LeishMANIAdb
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DUF2428 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DUF2428 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9ASC7_LEIMU
TriTrypDb:
LmxM.36.0090
Length:
1056

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
TermNameLevelCount
GO:0005634 nucleus 5 6
GO:0005643 nuclear pore 3 1
GO:0005737 cytoplasm 2 1
GO:0016020 membrane 2 1
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 6
GO:0043227 membrane-bounded organelle 3 6
GO:0043229 intracellular organelle 3 6
GO:0043231 intracellular membrane-bounded organelle 4 6
GO:0110165 cellular anatomical entity 1 8
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Expansion

Sequence features

E9ASC7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASC7

Function

Biological processes
TermNameLevelCount
GO:0006611 protein export from nucleus 5 1
GO:0006810 transport 3 1
GO:0006886 intracellular protein transport 4 1
GO:0006913 nucleocytoplasmic transport 5 1
GO:0008104 protein localization 4 1
GO:0009987 cellular process 1 1
GO:0015031 protein transport 4 1
GO:0033036 macromolecule localization 2 1
GO:0045184 establishment of protein localization 3 1
GO:0046907 intracellular transport 3 1
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Molecular functions
TermNameLevelCount
GO:0005049 nuclear export signal receptor activity 3 7
GO:0140104 molecular carrier activity 1 7
GO:0140142 nucleocytoplasmic carrier activity 2 7
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 566 570 PF00656 0.220
CLV_C14_Caspase3-7 822 826 PF00656 0.610
CLV_C14_Caspase3-7 910 914 PF00656 0.404
CLV_NRD_NRD_1 189 191 PF00675 0.476
CLV_NRD_NRD_1 392 394 PF00675 0.447
CLV_NRD_NRD_1 79 81 PF00675 0.388
CLV_PCSK_KEX2_1 189 191 PF00082 0.445
CLV_PCSK_KEX2_1 392 394 PF00082 0.447
CLV_PCSK_KEX2_1 79 81 PF00082 0.366
CLV_PCSK_SKI1_1 192 196 PF00082 0.335
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I0T0 Leptomonas seymouri 66% 100%
A0A1X0P8G9 Trypanosomatidae 28% 100%
A0A3R7MB24 Trypanosoma rangeli 30% 100%
A0A3S5H812 Leishmania donovani 93% 100%
A4HNL6 Leishmania braziliensis 81% 100%
A4ICX8 Leishmania infantum 93% 100%
D0A2H1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 94%
Q4Q269 Leishmania major 92% 100%
V5C008 Trypanosoma cruzi 29% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS