LeishMANIAdb
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PIH1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
PIH1 domain-containing protein
Gene product:
pre-RNA processing PIH1/Nop17, putative
Species:
Leishmania mexicana
UniProt:
E9AS97_LEIMU
TriTrypDb:
LmxM.19.1430
Length:
365

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 2, no: 9
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AS97
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS97

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 161 165 PF00656 0.606
CLV_NRD_NRD_1 157 159 PF00675 0.717
CLV_NRD_NRD_1 165 167 PF00675 0.722
CLV_NRD_NRD_1 247 249 PF00675 0.478
CLV_NRD_NRD_1 283 285 PF00675 0.471
CLV_PCSK_KEX2_1 247 249 PF00082 0.519
CLV_PCSK_KEX2_1 283 285 PF00082 0.531
CLV_PCSK_PC1ET2_1 283 285 PF00082 0.531
CLV_PCSK_SKI1_1 104 108 PF00082 0.352
CLV_PCSK_SKI1_1 203 207 PF00082 0.466
CLV_PCSK_SKI1_1 348 352 PF00082 0.412
DEG_Nend_Nbox_1 1 3 PF02207 0.444
DOC_CKS1_1 196 201 PF01111 0.593
DOC_CYCLIN_yCln2_LP_2 58 64 PF00134 0.437
DOC_MAPK_gen_1 348 358 PF00069 0.361
DOC_MAPK_MEF2A_6 297 306 PF00069 0.506
DOC_PP2B_LxvP_1 252 255 PF13499 0.537
DOC_PP2B_LxvP_1 336 339 PF13499 0.429
DOC_PP2B_LxvP_1 58 61 PF13499 0.437
DOC_PP4_FxxP_1 306 309 PF00568 0.508
DOC_SPAK_OSR1_1 292 296 PF12202 0.638
DOC_SPAK_OSR1_1 305 309 PF12202 0.381
DOC_USP7_MATH_1 216 220 PF00917 0.586
DOC_USP7_MATH_2 67 73 PF00917 0.414
DOC_USP7_UBL2_3 261 265 PF12436 0.671
DOC_WW_Pin1_4 195 200 PF00397 0.573
DOC_WW_Pin1_4 212 217 PF00397 0.671
DOC_WW_Pin1_4 256 261 PF00397 0.677
DOC_WW_Pin1_4 263 268 PF00397 0.586
LIG_CtBP_PxDLS_1 234 238 PF00389 0.450
LIG_deltaCOP1_diTrp_1 286 293 PF00928 0.580
LIG_EH_1 130 134 PF12763 0.345
LIG_EH1_1 52 60 PF00400 0.478
LIG_FHA_1 100 106 PF00498 0.419
LIG_FHA_1 196 202 PF00498 0.612
LIG_FHA_1 264 270 PF00498 0.755
LIG_FHA_1 324 330 PF00498 0.463
LIG_FHA_1 340 346 PF00498 0.432
LIG_FHA_1 351 357 PF00498 0.397
LIG_FHA_1 83 89 PF00498 0.487
LIG_FHA_2 15 21 PF00498 0.380
LIG_FHA_2 170 176 PF00498 0.635
LIG_LIR_Gen_1 287 295 PF02991 0.576
LIG_LIR_Nem_3 287 293 PF02991 0.648
LIG_PCNA_yPIPBox_3 188 196 PF02747 0.575
LIG_PTB_Apo_2 128 135 PF02174 0.554
LIG_PTB_Phospho_1 128 134 PF10480 0.560
LIG_SH2_SRC 49 52 PF00017 0.527
LIG_SH2_STAP1 75 79 PF00017 0.504
LIG_SH2_STAT5 134 137 PF00017 0.452
LIG_SH2_STAT5 24 27 PF00017 0.490
LIG_SH2_STAT5 49 52 PF00017 0.462
LIG_SH2_STAT5 77 80 PF00017 0.534
LIG_SH3_3 272 278 PF00018 0.576
LIG_SH3_3 31 37 PF00018 0.488
LIG_SH3_3 61 67 PF00018 0.480
