Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9ASB4_LEIMU

TriTrypDb:

LmxM.19.1610

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASB4

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016310	phosphorylation	5	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0004672	protein kinase activity	3	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140096	catalytic activity, acting on a protein	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:0004674	protein serine/threonine kinase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	4	6	PF00675	0.506
CLV_NRD_NRD_1	9	11	PF00675	0.450
CLV_PCSK_FUR_1	7	11	PF00082	0.534
CLV_PCSK_KEX2_1	4	6	PF00082	0.506
CLV_PCSK_KEX2_1	9	11	PF00082	0.450
CLV_PCSK_PC7_1	5	11	PF00082	0.574
CLV_PCSK_SKI1_1	103	107	PF00082	0.200
CLV_PCSK_SKI1_1	246	250	PF00082	0.460
CLV_PCSK_SKI1_1	86	90	PF00082	0.359
DEG_APCC_DBOX_1	106	114	PF00400	0.419
DEG_APCC_DBOX_1	4	12	PF00400	0.579
DEG_ODPH_VHL_1	179	190	PF01847	0.383
DEG_SCF_FBW7_1	88	95	PF00400	0.247
DOC_CKS1_1	89	94	PF01111	0.344
DOC_MAPK_gen_1	243	251	PF00069	0.459
DOC_PP1_RVXF_1	7	14	PF00149	0.519
DOC_PP4_FxxP_1	166	169	PF00568	0.419
DOC_USP7_MATH_1	125	129	PF00917	0.460
DOC_USP7_MATH_1	155	159	PF00917	0.255
DOC_USP7_MATH_1	3	7	PF00917	0.538
DOC_WW_Pin1_4	132	137	PF00397	0.390
DOC_WW_Pin1_4	148	153	PF00397	0.448
DOC_WW_Pin1_4	236	241	PF00397	0.460
DOC_WW_Pin1_4	88	93	PF00397	0.437
LIG_14-3-3_CanoR_1	118	122	PF00244	0.438
LIG_APCC_ABBA_1	121	126	PF00400	0.383
LIG_APCC_ABBA_1	179	184	PF00400	0.460
LIG_APCC_ABBA_1	64	69	PF00400	0.497
LIG_BIR_II_1	1	5	PF00653	0.611
LIG_BRCT_BRCA1_1	162	166	PF00533	0.460
LIG_Clathr_ClatBox_1	110	114	PF01394	0.419
LIG_deltaCOP1_diTrp_1	183	188	PF00928	0.378
LIG_deltaCOP1_diTrp_1	215	220	PF00928	0.323
LIG_FHA_1	195	201	PF00498	0.460
LIG_FHA_1	32	38	PF00498	0.557
LIG_FHA_1	89	95	PF00498	0.445
LIG_FHA_2	135	141	PF00498	0.169
LIG_FHA_2	207	213	PF00498	0.359
LIG_Integrin_isoDGR_2	54	56	PF01839	0.370
LIG_LIR_Apic_2	163	169	PF02991	0.376
LIG_LIR_Gen_1	163	172	PF02991	0.371
LIG_LIR_Gen_1	215	224	PF02991	0.327
LIG_LIR_Gen_1	62	68	PF02991	0.526
LIG_LIR_Gen_1	71	81	PF02991	0.337
LIG_LIR_Nem_3	201	207	PF02991	0.399
LIG_LIR_Nem_3	214	220	PF02991	0.289
LIG_LIR_Nem_3	62	66	PF02991	0.420
LIG_LIR_Nem_3	71	77	PF02991	0.409
LIG_SH2_CRK	193	197	PF00017	0.376
LIG_SH2_SRC	122	125	PF00017	0.427
LIG_SH2_STAT5	122	125	PF00017	0.438
