Putative DNA damage repair protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA damage repair protein, putative

Species:

Leishmania mexicana

UniProt:

E9ASC8_LEIMU

TriTrypDb:

LmxM.36.0100

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASC8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006281	DNA repair	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006950	response to stress	2	12
GO:0006974	DNA damage response	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0033554	cellular response to stress	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0050896	response to stimulus	1	12
GO:0051716	cellular response to stimulus	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000731	DNA synthesis involved in DNA repair	6	1
GO:0006301	postreplication repair	6	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019985	translesion synthesis	7	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0042276	error-prone translesion synthesis	8	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0070987	error-free translesion synthesis	8	1
GO:0071897	DNA biosynthetic process	5	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003684	damaged DNA binding	5	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003824	catalytic activity	1	2
GO:0003887	DNA-directed DNA polymerase activity	5	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016779	nucleotidyltransferase activity	4	2
GO:0017125	deoxycytidyl transferase activity	5	1
GO:0034061	DNA polymerase activity	4	2
GO:0140097	catalytic activity, acting on DNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.562
CLV_C14_Caspase3-7	338	342	PF00656	0.281
CLV_C14_Caspase3-7	535	539	PF00656	0.580
CLV_NRD_NRD_1	186	188	PF00675	0.298
CLV_NRD_NRD_1	359	361	PF00675	0.456
CLV_NRD_NRD_1	417	419	PF00675	0.403
CLV_NRD_NRD_1	562	564	PF00675	0.396
CLV_PCSK_KEX2_1	186	188	PF00082	0.265
CLV_PCSK_KEX2_1	279	281	PF00082	0.440
CLV_PCSK_KEX2_1	289	291	PF00082	0.613
CLV_PCSK_KEX2_1	321	323	PF00082	0.510
CLV_PCSK_KEX2_1	359	361	PF00082	0.454
CLV_PCSK_KEX2_1	505	507	PF00082	0.565
CLV_PCSK_KEX2_1	562	564	PF00082	0.436
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.418
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.615
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.534
CLV_PCSK_PC1ET2_1	505	507	PF00082	0.565
CLV_PCSK_PC7_1	285	291	PF00082	0.441
CLV_PCSK_PC7_1	317	323	PF00082	0.602
CLV_PCSK_SKI1_1	137	141	PF00082	0.262
CLV_PCSK_SKI1_1	187	191	PF00082	0.335
CLV_PCSK_SKI1_1	209	213	PF00082	0.231
CLV_PCSK_SKI1_1	280	284	PF00082	0.410
CLV_PCSK_SKI1_1	305	309	PF00082	0.404
CLV_PCSK_SKI1_1	348	352	PF00082	0.358
CLV_PCSK_SKI1_1	468	472	PF00082	0.381
CLV_PCSK_SKI1_1	582	586	PF00082	0.371
DEG_APCC_DBOX_1	279	287	PF00400	0.420
DEG_APCC_DBOX_1	347	355	PF00400	0.344
DEG_APCC_DBOX_1	581	589	PF00400	0.480
DOC_ANK_TNKS_1	263	270	PF00023	0.310
DOC_CKS1_1	507	512	PF01111	0.451
DOC_CYCLIN_RxL_1	184	193	PF00134	0.498
DOC_CYCLIN_RxL_1	345	353	PF00134	0.349
DOC_CYCLIN_yCln2_LP_2	612	618	PF00134	0.390
DOC_MAPK_DCC_7	418	426	PF00069	0.453
DOC_MAPK_gen_1	119	128	PF00069	0.535
DOC_MAPK_gen_1	137	147	PF00069	0.535
DOC_MAPK_gen_1	214	222	PF00069	0.474
DOC_MAPK_gen_1	389	397	PF00069	0.474
DOC_MAPK_gen_1	418	426	PF00069	0.567
DOC_MAPK_gen_1	505	515	PF00069	0.658
DOC_MAPK_MEF2A_6	389	397	PF00069	0.481
DOC_MAPK_MEF2A_6	57	64	PF00069	0.392
DOC_PP1_RVXF_1	21	27	PF00149	0.346
DOC_PP2B_LxvP_1	612	615	PF13499	0.406
DOC_USP7_MATH_1	243	247	PF00917	0.502
DOC_USP7_MATH_1	532	536	PF00917	0.571
DOC_USP7_UBL2_3	381	385	PF12436	0.415
DOC_WW_Pin1_4	419	424	PF00397	0.478
DOC_WW_Pin1_4	506	511	PF00397	0.652
DOC_WW_Pin1_4	516	521	PF00397	0.648
LIG_14-3-3_CanoR_1	137	143	PF00244	0.527
LIG_14-3-3_CanoR_1	209	217	PF00244	0.442
LIG_14-3-3_CanoR_1	369	373	PF00244	0.421
LIG_14-3-3_CanoR_1	468	473	PF00244	0.433
LIG_Actin_WH2_2	343	361	PF00022	0.458
LIG_Actin_WH2_2	444	462	PF00022	0.560
LIG_APCC_ABBAyCdc20_2	57	63	PF00400	0.442
LIG_BIR_III_4	266	270	PF00653	0.624
LIG_CaM_IQ_9	15	31	PF13499	0.350
LIG_CaM_IQ_9	272	287	PF13499	0.358
LIG_deltaCOP1_diTrp_1	40	48	PF00928	0.412
LIG_FHA_1	359	365	PF00498	0.375
LIG_FHA_1	454	460	PF00498	0.459
LIG_FHA_1	507	513	PF00498	0.626
LIG_FHA_1	539	545	PF00498	0.574
LIG_FHA_1	81	87	PF00498	0.536
LIG_FHA_2	263	269	PF00498	0.322
LIG_FHA_2	30	36	PF00498	0.495
LIG_FHA_2	369	375	PF00498	0.369
LIG_FHA_2	512	518	PF00498	0.770
LIG_FHA_2	598	604	PF00498	0.257
LIG_GBD_Chelix_1	364	372	PF00786	0.482
LIG_LIR_Gen_1	141	151	PF02991	0.446
LIG_LIR_Gen_1	172	181	PF02991	0.482
LIG_LIR_Gen_1	293	303	PF02991	0.448
LIG_LIR_Gen_1	58	67	PF02991	0.350
LIG_LIR_Gen_1	599	608	PF02991	0.503
LIG_LIR_Gen_1	77	86	PF02991	0.555
LIG_LIR_LC3C_4	448	451	PF02991	0.372
LIG_LIR_Nem_3	141	146	PF02991	0.520
LIG_LIR_Nem_3	172	178	PF02991	0.498
LIG_LIR_Nem_3	293	299	PF02991	0.374
LIG_LIR_Nem_3	341	347	PF02991	0.389
LIG_LIR_Nem_3	541	546	PF02991	0.473
LIG_LIR_Nem_3	573	577	PF02991	0.440
LIG_LIR_Nem_3	58	62	PF02991	0.383
LIG_LIR_Nem_3	589	594	PF02991	0.448
LIG_LIR_Nem_3	599	604	PF02991	0.413
LIG_LIR_Nem_3	65	71	PF02991	0.437
LIG_LIR_Nem_3	77	81	PF02991	0.431
LIG_LYPXL_yS_3	574	577	PF13949	0.483
LIG_MAD2	305	313	PF02301	0.515
LIG_PDZ_Class_3	614	619	PF00595	0.515
LIG_Pex14_2	26	30	PF04695	0.335
LIG_Pex14_2	38	42	PF04695	0.330
LIG_REV1ctd_RIR_1	499	506	PF16727	0.679
LIG_SH2_CRK	143	147	PF00017	0.466
LIG_SH2_CRK	175	179	PF00017	0.535
LIG_SH2_CRK	296	300	PF00017	0.407
LIG_SH2_GRB2like	114	117	PF00017	0.442
LIG_SH2_SRC	114	117	PF00017	0.442
LIG_SH2_SRC	143	146	PF00017	0.446
LIG_SH2_STAP1	130	134	PF00017	0.522
LIG_SH2_STAT5	102	105	PF00017	0.447
LIG_SH2_STAT5	114	117	PF00017	0.497
LIG_SH2_STAT5	25	28	PF00017	0.535
LIG_SH2_STAT5	543	546	PF00017	0.397
LIG_SH2_STAT5	580	583	PF00017	0.361
LIG_SH3_3	374	380	PF00018	0.368
LIG_SH3_3	392	398	PF00018	0.346
LIG_SH3_3	417	423	PF00018	0.472
LIG_SH3_3	504	510	PF00018	0.497
LIG_SH3_3	512	518	PF00018	0.585
LIG_SH3_3	525	531	PF00018	0.524
LIG_SUMO_SIM_anti_2	443	451	PF11976	0.551
LIG_SUMO_SIM_anti_2	511	517	PF11976	0.642
LIG_SUMO_SIM_par_1	422	428	PF11976	0.457
LIG_SUMO_SIM_par_1	511	517	PF11976	0.684
LIG_TRAF2_1	600	603	PF00917	0.260
LIG_TRFH_1	147	151	PF08558	0.439
LIG_TYR_ITIM	572	577	PF00017	0.475
LIG_TYR_ITSM	139	146	PF00017	0.535
LIG_TYR_ITSM	292	299	PF00017	0.404
LIG_WRC_WIRS_1	178	183	PF05994	0.518
LIG_WRC_WIRS_1	604	609	PF05994	0.441
MOD_CK1_1	5	11	PF00069	0.506
MOD_CK1_1	95	101	PF00069	0.453
MOD_CK2_1	114	120	PF00069	0.503
MOD_CK2_1	159	165	PF00069	0.442
MOD_CK2_1	177	183	PF00069	0.487
MOD_CK2_1	243	249	PF00069	0.581
MOD_CK2_1	29	35	PF00069	0.465
MOD_CK2_1	368	374	PF00069	0.348
MOD_CK2_1	429	435	PF00069	0.434
MOD_CK2_1	511	517	PF00069	0.719
MOD_CK2_1	597	603	PF00069	0.521
MOD_Cter_Amidation	287	290	PF01082	0.437
MOD_Cter_Amidation	319	322	PF01082	0.476
MOD_DYRK1A_RPxSP_1	506	510	PF00069	0.440
MOD_GlcNHglycan	116	119	PF01048	0.359
MOD_GlcNHglycan	190	193	PF01048	0.296
MOD_GlcNHglycan	490	493	PF01048	0.700
MOD_GlcNHglycan	566	569	PF01048	0.529
MOD_GSK3_1	150	157	PF00069	0.451
MOD_GSK3_1	177	184	PF00069	0.517
MOD_GSK3_1	425	432	PF00069	0.504
MOD_GSK3_1	468	475	PF00069	0.404
MOD_GSK3_1	603	610	PF00069	0.472
MOD_GSK3_1	92	99	PF00069	0.451
MOD_NEK2_1	177	182	PF00069	0.492
MOD_NEK2_1	190	195	PF00069	0.473
MOD_NEK2_1	368	373	PF00069	0.358
MOD_NEK2_1	425	430	PF00069	0.488
MOD_NEK2_1	440	445	PF00069	0.466
MOD_NEK2_1	607	612	PF00069	0.407
MOD_NEK2_1	67	72	PF00069	0.442
MOD_PIKK_1	380	386	PF00454	0.451
MOD_PKA_2	358	364	PF00069	0.402
MOD_PKA_2	368	374	PF00069	0.302
MOD_PKA_2	488	494	PF00069	0.643
MOD_PKA_2	5	11	PF00069	0.416
MOD_Plk_1	244	250	PF00069	0.445
MOD_Plk_1	533	539	PF00069	0.502
MOD_Plk_2-3	159	165	PF00069	0.431
MOD_Plk_2-3	262	268	PF00069	0.322
MOD_Plk_2-3	511	517	PF00069	0.642
MOD_Plk_4	138	144	PF00069	0.524
MOD_Plk_4	291	297	PF00069	0.495
MOD_Plk_4	368	374	PF00069	0.344
MOD_Plk_4	511	517	PF00069	0.706
MOD_Plk_4	538	544	PF00069	0.454
MOD_ProDKin_1	419	425	PF00069	0.476
MOD_ProDKin_1	506	512	PF00069	0.656
MOD_ProDKin_1	516	522	PF00069	0.647
MOD_SUMO_for_1	278	281	PF00179	0.486
MOD_SUMO_for_1	74	77	PF00179	0.456
TRG_DiLeu_BaLyEn_6	420	425	PF01217	0.491
TRG_ENDOCYTIC_2	143	146	PF00928	0.431
TRG_ENDOCYTIC_2	175	178	PF00928	0.498
TRG_ENDOCYTIC_2	296	299	PF00928	0.404
TRG_ENDOCYTIC_2	574	577	PF00928	0.421
TRG_ENDOCYTIC_2	78	81	PF00928	0.478
TRG_ER_diArg_1	185	187	PF00400	0.482
TRG_ER_diArg_1	358	360	PF00400	0.433
TRG_ER_diArg_1	561	563	PF00400	0.389
TRG_NES_CRM1_1	63	77	PF08389	0.431
TRG_NLS_MonoCore_2	504	509	PF00514	0.642
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.356

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA19	Leptomonas seymouri	70%	100%
A0A0S4JRX6	Bodo saltans	44%	87%
A0A1X0P8Q5	Trypanosomatidae	49%	98%
A0A3S7XA64	Leishmania donovani	93%	100%
A0A422NAZ8	Trypanosoma rangeli	48%	100%
A4HNL7	Leishmania braziliensis	82%	100%
A4ICX7	Leishmania infantum	92%	100%
D0A2H2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
Q4Q268	Leishmania major	93%	100%
V5BV86	Trypanosoma cruzi	50%	100%