LeishMANIAdb
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Phosphatidic acid phosphatase protein-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphatidic acid phosphatase protein-like protein
Gene product:
phosphatidic acid phosphatase protein-like protein
Species:
Leishmania mexicana
UniProt:
E9AS88_LEIMU
TriTrypDb:
LmxM.19.1351
Length:
330

Annotations

LeishMANIAdb annotations

Distinctively related to eukaryotic PLPP enzymes.. This family of protens expanded considerably in Kinetoplastids (might be due to metabolic dependence on host lipids)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

E9AS88
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 10
GO:0006644 phospholipid metabolic process 4 10
GO:0006793 phosphorus metabolic process 3 10
GO:0006796 phosphate-containing compound metabolic process 4 10
GO:0008152 metabolic process 1 10
GO:0009987 cellular process 1 10
GO:0019637 organophosphate metabolic process 3 10
GO:0044237 cellular metabolic process 2 10
GO:0044238 primary metabolic process 2 10
GO:0044255 cellular lipid metabolic process 3 10
GO:0071704 organic substance metabolic process 2 10
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0008195 phosphatidate phosphatase activity 6 1
GO:0016787 hydrolase activity 2 1
GO:0016788 hydrolase activity, acting on ester bonds 3 1
GO:0016791 phosphatase activity 5 1
GO:0042578 phosphoric ester hydrolase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 304 308 PF00656 0.466
CLV_NRD_NRD_1 310 312 PF00675 0.725
CLV_NRD_NRD_1 318 320 PF00675 0.631
CLV_NRD_NRD_1 4 6 PF00675 0.238
CLV_PCSK_KEX2_1 282 284 PF00082 0.780
CLV_PCSK_KEX2_1 310 312 PF00082 0.725
CLV_PCSK_KEX2_1 318 320 PF00082 0.631
CLV_PCSK_KEX2_1 4 6 PF00082 0.238
CLV_PCSK_PC1ET2_1 282 284 PF00082 0.740
CLV_PCSK_SKI1_1 4 8 PF00082 0.247
DEG_APCC_DBOX_1 73 81 PF00400 0.536
DEG_Nend_Nbox_1 1 3 PF02207 0.432
DOC_MAPK_DCC_7 178 188 PF00069 0.395
DOC_PP1_RVXF_1 139 145 PF00149 0.508
DOC_USP7_MATH_1 255 259 PF00917 0.427
DOC_USP7_MATH_1 270 274 PF00917 0.499
DOC_USP7_MATH_1 36 40 PF00917 0.628
DOC_WW_Pin1_4 251 256 PF00397 0.336
DOC_WW_Pin1_4 266 271 PF00397 0.343
DOC_WW_Pin1_4 290 295 PF00397 0.497
LIG_14-3-3_CanoR_1 141 145 PF00244 0.508
LIG_14-3-3_CanoR_1 172 177 PF00244 0.336
LIG_14-3-3_CanoR_1 288 295 PF00244 0.499
LIG_14-3-3_CanoR_1 297 305 PF00244 0.416
LIG_14-3-3_CanoR_1 5 11 PF00244 0.437
LIG_BIR_III_2 132 136 PF00653 0.538
LIG_BRCT_BRCA1_1 149 153 PF00533 0.508
LIG_BRCT_BRCA1_1 159 163 PF00533 0.356
LIG_DLG_GKlike_1 172 179 PF00625 0.336
LIG_FHA_1 175 181 PF00498 0.324
LIG_FHA_1 85 91 PF00498 0.593
LIG_FHA_2 120 126 PF00498 0.568
LIG_FHA_2 238 244 PF00498 0.412
LIG_FHA_2 302 308 PF00498 0.465
LIG_FHA_2 36 42 PF00498 0.591
LIG_IRF3_LxIS_1 180 187 PF10401 0.440
LIG_LIR_Apic_2 251 255 PF02991 0.347
LIG_LIR_Gen_1 125 135 PF02991 0.593
LIG_LIR_Gen_1 175 184 PF02991 0.336
LIG_LIR_Gen_1 217 226 PF02991 0.403
LIG_LIR_Gen_1 243 251 PF02991 0.404
LIG_LIR_Gen_1 43 52 PF02991 0.563
LIG_LIR_Nem_3 125 130 PF02991 0.589
LIG_LIR_Nem_3 175 179 PF02991 0.401
LIG_LIR_Nem_3 217 222 PF02991 0.353
LIG_LIR_Nem_3 225 229 PF02991 0.380
LIG_LIR_Nem_3 243 249 PF02991 0.310
LIG_LIR_Nem_3 43 48 PF02991 0.659
LIG_LYPXL_S_1 69 73 PF13949 0.358
LIG_LYPXL_yS_3 70 73 PF13949 0.556
LIG_MLH1_MIPbox_1 159 163 PF16413 0.286
LIG_PDZ_Wminus1_1 328 330 PF00595 0.445
LIG_Pex14_2 222 226 PF04695 0.349
LIG_PTB_Apo_2 120 127 PF02174 0.568
LIG_PTB_Phospho_1 120 126 PF10480 0.568
LIG_SH2_CRK 127 131 PF00017 0.536
LIG_SH2_CRK 246 250 PF00017 0.357
LIG_SH2_NCK_1 45 49 PF00017 0.605
LIG_SH2_SRC 45 48 PF00017 0.591
LIG_SH2_STAP1 110 114 PF00017 0.536
LIG_SH2_STAT5 101 104 PF00017 0.527
LIG_SH2_STAT5 110 113 PF00017 0.536
LIG_SH2_STAT5 127 130 PF00017 0.585
LIG_SH2_STAT5 236 239 PF00017 0.372
LIG_SH3_3 306 312 PF00018 0.482
LIG_SUMO_SIM_anti_2 187 192 PF11976 0.444
LIG_SUMO_SIM_par_1 184 189 PF11976 0.447
LIG_SUMO_SIM_par_1 299 308 PF11976 0.374
LIG_TYR_ITIM 244 249 PF00017 0.398
LIG_TYR_ITIM 68 73 PF00017 0.618
LIG_WRC_WIRS_1 219 224 PF05994 0.366
MOD_CDK_SPxxK_3 290 297 PF00069 0.487
MOD_CK1_1 112 118 PF00069 0.544
MOD_CK1_1 143 149 PF00069 0.508
MOD_CK1_1 258 264 PF00069 0.545
MOD_CK1_1 84 90 PF00069 0.538
MOD_CK2_1 35 41 PF00069 0.639
MOD_Cter_Amidation 2 5 PF01082 0.237
MOD_DYRK1A_RPxSP_1 290 294 PF00069 0.449
MOD_GlcNHglycan 145 148 PF01048 0.308
MOD_GlcNHglycan 216 219 PF01048 0.413
MOD_GlcNHglycan 261 264 PF01048 0.683
MOD_GlcNHglycan 290 293 PF01048 0.673
MOD_GlcNHglycan 8 11 PF01048 0.236
MOD_GSK3_1 108 115 PF00069 0.548
MOD_GSK3_1 143 150 PF00069 0.508
MOD_GSK3_1 214 221 PF00069 0.351
MOD_GSK3_1 251 258 PF00069 0.475
MOD_GSK3_1 266 273 PF00069 0.459
MOD_GSK3_1 301 308 PF00069 0.467
MOD_GSK3_1 31 38 PF00069 0.583
MOD_N-GLC_1 305 310 PF02516 0.666
MOD_NEK2_1 222 227 PF00069 0.397
MOD_NEK2_1 237 242 PF00069 0.290
MOD_NEK2_2 218 223 PF00069 0.342
MOD_PKA_1 310 316 PF00069 0.492
MOD_PKA_2 140 146 PF00069 0.508
MOD_PKA_2 296 302 PF00069 0.445
MOD_PKA_2 310 316 PF00069 0.544
MOD_Plk_1 305 311 PF00069 0.467
MOD_Plk_4 154 160 PF00069 0.406
MOD_Plk_4 186 192 PF00069 0.436
MOD_Plk_4 208 214 PF00069 0.383
MOD_ProDKin_1 251 257 PF00069 0.337
MOD_ProDKin_1 266 272 PF00069 0.343
MOD_ProDKin_1 290 296 PF00069 0.491
MOD_SUMO_rev_2 245 255 PF00179 0.457
TRG_DiLeu_BaLyEn_6 175 180 PF01217 0.315
TRG_ENDOCYTIC_2 127 130 PF00928 0.536
TRG_ENDOCYTIC_2 246 249 PF00928 0.409
TRG_ENDOCYTIC_2 45 48 PF00928 0.628
TRG_ENDOCYTIC_2 70 73 PF00928 0.540
TRG_ER_diArg_1 287 290 PF00400 0.461
TRG_ER_diArg_1 309 311 PF00400 0.518
TRG_ER_diArg_1 318 320 PF00400 0.424
TRG_ER_diArg_1 4 6 PF00400 0.438
TRG_ER_diArg_1 57 60 PF00400 0.637
TRG_ER_diArg_1 96 99 PF00400 0.508
TRG_Pf-PMV_PEXEL_1 318 322 PF00026 0.688

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P344 Leptomonas seymouri 59% 84%
A0A3Q8ID01 Leishmania donovani 32% 89%
A0A3Q8IK66 Leishmania donovani 88% 82%
A4HA84 Leishmania braziliensis 72% 100%
A4HXR8 Leishmania infantum 32% 89%
A4HYG7 Leishmania infantum 88% 82%
E9AS87 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
Q4QD76 Leishmania major 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS