Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9ASA1_LEIMU

TriTrypDb:

LmxM.19.1470

Length:

621

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ASA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASA1

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	23
GO:0006793	phosphorus metabolic process	3	23
GO:0006796	phosphate-containing compound metabolic process	4	23
GO:0006807	nitrogen compound metabolic process	2	23
GO:0008152	metabolic process	1	23
GO:0009987	cellular process	1	23
GO:0016310	phosphorylation	5	23
GO:0019538	protein metabolic process	3	23
GO:0036211	protein modification process	4	23
GO:0043170	macromolecule metabolic process	3	23
GO:0043412	macromolecule modification	4	23
GO:0044237	cellular metabolic process	2	23
GO:0044238	primary metabolic process	2	23
GO:0071704	organic substance metabolic process	2	23
GO:1901564	organonitrogen compound metabolic process	3	23
GO:0007165	signal transduction	2	2
GO:0018105	peptidyl-serine phosphorylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018209	peptidyl-serine modification	6	2
GO:0035556	intracellular signal transduction	3	2
GO:0046777	protein autophosphorylation	6	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	23
GO:0003824	catalytic activity	1	23
GO:0004672	protein kinase activity	3	23
GO:0005488	binding	1	23
GO:0005524	ATP binding	5	23
GO:0016301	kinase activity	4	23
GO:0016740	transferase activity	2	23
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	23
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	23
GO:0017076	purine nucleotide binding	4	23
GO:0030554	adenyl nucleotide binding	5	23
GO:0032553	ribonucleotide binding	3	23
GO:0032555	purine ribonucleotide binding	4	23
GO:0032559	adenyl ribonucleotide binding	5	23
GO:0035639	purine ribonucleoside triphosphate binding	4	23
GO:0036094	small molecule binding	2	23
GO:0043167	ion binding	2	23
GO:0043168	anion binding	3	23
GO:0097159	organic cyclic compound binding	2	23
GO:0097367	carbohydrate derivative binding	2	23
GO:0140096	catalytic activity, acting on a protein	2	23
GO:1901265	nucleoside phosphate binding	3	23
GO:1901363	heterocyclic compound binding	2	23
GO:0004674	protein serine/threonine kinase activity	4	12
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0004683	calmodulin-dependent protein kinase activity	5	2
GO:0005515	protein binding	2	2
GO:0005516	calmodulin binding	3	2
GO:0009931	calcium-dependent protein serine/threonine kinase activity	5	2
GO:0010857	calcium-dependent protein kinase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.391
CLV_NRD_NRD_1	161	163	PF00675	0.464
CLV_NRD_NRD_1	194	196	PF00675	0.311
CLV_NRD_NRD_1	203	205	PF00675	0.303
CLV_NRD_NRD_1	216	218	PF00675	0.402
CLV_NRD_NRD_1	415	417	PF00675	0.483
CLV_NRD_NRD_1	503	505	PF00675	0.275
CLV_NRD_NRD_1	571	573	PF00675	0.434
CLV_NRD_NRD_1	59	61	PF00675	0.695
CLV_PCSK_KEX2_1	161	163	PF00082	0.469
CLV_PCSK_KEX2_1	203	205	PF00082	0.424
CLV_PCSK_KEX2_1	216	218	PF00082	0.276
CLV_PCSK_KEX2_1	447	449	PF00082	0.334
CLV_PCSK_KEX2_1	503	505	PF00082	0.309
CLV_PCSK_KEX2_1	59	61	PF00082	0.695
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.334
CLV_PCSK_SKI1_1	162	166	PF00082	0.377
CLV_PCSK_SKI1_1	268	272	PF00082	0.406
CLV_PCSK_SKI1_1	286	290	PF00082	0.292
CLV_PCSK_SKI1_1	39	43	PF00082	0.346
CLV_PCSK_SKI1_1	417	421	PF00082	0.417
CLV_PCSK_SKI1_1	499	503	PF00082	0.337
DEG_APCC_DBOX_1	267	275	PF00400	0.393
DEG_APCC_DBOX_1	357	365	PF00400	0.311
DEG_SCF_FBW7_1	394	401	PF00400	0.334
DOC_CKS1_1	439	444	PF01111	0.514
DOC_CYCLIN_RxL_1	265	273	PF00134	0.388
DOC_MAPK_gen_1	286	295	PF00069	0.334
DOC_MAPK_gen_1	438	445	PF00069	0.420
DOC_MAPK_gen_1	572	580	PF00069	0.470
DOC_MAPK_MEF2A_6	221	228	PF00069	0.343
DOC_PP1_RVXF_1	95	101	PF00149	0.376
DOC_PP4_FxxP_1	404	407	PF00568	0.276
DOC_PP4_FxxP_1	486	489	PF00568	0.334
DOC_USP7_MATH_1	365	369	PF00917	0.334
DOC_USP7_MATH_1	423	427	PF00917	0.419
DOC_USP7_MATH_1	469	473	PF00917	0.309
DOC_USP7_MATH_1	607	611	PF00917	0.644
DOC_USP7_UBL2_3	192	196	PF12436	0.299
DOC_USP7_UBL2_3	26	30	PF12436	0.393
DOC_WW_Pin1_4	349	354	PF00397	0.334
DOC_WW_Pin1_4	394	399	PF00397	0.350
DOC_WW_Pin1_4	438	443	PF00397	0.605
LIG_14-3-3_CanoR_1	195	200	PF00244	0.352
LIG_14-3-3_CanoR_1	216	224	PF00244	0.489
LIG_14-3-3_CanoR_1	50	58	PF00244	0.383
LIG_14-3-3_CanoR_1	552	557	PF00244	0.557
LIG_14-3-3_CanoR_1	60	66	PF00244	0.443
LIG_BIR_III_4	582	586	PF00653	0.530
LIG_BRCT_BRCA1_1	137	141	PF00533	0.433
LIG_BRCT_BRCA1_1	196	200	PF00533	0.334
LIG_BRCT_BRCA1_1	560	564	PF00533	0.514
LIG_BRCT_MDC1_1	617	621	PF00533	0.527
LIG_CtBP_PxDLS_1	442	446	PF00389	0.385
LIG_deltaCOP1_diTrp_1	575	579	PF00928	0.509
LIG_DLG_GKlike_1	552	559	PF00625	0.430
LIG_EVH1_1	361	365	PF00568	0.247
LIG_FHA_1	163	169	PF00498	0.424
LIG_FHA_1	455	461	PF00498	0.305
LIG_FHA_2	137	143	PF00498	0.456
LIG_FHA_2	439	445	PF00498	0.421
LIG_FHA_2	461	467	PF00498	0.306
LIG_FHA_2	65	71	PF00498	0.451
LIG_GBD_Chelix_1	168	176	PF00786	0.391
LIG_GBD_Chelix_1	266	274	PF00786	0.276
LIG_Integrin_isoDGR_2	612	614	PF01839	0.445
LIG_LIR_Apic_2	401	407	PF02991	0.358
LIG_LIR_Apic_2	485	489	PF02991	0.334
LIG_LIR_Gen_1	154	164	PF02991	0.503
LIG_LIR_Gen_1	234	244	PF02991	0.345
LIG_LIR_Gen_1	247	257	PF02991	0.367
LIG_LIR_Gen_1	260	267	PF02991	0.353
LIG_LIR_Gen_1	326	337	PF02991	0.286
LIG_LIR_Gen_1	515	525	PF02991	0.247
LIG_LIR_Gen_1	555	564	PF02991	0.424
LIG_LIR_Gen_1	575	583	PF02991	0.515
LIG_LIR_Nem_3	154	159	PF02991	0.487
LIG_LIR_Nem_3	234	240	PF02991	0.373
LIG_LIR_Nem_3	247	252	PF02991	0.415
LIG_LIR_Nem_3	260	264	PF02991	0.387
LIG_LIR_Nem_3	326	332	PF02991	0.298
LIG_LIR_Nem_3	334	340	PF02991	0.288
LIG_LIR_Nem_3	515	520	PF02991	0.247
LIG_LIR_Nem_3	555	560	PF02991	0.657
LIG_LIR_Nem_3	575	580	PF02991	0.508
LIG_LIR_Nem_3	63	68	PF02991	0.448
LIG_LIR_Nem_3	77	81	PF02991	0.408
LIG_MLH1_MIPbox_1	137	141	PF16413	0.311
LIG_MYND_1	359	363	PF01753	0.227
LIG_Pex14_1	137	141	PF04695	0.340
LIG_REV1ctd_RIR_1	138	148	PF16727	0.329
LIG_SH2_CRK	156	160	PF00017	0.476
LIG_SH2_CRK	261	265	PF00017	0.334
LIG_SH2_CRK	337	341	PF00017	0.247
LIG_SH2_NCK_1	531	535	PF00017	0.518
LIG_SH2_PTP2	237	240	PF00017	0.389
LIG_SH2_PTP2	329	332	PF00017	0.311
LIG_SH2_STAP1	261	265	PF00017	0.334
LIG_SH2_STAP1	337	341	PF00017	0.365
LIG_SH2_STAT3	493	496	PF00017	0.334
LIG_SH2_STAT5	106	109	PF00017	0.512
LIG_SH2_STAT5	237	240	PF00017	0.395
LIG_SH2_STAT5	242	245	PF00017	0.383
LIG_SH2_STAT5	329	332	PF00017	0.311
LIG_SH2_STAT5	493	496	PF00017	0.296
LIG_SH2_STAT5	531	534	PF00017	0.535
LIG_SH2_STAT5	56	59	PF00017	0.633
LIG_SH3_3	123	129	PF00018	0.472
LIG_SH3_3	295	301	PF00018	0.272
LIG_SH3_3	356	362	PF00018	0.419
LIG_SH3_3	436	442	PF00018	0.611
LIG_SH3_3	491	497	PF00018	0.259
LIG_SH3_3	508	514	PF00018	0.428
LIG_SUMO_SIM_anti_2	262	267	PF11976	0.334
LIG_SUMO_SIM_anti_2	441	447	PF11976	0.466
LIG_SxIP_EBH_1	583	592	PF03271	0.437
LIG_TRAF2_1	374	377	PF00917	0.173
LIG_UBA3_1	172	179	PF00899	0.401
LIG_UBA3_1	501	509	PF00899	0.173
LIG_WW_2	359	362	PF00397	0.227
MOD_CDC14_SPxK_1	352	355	PF00782	0.192
MOD_CDK_SPxK_1	349	355	PF00069	0.192
MOD_CK1_1	32	38	PF00069	0.452
MOD_CK1_1	567	573	PF00069	0.506
MOD_CK1_1	63	69	PF00069	0.466
MOD_CK1_1	9	15	PF00069	0.465
MOD_CK1_1	90	96	PF00069	0.333
MOD_CK2_1	136	142	PF00069	0.527
MOD_CK2_1	460	466	PF00069	0.276
MOD_CK2_1	469	475	PF00069	0.276
MOD_CK2_1	512	518	PF00069	0.339
MOD_CK2_1	533	539	PF00069	0.698
MOD_CK2_1	600	606	PF00069	0.606
MOD_GlcNHglycan	4	7	PF01048	0.521
MOD_GlcNHglycan	410	413	PF01048	0.341
MOD_GlcNHglycan	485	489	PF01048	0.400
MOD_GlcNHglycan	514	517	PF01048	0.484
MOD_GlcNHglycan	552	555	PF01048	0.705
MOD_GSK3_1	194	201	PF00069	0.358
MOD_GSK3_1	2	9	PF00069	0.732
MOD_GSK3_1	25	32	PF00069	0.394
MOD_GSK3_1	315	322	PF00069	0.386
MOD_GSK3_1	394	401	PF00069	0.364
MOD_GSK3_1	529	536	PF00069	0.594
MOD_GSK3_1	560	567	PF00069	0.508
MOD_GSK3_1	60	67	PF00069	0.536
MOD_LATS_1	48	54	PF00433	0.349
MOD_N-GLC_1	322	327	PF02516	0.227
MOD_N-GLC_1	520	525	PF02516	0.311
MOD_N-GLC_1	550	555	PF02516	0.483
MOD_NEK2_1	10	15	PF00069	0.549
MOD_NEK2_1	168	173	PF00069	0.577
MOD_NEK2_1	22	27	PF00069	0.519
MOD_NEK2_1	270	275	PF00069	0.293
MOD_NEK2_1	392	397	PF00069	0.380
MOD_NEK2_1	484	489	PF00069	0.360
MOD_NEK2_1	520	525	PF00069	0.332
MOD_NEK2_1	559	564	PF00069	0.472
MOD_NEK2_1	586	591	PF00069	0.518
