SAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SAP domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ASC4_LEIMU

TriTrypDb:

LmxM.36.0065

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASC4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	263	265	PF00675	0.661
CLV_NRD_NRD_1	318	320	PF00675	0.618
CLV_NRD_NRD_1	6	8	PF00675	0.518
CLV_PCSK_KEX2_1	208	210	PF00082	0.376
CLV_PCSK_KEX2_1	317	319	PF00082	0.633
CLV_PCSK_KEX2_1	5	7	PF00082	0.536
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.376
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.536
CLV_PCSK_SKI1_1	112	116	PF00082	0.514
CLV_PCSK_SKI1_1	163	167	PF00082	0.672
CLV_PCSK_SKI1_1	189	193	PF00082	0.300
CLV_PCSK_SKI1_1	74	78	PF00082	0.541
CLV_Separin_Metazoa	190	194	PF03568	0.336
DEG_Nend_UBRbox_2	1	3	PF02207	0.588
DEG_SPOP_SBC_1	136	140	PF00917	0.640
DEG_SPOP_SBC_1	42	46	PF00917	0.620
DOC_CKS1_1	92	97	PF01111	0.541
DOC_CYCLIN_yCln2_LP_2	36	42	PF00134	0.656
DOC_MAPK_gen_1	29	38	PF00069	0.592
DOC_MAPK_gen_1	5	11	PF00069	0.515
DOC_MAPK_MEF2A_6	32	40	PF00069	0.636
DOC_PP2B_LxvP_1	36	39	PF13499	0.603
DOC_PP2B_LxvP_1	40	43	PF13499	0.649
DOC_PP4_FxxP_1	92	95	PF00568	0.536
DOC_USP7_MATH_1	136	140	PF00917	0.640
DOC_USP7_MATH_1	172	176	PF00917	0.544
DOC_USP7_MATH_1	215	219	PF00917	0.718
DOC_USP7_MATH_1	229	233	PF00917	0.549
DOC_USP7_MATH_1	259	263	PF00917	0.744
DOC_USP7_MATH_1	43	47	PF00917	0.661
DOC_USP7_UBL2_3	208	212	PF12436	0.376
DOC_WW_Pin1_4	154	159	PF00397	0.660
DOC_WW_Pin1_4	176	181	PF00397	0.522
DOC_WW_Pin1_4	22	27	PF00397	0.567
DOC_WW_Pin1_4	225	230	PF00397	0.499
DOC_WW_Pin1_4	251	256	PF00397	0.655
DOC_WW_Pin1_4	263	268	PF00397	0.645
DOC_WW_Pin1_4	38	43	PF00397	0.622
DOC_WW_Pin1_4	46	51	PF00397	0.620
DOC_WW_Pin1_4	91	96	PF00397	0.550
LIG_14-3-3_CanoR_1	105	109	PF00244	0.413
LIG_14-3-3_CanoR_1	171	177	PF00244	0.678
LIG_14-3-3_CanoR_1	234	244	PF00244	0.581
LIG_14-3-3_CanoR_1	260	267	PF00244	0.516
LIG_14-3-3_CanoR_1	296	300	PF00244	0.581
LIG_14-3-3_CanoR_1	91	95	PF00244	0.678
LIG_14-3-3_CterR_2	317	322	PF00244	0.562
LIG_BRCT_BRCA1_1	287	291	PF00533	0.460
LIG_BRCT_BRCA1_1	297	301	PF00533	0.580
LIG_BRCT_BRCA1_1	88	92	PF00533	0.574
LIG_FHA_1	222	228	PF00498	0.754
LIG_FHA_1	32	38	PF00498	0.706
LIG_FHA_2	138	144	PF00498	0.612
LIG_FHA_2	150	156	PF00498	0.651
LIG_FHA_2	182	188	PF00498	0.316
LIG_FHA_2	269	275	PF00498	0.635
LIG_FHA_2	92	98	PF00498	0.651
LIG_LIR_Apic_2	153	159	PF02991	0.477
LIG_LIR_Apic_2	89	95	PF02991	0.519
LIG_LIR_Nem_3	278	283	PF02991	0.468
LIG_LIR_Nem_3	79	83	PF02991	0.552
LIG_MYND_1	255	259	PF01753	0.623
LIG_NRBOX	187	193	PF00104	0.336
LIG_PDZ_Class_2	317	322	PF00595	0.610
LIG_Pex14_2	114	118	PF04695	0.530
LIG_SH2_CRK	156	160	PF00017	0.477
LIG_SH2_NCK_1	156	160	PF00017	0.477
LIG_SH2_STAT5	10	13	PF00017	0.515
LIG_SH3_1	156	162	PF00018	0.481
LIG_SH3_3	156	162	PF00018	0.602
LIG_SH3_3	223	229	PF00018	0.510
LIG_SH3_3	249	255	PF00018	0.665
LIG_SH3_3	36	42	PF00018	0.656
LIG_SH3_3	50	56	PF00018	0.656
LIG_SH3_CIN85_PxpxPR_1	158	163	PF14604	0.593
LIG_WW_3	55	59	PF00397	0.646
MOD_CDK_SPK_2	255	260	PF00069	0.558
MOD_CDK_SPK_2	91	96	PF00069	0.566
MOD_CDK_SPxxK_3	154	161	PF00069	0.662
MOD_CDK_SPxxK_3	22	29	PF00069	0.566
MOD_CDK_SPxxK_3	51	58	PF00069	0.670
MOD_CK1_1	107	113	PF00069	0.566
MOD_CK1_1	126	132	PF00069	0.582
MOD_CK1_1	134	140	PF00069	0.564
MOD_CK1_1	154	160	PF00069	0.590
MOD_CK1_1	181	187	PF00069	0.309
MOD_CK1_1	20	26	PF00069	0.575
MOD_CK1_1	232	238	PF00069	0.635
MOD_CK1_1	247	253	PF00069	0.631
MOD_CK1_1	258	264	PF00069	0.681
MOD_CK1_1	31	37	PF00069	0.578
MOD_CK1_1	41	47	PF00069	0.679
MOD_CK1_1	49	55	PF00069	0.650
MOD_CK2_1	137	143	PF00069	0.597
MOD_CK2_1	144	150	PF00069	0.564
MOD_CK2_1	181	187	PF00069	0.316
MOD_CK2_1	268	274	PF00069	0.576
MOD_GlcNHglycan	133	136	PF01048	0.637
MOD_GlcNHglycan	21	25	PF01048	0.622
MOD_GlcNHglycan	217	220	PF01048	0.668
MOD_GlcNHglycan	247	250	PF01048	0.659
MOD_GlcNHglycan	87	91	PF01048	0.476
MOD_GSK3_1	126	133	PF00069	0.648
MOD_GSK3_1	150	157	PF00069	0.574
MOD_GSK3_1	172	179	PF00069	0.523
MOD_GSK3_1	221	228	PF00069	0.645
MOD_GSK3_1	232	239	PF00069	0.640
MOD_GSK3_1	244	251	PF00069	0.651
MOD_GSK3_1	255	262	PF00069	0.529
MOD_GSK3_1	38	45	PF00069	0.653
MOD_GSK3_1	86	93	PF00069	0.636
MOD_N-GLC_1	275	280	PF02516	0.548
MOD_NEK2_1	149	154	PF00069	0.731
MOD_NEK2_1	197	202	PF00069	0.367
MOD_NEK2_1	236	241	PF00069	0.636
MOD_PIKK_1	178	184	PF00454	0.309
MOD_PIKK_1	229	235	PF00454	0.496
MOD_PIKK_1	259	265	PF00454	0.650
MOD_PIKK_1	43	49	PF00454	0.668
MOD_PK_1	195	201	PF00069	0.328
MOD_PK_1	275	281	PF00069	0.527
MOD_PKA_2	104	110	PF00069	0.362
MOD_PKA_2	172	178	PF00069	0.641
MOD_PKA_2	259	265	PF00069	0.709
MOD_PKA_2	28	34	PF00069	0.587
MOD_PKA_2	295	301	PF00069	0.584
MOD_PKA_2	303	309	PF00069	0.608
MOD_PKA_2	90	96	PF00069	0.561
MOD_PKB_1	193	201	PF00069	0.328
MOD_Plk_1	242	248	PF00069	0.489
MOD_Plk_1	275	281	PF00069	0.563
MOD_Plk_2-3	144	150	PF00069	0.677
MOD_Plk_4	137	143	PF00069	0.637
MOD_Plk_4	275	281	PF00069	0.563
MOD_ProDKin_1	154	160	PF00069	0.661
MOD_ProDKin_1	176	182	PF00069	0.519
MOD_ProDKin_1	22	28	PF00069	0.566
MOD_ProDKin_1	225	231	PF00069	0.499
MOD_ProDKin_1	251	257	PF00069	0.661
MOD_ProDKin_1	263	269	PF00069	0.643
MOD_ProDKin_1	38	44	PF00069	0.623
MOD_ProDKin_1	46	52	PF00069	0.622
MOD_ProDKin_1	91	97	PF00069	0.546
MOD_SUMO_rev_2	181	191	PF00179	0.273
TRG_DiLeu_BaEn_1	14	19	PF01217	0.517
TRG_DiLeu_BaEn_1	187	192	PF01217	0.295
TRG_DiLeu_BaEn_4	144	150	PF01217	0.657
TRG_DiLeu_BaLyEn_6	32	37	PF01217	0.604
TRG_ENDOCYTIC_2	80	83	PF00928	0.601
TRG_ER_diArg_1	169	172	PF00400	0.680
TRG_ER_diArg_1	192	195	PF00400	0.396
TRG_ER_diArg_1	317	319	PF00400	0.638
TRG_ER_diArg_1	6	8	PF00400	0.518
TRG_NLS_MonoExtN_4	3	9	PF00514	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II75	Leptomonas seymouri	55%	100%
A0A1X0P8R1	Trypanosomatidae	30%	100%
A0A3S7XA97	Leishmania donovani	86%	100%
A4HNL1	Leishmania braziliensis	68%	100%
A4ICY1	Leishmania infantum	87%	100%
Q4Q272	Leishmania major	86%	100%