Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania mexicana

UniProt:

E9ASA8_LEIMU

TriTrypDb:

LmxM.19.1550

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	10
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:1990904	ribonucleoprotein complex	2	10

Expansion

Sequence features

E9ASA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASA8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	339	343	PF00656	0.534
CLV_MEL_PAP_1	297	303	PF00089	0.341
CLV_PCSK_KEX2_1	14	16	PF00082	0.541
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.536
CLV_PCSK_SKI1_1	27	31	PF00082	0.410
CLV_PCSK_SKI1_1	316	320	PF00082	0.317
CLV_PCSK_SKI1_1	338	342	PF00082	0.487
CLV_PCSK_SKI1_1	390	394	PF00082	0.322
DEG_Nend_Nbox_1	1	3	PF02207	0.690
DOC_CYCLIN_RxL_1	24	32	PF00134	0.373
DOC_MAPK_gen_1	207	216	PF00069	0.410
DOC_MAPK_gen_1	242	252	PF00069	0.513
DOC_MAPK_gen_1	374	381	PF00069	0.395
DOC_PP2B_LxvP_1	152	155	PF13499	0.454
DOC_PP4_FxxP_1	261	264	PF00568	0.349
DOC_USP7_MATH_1	157	161	PF00917	0.476
DOC_USP7_MATH_1	177	181	PF00917	0.519
DOC_USP7_MATH_1	196	200	PF00917	0.317
DOC_USP7_MATH_1	25	29	PF00917	0.397
DOC_USP7_MATH_1	3	7	PF00917	0.509
LIG_14-3-3_CanoR_1	215	221	PF00244	0.420
LIG_14-3-3_CanoR_1	300	307	PF00244	0.407
LIG_Actin_WH2_2	343	360	PF00022	0.464
LIG_ActinCP_TwfCPI_2	261	270	PF01115	0.394
LIG_deltaCOP1_diTrp_1	35	45	PF00928	0.377
LIG_FHA_1	110	116	PF00498	0.465
LIG_FHA_1	211	217	PF00498	0.452
LIG_FHA_1	326	332	PF00498	0.445
LIG_FHA_1	69	75	PF00498	0.523
LIG_FHA_2	30	36	PF00498	0.315
LIG_FHA_2	337	343	PF00498	0.476
LIG_LIR_Apic_2	258	264	PF02991	0.331
LIG_LIR_Gen_1	28	39	PF02991	0.406
LIG_LIR_Gen_1	42	52	PF02991	0.364
LIG_LIR_Nem_3	28	34	PF02991	0.410
LIG_LIR_Nem_3	42	48	PF02991	0.385
LIG_Pex14_2	34	38	PF04695	0.297
LIG_SH2_CRK	170	174	PF00017	0.543
LIG_SH2_CRK	332	336	PF00017	0.357
LIG_SH2_GRB2like	231	234	PF00017	0.331
LIG_SH2_SRC	231	234	PF00017	0.331
LIG_SH2_SRC	294	297	PF00017	0.338
LIG_SH2_STAT5	296	299	PF00017	0.349
LIG_SH2_STAT5	31	34	PF00017	0.347
LIG_SH3_2	202	207	PF14604	0.514
LIG_SH3_3	199	205	PF00018	0.416
LIG_SH3_3	261	267	PF00018	0.452
LIG_SH3_3	71	77	PF00018	0.433
LIG_TRAF2_1	353	356	PF00917	0.390
LIG_TYR_ITIM	292	297	PF00017	0.345
LIG_UBA3_1	238	245	PF00899	0.372
MOD_CK1_1	103	109	PF00069	0.507
MOD_CK1_1	134	140	PF00069	0.627
MOD_CK1_1	144	150	PF00069	0.554
MOD_CK1_1	302	308	PF00069	0.338
MOD_CK1_1	4	10	PF00069	0.626
MOD_CK1_1	90	96	PF00069	0.554
MOD_CK2_1	271	277	PF00069	0.327
MOD_CK2_1	4	10	PF00069	0.572
