Stress-inducible protein STI1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

stress-inducible protein STI1 homolog

Species:

Leishmania mexicana

UniProt:

E9ASC5_LEIMU

TriTrypDb:

LmxM.36.0070

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASC5

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0009987	cellular process	1	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0030544	Hsp70 protein binding	4	12
GO:0031072	heat shock protein binding	3	12
GO:0051879	Hsp90 protein binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	211	213	PF00675	0.570
CLV_PCSK_KEX2_1	15	17	PF00082	0.463
CLV_PCSK_KEX2_1	211	213	PF00082	0.570
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.463
CLV_PCSK_SKI1_1	223	227	PF00082	0.708
DEG_Nend_UBRbox_2	1	3	PF02207	0.672
DOC_CYCLIN_RxL_1	93	102	PF00134	0.502
DOC_MAPK_MEF2A_6	73	82	PF00069	0.424
DOC_PP1_SILK_1	244	249	PF00149	0.676
DOC_USP7_MATH_1	240	244	PF00917	0.611
DOC_USP7_MATH_1	58	62	PF00917	0.695
DOC_USP7_MATH_1	81	85	PF00917	0.360
DOC_USP7_UBL2_3	93	97	PF12436	0.502
DOC_WW_Pin1_4	130	135	PF00397	0.642
DOC_WW_Pin1_4	233	238	PF00397	0.633
DOC_WW_Pin1_4	99	104	PF00397	0.475
LIG_deltaCOP1_diTrp_1	70	76	PF00928	0.440
LIG_FHA_1	156	162	PF00498	0.475
LIG_FHA_1	163	169	PF00498	0.712
LIG_FHA_1	23	29	PF00498	0.355
LIG_FHA_2	131	137	PF00498	0.618
LIG_LIR_Gen_1	185	192	PF02991	0.610
LIG_LIR_Gen_1	47	54	PF02991	0.707
LIG_LIR_Nem_3	47	51	PF02991	0.694
LIG_Pex14_1	71	75	PF04695	0.440
LIG_PTB_Apo_2	139	146	PF02174	0.370
LIG_REV1ctd_RIR_1	142	150	PF16727	0.424
LIG_SH2_GRB2like	175	178	PF00017	0.646
LIG_SH2_GRB2like	41	44	PF00017	0.600
LIG_SH2_NCK_1	150	154	PF00017	0.367
LIG_SH2_NCK_1	229	233	PF00017	0.592
LIG_SH2_NCK_1	88	92	PF00017	0.422
LIG_SH2_SRC	17	20	PF00017	0.391
LIG_SH2_SRC	88	91	PF00017	0.347
LIG_SH2_STAP1	150	154	PF00017	0.365
LIG_SH2_STAP1	157	161	PF00017	0.340
LIG_SH2_STAP1	175	179	PF00017	0.517
LIG_SH2_STAP1	188	192	PF00017	0.609
LIG_SH2_STAP1	24	28	PF00017	0.377
LIG_SH2_STAP1	41	45	PF00017	0.598
LIG_SH2_STAT5	157	160	PF00017	0.475
LIG_SH2_STAT5	175	178	PF00017	0.605
LIG_SH2_STAT5	209	212	PF00017	0.699
LIG_SH2_STAT5	229	232	PF00017	0.706
LIG_SH2_STAT5	24	27	PF00017	0.355
LIG_SH2_STAT5	75	78	PF00017	0.453
LIG_TRAF2_1	133	136	PF00917	0.662
MOD_CK2_1	130	136	PF00069	0.617
MOD_GlcNHglycan	34	39	PF01048	0.479
MOD_GSK3_1	182	189	PF00069	0.687
MOD_GSK3_1	227	234	PF00069	0.644
MOD_NEK2_1	140	145	PF00069	0.467
MOD_PIKK_1	125	131	PF00454	0.769
MOD_PIKK_1	240	246	PF00454	0.605
MOD_PK_1	231	237	PF00069	0.673
MOD_Plk_4	140	146	PF00069	0.355
MOD_Plk_4	186	192	PF00069	0.710
MOD_ProDKin_1	130	136	PF00069	0.637
MOD_ProDKin_1	233	239	PF00069	0.635
MOD_ProDKin_1	99	105	PF00069	0.475
MOD_SUMO_rev_2	135	140	PF00179	0.653
MOD_SUMO_rev_2	2	6	PF00179	0.393
TRG_DiLeu_BaEn_4	135	141	PF01217	0.724
TRG_DiLeu_BaLyEn_6	248	253	PF01217	0.453
TRG_ENDOCYTIC_2	188	191	PF00928	0.594
TRG_ENDOCYTIC_2	216	219	PF00928	0.535
TRG_ENDOCYTIC_2	75	78	PF00928	0.424
TRG_ER_diArg_1	210	212	PF00400	0.576
TRG_ER_diArg_1	65	68	PF00400	0.687
TRG_NES_CRM1_1	70	83	PF08389	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTR8	Leptomonas seymouri	82%	100%
A0A0N1IBD2	Leptomonas seymouri	26%	76%
A0A0S4JPS0	Bodo saltans	60%	99%
A0A0S4JRK3	Bodo saltans	26%	73%
A0A1X0P8F0	Trypanosomatidae	55%	99%
A0A3Q8IJP8	Leishmania donovani	94%	100%
A0A3R7LE97	Trypanosoma rangeli	22%	71%
A0A3S7WZC1	Leishmania donovani	24%	76%
A0A422NB01	Trypanosoma rangeli	55%	99%
A4HEB3	Leishmania braziliensis	25%	100%
A4HNL2	Leishmania braziliensis	85%	100%
A4I1Q9	Leishmania infantum	24%	76%
A4ICY0	Leishmania infantum	94%	100%
A4K2V0	Pongo abelii	24%	83%
D0A2G9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	99%
E9AXU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	76%
O13797	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	80%
O16259	Caenorhabditis elegans	27%	80%
Q15785	Homo sapiens	24%	83%
Q3KRD5	Rattus norvegicus	24%	83%
Q4Q271	Leishmania major	95%	100%
Q4Q9M8	Leishmania major	24%	72%
Q9CYG7	Mus musculus	25%	83%
V5BA34	Trypanosoma cruzi	54%	99%