Putative potassium voltage-gated channel

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

potassium voltage-gated channel, putative

Species:

Leishmania mexicana

UniProt:

E9ASB5_LEIMU

TriTrypDb:

LmxM.19.1620

Length:

308

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0008076	voltage-gated potassium channel complex	4	1
GO:0016020	membrane	2	1
GO:0032991	protein-containing complex	1	1
GO:0034702	monoatomic ion channel complex	4	1
GO:0034703	cation channel complex	5	1
GO:0034705	potassium channel complex	6	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0098797	plasma membrane protein complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990351	transporter complex	2	1

Expansion

Sequence features

E9ASB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASB5

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0043933	protein-containing complex organization	4	12
GO:0051259	protein complex oligomerization	6	12
GO:0051260	protein homooligomerization	7	12
GO:0065003	protein-containing complex assembly	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006813	potassium ion transport	7	1
GO:0030001	metal ion transport	6	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005216	monoatomic ion channel activity	4	1
GO:0005242	inward rectifier potassium channel activity	7	1
GO:0005244	voltage-gated monoatomic ion channel activity	4	1
GO:0005249	voltage-gated potassium channel activity	6	1
GO:0005261	monoatomic cation channel activity	5	1
GO:0005267	potassium channel activity	6	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015079	potassium ion transmembrane transporter activity	6	1
GO:0015267	channel activity	4	1
GO:0015272	ATP-activated inward rectifier potassium channel activity	8	1
GO:0015276	ligand-gated monoatomic ion channel activity	5	1
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	1
GO:0022803	passive transmembrane transporter activity	3	1
GO:0022832	voltage-gated channel activity	6	1
GO:0022834	ligand-gated channel activity	6	1
GO:0022836	gated channel activity	5	1
GO:0022843	voltage-gated monoatomic cation channel activity	5	1
GO:0022857	transmembrane transporter activity	2	1
GO:0022890	inorganic cation transmembrane transporter activity	4	1
GO:0046873	metal ion transmembrane transporter activity	5	1
GO:0099094	ligand-gated monoatomic cation channel activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.633
CLV_NRD_NRD_1	159	161	PF00675	0.414
CLV_NRD_NRD_1	167	169	PF00675	0.374
CLV_NRD_NRD_1	249	251	PF00675	0.380
CLV_PCSK_KEX2_1	144	146	PF00082	0.374
CLV_PCSK_KEX2_1	167	169	PF00082	0.403
CLV_PCSK_KEX2_1	249	251	PF00082	0.376
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.362
CLV_PCSK_SKI1_1	160	164	PF00082	0.414
CLV_PCSK_SKI1_1	187	191	PF00082	0.326
CLV_PCSK_SKI1_1	3	7	PF00082	0.362
DEG_APCC_DBOX_1	249	257	PF00400	0.574
DOC_CKS1_1	43	48	PF01111	0.454
DOC_CYCLIN_RxL_1	66	76	PF00134	0.331
DOC_MAPK_gen_1	144	150	PF00069	0.346
DOC_MAPK_gen_1	75	83	PF00069	0.376
DOC_MAPK_MEF2A_6	75	83	PF00069	0.411
DOC_PP1_RVXF_1	285	291	PF00149	0.630
DOC_PP1_RVXF_1	67	74	PF00149	0.411
DOC_USP7_MATH_1	37	41	PF00917	0.373
DOC_USP7_MATH_1	52	56	PF00917	0.481
DOC_WW_Pin1_4	228	233	PF00397	0.405
DOC_WW_Pin1_4	290	295	PF00397	0.592
DOC_WW_Pin1_4	42	47	PF00397	0.406
LIG_14-3-3_CanoR_1	17	22	PF00244	0.373
LIG_BIR_III_2	61	65	PF00653	0.360
LIG_FHA_1	161	167	PF00498	0.339
LIG_FHA_1	191	197	PF00498	0.346
LIG_FHA_1	203	209	PF00498	0.352
LIG_FHA_1	214	220	PF00498	0.400
LIG_FHA_1	223	229	PF00498	0.428
LIG_FHA_1	74	80	PF00498	0.314
LIG_FHA_2	51	57	PF00498	0.331
LIG_LIR_Gen_1	225	235	PF02991	0.398
LIG_LIR_Gen_1	26	37	PF02991	0.331
LIG_LIR_Gen_1	273	283	PF02991	0.603
LIG_LIR_Gen_1	65	74	PF02991	0.331
LIG_LIR_Gen_1	98	107	PF02991	0.329
LIG_LIR_Nem_3	176	182	PF02991	0.349
LIG_LIR_Nem_3	225	230	PF02991	0.387
LIG_LIR_Nem_3	273	278	PF02991	0.604
LIG_LIR_Nem_3	65	70	PF02991	0.331
LIG_MYND_1	254	258	PF01753	0.362
LIG_MYND_3	253	257	PF01753	0.583
LIG_NRBOX	17	23	PF00104	0.411
LIG_PCNA_yPIPBox_3	12	22	PF02747	0.411
LIG_Pex14_2	29	33	PF04695	0.360
LIG_PTB_Apo_2	242	249	PF02174	0.311
LIG_SH2_GRB2like	275	278	PF00017	0.595
LIG_SH2_PTP2	227	230	PF00017	0.366
LIG_SH2_STAT5	13	16	PF00017	0.411
LIG_SH2_STAT5	227	230	PF00017	0.370
LIG_SH3_2	282	287	PF14604	0.597
LIG_SH3_3	248	254	PF00018	0.449
LIG_SH3_3	279	285	PF00018	0.542
LIG_SH3_3	291	297	PF00018	0.588
LIG_SH3_3	40	46	PF00018	0.416
LIG_SUMO_SIM_par_1	121	127	PF11976	0.538
MOD_CDC14_SPxK_1	293	296	PF00782	0.628
MOD_CDK_SPxK_1	290	296	PF00069	0.624
MOD_CK1_1	226	232	PF00069	0.389
MOD_CK1_1	44	50	PF00069	0.330
MOD_CK2_1	50	56	PF00069	0.421
MOD_GlcNHglycan	108	111	PF01048	0.524
MOD_GlcNHglycan	37	40	PF01048	0.386
MOD_GSK3_1	13	20	PF00069	0.266
MOD_GSK3_1	202	209	PF00069	0.368
MOD_GSK3_1	222	229	PF00069	0.485
MOD_GSK3_1	37	44	PF00069	0.251
MOD_NEK2_1	148	153	PF00069	0.350
MOD_NEK2_1	174	179	PF00069	0.372
MOD_NEK2_1	190	195	PF00069	0.476
MOD_NEK2_1	204	209	PF00069	0.353
MOD_NEK2_1	223	228	PF00069	0.586
MOD_NEK2_1	73	78	PF00069	0.266
MOD_PIKK_1	160	166	PF00454	0.338
MOD_PIKK_1	206	212	PF00454	0.362
MOD_PKA_1	160	166	PF00069	0.373
MOD_PKA_2	16	22	PF00069	0.411
MOD_Plk_1	260	266	PF00069	0.665
MOD_Plk_4	17	23	PF00069	0.272
MOD_Plk_4	174	180	PF00069	0.359
MOD_Plk_4	223	229	PF00069	0.374
MOD_Plk_4	260	266	PF00069	0.578
MOD_ProDKin_1	228	234	PF00069	0.408
MOD_ProDKin_1	290	296	PF00069	0.588
MOD_ProDKin_1	42	48	PF00069	0.406
TRG_DiLeu_BaEn_1	118	123	PF01217	0.489
TRG_ENDOCYTIC_2	227	230	PF00928	0.395
TRG_ENDOCYTIC_2	275	278	PF00928	0.607
TRG_ER_diArg_1	166	168	PF00400	0.415
TRG_ER_diArg_1	248	250	PF00400	0.363
TRG_NES_CRM1_1	124	135	PF08389	0.358
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A6	Leptomonas seymouri	80%	97%
A0A0S4JGQ4	Bodo saltans	53%	89%
A0A1X0P666	Trypanosomatidae	59%	100%
A0A3R7KT76	Trypanosoma rangeli	59%	100%
A0A3S7WVV0	Leishmania donovani	95%	100%
A4HAB1	Leishmania braziliensis	92%	100%
A4HYJ1	Leishmania infantum	95%	100%
D0A0W5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
Q4QD47	Leishmania major	96%	100%
V5AP17	Trypanosoma cruzi	58%	100%