PDZ domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AS91_LEIMU

TriTrypDb:

LmxM.19.1370

Length:

741

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AS91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS91

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.697
CLV_C14_Caspase3-7	413	417	PF00656	0.517
CLV_C14_Caspase3-7	422	426	PF00656	0.557
CLV_MEL_PAP_1	540	546	PF00089	0.329
CLV_NRD_NRD_1	249	251	PF00675	0.613
CLV_NRD_NRD_1	292	294	PF00675	0.633
CLV_NRD_NRD_1	310	312	PF00675	0.460
CLV_NRD_NRD_1	402	404	PF00675	0.543
CLV_NRD_NRD_1	629	631	PF00675	0.665
CLV_PCSK_FUR_1	399	403	PF00082	0.553
CLV_PCSK_KEX2_1	249	251	PF00082	0.613
CLV_PCSK_KEX2_1	310	312	PF00082	0.647
CLV_PCSK_KEX2_1	401	403	PF00082	0.571
CLV_PCSK_KEX2_1	408	410	PF00082	0.536
CLV_PCSK_PC1ET2_1	408	410	PF00082	0.600
CLV_PCSK_SKI1_1	257	261	PF00082	0.561
CLV_PCSK_SKI1_1	408	412	PF00082	0.599
CLV_PCSK_SKI1_1	476	480	PF00082	0.641
CLV_PCSK_SKI1_1	624	628	PF00082	0.681
DEG_APCC_DBOX_1	111	119	PF00400	0.628
DEG_APCC_DBOX_1	508	516	PF00400	0.654
DEG_APCC_DBOX_1	527	535	PF00400	0.328
DEG_APCC_DBOX_1	578	586	PF00400	0.414
DOC_CKS1_1	196	201	PF01111	0.507
DOC_CKS1_1	286	291	PF01111	0.500
DOC_CYCLIN_yCln2_LP_2	729	732	PF00134	0.409
DOC_MAPK_gen_1	209	216	PF00069	0.520
DOC_MAPK_gen_1	509	517	PF00069	0.655
DOC_MAPK_gen_1	719	728	PF00069	0.424
DOC_MAPK_MEF2A_6	528	536	PF00069	0.462
DOC_MAPK_MEF2A_6	579	586	PF00069	0.392
DOC_MAPK_MEF2A_6	67	76	PF00069	0.588
DOC_MAPK_MEF2A_6	722	730	PF00069	0.419
DOC_MIT_MIM_1	507	515	PF04212	0.584
DOC_PP2B_LxvP_1	728	731	PF13499	0.403
DOC_PP4_FxxP_1	196	199	PF00568	0.504
DOC_PP4_FxxP_1	203	206	PF00568	0.487
DOC_PP4_FxxP_1	353	356	PF00568	0.596
DOC_USP7_MATH_1	143	147	PF00917	0.683
DOC_USP7_MATH_1	169	173	PF00917	0.756
DOC_USP7_MATH_1	175	179	PF00917	0.700
DOC_USP7_MATH_1	182	186	PF00917	0.591
DOC_USP7_MATH_1	199	203	PF00917	0.657
DOC_USP7_MATH_1	225	229	PF00917	0.725
DOC_USP7_MATH_1	300	304	PF00917	0.684
DOC_USP7_MATH_1	348	352	PF00917	0.820
DOC_USP7_MATH_1	368	372	PF00917	0.502
DOC_USP7_MATH_1	661	665	PF00917	0.644
DOC_USP7_MATH_1	681	685	PF00917	0.531
DOC_USP7_MATH_1	735	739	PF00917	0.461
DOC_USP7_MATH_2	448	454	PF00917	0.521
DOC_WW_Pin1_4	154	159	PF00397	0.621
DOC_WW_Pin1_4	165	170	PF00397	0.662
DOC_WW_Pin1_4	195	200	PF00397	0.584
DOC_WW_Pin1_4	214	219	PF00397	0.571
DOC_WW_Pin1_4	230	235	PF00397	0.667
DOC_WW_Pin1_4	285	290	PF00397	0.504