MOD_GlcNHglycan	133	136	PF01048	0.522
MOD_GlcNHglycan	137	140	PF01048	0.550
MOD_GlcNHglycan	170	173	PF01048	0.281
MOD_GlcNHglycan	3	6	PF01048	0.697
MOD_GlcNHglycan	320	323	PF01048	0.330
MOD_GlcNHglycan	7	10	PF01048	0.625
MOD_GlcNHglycan	93	96	PF01048	0.610
MOD_GlcNHglycan	97	100	PF01048	0.604
MOD_GSK3_1	1	8	PF00069	0.619
MOD_GSK3_1	127	134	PF00069	0.446
MOD_GSK3_1	137	144	PF00069	0.436
MOD_GSK3_1	177	184	PF00069	0.598
MOD_GSK3_1	25	32	PF00069	0.445
MOD_GSK3_1	302	309	PF00069	0.368
MOD_GSK3_1	381	388	PF00069	0.305
MOD_GSK3_1	87	94	PF00069	0.461
MOD_GSK3_1	95	102	PF00069	0.590
MOD_N-GLC_1	103	108	PF02516	0.691
MOD_N-GLC_1	372	377	PF02516	0.411
MOD_N-GLC_1	87	92	PF02516	0.480
MOD_NEK2_1	1	6	PF00069	0.622
MOD_NEK2_1	120	125	PF00069	0.448
MOD_NEK2_1	127	132	PF00069	0.438
MOD_NEK2_1	271	276	PF00069	0.344
MOD_NEK2_1	29	34	PF00069	0.383
MOD_NEK2_1	385	390	PF00069	0.313
MOD_NEK2_1	392	397	PF00069	0.341
MOD_NEK2_1	91	96	PF00069	0.688
MOD_NEK2_2	336	341	PF00069	0.440
MOD_NEK2_2	56	61	PF00069	0.371
MOD_PIKK_1	240	246	PF00454	0.430
MOD_PK_1	181	187	PF00069	0.485
MOD_PKA_1	14	20	PF00069	0.472
MOD_PKA_2	14	20	PF00069	0.483
MOD_PKA_2	168	174	PF00069	0.485
MOD_PKA_2	190	196	PF00069	0.461
MOD_PKA_2	299	305	PF00069	0.366
MOD_PKA_2	95	101	PF00069	0.455
MOD_Plk_1	127	133	PF00069	0.520
MOD_Plk_1	325	331	PF00069	0.302
MOD_Plk_1	336	342	PF00069	0.379
MOD_Plk_1	385	391	PF00069	0.305
MOD_Plk_1	87	93	PF00069	0.531
MOD_Plk_4	147	153	PF00069	0.481
MOD_Plk_4	157	163	PF00069	0.450
MOD_Plk_4	25	31	PF00069	0.462
MOD_Plk_4	302	308	PF00069	0.338
MOD_Plk_4	56	62	PF00069	0.394
MOD_SUMO_rev_2	232	239	PF00179	0.369
TRG_ENDOCYTIC_2	294	297	PF00928	0.338
TRG_ENDOCYTIC_2	31	34	PF00928	0.327
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.322
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.370

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF14	Leptomonas seymouri	82%	100%
A0A0S4IXZ3	Bodo saltans	66%	100%
A0A1X0P6T7	Trypanosomatidae	66%	100%
A0A3R7NXE0	Trypanosoma rangeli	67%	100%
A0A3S7WVM1	Leishmania donovani	95%	100%
A4HAA4	Leishmania braziliensis	90%	98%
A4HYI4	Leishmania infantum	95%	100%
A4QNE6	Xenopus tropicalis	43%	100%
A8J3F6	Chlamydomonas reinhardtii	45%	100%
D0A0V7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
Q29RZ9	Bos taurus	45%	100%
Q4QD54	Leishmania major	96%	100%
Q561Y0	Danio rerio	43%	100%
Q5M7F6	Xenopus laevis	44%	100%
Q8BGF3	Mus musculus	46%	100%
Q96MX6	Homo sapiens	45%	100%
V5B8V8	Trypanosoma cruzi	69%	100%