MOD_NEK2_1	608	613	PF00069	0.575
MOD_NEK2_2	136	141	PF00069	0.391
MOD_NMyristoyl	1	7	PF02799	0.500
MOD_OFUCOSY	23	29	PF10250	0.333
MOD_PIKK_1	119	125	PF00454	0.421
MOD_PIKK_1	492	498	PF00454	0.344
MOD_PKA_1	195	201	PF00069	0.334
MOD_PKA_1	216	222	PF00069	0.173
MOD_PKA_2	194	200	PF00069	0.399
MOD_PKA_2	216	222	PF00069	0.335
MOD_PKA_2	354	360	PF00069	0.243
MOD_PKA_2	423	429	PF00069	0.578
MOD_PKA_2	470	476	PF00069	0.441
MOD_PKA_2	512	518	PF00069	0.361
MOD_Plk_1	520	526	PF00069	0.321
MOD_Plk_2-3	533	539	PF00069	0.639
MOD_Plk_2-3	600	606	PF00069	0.493
MOD_Plk_4	136	142	PF00069	0.448
MOD_Plk_4	155	161	PF00069	0.393
MOD_Plk_4	195	201	PF00069	0.314
MOD_Plk_4	520	526	PF00069	0.325
MOD_Plk_4	552	558	PF00069	0.547
MOD_Plk_4	6	12	PF00069	0.434
MOD_Plk_4	64	70	PF00069	0.433
MOD_Plk_4	87	93	PF00069	0.390
MOD_ProDKin_1	349	355	PF00069	0.334
MOD_ProDKin_1	394	400	PF00069	0.350
MOD_ProDKin_1	438	444	PF00069	0.603
MOD_SUMO_for_1	288	291	PF00179	0.358
MOD_SUMO_rev_2	171	181	PF00179	0.582
TRG_DiLeu_BaEn_1	111	116	PF01217	0.325
TRG_DiLeu_BaEn_2	141	147	PF01217	0.327
TRG_DiLeu_BaEn_2	271	277	PF01217	0.247
TRG_DiLeu_BaEn_2	574	580	PF01217	0.516
TRG_ENDOCYTIC_2	156	159	PF00928	0.491
TRG_ENDOCYTIC_2	237	240	PF00928	0.417
TRG_ENDOCYTIC_2	261	264	PF00928	0.334
TRG_ENDOCYTIC_2	329	332	PF00928	0.325
TRG_ENDOCYTIC_2	337	340	PF00928	0.347
TRG_ER_diArg_1	160	162	PF00400	0.336
TRG_ER_diArg_1	202	204	PF00400	0.317
TRG_ER_diArg_1	215	217	PF00400	0.279
TRG_ER_diArg_1	502	504	PF00400	0.260
TRG_ER_diArg_1	58	60	PF00400	0.481
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	268	272	PF00026	0.382
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6Q7	Leptomonas seymouri	25%	100%
A0A0N1IM89	Leptomonas seymouri	63%	100%
A0A0S4JQP0	Bodo saltans	23%	100%
A0A0S4KKJ1	Bodo saltans	39%	98%
A0A1X0P834	Trypanosomatidae	22%	100%
A0A3S5H5G0	Leishmania donovani	25%	100%
A0A3S7WVR6	Leishmania donovani	92%	100%
A0A3S7WY10	Leishmania donovani	25%	100%
A0A3S7X8Z8	Leishmania donovani	25%	100%
A4H459	Leishmania braziliensis	27%	92%
A4HA97	Leishmania braziliensis	82%	100%
A4HD79	Leishmania braziliensis	25%	100%
A4HFF3	Leishmania braziliensis	24%	100%
A4HSE2	Leishmania infantum	25%	100%
A4HYH7	Leishmania infantum	92%	100%
A4IB02	Leishmania infantum	25%	100%
C9ZTU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
C9ZX15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AET0	Leishmania major	26%	100%
E9AH34	Leishmania infantum	25%	100%
E9AKB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AWL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B5Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
P15791	Rattus norvegicus	23%	100%
Q4QD63	Leishmania major	90%	100%
Q4QJJ0	Leishmania major	24%	96%
Q93VD3	Arabidopsis thaliana	24%	100%