DOC_WW_Pin1_4	333	338	PF00397	0.780
DOC_WW_Pin1_4	378	383	PF00397	0.641
DOC_WW_Pin1_4	384	389	PF00397	0.556
DOC_WW_Pin1_4	444	449	PF00397	0.568
DOC_WW_Pin1_4	461	466	PF00397	0.694
DOC_WW_Pin1_4	618	623	PF00397	0.669
DOC_WW_Pin1_4	685	690	PF00397	0.666
LIG_14-3-3_CanoR_1	112	116	PF00244	0.523
LIG_14-3-3_CanoR_1	193	199	PF00244	0.692
LIG_14-3-3_CanoR_1	211	217	PF00244	0.511
LIG_14-3-3_CanoR_1	257	262	PF00244	0.759
LIG_14-3-3_CanoR_1	374	380	PF00244	0.705
LIG_14-3-3_CanoR_1	476	486	PF00244	0.634
LIG_14-3-3_CanoR_1	522	532	PF00244	0.503
LIG_14-3-3_CanoR_1	547	552	PF00244	0.541
LIG_14-3-3_CanoR_1	559	565	PF00244	0.375
LIG_14-3-3_CanoR_1	662	669	PF00244	0.585
LIG_14-3-3_CanoR_1	670	675	PF00244	0.589
LIG_14-3-3_CanoR_1	682	690	PF00244	0.543
LIG_14-3-3_CanoR_1	89	97	PF00244	0.367
LIG_Actin_WH2_2	417	432	PF00022	0.649
LIG_Actin_WH2_2	533	551	PF00022	0.557
LIG_Actin_WH2_2	723	739	PF00022	0.456
LIG_BIR_II_1	1	5	PF00653	0.766
LIG_BRCT_BRCA1_1	146	150	PF00533	0.517
LIG_BRCT_BRCA1_1	199	203	PF00533	0.504
LIG_BRCT_BRCA1_2	146	152	PF00533	0.510
LIG_BRCT_MDC1_1	737	741	PF00533	0.639
LIG_Clathr_ClatBox_1	531	535	PF01394	0.559
LIG_CSL_BTD_1	385	388	PF09270	0.655
LIG_EH1_1	723	731	PF00400	0.291
LIG_FHA_1	258	264	PF00498	0.725
LIG_FHA_1	307	313	PF00498	0.493
LIG_FHA_1	493	499	PF00498	0.668
LIG_FHA_1	725	731	PF00498	0.498
LIG_FHA_1	91	97	PF00498	0.564
LIG_FHA_2	286	292	PF00498	0.528
LIG_FHA_2	345	351	PF00498	0.640
LIG_FHA_2	420	426	PF00498	0.454
LIG_FHA_2	445	451	PF00498	0.651
LIG_FHA_2	499	505	PF00498	0.591
LIG_GBD_Chelix_1	392	400	PF00786	0.665
LIG_Integrin_RGD_1	468	470	PF01839	0.673
LIG_LIR_Apic_2	194	199	PF02991	0.507
LIG_LIR_Apic_2	200	206	PF02991	0.493
LIG_LIR_Apic_2	350	356	PF02991	0.607
LIG_LIR_Apic_2	384	389	PF02991	0.641
LIG_LIR_Apic_2	618	622	PF02991	0.480
LIG_LIR_Gen_1	57	63	PF02991	0.479
LIG_LIR_Nem_3	404	410	PF02991	0.653
LIG_LIR_Nem_3	484	490	PF02991	0.569
LIG_LIR_Nem_3	550	555	PF02991	0.558
LIG_LIR_Nem_3	57	62	PF02991	0.488
LIG_PCNA_yPIPBox_3	249	262	PF02747	0.464
LIG_Pex14_2	605	609	PF04695	0.623
LIG_Pex14_2	690	694	PF04695	0.650
LIG_RPA_C_Fungi	640	652	PF08784	0.686
LIG_SH2_CRK	487	491	PF00017	0.576
LIG_SH2_CRK	619	623	PF00017	0.489
LIG_SH2_PTP2	583	586	PF00017	0.348
LIG_SH2_PTP2	598	601	PF00017	0.384
LIG_SH2_SRC	518	521	PF00017	0.542
LIG_SH2_STAP1	523	527	PF00017	0.626
LIG_SH2_STAP1	55	59	PF00017	0.490