LIG_SUMO_SIM_anti_2 353 359 PF11976 0.470
LIG_SUMO_SIM_par_1 102 109 PF11976 0.537
LIG_SUMO_SIM_par_1 353 359 PF11976 0.447
LIG_SUMO_SIM_par_1 360 365 PF11976 0.462
LIG_SUMO_SIM_par_1 60 66 PF11976 0.504
LIG_UBA3_1 97 104 PF00899 0.491
MOD_CDK_SPK_2 256 261 PF00069 0.483
MOD_CDK_SPxxK_3 195 202 PF00069 0.565
MOD_CK1_1 144 150 PF00069 0.564
MOD_CK1_1 160 166 PF00069 0.672
MOD_CK1_1 220 226 PF00069 0.633
MOD_CK1_1 268 274 PF00069 0.572
MOD_CK1_1 311 317 PF00069 0.497
MOD_CK2_1 14 20 PF00069 0.475
MOD_CK2_1 144 150 PF00069 0.606
MOD_CK2_1 169 175 PF00069 0.522
MOD_CK2_1 233 239 PF00069 0.599
MOD_CK2_1 60 66 PF00069 0.543
MOD_GlcNHglycan 221 225 PF01048 0.615
MOD_GlcNHglycan 271 274 PF01048 0.755
MOD_GlcNHglycan 319 323 PF01048 0.559
MOD_GlcNHglycan 4 7 PF01048 0.471
MOD_GlcNHglycan 71 74 PF01048 0.214
MOD_GSK3_1 135 142 PF00069 0.565
MOD_GSK3_1 14 21 PF00069 0.375
MOD_GSK3_1 158 165 PF00069 0.582
MOD_GSK3_1 212 219 PF00069 0.571
MOD_GSK3_1 259 266 PF00069 0.783
MOD_GSK3_1 291 298 PF00069 0.524
MOD_N-GLC_1 288 293 PF02516 0.490
MOD_N-GLC_1 329 334 PF02516 0.605
MOD_N-GLC_2 115 117 PF02516 0.248
MOD_N-GLC_2 27 29 PF02516 0.222
MOD_NEK2_1 13 18 PF00069 0.259
MOD_NEK2_1 2 7 PF00069 0.420
MOD_NEK2_1 269 274 PF00069 0.490
MOD_NEK2_1 356 361 PF00069 0.342
MOD_NEK2_1 38 43 PF00069 0.527
MOD_PIKK_1 331 337 PF00454 0.551
MOD_PKA_1 158 164 PF00069 0.474
MOD_PKA_2 157 163 PF00069 0.594
MOD_PKA_2 291 297 PF00069 0.644
MOD_Plk_1 288 294 PF00069 0.632
MOD_Plk_2-3 169 175 PF00069 0.613
MOD_Plk_4 144 150 PF00069 0.533
MOD_Plk_4 20 26 PF00069 0.317
MOD_Plk_4 82 88 PF00069 0.506
MOD_ProDKin_1 195 201 PF00069 0.570
MOD_ProDKin_1 212 218 PF00069 0.670
MOD_ProDKin_1 256 262 PF00069 0.677
MOD_ProDKin_1 263 269 PF00069 0.586
MOD_SUMO_rev_2 63 72 PF00179 0.539
TRG_DiLeu_BaEn_1 175 180 PF01217 0.406
TRG_DiLeu_BaLyEn_6 187 192 PF01217 0.486
TRG_DiLeu_BaLyEn_6 93 98 PF01217 0.559
TRG_ER_diArg_1 247 249 PF00400 0.499
TRG_NES_CRM1_1 99 111 PF08389 0.506
TRG_Pf-PMV_PEXEL_1 305 310 PF00026 0.454

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2M6 Leptomonas seymouri 56% 100%
A0A0S4KEM5 Bodo saltans 34% 75%
A0A1X0P5Z2 Trypanosomatidae 37% 100%
A0A3S5H773 Leishmania donovani 86% 100%
A0A422NUP7 Trypanosoma rangeli 37% 100%
A4HA93 Leishmania braziliensis 74% 99%
A4HYH3 Leishmania infantum 87% 100%
D0A0U7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
Q4QD67 Leishmania major 88% 100%
V5D4Q0 Trypanosoma cruzi 37% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS