Putative cation transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cation transporter, putative

Species:

Leishmania mexicana

UniProt:

E9AS92_LEIMU

TriTrypDb:

LmxM.19.1380

Length:

612

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9AS92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS92

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0022857	transmembrane transporter activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	463	467	PF00656	0.590
CLV_C14_Caspase3-7	590	594	PF00656	0.754
CLV_NRD_NRD_1	104	106	PF00675	0.298
CLV_NRD_NRD_1	173	175	PF00675	0.470
CLV_NRD_NRD_1	255	257	PF00675	0.321
CLV_NRD_NRD_1	391	393	PF00675	0.496
CLV_NRD_NRD_1	438	440	PF00675	0.424
CLV_PCSK_KEX2_1	173	175	PF00082	0.488
CLV_PCSK_KEX2_1	255	257	PF00082	0.268
CLV_PCSK_KEX2_1	438	440	PF00082	0.424
CLV_PCSK_SKI1_1	247	251	PF00082	0.267
CLV_PCSK_SKI1_1	552	556	PF00082	0.427
DEG_SPOP_SBC_1	478	482	PF00917	0.632
DEG_SPOP_SBC_1	7	11	PF00917	0.765
DOC_CYCLIN_RxL_1	244	254	PF00134	0.368
DOC_MAPK_gen_1	105	117	PF00069	0.491
DOC_MAPK_gen_1	392	400	PF00069	0.595
DOC_MAPK_gen_1	45	55	PF00069	0.493
DOC_MAPK_HePTP_8	390	402	PF00069	0.632
DOC_MAPK_MEF2A_6	393	402	PF00069	0.626
DOC_PP1_RVXF_1	245	252	PF00149	0.368
DOC_PP4_FxxP_1	541	544	PF00568	0.662
DOC_USP7_MATH_1	195	199	PF00917	0.599
DOC_USP7_MATH_1	240	244	PF00917	0.368
DOC_USP7_MATH_1	365	369	PF00917	0.747
DOC_USP7_MATH_1	370	374	PF00917	0.773
DOC_USP7_MATH_1	381	385	PF00917	0.635
DOC_USP7_MATH_1	437	441	PF00917	0.563
DOC_USP7_MATH_1	478	482	PF00917	0.787
DOC_USP7_MATH_1	494	498	PF00917	0.652
DOC_USP7_MATH_1	591	595	PF00917	0.744
DOC_USP7_MATH_1	608	612	PF00917	0.743
DOC_USP7_MATH_1	74	78	PF00917	0.310
DOC_WW_Pin1_4	185	190	PF00397	0.539
DOC_WW_Pin1_4	374	379	PF00397	0.803
DOC_WW_Pin1_4	490	495	PF00397	0.624
DOC_WW_Pin1_4	511	516	PF00397	0.735
LIG_14-3-3_CanoR_1	438	442	PF00244	0.663
LIG_14-3-3_CanoR_1	530	536	PF00244	0.651
LIG_14-3-3_CanoR_1	546	550	PF00244	0.660
LIG_14-3-3_CanoR_1	552	557	PF00244	0.576
LIG_Actin_WH2_2	333	348	PF00022	0.644
LIG_APCC_ABBA_1	220	225	PF00400	0.303
LIG_BRCT_BRCA1_1	497	501	PF00533	0.689
LIG_deltaCOP1_diTrp_1	276	285	PF00928	0.169
LIG_FHA_1	14	20	PF00498	0.640
LIG_FHA_1	159	165	PF00498	0.311
LIG_FHA_1	239	245	PF00498	0.348
LIG_FHA_1	252	258	PF00498	0.398
LIG_FHA_1	412	418	PF00498	0.572
LIG_FHA_1	446	452	PF00498	0.619
LIG_FHA_1	512	518	PF00498	0.760
LIG_FHA_1	540	546	PF00498	0.706
LIG_FHA_1	551	557	PF00498	0.576
LIG_FHA_1	87	93	PF00498	0.417
LIG_FHA_2	151	157	PF00498	0.273
LIG_FHA_2	588	594	PF00498	0.664
LIG_LIR_Apic_2	540	544	PF02991	0.619
LIG_LIR_Gen_1	216	223	PF02991	0.489
LIG_LIR_Gen_1	445	452	PF02991	0.583
LIG_LIR_Gen_1	537	545	PF02991	0.665
LIG_LIR_Gen_1	83	93	PF02991	0.240
LIG_LIR_Gen_1	97	103	PF02991	0.290
LIG_LIR_Nem_3	145	151	PF02991	0.327
LIG_LIR_Nem_3	323	327	PF02991	0.534
LIG_LIR_Nem_3	445	450	PF02991	0.577
LIG_LIR_Nem_3	537	541	PF02991	0.578
LIG_LIR_Nem_3	60	66	PF02991	0.313
LIG_LIR_Nem_3	83	88	PF02991	0.249
LIG_LIR_Nem_3	97	101	PF02991	0.275
LIG_Pex14_2	397	401	PF04695	0.631
LIG_SH2_GRB2like	327	330	PF00017	0.639
LIG_SH2_NCK_1	418	422	PF00017	0.652
LIG_SH2_PTP2	98	101	PF00017	0.346
LIG_SH2_SRC	327	330	PF00017	0.639
LIG_SH2_STAP1	223	227	PF00017	0.337
LIG_SH2_STAP1	409	413	PF00017	0.542
LIG_SH2_STAT3	46	49	PF00017	0.494
LIG_SH2_STAT5	456	459	PF00017	0.756
LIG_SH2_STAT5	46	49	PF00017	0.494
LIG_SH2_STAT5	98	101	PF00017	0.310
LIG_SUMO_SIM_anti_2	150	157	PF11976	0.162
LIG_SUMO_SIM_anti_2	77	83	PF11976	0.248
LIG_SUMO_SIM_par_1	150	157	PF11976	0.290
LIG_SUMO_SIM_par_1	413	420	PF11976	0.584
LIG_SUMO_SIM_par_1	448	454	PF11976	0.682
LIG_SUMO_SIM_par_1	550	561	PF11976	0.486
LIG_TRAF2_1	202	205	PF00917	0.495
LIG_TRAF2_1	534	537	PF00917	0.658
LIG_TRAF2_1	548	551	PF00917	0.490
LIG_TYR_ITIM	416	421	PF00017	0.642
LIG_TYR_ITIM	96	101	PF00017	0.274
LIG_WRC_WIRS_1	538	543	PF05994	0.617
MOD_CK1_1	185	191	PF00069	0.559
MOD_CK1_1	34	40	PF00069	0.714
MOD_CK1_1	374	380	PF00069	0.757
MOD_CK1_1	454	460	PF00069	0.672
MOD_CK1_1	482	488	PF00069	0.719
MOD_CK1_1	497	503	PF00069	0.592
MOD_CK1_1	510	516	PF00069	0.639
MOD_CK1_1	558	564	PF00069	0.642
MOD_CK1_1	581	587	PF00069	0.668
MOD_CK1_1	603	609	PF00069	0.787
MOD_CK2_1	150	156	PF00069	0.247
MOD_CK2_1	199	205	PF00069	0.591
MOD_CK2_1	317	323	PF00069	0.440
MOD_CK2_1	365	371	PF00069	0.684
MOD_CK2_1	380	386	PF00069	0.678
MOD_CK2_1	531	537	PF00069	0.654
MOD_CK2_1	545	551	PF00069	0.476
MOD_CK2_1	567	573	PF00069	0.673
MOD_GlcNHglycan	121	125	PF01048	0.368
MOD_GlcNHglycan	184	187	PF01048	0.761
MOD_GlcNHglycan	278	281	PF01048	0.275
MOD_GlcNHglycan	3	6	PF01048	0.581
MOD_GlcNHglycan	331	336	PF01048	0.356
MOD_GlcNHglycan	367	370	PF01048	0.539
MOD_GlcNHglycan	42	45	PF01048	0.389
MOD_GlcNHglycan	421	424	PF01048	0.454
MOD_GlcNHglycan	473	478	PF01048	0.465
MOD_GlcNHglycan	481	484	PF01048	0.518
MOD_GlcNHglycan	497	500	PF01048	0.425
MOD_GlcNHglycan	508	512	PF01048	0.465
MOD_GlcNHglycan	580	583	PF01048	0.439
MOD_GlcNHglycan	585	588	PF01048	0.503
MOD_GlcNHglycan	593	596	PF01048	0.522
MOD_GlcNHglycan	72	75	PF01048	0.504
MOD_GSK3_1	150	157	PF00069	0.311
MOD_GSK3_1	181	188	PF00069	0.548
MOD_GSK3_1	195	202	PF00069	0.586
MOD_GSK3_1	370	377	PF00069	0.763
MOD_GSK3_1	456	463	PF00069	0.770
MOD_GSK3_1	473	480	PF00069	0.667
MOD_GSK3_1	490	497	PF00069	0.688
MOD_GSK3_1	507	514	PF00069	0.666
MOD_GSK3_1	552	559	PF00069	0.616
MOD_GSK3_1	578	585	PF00069	0.591
MOD_GSK3_1	587	594	PF00069	0.650
MOD_GSK3_1	70	77	PF00069	0.310
MOD_GSK3_1	8	15	PF00069	0.712
MOD_N-GLC_1	181	186	PF02516	0.690
MOD_N-GLC_1	454	459	PF02516	0.495
MOD_NEK2_1	120	125	PF00069	0.511
MOD_NEK2_1	154	159	PF00069	0.320
MOD_NEK2_1	251	256	PF00069	0.438
MOD_NEK2_1	303	308	PF00069	0.288
MOD_NEK2_1	317	322	PF00069	0.459
MOD_NEK2_1	451	456	PF00069	0.705
MOD_NEK2_1	64	69	PF00069	0.338
MOD_PIKK_1	356	362	PF00454	0.589
MOD_PKA_2	1	7	PF00069	0.721
MOD_PKA_2	251	257	PF00069	0.432
MOD_PKA_2	437	443	PF00069	0.588
MOD_PKA_2	545	551	PF00069	0.666
MOD_Plk_1	331	337	PF00069	0.606
MOD_Plk_1	386	392	PF00069	0.695
MOD_Plk_1	460	466	PF00069	0.703
MOD_Plk_1	550	556	PF00069	0.660
MOD_Plk_1	566	572	PF00069	0.619
MOD_Plk_2-3	150	156	PF00069	0.214
MOD_Plk_2-3	567	573	PF00069	0.646
MOD_Plk_4	150	156	PF00069	0.358
MOD_Plk_4	240	246	PF00069	0.344
MOD_Plk_4	317	323	PF00069	0.429
MOD_Plk_4	411	417	PF00069	0.540
MOD_Plk_4	446	452	PF00069	0.620
MOD_ProDKin_1	185	191	PF00069	0.543
MOD_ProDKin_1	374	380	PF00069	0.806
MOD_ProDKin_1	490	496	PF00069	0.623
MOD_ProDKin_1	511	517	PF00069	0.737
MOD_SUMO_rev_2	467	477	PF00179	0.588
TRG_DiLeu_BaEn_1	428	433	PF01217	0.650
TRG_DiLeu_BaLyEn_6	512	517	PF01217	0.573
TRG_DiLeu_BaLyEn_6	575	580	PF01217	0.567
TRG_ENDOCYTIC_2	314	317	PF00928	0.325
TRG_ENDOCYTIC_2	418	421	PF00928	0.668
TRG_ENDOCYTIC_2	98	101	PF00928	0.274
TRG_ER_diArg_1	255	257	PF00400	0.549
TRG_NES_CRM1_1	142	156	PF08389	0.162
TRG_NLS_MonoExtC_3	104	109	PF00514	0.491
TRG_Pf-PMV_PEXEL_1	439	444	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHD4	Leptomonas seymouri	62%	97%
A0A0S4IWL9	Bodo saltans	36%	100%
A0A1X0P615	Trypanosomatidae	49%	100%
A0A3Q8IBF0	Leishmania donovani	92%	100%
A0A3R7MPI1	Trypanosoma rangeli	44%	100%
A4HA88	Leishmania braziliensis	79%	100%
A4HYG8	Leishmania infantum	91%	100%
D0A0T8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
Q4QD72	Leishmania major	91%	100%
V5B132	Trypanosoma cruzi	45%	100%