LIG_SH2_STAT5	164	167	PF00017	0.339
LIG_SH2_STAT5	59	62	PF00017	0.428
LIG_SH2_STAT5	63	66	PF00017	0.424
LIG_SH3_3	175	181	PF00018	0.419
LIG_SH3_3	197	203	PF00018	0.429
LIG_SUMO_SIM_anti_2	34	42	PF11976	0.580
LIG_SUMO_SIM_par_1	109	114	PF11976	0.460
LIG_SUMO_SIM_par_1	18	24	PF11976	0.508
LIG_TYR_ITIM	191	196	PF00017	0.460
LIG_ULM_U2AF65_1	9	14	PF00076	0.454
LIG_WRC_WIRS_1	94	99	PF05994	0.169
MOD_CDK_SPxxK_3	236	243	PF00069	0.460
MOD_CK1_1	135	141	PF00069	0.466
MOD_CK1_1	211	217	PF00069	0.407
MOD_CK1_1	239	245	PF00069	0.460
MOD_CK1_1	93	99	PF00069	0.280
MOD_CK2_1	262	268	PF00069	0.411
MOD_CK2_1	93	99	PF00069	0.263
MOD_GlcNHglycan	1	4	PF01048	0.583
MOD_GlcNHglycan	157	160	PF01048	0.309
MOD_GlcNHglycan	264	267	PF01048	0.466
MOD_GSK3_1	131	138	PF00069	0.395
MOD_GSK3_1	194	201	PF00069	0.437
MOD_GSK3_1	270	277	PF00069	0.363
MOD_GSK3_1	77	84	PF00069	0.449
MOD_GSK3_1	88	95	PF00069	0.387
MOD_NEK2_1	270	275	PF00069	0.419
MOD_NEK2_1	77	82	PF00069	0.401
MOD_PKA_2	117	123	PF00069	0.460
MOD_PKA_2	242	248	PF00069	0.435
MOD_PKA_2	262	268	PF00069	0.130
MOD_PKA_2	3	9	PF00069	0.522
MOD_Plk_1	125	131	PF00069	0.376
MOD_Plk_2-3	31	37	PF00069	0.372
MOD_Plk_4	117	123	PF00069	0.457
MOD_Plk_4	160	166	PF00069	0.340
MOD_Plk_4	270	276	PF00069	0.452
MOD_ProDKin_1	132	138	PF00069	0.390
MOD_ProDKin_1	148	154	PF00069	0.448
MOD_ProDKin_1	236	242	PF00069	0.460
MOD_ProDKin_1	88	94	PF00069	0.437
TRG_DiLeu_BaEn_2	246	252	PF01217	0.460
TRG_ENDOCYTIC_2	164	167	PF00928	0.400
TRG_ENDOCYTIC_2	193	196	PF00928	0.376
TRG_ENDOCYTIC_2	217	220	PF00928	0.460
TRG_ENDOCYTIC_2	63	66	PF00928	0.413
TRG_ENDOCYTIC_2	74	77	PF00928	0.410
TRG_ER_diArg_1	4	7	PF00400	0.501
TRG_ER_diArg_1	45	48	PF00400	0.548
TRG_ER_diArg_1	8	10	PF00400	0.472
TRG_NES_CRM1_1	17	31	PF08389	0.548
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8N2	Leptomonas seymouri	46%	89%
A0A0S4IKC2	Bodo saltans	30%	73%
A0A0S4IQX7	Bodo saltans	24%	72%
A0A1X0P6Y5	Trypanosomatidae	30%	94%
A0A3Q8IEN2	Leishmania donovani	94%	100%
A0A3R7KMF0	Trypanosoma rangeli	26%	79%
A4HAB0	Leishmania braziliensis	85%	100%
A4HYJ0	Leishmania infantum	94%	100%
A9RWC9	Physcomitrium patens	28%	79%
D0A0W4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	82%
O14047	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	89%
Q4QD48	Leishmania major	92%	100%
Q94A06	Arabidopsis thaliana	25%	79%
Q9S7U9	Arabidopsis thaliana	27%	77%