Oxidoreductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oxidoreductase-like protein

Species:

Leishmania mexicana

UniProt:

E9AS99_LEIMU

TriTrypDb:

LmxM.19.1450

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AS99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS99

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016491	oxidoreductase activity	2	10
GO:0000166	nucleotide binding	3	1
GO:0004497	monooxygenase activity	3	4
GO:0004517	nitric-oxide synthase activity	5	4
GO:0005488	binding	1	1
GO:0010181	FMN binding	4	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	4
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	4	4
GO:0032553	ribonucleotide binding	3	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0050660	flavin adenine dinucleotide binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.493
CLV_NRD_NRD_1	298	300	PF00675	0.514
CLV_NRD_NRD_1	325	327	PF00675	0.570
CLV_NRD_NRD_1	447	449	PF00675	0.328
CLV_PCSK_KEX2_1	2	4	PF00082	0.488
CLV_PCSK_KEX2_1	298	300	PF00082	0.566
CLV_PCSK_KEX2_1	325	327	PF00082	0.570
CLV_PCSK_KEX2_1	447	449	PF00082	0.331
CLV_PCSK_SKI1_1	125	129	PF00082	0.564
CLV_PCSK_SKI1_1	185	189	PF00082	0.492
CLV_PCSK_SKI1_1	375	379	PF00082	0.709
CLV_PCSK_SKI1_1	479	483	PF00082	0.279
CLV_PCSK_SKI1_1	505	509	PF00082	0.277
CLV_PCSK_SKI1_1	535	539	PF00082	0.368
CLV_PCSK_SKI1_1	88	92	PF00082	0.556
CLV_Separin_Metazoa	97	101	PF03568	0.229
DEG_Nend_UBRbox_1	1	4	PF02207	0.431
DEG_ODPH_VHL_1	434	446	PF01847	0.398
DEG_SPOP_SBC_1	226	230	PF00917	0.495
DEG_SPOP_SBC_1	70	74	PF00917	0.360
DOC_CYCLIN_RxL_1	151	159	PF00134	0.382
DOC_CYCLIN_RxL_1	532	542	PF00134	0.468
DOC_CYCLIN_yCln2_LP_2	183	189	PF00134	0.332
DOC_MAPK_RevD_3	283	299	PF00069	0.313
DOC_PP1_RVXF_1	569	575	PF00149	0.566
DOC_PP2B_PxIxI_1	110	116	PF00149	0.333
DOC_USP7_MATH_1	245	249	PF00917	0.402
DOC_USP7_MATH_1	324	328	PF00917	0.379
DOC_USP7_MATH_1	369	373	PF00917	0.375
DOC_USP7_MATH_1	452	456	PF00917	0.500
DOC_WW_Pin1_4	104	109	PF00397	0.401
DOC_WW_Pin1_4	166	171	PF00397	0.315
DOC_WW_Pin1_4	229	234	PF00397	0.518
DOC_WW_Pin1_4	310	315	PF00397	0.416
DOC_WW_Pin1_4	411	416	PF00397	0.335
DOC_WW_Pin1_4	5	10	PF00397	0.172
DOC_WW_Pin1_4	73	78	PF00397	0.437
LIG_14-3-3_CanoR_1	100	106	PF00244	0.319
LIG_14-3-3_CanoR_1	216	223	PF00244	0.351
LIG_14-3-3_CanoR_1	298	303	PF00244	0.315
LIG_14-3-3_CanoR_1	325	333	PF00244	0.422
LIG_14-3-3_CanoR_1	447	457	PF00244	0.505
LIG_Actin_WH2_2	434	449	PF00022	0.353
LIG_APCC_ABBA_1	215	220	PF00400	0.353
LIG_BRCT_BRCA1_1	422	426	PF00533	0.374
LIG_BRCT_BRCA1_1	454	458	PF00533	0.589
LIG_Clathr_ClatBox_1	563	567	PF01394	0.550
LIG_CSL_BTD_1	179	182	PF09270	0.310
LIG_deltaCOP1_diTrp_1	575	583	PF00928	0.552
LIG_eIF4E_1	390	396	PF01652	0.297
LIG_FHA_1	16	22	PF00498	0.328
LIG_FHA_1	482	488	PF00498	0.556
LIG_FHA_1	506	512	PF00498	0.448
LIG_FHA_1	517	523	PF00498	0.570
LIG_FHA_1	577	583	PF00498	0.592
LIG_FHA_2	466	472	PF00498	0.514
LIG_FHA_2	475	481	PF00498	0.455
LIG_FHA_2	6	12	PF00498	0.178
LIG_LIR_Gen_1	194	204	PF02991	0.326
LIG_LIR_Gen_1	209	218	PF02991	0.328
LIG_LIR_Gen_1	23	32	PF02991	0.288
LIG_LIR_Gen_1	276	285	PF02991	0.355
LIG_LIR_Gen_1	392	401	PF02991	0.344
LIG_LIR_Nem_3	194	199	PF02991	0.315
LIG_LIR_Nem_3	209	214	PF02991	0.347
LIG_LIR_Nem_3	23	29	PF02991	0.288
LIG_LIR_Nem_3	276	281	PF02991	0.347
LIG_LIR_Nem_3	392	396	PF02991	0.336
LIG_LYPXL_yS_3	268	271	PF13949	0.334
LIG_NRBOX	188	194	PF00104	0.321
LIG_NRBOX	254	260	PF00104	0.297
LIG_Pex14_1	22	26	PF04695	0.263
LIG_Pex14_2	211	215	PF04695	0.299
LIG_PTB_Apo_2	395	402	PF02174	0.342
LIG_SH2_NCK_1	300	304	PF00017	0.340
LIG_SH2_PTP2	196	199	PF00017	0.311
LIG_SH2_PTP2	65	68	PF00017	0.409
LIG_SH2_SRC	196	199	PF00017	0.311
LIG_SH2_SRC	490	493	PF00017	0.510
LIG_SH2_SRC	65	68	PF00017	0.369
LIG_SH2_STAP1	26	30	PF00017	0.310
LIG_SH2_STAP1	474	478	PF00017	0.589
LIG_SH2_STAP1	490	494	PF00017	0.364
LIG_SH2_STAT5	196	199	PF00017	0.270
LIG_SH2_STAT5	204	207	PF00017	0.297
LIG_SH2_STAT5	390	393	PF00017	0.313
LIG_SH2_STAT5	506	509	PF00017	0.488
LIG_SH2_STAT5	57	60	PF00017	0.343
LIG_SH2_STAT5	65	68	PF00017	0.355
LIG_SH3_3	1	7	PF00018	0.266
LIG_SH3_3	105	111	PF00018	0.361
LIG_SH3_3	167	173	PF00018	0.325
LIG_SH3_3	176	182	PF00018	0.302
LIG_SH3_3	278	284	PF00018	0.363
LIG_SH3_3	288	294	PF00018	0.281
LIG_SH3_3	308	314	PF00018	0.294
LIG_SH3_3	527	533	PF00018	0.552
LIG_SUMO_SIM_anti_2	131	138	PF11976	0.345
LIG_SUMO_SIM_anti_2	270	276	PF11976	0.325
LIG_SUMO_SIM_anti_2	94	100	PF11976	0.312
LIG_SUMO_SIM_par_1	270	276	PF11976	0.325
LIG_SUMO_SIM_par_1	286	292	PF11976	0.306
LIG_SUMO_SIM_par_1	536	542	PF11976	0.410
LIG_SUMO_SIM_par_1	562	567	PF11976	0.546
LIG_TRAF2_1	48	51	PF00917	0.601
LIG_TRAF2_1	495	498	PF00917	0.463
LIG_TRAF2_1	557	560	PF00917	0.621
LIG_TYR_ITIM	24	29	PF00017	0.263
LIG_TYR_ITIM	266	271	PF00017	0.388
LIG_UBA3_1	214	222	PF00899	0.375
LIG_UBA3_1	255	261	PF00899	0.465
LIG_WRC_WIRS_1	277	282	PF05994	0.353
LIG_WRC_WIRS_1	390	395	PF05994	0.388
MOD_CK1_1	104	110	PF00069	0.450
MOD_CK1_1	140	146	PF00069	0.502
MOD_CK1_1	15	21	PF00069	0.328
MOD_CK1_1	200	206	PF00069	0.342
MOD_CK1_1	221	227	PF00069	0.499
MOD_CK1_1	228	234	PF00069	0.497
MOD_CK1_1	248	254	PF00069	0.236
MOD_CK1_1	260	266	PF00069	0.432
MOD_CK1_1	420	426	PF00069	0.376
MOD_CK1_1	521	527	PF00069	0.380
MOD_CK2_1	206	212	PF00069	0.358
MOD_CK2_1	45	51	PF00069	0.598
MOD_CK2_1	465	471	PF00069	0.488
MOD_CK2_1	474	480	PF00069	0.537
MOD_CK2_1	492	498	PF00069	0.462
MOD_CK2_1	5	11	PF00069	0.172
MOD_CK2_1	536	542	PF00069	0.464
MOD_CK2_1	554	560	PF00069	0.544
MOD_CK2_1	73	79	PF00069	0.411
MOD_GlcNHglycan	120	123	PF01048	0.687
MOD_GlcNHglycan	14	17	PF01048	0.463
MOD_GlcNHglycan	193	196	PF01048	0.562
MOD_GlcNHglycan	224	227	PF01048	0.762
MOD_GlcNHglycan	262	265	PF01048	0.533
MOD_GlcNHglycan	290	294	PF01048	0.537
MOD_GlcNHglycan	326	329	PF01048	0.559
MOD_GlcNHglycan	371	374	PF01048	0.540
MOD_GlcNHglycan	379	382	PF01048	0.699
MOD_GlcNHglycan	454	457	PF01048	0.297
MOD_GSK3_1	100	107	PF00069	0.330
MOD_GSK3_1	218	225	PF00069	0.354
MOD_GSK3_1	227	234	PF00069	0.464
MOD_GSK3_1	294	301	PF00069	0.362
MOD_GSK3_1	306	313	PF00069	0.382
MOD_GSK3_1	348	355	PF00069	0.436
MOD_GSK3_1	369	376	PF00069	0.277
MOD_GSK3_1	407	414	PF00069	0.244
MOD_GSK3_1	448	455	PF00069	0.546
MOD_GSK3_1	69	76	PF00069	0.372
MOD_N-GLC_1	397	402	PF02516	0.614
MOD_NEK2_1	118	123	PF00069	0.410
MOD_NEK2_1	206	211	PF00069	0.313
MOD_NEK2_1	259	264	PF00069	0.434
MOD_NEK2_1	289	294	PF00069	0.317
MOD_NEK2_1	363	368	PF00069	0.367
MOD_NEK2_1	377	382	PF00069	0.432
MOD_NEK2_1	389	394	PF00069	0.252
MOD_NEK2_1	396	401	PF00069	0.241
MOD_NEK2_1	71	76	PF00069	0.327
MOD_NEK2_2	101	106	PF00069	0.335
MOD_NEK2_2	474	479	PF00069	0.405
MOD_NEK2_2	536	541	PF00069	0.563
MOD_PIKK_1	140	146	PF00454	0.517
MOD_PIKK_1	348	354	PF00454	0.456
MOD_PIKK_1	420	426	PF00454	0.406
MOD_PIKK_1	43	49	PF00454	0.491
MOD_PIKK_1	439	445	PF00454	0.393
MOD_PKA_1	298	304	PF00069	0.312
MOD_PKA_1	447	453	PF00069	0.455
MOD_PKA_2	298	304	PF00069	0.353
MOD_PKA_2	324	330	PF00069	0.398
MOD_PKA_2	348	354	PF00069	0.271
MOD_PKA_2	447	453	PF00069	0.480
MOD_PKA_2	99	105	PF00069	0.312
MOD_Plk_1	397	403	PF00069	0.222
MOD_Plk_1	474	480	PF00069	0.509
MOD_Plk_1	554	560	PF00069	0.545
MOD_Plk_2-3	554	560	PF00069	0.523
MOD_Plk_4	101	107	PF00069	0.333
MOD_Plk_4	200	206	PF00069	0.307
MOD_Plk_4	267	273	PF00069	0.352
MOD_Plk_4	57	63	PF00069	0.338
MOD_ProDKin_1	104	110	PF00069	0.400
MOD_ProDKin_1	166	172	PF00069	0.315
MOD_ProDKin_1	229	235	PF00069	0.505
MOD_ProDKin_1	310	316	PF00069	0.411
MOD_ProDKin_1	411	417	PF00069	0.344
MOD_ProDKin_1	5	11	PF00069	0.172
MOD_ProDKin_1	73	79	PF00069	0.433
MOD_SUMO_for_1	488	491	PF00179	0.497
MOD_SUMO_rev_2	219	224	PF00179	0.374
TRG_DiLeu_BaEn_1	238	243	PF01217	0.402
TRG_DiLeu_BaEn_1	560	565	PF01217	0.560
TRG_DiLeu_BaEn_2	275	281	PF01217	0.362
TRG_DiLeu_BaEn_2	524	530	PF01217	0.463
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.419
TRG_DiLeu_BaLyEn_6	284	289	PF01217	0.286
TRG_DiLeu_BaLyEn_6	433	438	PF01217	0.398
TRG_DiLeu_BaLyEn_6	559	564	PF01217	0.567
TRG_DiLeu_LyEn_5	238	243	PF01217	0.383
TRG_ENDOCYTIC_2	196	199	PF00928	0.311
TRG_ENDOCYTIC_2	26	29	PF00928	0.297
TRG_ENDOCYTIC_2	268	271	PF00928	0.379
TRG_ENDOCYTIC_2	390	393	PF00928	0.321
TRG_ER_diArg_1	1	3	PF00400	0.401
TRG_ER_diArg_1	298	300	PF00400	0.322
TRG_ER_diArg_1	446	448	PF00400	0.531
TRG_ER_diArg_1	569	572	PF00400	0.577
TRG_NES_CRM1_1	273	286	PF08389	0.364
TRG_Pf-PMV_PEXEL_1	562	567	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IB19	Leptomonas seymouri	60%	100%
A0A0S4INF0	Bodo saltans	26%	100%
A0A1X0P608	Trypanosomatidae	37%	94%
A0A3Q8IK79	Leishmania donovani	93%	100%
A4HA95	Leishmania braziliensis	84%	100%
A4HYH5	Leishmania infantum	93%	100%
D0A0U9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	93%
Q4QD65	Leishmania major	94%	100%