Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASA5_LEIMU

TriTrypDb:

LmxM.19.1520

Length:

785

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASA5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.622
CLV_NRD_NRD_1	136	138	PF00675	0.633
CLV_NRD_NRD_1	190	192	PF00675	0.678
CLV_NRD_NRD_1	323	325	PF00675	0.551
CLV_NRD_NRD_1	358	360	PF00675	0.439
CLV_NRD_NRD_1	383	385	PF00675	0.286
CLV_NRD_NRD_1	413	415	PF00675	0.676
CLV_NRD_NRD_1	431	433	PF00675	0.330
CLV_NRD_NRD_1	454	456	PF00675	0.445
CLV_NRD_NRD_1	617	619	PF00675	0.608
CLV_NRD_NRD_1	758	760	PF00675	0.580
CLV_PCSK_FUR_1	134	138	PF00082	0.717
CLV_PCSK_FUR_1	381	385	PF00082	0.276
CLV_PCSK_FUR_1	756	760	PF00082	0.690
CLV_PCSK_KEX2_1	136	138	PF00082	0.657
CLV_PCSK_KEX2_1	190	192	PF00082	0.641
CLV_PCSK_KEX2_1	322	324	PF00082	0.564
CLV_PCSK_KEX2_1	383	385	PF00082	0.286
CLV_PCSK_KEX2_1	413	415	PF00082	0.676
CLV_PCSK_KEX2_1	431	433	PF00082	0.330
CLV_PCSK_KEX2_1	454	456	PF00082	0.481
CLV_PCSK_KEX2_1	546	548	PF00082	0.490
CLV_PCSK_KEX2_1	707	709	PF00082	0.470
CLV_PCSK_KEX2_1	758	760	PF00082	0.581
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.490
CLV_PCSK_PC1ET2_1	707	709	PF00082	0.470
CLV_PCSK_SKI1_1	338	342	PF00082	0.552
CLV_PCSK_SKI1_1	513	517	PF00082	0.381
CLV_PCSK_SKI1_1	647	651	PF00082	0.488
CLV_PCSK_SKI1_1	747	751	PF00082	0.512
DEG_SCF_FBW7_1	401	408	PF00400	0.582
DEG_SPOP_SBC_1	57	61	PF00917	0.615
DOC_ANK_TNKS_1	383	390	PF00023	0.314
DOC_CKS1_1	402	407	PF01111	0.583
DOC_CKS1_1	528	533	PF01111	0.395
DOC_MAPK_gen_1	196	205	PF00069	0.593
DOC_MAPK_gen_1	356	366	PF00069	0.421
DOC_MAPK_gen_1	431	439	PF00069	0.393
DOC_MAPK_gen_1	451	459	PF00069	0.486
DOC_MAPK_gen_1	474	482	PF00069	0.480
DOC_MAPK_gen_1	546	552	PF00069	0.397
DOC_MAPK_gen_1	618	628	PF00069	0.581
DOC_MAPK_gen_1	645	653	PF00069	0.456
DOC_MAPK_gen_1	707	713	PF00069	0.474
DOC_MAPK_MEF2A_6	432	441	PF00069	0.404
DOC_MAPK_MEF2A_6	454	461	PF00069	0.500
DOC_MAPK_MEF2A_6	488	495	PF00069	0.461
DOC_MAPK_MEF2A_6	518	525	PF00069	0.409
DOC_MAPK_MEF2A_6	645	653	PF00069	0.492
DOC_MAPK_NFAT4_5	454	462	PF00069	0.437
DOC_PP1_RVXF_1	603	610	PF00149	0.420
DOC_PP2B_LxvP_1	119	122	PF13499	0.483
DOC_PP4_FxxP_1	385	388	PF00568	0.508
DOC_PP4_FxxP_1	528	531	PF00568	0.390
DOC_PP4_FxxP_1	7	10	PF00568	0.571
DOC_USP7_MATH_1	10	14	PF00917	0.619
DOC_USP7_MATH_1	142	146	PF00917	0.653
