Eukaryotic translation initiation factor-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic translation initiation factor 4E-2

Species:

Leishmania mexicana

UniProt:

E9ASA2_LEIMU

TriTrypDb:

LmxM.19.1480

Length:

281

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016281	eukaryotic translation initiation factor 4F complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASA2

Function

Biological processes
Term	Name	Level	Count
GO:0006413	translational initiation	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003743	translation initiation factor activity	4	12
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0000339	RNA cap binding	5	1
GO:0000340	RNA 7-methylguanosine cap binding	6	1
GO:0000342	RNA cap 4 binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	83	85	PF00675	0.220
CLV_NRD_NRD_1	97	99	PF00675	0.188
CLV_PCSK_KEX2_1	97	99	PF00082	0.245
DEG_Nend_UBRbox_2	1	3	PF02207	0.646
DOC_CYCLIN_RxL_1	189	200	PF00134	0.459
DOC_MAPK_DCC_7	112	122	PF00069	0.335
DOC_MAPK_gen_1	267	276	PF00069	0.492
DOC_MAPK_gen_1	97	106	PF00069	0.421
DOC_MAPK_MEF2A_6	267	276	PF00069	0.418
DOC_USP7_MATH_1	76	80	PF00917	0.513
DOC_WW_Pin1_4	222	227	PF00397	0.658
LIG_14-3-3_CanoR_1	152	157	PF00244	0.498
LIG_14-3-3_CanoR_1	267	273	PF00244	0.518
LIG_APCC_ABBA_1	218	223	PF00400	0.434
LIG_deltaCOP1_diTrp_1	167	173	PF00928	0.421
LIG_deltaCOP1_diTrp_1	59	65	PF00928	0.513
LIG_FHA_1	160	166	PF00498	0.431
LIG_FHA_1	210	216	PF00498	0.448
LIG_FHA_1	269	275	PF00498	0.537
LIG_FHA_1	41	47	PF00498	0.477
LIG_GBD_Chelix_1	186	194	PF00786	0.313
LIG_LIR_Gen_1	121	132	PF02991	0.421
LIG_LIR_Gen_1	26	32	PF02991	0.410
LIG_LIR_Nem_3	121	127	PF02991	0.417
LIG_LIR_Nem_3	59	65	PF02991	0.410
LIG_LIR_Nem_3	79	83	PF02991	0.321
LIG_PCNA_yPIPBox_3	180	190	PF02747	0.437
LIG_PDZ_Class_3	276	281	PF00595	0.492
LIG_Pex14_1	102	106	PF04695	0.410
LIG_Pex14_2	61	65	PF04695	0.513
LIG_SH2_STAP1	270	274	PF00017	0.477
LIG_SH2_STAT5	189	192	PF00017	0.460
LIG_SH2_STAT5	242	245	PF00017	0.338
LIG_SH2_STAT5	270	273	PF00017	0.483
LIG_SH2_STAT5	81	84	PF00017	0.455
LIG_SH3_3	213	219	PF00018	0.591
LIG_SUMO_SIM_par_1	270	275	PF11976	0.408
LIG_TRAF2_1	251	254	PF00917	0.428
LIG_UBA3_1	196	201	PF00899	0.469
MOD_CDK_SPxxK_3	222	229	PF00069	0.682
MOD_CK1_1	10	16	PF00069	0.588
MOD_CK1_1	209	215	PF00069	0.681
MOD_CK1_1	234	240	PF00069	0.607
MOD_CK2_1	108	114	PF00069	0.469
MOD_CMANNOS	22	25	PF00535	0.210
MOD_GlcNHglycan	129	132	PF01048	0.332
MOD_GlcNHglycan	157	160	PF01048	0.282
MOD_GlcNHglycan	208	211	PF01048	0.708
MOD_GlcNHglycan	232	236	PF01048	0.727
MOD_GlcNHglycan	237	240	PF01048	0.525
MOD_GlcNHglycan	56	59	PF01048	0.281
MOD_GlcNHglycan	9	12	PF01048	0.488
MOD_GSK3_1	104	111	PF00069	0.453
MOD_GSK3_1	155	162	PF00069	0.553
MOD_GSK3_1	197	204	PF00069	0.702
MOD_GSK3_1	227	234	PF00069	0.623
MOD_GSK3_1	65	72	PF00069	0.410
MOD_N-GLC_1	65	70	PF02516	0.293
MOD_N-GLC_1	76	81	PF02516	0.250
MOD_NEK2_1	127	132	PF00069	0.513
MOD_NEK2_1	65	70	PF00069	0.515
MOD_PIKK_1	179	185	PF00454	0.434
MOD_PIKK_1	69	75	PF00454	0.434
MOD_PKA_2	179	185	PF00069	0.452
MOD_PKB_1	150	158	PF00069	0.431
MOD_Plk_1	65	71	PF00069	0.477
MOD_Plk_4	16	22	PF00069	0.479
MOD_Plk_4	160	166	PF00069	0.413
MOD_Plk_4	238	244	PF00069	0.359
MOD_Plk_4	65	71	PF00069	0.522
MOD_Plk_4	76	82	PF00069	0.540
MOD_ProDKin_1	222	228	PF00069	0.660
MOD_SUMO_for_1	251	254	PF00179	0.509
MOD_SUMO_rev_2	163	170	PF00179	0.458
TRG_DiLeu_BaEn_1	211	216	PF01217	0.579
TRG_ENDOCYTIC_2	80	83	PF00928	0.425
TRG_NES_CRM1_1	188	202	PF08389	0.366
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A8	Leptomonas seymouri	62%	100%
A0A0N0P8F2	Leptomonas seymouri	22%	100%
A0A0S4KG92	Bodo saltans	45%	96%
A0A1X0P6Z9	Trypanosomatidae	42%	100%
A0A3Q7FGP1	Solanum lycopersicum	30%	100%
A0A3S5H774	Leishmania donovani	88%	100%
A0A3S5IRX1	Trypanosoma rangeli	41%	97%
A4HA98	Leishmania braziliensis	80%	100%
A4HYH8	Leishmania infantum	89%	100%
D0A0V2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AZ65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
P07260	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P29557	Triticum aestivum	30%	100%
Q00LS8	Cucumis melo	30%	100%
Q0GRC4	Pisum sativum	29%	100%
Q21693	Caenorhabditis elegans	27%	100%
Q3UTA9	Mus musculus	24%	100%
Q4QD60	Leishmania major	88%	100%
Q66WU1	Nicotiana tabacum	29%	100%
V5AP07	Trypanosoma cruzi	43%	100%