.423
MOD_Plk_4	348	354	PF00069	0.280
MOD_Plk_4	40	46	PF00069	0.391
MOD_Plk_4	58	64	PF00069	0.366
MOD_ProDKin_1	231	237	PF00069	0.625
MOD_SUMO_for_1	147	150	PF00179	0.497
MOD_SUMO_for_1	217	220	PF00179	0.434
MOD_SUMO_rev_2	124	128	PF00179	0.443
MOD_SUMO_rev_2	2	8	PF00179	0.610
TRG_DiLeu_BaEn_1	325	330	PF01217	0.337
TRG_DiLeu_BaEn_4	125	131	PF01217	0.486
TRG_DiLeu_BaLyEn_6	288	293	PF01217	0.337
TRG_DiLeu_LyEn_5	325	330	PF01217	0.292
TRG_ER_diArg_1	118	121	PF00400	0.476
TRG_ER_diArg_1	154	156	PF00400	0.486
TRG_ER_diArg_1	174	176	PF00400	0.273
TRG_ER_diArg_1	274	277	PF00400	0.421
TRG_ER_diArg_1	354	356	PF00400	0.337
TRG_ER_FFAT_1	201	209	PF00635	0.385
TRG_NES_CRM1_1	150	162	PF08389	0.480
TRG_NLS_MonoExtC_3	274	279	PF00514	0.354
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I208	Leptomonas seymouri	63%	99%
A0A0S4JLL2	Bodo saltans	42%	94%
A0A1X0P8K7	Trypanosomatidae	47%	100%
A0A3S5IQV7	Trypanosoma rangeli	48%	100%
A0A3S7XA96	Leishmania donovani	91%	100%
A4HNM0	Leishmania braziliensis	79%	100%
A4ICX4	Leishmania infantum	90%	100%
D0A2H5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	89%
Q4Q265	Leishmania major	89%	100%
V5BQK6	Trypanosoma cruzi	44%	100%