Putative L-ribulokinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

L-ribulokinase, putative

Species:

Leishmania mexicana

UniProt:

E9ASC3_LEIMU

TriTrypDb:

LmxM.36.0060

Length:

563

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9ASC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASC3

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	8
GO:0005996	monosaccharide metabolic process	3	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0008152	metabolic process	1	8
GO:0009056	catabolic process	2	8
GO:0009058	biosynthetic process	2	8
GO:0009987	cellular process	1	8
GO:0016052	carbohydrate catabolic process	4	8
GO:0019321	pentose metabolic process	4	8
GO:0019323	pentose catabolic process	5	8
GO:0019566	arabinose metabolic process	5	8
GO:0019568	arabinose catabolic process	6	8
GO:0019569	L-arabinose catabolic process to xylulose 5-phosphate	6	8
GO:0019572	L-arabinose catabolic process	7	8
GO:0019637	organophosphate metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044281	small molecule metabolic process	2	8
GO:0044282	small molecule catabolic process	3	8
GO:0046365	monosaccharide catabolic process	4	8
GO:0046373	L-arabinose metabolic process	6	8
GO:0051167	xylulose 5-phosphate metabolic process	4	8
GO:0071704	organic substance metabolic process	2	8
GO:0090407	organophosphate biosynthetic process	4	8
GO:1901135	carbohydrate derivative metabolic process	3	8
GO:1901137	carbohydrate derivative biosynthetic process	4	8
GO:1901159	xylulose 5-phosphate biosynthetic process	5	8
GO:1901575	organic substance catabolic process	3	8
GO:1901576	organic substance biosynthetic process	3	8
GO:0016310	phosphorylation	5	1
GO:0044262	obsolete cellular carbohydrate metabolic process	3	1
GO:0046835	carbohydrate phosphorylation	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0008741	ribulokinase activity	5	8
GO:0016301	kinase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0019200	carbohydrate kinase activity	5	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:0019150	D-ribulokinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	263	265	PF00675	0.309
CLV_NRD_NRD_1	316	318	PF00675	0.317
CLV_NRD_NRD_1	377	379	PF00675	0.364
CLV_NRD_NRD_1	382	384	PF00675	0.398
CLV_NRD_NRD_1	411	413	PF00675	0.267
CLV_NRD_NRD_1	456	458	PF00675	0.361
CLV_PCSK_FUR_1	454	458	PF00082	0.361
CLV_PCSK_KEX2_1	263	265	PF00082	0.250
CLV_PCSK_KEX2_1	316	318	PF00082	0.317
CLV_PCSK_KEX2_1	377	379	PF00082	0.372
CLV_PCSK_KEX2_1	381	383	PF00082	0.389
CLV_PCSK_KEX2_1	411	413	PF00082	0.267
CLV_PCSK_KEX2_1	456	458	PF00082	0.361
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.391
CLV_PCSK_PC7_1	377	383	PF00082	0.167
CLV_PCSK_SKI1_1	22	26	PF00082	0.267
CLV_PCSK_SKI1_1	226	230	PF00082	0.374
CLV_PCSK_SKI1_1	316	320	PF00082	0.399
CLV_PCSK_SKI1_1	378	382	PF00082	0.272
DEG_APCC_DBOX_1	21	29	PF00400	0.361
DEG_APCC_DBOX_1	381	389	PF00400	0.417
DOC_CYCLIN_yCln2_LP_2	486	492	PF00134	0.267
DOC_MAPK_FxFP_2	39	42	PF00069	0.350
DOC_MAPK_gen_1	454	462	PF00069	0.267
DOC_MAPK_gen_1	473	481	PF00069	0.267
DOC_MAPK_MEF2A_6	473	481	PF00069	0.361
DOC_MAPK_MEF2A_6	84	92	PF00069	0.320
DOC_PP2B_LxvP_1	486	489	PF13499	0.267
DOC_PP4_FxxP_1	39	42	PF00568	0.350
DOC_USP7_MATH_1	142	146	PF00917	0.350
DOC_USP7_MATH_1	338	342	PF00917	0.302
DOC_USP7_MATH_1	397	401	PF00917	0.350
DOC_USP7_MATH_1	445	449	PF00917	0.267
DOC_USP7_MATH_1	500	504	PF00917	0.361
DOC_USP7_MATH_1	525	529	PF00917	0.423
DOC_WW_Pin1_4	104	109	PF00397	0.267
DOC_WW_Pin1_4	143	148	PF00397	0.304
DOC_WW_Pin1_4	410	415	PF00397	0.267
DOC_WW_Pin1_4	472	477	PF00397	0.230
DOC_WW_Pin1_4	95	100	PF00397	0.298
LIG_14-3-3_CanoR_1	240	250	PF00244	0.369
LIG_14-3-3_CanoR_1	264	273	PF00244	0.363
LIG_14-3-3_CanoR_1	360	368	PF00244	0.267
LIG_14-3-3_CanoR_1	383	389	PF00244	0.285
LIG_BRCT_BRCA1_1	158	162	PF00533	0.267
LIG_BRCT_BRCA1_1	35	39	PF00533	0.350
LIG_deltaCOP1_diTrp_1	160	163	PF00928	0.267
LIG_deltaCOP1_diTrp_1	188	194	PF00928	0.361
LIG_deltaCOP1_diTrp_1	218	223	PF00928	0.267
LIG_eIF4E_1	356	362	PF01652	0.267
LIG_eIF4E_1	49	55	PF01652	0.267
LIG_EVH1_2	224	228	PF00568	0.267
LIG_FHA_1	245	251	PF00498	0.350
LIG_FHA_1	267	273	PF00498	0.290
LIG_FHA_1	363	369	PF00498	0.388
LIG_FHA_1	507	513	PF00498	0.320
LIG_FHA_1	71	77	PF00498	0.415
LIG_FHA_2	254	260	PF00498	0.361
LIG_FHA_2	385	391	PF00498	0.350
LIG_FHA_2	43	49	PF00498	0.167
LIG_Integrin_isoDGR_2	409	411	PF01839	0.267
LIG_LIR_Apic_2	36	42	PF02991	0.409
LIG_LIR_Gen_1	146	157	PF02991	0.361
LIG_LIR_Gen_1	198	204	PF02991	0.361
LIG_LIR_Gen_1	227	236	PF02991	0.267
LIG_LIR_Gen_1	293	298	PF02991	0.264
LIG_LIR_Gen_1	345	354	PF02991	0.267
LIG_LIR_Gen_1	557	563	PF02991	0.445
LIG_LIR_Nem_3	146	152	PF02991	0.273
LIG_LIR_Nem_3	198	203	PF02991	0.361
LIG_LIR_Nem_3	218	223	PF02991	0.134
LIG_LIR_Nem_3	227	232	PF02991	0.286
LIG_LIR_Nem_3	293	297	PF02991	0.284
LIG_LIR_Nem_3	341	346	PF02991	0.305
LIG_LIR_Nem_3	435	440	PF02991	0.302
LIG_LIR_Nem_3	543	549	PF02991	0.336
LIG_PALB2_WD40_1	345	353	PF16756	0.221
LIG_PCNA_yPIPBox_3	411	424	PF02747	0.350
LIG_SH2_CRK	200	204	PF00017	0.302
LIG_SH2_CRK	292	296	PF00017	0.337
LIG_SH2_CRK	437	441	PF00017	0.302
LIG_SH2_CRK	514	518	PF00017	0.384
LIG_SH2_PTP2	549	552	PF00017	0.412
LIG_SH2_STAP1	157	161	PF00017	0.267
LIG_SH2_STAP1	542	546	PF00017	0.396
LIG_SH2_STAT5	149	152	PF00017	0.276
LIG_SH2_STAT5	49	52	PF00017	0.302
LIG_SH2_STAT5	549	552	PF00017	0.412
LIG_TYR_ITIM	512	517	PF00017	0.230
LIG_UBA3_1	122	127	PF00899	0.267