LIG_SH2_STAT3	593	596	PF00017	0.425
LIG_SH2_STAT5	555	558	PF00017	0.402
LIG_SH2_STAT5	583	586	PF00017	0.348
LIG_SH2_STAT5	598	601	PF00017	0.384
LIG_SH2_STAT5	707	710	PF00017	0.460
LIG_SH3_1	335	341	PF00018	0.542
LIG_SH3_3	17	23	PF00018	0.678
LIG_SH3_3	219	225	PF00018	0.660
LIG_SH3_3	335	341	PF00018	0.600
LIG_SH3_3	376	382	PF00018	0.699
LIG_SH3_3	514	520	PF00018	0.540
LIG_SH3_3	536	542	PF00018	0.459
LIG_SUMO_SIM_anti_2	725	730	PF11976	0.412
LIG_SUMO_SIM_par_1	259	265	PF11976	0.712
LIG_TRAF2_1	447	450	PF00917	0.639
LIG_TRAF2_1	501	504	PF00917	0.595
LIG_TYR_ITIM	708	713	PF00017	0.423
LIG_UBA3_1	58	67	PF00899	0.467
LIG_WRC_WIRS_1	606	611	PF05994	0.558
LIG_WRC_WIRS_1	691	696	PF05994	0.627
MOD_CDC14_SPxK_1	621	624	PF00782	0.679
MOD_CDK_SPxK_1	618	624	PF00069	0.673
MOD_CDK_SPxxK_3	444	451	PF00069	0.567
MOD_CDK_SPxxK_3	461	468	PF00069	0.683
MOD_CK1_1	16	22	PF00069	0.574
MOD_CK1_1	165	171	PF00069	0.627
MOD_CK1_1	194	200	PF00069	0.703
MOD_CK1_1	232	238	PF00069	0.670
MOD_CK1_1	287	293	PF00069	0.569
MOD_CK1_1	32	38	PF00069	0.438
MOD_CK1_1	336	342	PF00069	0.736
MOD_CK1_1	378	384	PF00069	0.768
MOD_CK1_1	481	487	PF00069	0.506
MOD_CK1_1	575	581	PF00069	0.418
MOD_CK2_1	285	291	PF00069	0.563
MOD_CK2_1	300	306	PF00069	0.608
MOD_CK2_1	344	350	PF00069	0.642
MOD_CK2_1	444	450	PF00069	0.652
MOD_CK2_1	498	504	PF00069	0.589
MOD_CK2_1	507	513	PF00069	0.487
MOD_CK2_1	6	12	PF00069	0.534
MOD_GlcNHglycan	118	121	PF01048	0.647
MOD_GlcNHglycan	123	126	PF01048	0.684
MOD_GlcNHglycan	140	143	PF01048	0.536
MOD_GlcNHglycan	185	188	PF01048	0.647
MOD_GlcNHglycan	199	202	PF01048	0.611
MOD_GlcNHglycan	268	271	PF01048	0.583
MOD_GlcNHglycan	344	347	PF01048	0.698
MOD_GlcNHglycan	383	386	PF01048	0.492
MOD_GlcNHglycan	663	666	PF01048	0.679
MOD_GlcNHglycan	683	686	PF01048	0.526
MOD_GlcNHglycan	695	698	PF01048	0.451
MOD_GlcNHglycan	737	740	PF01048	0.625
MOD_GSK3_1	165	172	PF00069	0.733
MOD_GSK3_1	191	198	PF00069	0.625
MOD_GSK3_1	2	9	PF00069	0.525
MOD_GSK3_1	210	217	PF00069	0.502
MOD_GSK3_1	225	232	PF00069	0.619
MOD_GSK3_1	280	287	PF00069	0.652
MOD_GSK3_1	29	36	PF00069	0.494
MOD_GSK3_1	333	340	PF00069	0.724
MOD_GSK3_1	344	351	PF00069	0.592
MOD_GSK3_1	374	381	PF00069	0.748
MOD_GSK3_1	425	432	PF00069	0.535
MOD_GSK3_1	477	484	PF00069	0.558
MOD_GSK3_1	681	688	PF00069	0.676
MOD_GSK3_1	689	696	PF00069	0.568
MOD_N-GLC_1	162	167	PF02516	0.542
MOD_NEK2_1	1	6	PF00069	0.597
MOD_NEK2_1	111	116	PF00069	0.522
