PAP-associated domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cid1 family poly A polymerase, putative

Species:

Leishmania mexicana

UniProt:

E9AS95_LEIMU

TriTrypDb:

LmxM.19.1410

Length:

936

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AS95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS95

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0031123	RNA 3'-end processing	7	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071076	RNA 3' uridylation	8	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016779	nucleotidyltransferase activity	4	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0050265	RNA uridylyltransferase activity	4	7
GO:0070569	uridylyltransferase activity	5	7
GO:0140098	catalytic activity, acting on RNA	3	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	330	334	PF00656	0.550
CLV_NRD_NRD_1	179	181	PF00675	0.517
CLV_NRD_NRD_1	266	268	PF00675	0.348
CLV_NRD_NRD_1	299	301	PF00675	0.306
CLV_NRD_NRD_1	351	353	PF00675	0.369
CLV_NRD_NRD_1	358	360	PF00675	0.389
CLV_NRD_NRD_1	384	386	PF00675	0.300
CLV_NRD_NRD_1	432	434	PF00675	0.511
CLV_NRD_NRD_1	577	579	PF00675	0.734
CLV_NRD_NRD_1	595	597	PF00675	0.523
CLV_NRD_NRD_1	681	683	PF00675	0.679
CLV_NRD_NRD_1	756	758	PF00675	0.703
CLV_PCSK_FUR_1	266	270	PF00082	0.410
CLV_PCSK_KEX2_1	234	236	PF00082	0.330
CLV_PCSK_KEX2_1	266	268	PF00082	0.348
CLV_PCSK_KEX2_1	345	347	PF00082	0.364
CLV_PCSK_KEX2_1	351	353	PF00082	0.346
CLV_PCSK_KEX2_1	358	360	PF00082	0.358
CLV_PCSK_KEX2_1	384	386	PF00082	0.343
CLV_PCSK_KEX2_1	432	434	PF00082	0.511
CLV_PCSK_KEX2_1	577	579	PF00082	0.634
CLV_PCSK_KEX2_1	597	599	PF00082	0.512
CLV_PCSK_KEX2_1	681	683	PF00082	0.679
CLV_PCSK_KEX2_1	756	758	PF00082	0.688
CLV_PCSK_KEX2_1	859	861	PF00082	0.578
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.330
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.426
CLV_PCSK_PC1ET2_1	345	347	PF00082	0.387
CLV_PCSK_PC1ET2_1	597	599	PF00082	0.571
CLV_PCSK_PC1ET2_1	859	861	PF00082	0.578
CLV_PCSK_PC7_1	855	861	PF00082	0.565
CLV_PCSK_SKI1_1	181	185	PF00082	0.430
CLV_PCSK_SKI1_1	483	487	PF00082	0.455
CLV_PCSK_SKI1_1	552	556	PF00082	0.517
CLV_PCSK_SKI1_1	855	859	PF00082	0.532
CLV_PCSK_SKI1_1	899	903	PF00082	0.629
CLV_Separin_Metazoa	273	277	PF03568	0.615
DEG_APCC_DBOX_1	106	114	PF00400	0.527
DOC_CKS1_1	592	597	PF01111	0.411
DOC_CYCLIN_RxL_1	319	333	PF00134	0.583
DOC_CYCLIN_RxL_1	745	755	PF00134	0.451
DOC_CYCLIN_yCln2_LP_2	723	726	PF00134	0.496
DOC_MAPK_DCC_7	899	909	PF00069	0.410
DOC_MAPK_gen_1	323	331	PF00069	0.554
DOC_MAPK_gen_1	432	438	PF00069	0.293
DOC_MAPK_gen_1	858	867	PF00069	0.388
DOC_MAPK_MEF2A_6	283	290	PF00069	0.455
DOC_MAPK_MEF2A_6	323	331	PF00069	0.555
DOC_MAPK_MEF2A_6	522	530	PF00069	0.316
DOC_MAPK_MEF2A_6	558	566	PF00069	0.304
DOC_MIT_MIM_1	654	662	PF04212	0.353
DOC_PP1_RVXF_1	411	417	PF00149	0.469
DOC_PP1_RVXF_1	561	567	PF00149	0.293
DOC_PP2B_LxvP_1	329	332	PF13499	0.559
DOC_PP2B_LxvP_1	723	726	PF13499	0.481
DOC_PP2B_LxvP_1	879	882	PF13499	0.324
DOC_PP2B_LxvP_1	890	893	PF13499	0.382
DOC_PP4_FxxP_1	146	149	PF00568	0.513
DOC_PP4_FxxP_1	438	441	PF00568	0.308
DOC_USP7_MATH_1	13	17	PF00917	0.637
DOC_USP7_MATH_1	211	215	PF00917	0.704
DOC_USP7_MATH_1	223	227	PF00917	0.589
DOC_USP7_MATH_1	281	285	PF00917	0.602
DOC_USP7_MATH_1	317	321	PF00917	0.553
DOC_USP7_MATH_1	332	336	PF00917	0.450
DOC_USP7_MATH_1	505	509	PF00917	0.269
DOC_USP7_MATH_1	71	75	PF00917	0.678
DOC_USP7_MATH_1	771	775	PF00917	0.473
DOC_USP7_UBL2_3	401	405	PF12436	0.508
DOC_WW_Pin1_4	207	212	PF00397	0.660
DOC_WW_Pin1_4	357	362	PF00397	0.592
DOC_WW_Pin1_4	552	557	PF00397	0.315
DOC_WW_Pin1_4	581	586	PF00397	0.452
DOC_WW_Pin1_4	591	596	PF00397	0.345
DOC_WW_Pin1_4	684	689	PF00397	0.473
DOC_WW_Pin1_4	730	735	PF00397	0.403
DOC_WW_Pin1_4	902	907	PF00397	0.407
LIG_14-3-3_CanoR_1	276	281	PF00244	0.535
LIG_14-3-3_CanoR_1	306	312	PF00244	0.540
LIG_14-3-3_CanoR_1	323	328	PF00244	0.568
LIG_14-3-3_CanoR_1	378	382	PF00244	0.491
LIG_14-3-3_CanoR_1	681	685	PF00244	0.516
LIG_14-3-3_CanoR_1	814	818	PF00244	0.401
LIG_14-3-3_CanoR_1	850	854	PF00244	0.349
LIG_14-3-3_CanoR_1	860	866	PF00244	0.447
LIG_Actin_WH2_2	194	209	PF00022	0.658
LIG_Actin_WH2_2	418	434	PF00022	0.304
LIG_Actin_WH2_2	817	834	PF00022	0.387
LIG_BRCT_BRCA1_1	364	368	PF00533	0.498
LIG_BRCT_BRCA1_1	389	393	PF00533	0.469
LIG_DLG_GKlike_1	323	331	PF00625	0.512
LIG_FHA_1	473	479	PF00498	0.297
LIG_FHA_1	523	529	PF00498	0.279
LIG_FHA_1	701	707	PF00498	0.511
LIG_FHA_1	816	822	PF00498	0.373
LIG_FHA_2	174	180	PF00498	0.663
LIG_FHA_2	512	518	PF00498	0.269
LIG_FHA_2	692	698	PF00498	0.490
LIG_LIR_Apic_2	143	149	PF02991	0.508
LIG_LIR_Apic_2	435	441	PF02991	0.306
LIG_LIR_Apic_2	683	689	PF02991	0.517
LIG_LIR_Gen_1	141	152	PF02991	0.520
LIG_LIR_Gen_1	423	431	PF02991	0.304
LIG_LIR_Gen_1	586	595	PF02991	0.403
LIG_LIR_Gen_1	672	679	PF02991	0.466
LIG_LIR_Gen_1	697	706	PF02991	0.512
LIG_LIR_Gen_1	869	879	PF02991	0.372
LIG_LIR_Gen_1	905	912	PF02991	0.425
LIG_LIR_Nem_3	135	139	PF02991	0.540
LIG_LIR_Nem_3	141	147	PF02991	0.486
LIG_LIR_Nem_3	423	429	PF02991	0.304
LIG_LIR_Nem_3	455	461	PF02991	0.334
LIG_LIR_Nem_3	586	592	PF02991	0.401
LIG_LIR_Nem_3	697	701	PF02991	0.606
LIG_LIR_Nem_3	869	875	PF02991	0.390
LIG_LIR_Nem_3	905	911	PF02991	0.426
LIG_LIR_Nem_3	97	103	PF02991	0.595
LIG_MYND_1	900	904	PF01753	0.458
LIG_NRBOX	109	115	PF00104	0.517
LIG_NRBOX	477	483	PF00104	0.316
LIG_Pex14_2	364	368	PF04695	0.498
LIG_Pex14_2	399	403	PF04695	0.493
LIG_PTB_Apo_2	529	536	PF02174	0.198
LIG_PTB_Phospho_1	529	535	PF10480	0.198
LIG_SH2_CRK	152	156	PF00017	0.653
LIG_SH2_CRK	608	612	PF00017	0.455
LIG_SH2_CRK	686	690	PF00017	0.459
LIG_SH2_NCK_1	152	156	PF00017	0.653
LIG_SH2_NCK_1	686	690	PF00017	0.481
LIG_SH2_PTP2	458	461	PF00017	0.314
LIG_SH2_SRC	886	889	PF00017	0.491
LIG_SH2_STAP1	420	424	PF00017	0.304
LIG_SH2_STAP1	544	548	PF00017	0.269
LIG_SH2_STAP1	608	612	PF00017	0.455
LIG_SH2_STAP1	759	763	PF00017	0.455
LIG_SH2_STAP1	811	815	PF00017	0.411
LIG_SH2_STAP1	872	876	PF00017	0.329
LIG_SH2_STAT3	386	389	PF00017	0.498
LIG_SH2_STAT3	800	803	PF00017	0.478
LIG_SH2_STAT5	125	128	PF00017	0.494
LIG_SH2_STAT5	386	389	PF00017	0.544
LIG_SH2_STAT5	428	431	PF00017	0.304
LIG_SH2_STAT5	458	461	PF00017	0.314
LIG_SH2_STAT5	487	490	PF00017	0.263
LIG_SH2_STAT5	610	613	PF00017	0.455
LIG_SH2_STAT5	648	651	PF00017	0.337
LIG_SH2_STAT5	686	689	PF00017	0.574
LIG_SH2_STAT5	856	859	PF00017	0.337
LIG_SH2_STAT5	886	889	PF00017	0.442
LIG_SH3_1	64	70	PF00018	0.541
LIG_SH3_1	686	692	PF00018	0.469
LIG_SH3_2	67	72	PF14604	0.563
LIG_SH3_3	442	448	PF00018	0.349
LIG_SH3_3	454	460	PF00018	0.341
LIG_SH3_3	59	65	PF00018	0.575
LIG_SH3_3	686	692	PF00018	0.481
LIG_SH3_3	879	885	PF00018	0.434
LIG_SUMO_SIM_anti_2	523	530	PF11976	0.316
LIG_SUMO_SIM_anti_2	827	833	PF11976	0.343
LIG_SUMO_SIM_par_1	326	336	PF11976	0.473
LIG_TRAF2_1	270	273	PF00917	0.667
LIG_TRAF2_1	295	298	PF00917	0.466
LIG_TYR_ITIM	456	461	PF00017	0.373
LIG_UBA3_1	853	859	PF00899	0.422
LIG_WW_2	67	70	PF00397	0.411
LIG_WW_3	273	277	PF00397	0.442
MOD_CDC14_SPxK_1	210	213	PF00782	0.581
MOD_CDK_SPK_2	591	596	PF00069	0.487
MOD_CDK_SPxK_1	207	213	PF00069	0.575
MOD_CDK_SPxK_1	552	558	PF00069	0.364
MOD_CDK_SPxK_1	591	597	PF00069	0.495
MOD_CDK_SPxxK_3	591	598	PF00069	0.496
MOD_CK1_1	12	18	PF00069	0.537
MOD_CK1_1	129	135	PF00069	0.352
MOD_CK1_1	226	232	PF00069	0.467
MOD_CK2_1	169	175	PF00069	0.758
MOD_CK2_1	188	194	PF00069	0.506
MOD_CK2_1	26	32	PF00069	0.647
MOD_CK2_1	691	697	PF00069	0.712
MOD_DYRK1A_RPxSP_1	581	585	PF00069	0.422
MOD_GlcNHglycan	11	14	PF01048	0.603
MOD_GlcNHglycan	201	204	PF01048	0.612
MOD_GlcNHglycan	225	228	PF01048	0.581
MOD_GlcNHglycan	278	281	PF01048	0.413
MOD_GlcNHglycan	28	31	PF01048	0.365
MOD_GlcNHglycan	462	465	PF01048	0.328
MOD_GlcNHglycan	507	510	PF01048	0.308
MOD_GlcNHglycan	633	637	PF01048	0.515
MOD_GlcNHglycan	788	791	PF01048	0.560
MOD_GlcNHglycan	916	919	PF01048	0.603
MOD_GSK3_1	169	176	PF00069	0.643
MOD_GSK3_1	197	204	PF00069	0.567
MOD_GSK3_1	207	214	PF00069	0.534
MOD_GSK3_1	222	229	PF00069	0.564
MOD_GSK3_1	302	309	PF00069	0.468
MOD_GSK3_1	323	330	PF00069	0.347
MOD_GSK3_1	416	423	PF00069	0.304
MOD_GSK3_1	494	501	PF00069	0.303
MOD_GSK3_1	520	527	PF00069	0.295
MOD_GSK3_1	680	687	PF00069	0.603
MOD_GSK3_1	786	793	PF00069	0.499
MOD_GSK3_1	9	16	PF00069	0.594
MOD_LATS_1	321	327	PF00433	0.446
MOD_N-GLC_1	317	322	PF02516	0.425
MOD_N-GLC_1	409	414	PF02516	0.381
MOD_N-GLC_2	532	534	PF02516	0.205
MOD_NEK2_1	126	131	PF00069	0.377
MOD_NEK2_1	327	332	PF00069	0.314
MOD_NEK2_1	368	373	PF00069	0.335
MOD_NEK2_1	399	404	PF00069	0.473
MOD_NEK2_1	416	421	PF00069	0.237
MOD_NEK2_1	752	757	PF00069	0.567
MOD_NEK2_1	786	791	PF00069	0.569
MOD_NEK2_1	861	866	PF00069	0.469
MOD_NEK2_1	9	14	PF00069	0.560
MOD_NEK2_1	907	912	PF00069	0.563
MOD_NEK2_2	790	795	PF00069	0.516
MOD_PIKK_1	339	345	PF00454	0.357
MOD_PIKK_1	71	77	PF00454	0.621
MOD_PKA_2	302	308	PF00069	0.387
MOD_PKA_2	377	383	PF00069	0.330
MOD_PKA_2	680	686	PF00069	0.641
MOD_PKA_2	71	77	PF00069	0.529
MOD_PKA_2	813	819	PF00069	0.516
MOD_PKA_2	849	855	PF00069	0.360
MOD_Plk_1	142	148	PF00069	0.413
MOD_Plk_1	187	193	PF00069	0.663
MOD_Plk_1	409	415	PF00069	0.378
MOD_Plk_1	868	874	PF00069	0.343
MOD_Plk_2-3	188	194	PF00069	0.579
MOD_Plk_2-3	362	368	PF00069	0.344
MOD_Plk_2-3	76	82	PF00069	0.427
MOD_Plk_4	126	132	PF00069	0.355
MOD_Plk_4	377	383	PF00069	0.330
MOD_Plk_4	420	426	PF00069	0.284
MOD_Plk_4	524	530	PF00069	0.369
MOD_Plk_4	790	796	PF00069	0.555
MOD_Plk_4	849	855	PF00069	0.380
MOD_Plk_4	861	867	PF00069	0.411
MOD_Plk_4	907	913	PF00069	0.513
MOD_ProDKin_1	207	213	PF00069	0.575
MOD_ProDKin_1	357	363	PF00069	0.464
MOD_ProDKin_1	552	558	PF00069	0.364
MOD_ProDKin_1	581	587	PF00069	0.547
MOD_ProDKin_1	591	597	PF00069	0.419
MOD_ProDKin_1	684	690	PF00069	0.590
MOD_ProDKin_1	730	736	PF00069	0.490
MOD_ProDKin_1	902	908	PF00069	0.490
MOD_SUMO_rev_2	173	183	PF00179	0.530
MOD_SUMO_rev_2	463	470	PF00179	0.315
TRG_DiLeu_BaEn_1	5	10	PF01217	0.555
TRG_DiLeu_BaLyEn_6	109	114	PF01217	0.363
TRG_ENDOCYTIC_2	428	431	PF00928	0.304
TRG_ENDOCYTIC_2	458	461	PF00928	0.366
TRG_ENDOCYTIC_2	535	538	PF00928	0.304
TRG_ENDOCYTIC_2	608	611	PF00928	0.502
TRG_ENDOCYTIC_2	872	875	PF00928	0.450
TRG_ER_diArg_1	265	267	PF00400	0.390
TRG_ER_diArg_1	350	352	PF00400	0.396
TRG_ER_diArg_1	383	385	PF00400	0.409
TRG_ER_diArg_1	431	433	PF00400	0.336
TRG_ER_diArg_1	530	533	PF00400	0.205
TRG_ER_diArg_1	595	598	PF00400	0.448
TRG_NLS_MonoExtN_4	855	862	PF00514	0.383
TRG_Pf-PMV_PEXEL_1	385	389	PF00026	0.373
TRG_Pf-PMV_PEXEL_1	552	557	PF00026	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZT3	Leptomonas seymouri	47%	95%
A0A3Q8IEM2	Leishmania donovani	91%	100%
A4HA91	Leishmania braziliensis	71%	100%
A4HYH1	Leishmania infantum	92%	100%
Q4QD69	Leishmania major	90%	100%