LIG_WRC_WIRS_1	149	154	PF05994	0.361
LIG_WW_3	223	227	PF00397	0.361
MOD_CK1_1	241	247	PF00069	0.313
MOD_CK1_1	386	392	PF00069	0.167
MOD_CK1_1	526	532	PF00069	0.381
MOD_CK2_1	128	134	PF00069	0.312
MOD_CK2_1	253	259	PF00069	0.361
MOD_CK2_1	384	390	PF00069	0.312
MOD_CK2_1	42	48	PF00069	0.211
MOD_CK2_1	513	519	PF00069	0.375
MOD_Cter_Amidation	409	412	PF01082	0.267
MOD_GlcNHglycan	19	22	PF01048	0.240
MOD_GlcNHglycan	340	343	PF01048	0.302
MOD_GlcNHglycan	35	38	PF01048	0.374
MOD_GlcNHglycan	357	360	PF01048	0.302
MOD_GlcNHglycan	502	505	PF01048	0.375
MOD_GlcNHglycan	525	528	PF01048	0.376
MOD_GSK3_1	143	150	PF00069	0.362
MOD_GSK3_1	192	199	PF00069	0.267
MOD_GSK3_1	386	393	PF00069	0.267
MOD_GSK3_1	428	435	PF00069	0.288
MOD_GSK3_1	441	448	PF00069	0.230
MOD_GSK3_1	488	495	PF00069	0.366
MOD_GSK3_1	523	530	PF00069	0.377
MOD_GSK3_1	91	98	PF00069	0.281
MOD_NEK2_1	203	208	PF00069	0.391
MOD_NEK2_1	238	243	PF00069	0.350
MOD_NEK2_1	265	270	PF00069	0.273
MOD_NEK2_1	298	303	PF00069	0.303
MOD_NEK2_1	354	359	PF00069	0.361
MOD_NEK2_1	361	366	PF00069	0.361
MOD_NEK2_1	384	389	PF00069	0.361
MOD_NEK2_1	92	97	PF00069	0.270
MOD_NEK2_2	398	403	PF00069	0.350
MOD_OFUCOSY	100	106	PF10250	0.361
MOD_PIKK_1	174	180	PF00454	0.373
MOD_PKA_2	111	117	PF00069	0.350
MOD_PKA_2	241	247	PF00069	0.361
MOD_PKA_2	42	48	PF00069	0.296
MOD_Plk_1	127	133	PF00069	0.267
MOD_Plk_1	147	153	PF00069	0.250
MOD_Plk_1	308	314	PF00069	0.465
MOD_Plk_1	390	396	PF00069	0.398
MOD_Plk_1	398	404	PF00069	0.318
MOD_Plk_1	441	447	PF00069	0.267
MOD_Plk_2-3	128	134	PF00069	0.267
MOD_Plk_4	290	296	PF00069	0.317
MOD_Plk_4	308	314	PF00069	0.267
MOD_Plk_4	325	331	PF00069	0.163
MOD_Plk_4	419	425	PF00069	0.388
MOD_Plk_4	432	438	PF00069	0.219
MOD_ProDKin_1	104	110	PF00069	0.267
MOD_ProDKin_1	143	149	PF00069	0.304
MOD_ProDKin_1	410	416	PF00069	0.267
MOD_ProDKin_1	472	478	PF00069	0.230
MOD_ProDKin_1	95	101	PF00069	0.298
MOD_SUMO_for_1	372	375	PF00179	0.350
TRG_DiLeu_BaLyEn_6	357	362	PF01217	0.363
TRG_ENDOCYTIC_2	149	152	PF00928	0.361
TRG_ENDOCYTIC_2	181	184	PF00928	0.267
TRG_ENDOCYTIC_2	200	203	PF00928	0.267
TRG_ENDOCYTIC_2	292	295	PF00928	0.339
TRG_ENDOCYTIC_2	343	346	PF00928	0.298
TRG_ENDOCYTIC_2	437	440	PF00928	0.302
TRG_ENDOCYTIC_2	514	517	PF00928	0.327
TRG_ENDOCYTIC_2	542	545	PF00928	0.319
TRG_ENDOCYTIC_2	549	552	PF00928	0.329
TRG_ENDOCYTIC_2	560	563	PF00928	0.435
TRG_ER_diArg_1	204	207	PF00400	0.361
TRG_ER_diArg_1	239	242	PF00400	0.267
TRG_ER_diArg_1	26	29	PF00400	0.328
TRG_ER_diArg_1	263	265	PF00400	0.309
TRG_ER_diArg_1	316	318	PF00400	0.319
TRG_ER_diArg_1	376	378	PF00400	0.185
TRG_ER_diArg_1	382	384	PF00400	0.230
TRG_ER_diArg_1	455	457	PF00400	0.361
TRG_NES_CRM1_1	418	432	PF08389	0.361
TRG_NLS_MonoExtN_4	378	385	PF00514	0.320