MOD_NEK2_1	191	196	PF00069	0.704
MOD_NEK2_1	229	234	PF00069	0.749
MOD_NEK2_1	419	424	PF00069	0.610
MOD_NEK2_1	605	610	PF00069	0.547
MOD_NEK2_1	62	67	PF00069	0.454
MOD_NEK2_1	680	685	PF00069	0.600
MOD_NEK2_1	690	695	PF00069	0.538
MOD_PIKK_1	162	168	PF00454	0.694
MOD_PIKK_1	2	8	PF00454	0.694
MOD_PIKK_1	216	222	PF00454	0.602
MOD_PIKK_1	369	375	PF00454	0.708
MOD_PIKK_1	478	484	PF00454	0.381
MOD_PIKK_1	48	54	PF00454	0.490
MOD_PKA_1	152	158	PF00069	0.506
MOD_PKA_2	111	117	PF00069	0.575
MOD_PKA_2	176	182	PF00069	0.748
MOD_PKA_2	192	198	PF00069	0.524
MOD_PKA_2	210	216	PF00069	0.509
MOD_PKA_2	248	254	PF00069	0.616
MOD_PKA_2	429	435	PF00069	0.510
MOD_PKA_2	450	456	PF00069	0.705
MOD_PKA_2	661	667	PF00069	0.641
MOD_PKA_2	669	675	PF00069	0.580
MOD_PKA_2	681	687	PF00069	0.513
MOD_Plk_1	191	197	PF00069	0.724
MOD_Plk_1	32	38	PF00069	0.344
MOD_Plk_1	420	426	PF00069	0.637
MOD_Plk_1	624	630	PF00069	0.748
MOD_Plk_1	724	730	PF00069	0.501
MOD_Plk_2-3	45	51	PF00069	0.505
MOD_Plk_4	199	205	PF00069	0.753
MOD_Plk_4	257	263	PF00069	0.726
MOD_Plk_4	26	32	PF00069	0.554
MOD_Plk_4	724	730	PF00069	0.413
MOD_ProDKin_1	154	160	PF00069	0.622
MOD_ProDKin_1	165	171	PF00069	0.664
MOD_ProDKin_1	195	201	PF00069	0.585
MOD_ProDKin_1	214	220	PF00069	0.596
MOD_ProDKin_1	230	236	PF00069	0.664
MOD_ProDKin_1	285	291	PF00069	0.501
MOD_ProDKin_1	333	339	PF00069	0.783
MOD_ProDKin_1	378	384	PF00069	0.635
MOD_ProDKin_1	444	450	PF00069	0.566
MOD_ProDKin_1	461	467	PF00069	0.688
MOD_ProDKin_1	618	624	PF00069	0.673
MOD_ProDKin_1	685	691	PF00069	0.667
MOD_SUMO_for_1	130	133	PF00179	0.648
MOD_SUMO_for_1	151	154	PF00179	0.681
MOD_SUMO_rev_2	404	410	PF00179	0.497
TRG_DiLeu_BaEn_4	503	509	PF01217	0.591
TRG_DiLeu_BaLyEn_6	527	532	PF01217	0.626
TRG_ENDOCYTIC_2	487	490	PF00928	0.577
TRG_ENDOCYTIC_2	55	58	PF00928	0.490
TRG_ENDOCYTIC_2	583	586	PF00928	0.380
TRG_ENDOCYTIC_2	598	601	PF00928	0.417
TRG_ENDOCYTIC_2	710	713	PF00928	0.418
TRG_ER_diArg_1	310	312	PF00400	0.543
TRG_ER_diArg_1	399	402	PF00400	0.555
TRG_ER_diArg_1	508	511	PF00400	0.653
TRG_ER_diArg_1	546	549	PF00400	0.536
TRG_NES_CRM1_1	252	265	PF08389	0.472
TRG_NES_CRM1_1	600	614	PF08389	0.626
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P342	Leptomonas seymouri	39%	100%
A0A3Q8IBI1	Leishmania donovani	84%	99%
A4HA87	Leishmania braziliensis	65%	100%
A4HYG4	Leishmania infantum	84%	99%
Q4QD73	Leishmania major	83%	100%