DOC_USP7_MATH_1	236	240	PF00917	0.736
DOC_USP7_MATH_1	275	279	PF00917	0.496
DOC_USP7_MATH_1	3	7	PF00917	0.659
DOC_USP7_MATH_1	392	396	PF00917	0.541
DOC_USP7_MATH_1	405	409	PF00917	0.501
DOC_USP7_MATH_1	53	57	PF00917	0.668
DOC_USP7_MATH_1	58	62	PF00917	0.656
DOC_USP7_MATH_1	63	67	PF00917	0.605
DOC_USP7_MATH_1	690	694	PF00917	0.578
DOC_USP7_MATH_1	76	80	PF00917	0.437
DOC_USP7_UBL2_3	356	360	PF12436	0.346
DOC_USP7_UBL2_3	615	619	PF12436	0.551
DOC_WW_Pin1_4	279	284	PF00397	0.673
DOC_WW_Pin1_4	401	406	PF00397	0.754
DOC_WW_Pin1_4	527	532	PF00397	0.400
DOC_WW_Pin1_4	576	581	PF00397	0.521
DOC_WW_Pin1_4	585	590	PF00397	0.490
DOC_WW_Pin1_4	59	64	PF00397	0.588
DOC_WW_Pin1_4	6	11	PF00397	0.742
DOC_WW_Pin1_4	68	73	PF00397	0.589
DOC_WW_Pin1_4	719	724	PF00397	0.573
LIG_14-3-3_CanoR_1	148	156	PF00244	0.590
LIG_14-3-3_CanoR_1	240	247	PF00244	0.669
LIG_14-3-3_CanoR_1	33	41	PF00244	0.734
LIG_14-3-3_CanoR_1	578	587	PF00244	0.459
LIG_14-3-3_CanoR_1	677	681	PF00244	0.524
LIG_14-3-3_CanoR_1	731	741	PF00244	0.661
LIG_14-3-3_CterR_2	780	785	PF00244	0.546
LIG_BIR_II_1	1	5	PF00653	0.549
LIG_BRCT_BRCA1_1	142	146	PF00533	0.683
LIG_BRCT_BRCA1_1	392	396	PF00533	0.439
LIG_BRCT_BRCA1_1	93	97	PF00533	0.652
LIG_EH1_1	368	376	PF00400	0.395
LIG_FHA_1	288	294	PF00498	0.605
LIG_FHA_1	346	352	PF00498	0.525
LIG_FHA_1	353	359	PF00498	0.483
LIG_FHA_1	40	46	PF00498	0.638
LIG_FHA_1	766	772	PF00498	0.709
LIG_FHA_1	91	97	PF00498	0.624
LIG_FHA_2	182	188	PF00498	0.529
LIG_FHA_2	304	310	PF00498	0.703
LIG_FHA_2	402	408	PF00498	0.717
LIG_FHA_2	528	534	PF00498	0.375
LIG_FHA_2	725	731	PF00498	0.571
LIG_FHA_2	76	82	PF00498	0.549
LIG_Integrin_RGD_1	667	669	PF01839	0.531
LIG_LIR_Apic_2	5	10	PF02991	0.573
LIG_LIR_Apic_2	526	531	PF02991	0.398
LIG_LIR_Gen_1	143	154	PF02991	0.600
LIG_LIR_Gen_1	377	387	PF02991	0.399
LIG_LIR_Gen_1	563	573	PF02991	0.362
LIG_LIR_Gen_1	606	616	PF02991	0.531
LIG_LIR_Nem_3	123	129	PF02991	0.546
LIG_LIR_Nem_3	143	149	PF02991	0.611
LIG_LIR_Nem_3	314	319	PF02991	0.546
LIG_LIR_Nem_3	377	382	PF02991	0.396
LIG_LIR_Nem_3	533	538	PF02991	0.396
LIG_LIR_Nem_3	563	568	PF02991	0.413
LIG_LIR_Nem_3	606	612	PF02991	0.430
LIG_PTB_Apo_2	222	229	PF02174	0.580
LIG_SH2_GRB2like	319	322	PF00017	0.540
LIG_SH2_NCK_1	178	182	PF00017	0.645
LIG_SH2_NCK_1	565	569	PF00017	0.354
LIG_SH2_SRC	178	181	PF00017	0.645
LIG_SH2_SRC	565	568	PF00017	0.480
LIG_SH2_SRC	571	574	PF00017	0.344
LIG_SH2_STAP1	178	182	PF00017	0.645
LIG_SH2_STAP1	565	569	PF00017	0.422
LIG_SH2_STAT3	182	185	PF00017	0.648
LIG_SH2_STAT3	734	737	PF00017	0.529
LIG_SH2_STAT5	365	368	PF00017	0.463
LIG_SH2_STAT5	571	574	PF00017	0.383
LIG_SH2_STAT5	608	611	PF00017	0.440
LIG_SH2_STAT5	655	658	PF00017	0.460
LIG_SH2_STAT5	734	737	PF00017	0.673
LIG_SH3_3	223	229	PF00018	0.587
LIG_SH3_3	277	283	PF00018	0.666
LIG_SH3_3	395	401	PF00018	0.570
LIG_SH3_3	479	485	PF00018	0.503
LIG_SH3_3	581	587	PF00018	0.451
LIG_SH3_3	66	72	PF00018	0.594
LIG_SH3_3	667	673	PF00018	0.547
LIG_SH3_3	720	726	PF00018	0.578
LIG_SUMO_SIM_par_1	16	23	PF11976	0.511
LIG_TRAF2_1	184	187	PF00917	0.569
LIG_TRAF2_1	426	429	PF00917	0.531
LIG_TRAF2_1	72	75	PF00917	0.692
LIG_UBA3_1	541	546	PF00899	0.430
LIG_UBA3_1	652	658	PF00899	0.465
MOD_CDK_SPK_2	527	532	PF00069	0.400
MOD_CDK_SPK_2	576	581	PF00069	0.498
MOD_CK1_1	189	195	PF00069	0.601
MOD_CK1_1	239	245	PF00069	0.589
MOD_CK1_1	256	262	PF00069	0.460
MOD_CK1_1	278	284	PF00069	0.627
MOD_CK1_1	36	42	PF00069	0.692
MOD_CK1_1	449	455	PF00069	0.510
MOD_CK1_1	56	62	PF00069	0.671
MOD_CK1_1	579	585	PF00069	0.510
MOD_CK1_1	6	12	PF00069	0.614
MOD_CK1_1	65	71	PF00069	0.701
MOD_CK1_1	679	685	PF00069	0.523
MOD_CK1_1	688	694	PF00069	0.500
MOD_CK2_1	181	187	PF00069	0.523
MOD_CK2_1	239	245	PF00069	0.628
MOD_CK2_1	303	309	PF00069	0.621
MOD_CK2_1	346	352	PF00069	0.662
MOD_CK2_1	527	533	PF00069	0.387
MOD_CK2_1	68	74	PF00069	0.658
MOD_CK2_1	690	696	PF00069	0.538
MOD_CK2_1	75	81	PF00069	0.547
MOD_CK2_1	770	776	PF00069	0.682
MOD_Cter_Amidation	134	137	PF01082	0.629
MOD_Cter_Amidation	705	708	PF01082	0.478
MOD_GlcNHglycan	1	4	PF01048	0.631
MOD_GlcNHglycan	10	13	PF01048	0.727
MOD_GlcNHglycan	255	258	PF01048	0.690
MOD_GlcNHglycan	326	331	PF01048	0.568
MOD_GlcNHglycan	55	58	PF01048	0.628
MOD_GSK3_1	236	243	PF00069	0.650
MOD_GSK3_1	253	260	PF00069	0.561
MOD_GSK3_1	275	282	PF00069	0.672
MOD_GSK3_1	32	39	PF00069	0.641
MOD_GSK3_1	401	408	PF00069	0.734
MOD_GSK3_1	523	530	PF00069	0.385
MOD_GSK3_1	53	60	PF00069	0.642
MOD_GSK3_1	572	579	PF00069	0.437
MOD_GSK3_1	6	13	PF00069	0.662
MOD_GSK3_1	676	683	PF00069	0.529
MOD_GSK3_1	770	777	PF00069	0.718
MOD_GSK3_1	92	99	PF00069	0.540
MOD_LATS_1	238	244	PF00433	0.631
MOD_N-GLC_1	236	241	PF02516	0.561
MOD_N-GLC_1	523	528	PF02516	0.374
MOD_N-GLC_1	629	634	PF02516	0.554
MOD_N-GLC_1	754	759	PF02516	0.514
MOD_N-GLC_2	204	206	PF02516	0.567
MOD_NEK2_1	129	134	PF00069	0.721
MOD_NEK2_1	676	681	PF00069	0.551
MOD_NEK2_1	732	737	PF00069	0.661
MOD_NEK2_2	92	97	PF00069	0.608
MOD_PIKK_1	129	135	PF00454	0.630
MOD_PIKK_1	181	187	PF00454	0.627
MOD_PIKK_1	189	195	PF00454	0.673
MOD_PIKK_1	446	452	PF00454	0.566
MOD_PIKK_1	724	730	PF00454	0.642
MOD_PKA_1	359	365	PF00069	0.423
MOD_PKA_2	189	195	PF00069	0.751
MOD_PKA_2	239	245	PF00069	0.628
MOD_PKA_2	275	281	PF00069	0.687
MOD_PKA_2	300	306	PF00069	0.679
MOD_PKA_2	32	38	PF00069	0.645
MOD_PKA_2	39	45	PF00069	0.776
MOD_PKA_2	676	682	PF00069	0.529
MOD_Plk_1	303	309	PF00069	0.565
MOD_Plk_1	326	332	PF00069	0.582
MOD_Plk_1	774	780	PF00069	0.575
MOD_Plk_2-3	407	413	PF00069	0.517
MOD_Plk_4	275	281	PF00069	0.663
MOD_Plk_4	303	309	PF00069	0.565
MOD_Plk_4	359	365	PF00069	0.423
MOD_Plk_4	537	543	PF00069	0.400
MOD_Plk_4	92	98	PF00069	0.517
MOD_ProDKin_1	279	285	PF00069	0.672
MOD_ProDKin_1	401	407	PF00069	0.756
MOD_ProDKin_1	527	533	PF00069	0.402
MOD_ProDKin_1	576	582	PF00069	0.523
MOD_ProDKin_1	585	591	PF00069	0.490
MOD_ProDKin_1	59	65	PF00069	0.590
MOD_ProDKin_1	6	12	PF00069	0.742
MOD_ProDKin_1	68	74	PF00069	0.588
MOD_ProDKin_1	719	725	PF00069	0.564
MOD_SUMO_for_1	626	629	PF00179	0.582
MOD_SUMO_rev_2	742	749	PF00179	0.496
TRG_ENDOCYTIC_2	126	129	PF00928	0.554
TRG_ENDOCYTIC_2	565	568	PF00928	0.363
TRG_ER_diArg_1	134	137	PF00400	0.637
TRG_ER_diArg_1	322	324	PF00400	0.452
TRG_ER_diArg_1	380	383	PF00400	0.403
TRG_ER_diArg_1	413	415	PF00400	0.676
TRG_ER_diArg_1	431	433	PF00400	0.330
TRG_ER_diArg_1	454	456	PF00400	0.445
TRG_ER_diArg_1	756	759	PF00400	0.690
TRG_NES_CRM1_1	467	478	PF08389	0.434
TRG_NES_CRM1_1	742	754	PF08389	0.561
TRG_NLS_MonoExtC_3	355	360	PF00514	0.349
TRG_NLS_MonoExtN_4	615	622	PF00514	0.500
TRG_Pf-PMV_PEXEL_1	14	19	PF00026	0.687
TRG_Pf-PMV_PEXEL_1	599	604	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A9	Leptomonas seymouri	69%	85%
A0A0S4JN96	Bodo saltans	47%	100%
A0A1X0P5Z6	Trypanosomatidae	53%	100%
A0A3Q8IBG1	Leishmania donovani	94%	100%
A0A3S5IRX2	Trypanosoma rangeli	52%	100%
A4HAA1	Leishmania braziliensis	85%	100%
A4HYI2	Leishmania infantum	94%	100%
D0A0V4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	98%
Q4QD57	Leishmania major	94%	100%
V5B4C3	Trypanosoma cruzi	52%	87%