TRG_Pf-PMV_PEXEL_1	366	370	PF00026	0.246
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.267
TRG_Pf-PMV_PEXEL_1	449	453	PF00026	0.267
TRG_PTS1	560	563	PF00515	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3T2	Leptomonas seymouri	80%	100%
A0A0N0P704	Leptomonas seymouri	24%	100%
A0A1X0P8E5	Trypanosomatidae	62%	100%
A0A1X0P984	Trypanosomatidae	23%	100%
A0A3S7XA52	Leishmania donovani	94%	100%
A0A422NB41	Trypanosoma rangeli	62%	100%
A1A7B0	Escherichia coli O1:K1 / APEC	49%	99%
A2AJL3	Mus musculus	26%	100%
A4ICY2	Leishmania infantum	94%	100%
A4IPA2	Geobacillus thermodenitrificans (strain NG80-2)	35%	100%
A4W6G7	Enterobacter sp. (strain 638)	49%	99%
A6QEK4	Staphylococcus aureus (strain Newman)	32%	100%
A6T4K1	Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)	50%	99%
A7WYY2	Staphylococcus aureus (strain Mu3 / ATCC 700698)	32%	100%
A7ZHF4	Escherichia coli O139:H28 (strain E24377A / ETEC)	49%	99%
A7ZW13	Escherichia coli O9:H4 (strain HS)	49%	99%
A8ALN9	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	50%	99%
A8GE05	Serratia proteamaculans (strain 568)	50%	100%
A9MQF0	Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)	49%	99%
A9MYN9	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	50%	99%
B1IRB5	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	49%	99%
B1LFZ7	Escherichia coli (strain SMS-3-5 / SECEC)	49%	99%
B2U269	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	49%	99%
B2VEQ9	Erwinia tasmaniensis (strain DSM 17950 / CFBP 7177 / CIP 109463 / NCPPB 4357 / Et1/99)	47%	100%
B4SU24	Salmonella newport (strain SL254)	50%	99%
B4TJ60	Salmonella heidelberg (strain SL476)	49%	99%
B4TWU9	Salmonella schwarzengrund (strain CVM19633)	50%	99%
B5BL44	Salmonella paratyphi A (strain AKU_12601)	50%	99%
B5F784	Salmonella agona (strain SL483)	50%	99%
B5FI46	Salmonella dublin (strain CT_02021853)	49%	99%
B5R1U0	Salmonella enteritidis PT4 (strain P125109)	49%	99%
B5RGD4	Salmonella gallinarum (strain 287/91 / NCTC 13346)	49%	99%
B5Y1Y0	Klebsiella pneumoniae (strain 342)	50%	99%
B5YZ99	Escherichia coli O157:H7 (strain EC4115 / EHEC)	49%	99%
B6HZ43	Escherichia coli (strain SE11)	49%	99%
B7GGV9	Anoxybacillus flavithermus (strain DSM 21510 / WK1)	34%	100%
B7L4I4	Escherichia coli (strain 55989 / EAEC)	49%	99%
B7LVT4	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	50%	99%
B7M0F8	Escherichia coli O8 (strain IAI1)	49%	99%
B7MAI6	Escherichia coli O45:K1 (strain S88 / ExPEC)	49%	99%
B7MNS0	Escherichia coli O81 (strain ED1a)	49%	99%
B7N7T7	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	49%	99%
B7NHG9	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	49%	99%
B7UIA9	Escherichia coli O127:H6 (strain E2348/69 / EPEC)	49%	99%
C4ZPY6	Escherichia coli (strain K12 / MC4100 / BW2952)	48%	99%
C6DH20	Pectobacterium carotovorum subsp. carotovorum (strain PC1)	47%	99%
E9ASE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
P06188	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	49%	99%
P08204	Escherichia coli (strain K12)	49%	99%
P58541	Escherichia coli O157:H7	49%	99%
P58542	Salmonella typhi	50%	99%
P58543	Yersinia pestis	47%	100%
P63549	Staphylococcus aureus (strain Mu50 / ATCC 700699)	32%	100%
P63550	Staphylococcus aureus (strain N315)	32%	100%
P94524	Bacillus subtilis (strain 168)	36%	100%
Q04585	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	79%
Q0T8D4	Shigella flexneri serotype 5b (strain 8401)	48%	99%
Q0TLS7	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	49%	99%
Q1C7J2	Yersinia pestis bv. Antiqua (strain Antiqua)	47%	99%
Q1CIX8	Yersinia pestis bv. Antiqua (strain Nepal516)	47%	99%
Q1RGD6	Escherichia coli (strain UTI89 / UPEC)	49%	99%
Q2FJ88	Staphylococcus aureus (strain USA300)	32%	100%
Q2G0M6	Staphylococcus aureus (strain NCTC 8325 / PS 47)	32%	100%
Q2YSA9	Staphylococcus aureus (strain bovine RF122 / ET3-1)	31%	100%
Q326H2	Shigella boydii serotype 4 (strain Sb227)	48%	99%
Q32K30	Shigella dysenteriae serotype 1 (strain Sd197)	48%	99%
Q3Z5U8	Shigella sonnei (strain Ss046)	49%	99%
Q49V87	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	35%	100%
Q49ZR6	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	31%	100%
Q4Q273	Leishmania major	93%	100%
Q5HIC3	Staphylococcus aureus (strain COL)	32%	100%
Q5HLQ6	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	30%	100%
Q5KYP6	Geobacillus kaustophilus (strain HTA426)	35%	100%
Q5PDF1	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	50%	99%
Q5WL06	Alkalihalobacillus clausii (strain KSM-K16)	35%	100%
Q65GC1	Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46)	36%	100%
Q66AF7	Yersinia pseudotuberculosis serotype I (strain IP32953)	47%	100%
Q6D4W6	Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)	48%	100%
Q6DCD1	Xenopus laevis	25%	100%
Q6GBT5	Staphylococcus aureus (strain MSSA476)	32%	100%
Q6GJB6	Staphylococcus aureus (strain MRSA252)	32%	100%
Q6NUW9	Danio rerio	25%	100%
Q7N2E1	Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)	23%	100%
Q83MG5	Shigella flexneri	49%	99%
Q87FK5	Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)	47%	99%
Q8CRC6	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	30%	100%
Q8FL88	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	49%	99%
Q8NXY1	Staphylococcus aureus (strain MW2)	32%	100%
Q96C11	Homo sapiens	26%	100%
Q9KBQ3	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	36%	100%
Q9LBQ3	Mycolicibacterium smegmatis	35%	100%
Q9S468	Geobacillus stearothermophilus	35%	100%