LeishMANIAdb
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Phosphatidic acid phosphatase protein-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphatidic acid phosphatase protein-like protein
Gene product:
phosphatidic acid phosphatase protein-like protein
Species:
Leishmania mexicana
UniProt:
E9AS87_LEIMU
TriTrypDb:
LmxM.19.1350
Length:
399

Annotations

LeishMANIAdb annotations

Distinctively related to eukaryotic PLPP enzymes.. This family of protens expanded considerably in Kinetoplastids (might be due to metabolic dependence on host lipids)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 24
NetGPI no yes: 0, no: 24
Cellular components
Term Name Level Count
GO:0016020 membrane 2 25
GO:0110165 cellular anatomical entity 1 25

Expansion

Sequence features

E9AS87
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS87

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 25
GO:0006644 phospholipid metabolic process 4 25
GO:0006793 phosphorus metabolic process 3 25
GO:0006796 phosphate-containing compound metabolic process 4 25
GO:0008152 metabolic process 1 25
GO:0009987 cellular process 1 25
GO:0019637 organophosphate metabolic process 3 25
GO:0044237 cellular metabolic process 2 25
GO:0044238 primary metabolic process 2 25
GO:0044255 cellular lipid metabolic process 3 25
GO:0071704 organic substance metabolic process 2 25
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0008195 phosphatidate phosphatase activity 6 3
GO:0016787 hydrolase activity 2 3
GO:0016788 hydrolase activity, acting on ester bonds 3 3
GO:0016791 phosphatase activity 5 3
GO:0042578 phosphoric ester hydrolase activity 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 373 377 PF00656 0.441
CLV_NRD_NRD_1 379 381 PF00675 0.780
CLV_NRD_NRD_1 387 389 PF00675 0.710
CLV_PCSK_KEX2_1 351 353 PF00082 0.792
CLV_PCSK_KEX2_1 379 381 PF00082 0.780
CLV_PCSK_KEX2_1 387 389 PF00082 0.710
CLV_PCSK_PC1ET2_1 351 353 PF00082 0.688
DEG_APCC_DBOX_1 142 150 PF00400 0.513
DOC_MAPK_DCC_7 247 257 PF00069 0.302
DOC_PP1_RVXF_1 208 214 PF00149 0.439
DOC_PP4_FxxP_1 91 94 PF00568 0.672
DOC_USP7_MATH_1 105 109 PF00917 0.676
DOC_USP7_MATH_1 324 328 PF00917 0.534
DOC_USP7_MATH_1 339 343 PF00917 0.568
DOC_USP7_MATH_1 52 56 PF00917 0.376
DOC_WW_Pin1_4 320 325 PF00397 0.441
DOC_WW_Pin1_4 335 340 PF00397 0.422
DOC_WW_Pin1_4 359 364 PF00397 0.543
LIG_14-3-3_CanoR_1 210 214 PF00244 0.430
LIG_14-3-3_CanoR_1 241 246 PF00244 0.257
LIG_14-3-3_CanoR_1 357 364 PF00244 0.552
LIG_14-3-3_CanoR_1 366 374 PF00244 0.499
LIG_BIR_III_2 201 205 PF00653 0.430
LIG_BRCT_BRCA1_1 218 222 PF00533 0.304
LIG_BRCT_BRCA1_1 228 232 PF00533 0.304
LIG_BRCT_BRCA1_1 4 8 PF00533 0.424
LIG_BRCT_BRCA1_1 71 75 PF00533 0.355
LIG_DLG_GKlike_1 241 248 PF00625 0.298
LIG_FHA_1 154 160 PF00498 0.517
LIG_FHA_1 244 250 PF00498 0.385
LIG_FHA_1 28 34 PF00498 0.224
LIG_FHA_2 105 111 PF00498 0.669
LIG_FHA_2 189 195 PF00498 0.513
LIG_FHA_2 307 313 PF00498 0.450
LIG_FHA_2 371 377 PF00498 0.448
LIG_FHA_2 57 63 PF00498 0.394
LIG_IRF3_LxIS_1 249 256 PF10401 0.310
LIG_LIR_Apic_2 320 324 PF02991 0.314
LIG_LIR_Apic_2 89 94 PF02991 0.655
LIG_LIR_Gen_1 112 121 PF02991 0.642
LIG_LIR_Gen_1 19 28 PF02991 0.356
LIG_LIR_Gen_1 194 204 PF02991 0.480
LIG_LIR_Gen_1 244 253 PF02991 0.371
LIG_LIR_Gen_1 286 295 PF02991 0.416
LIG_LIR_Gen_1 312 320 PF02991 0.473
LIG_LIR_Nem_3 112 117 PF02991 0.699
LIG_LIR_Nem_3 19 23 PF02991 0.355
LIG_LIR_Nem_3 194 199 PF02991 0.478
LIG_LIR_Nem_3 244 248 PF02991 0.322
LIG_LIR_Nem_3 286 291 PF02991 0.375
LIG_LIR_Nem_3 294 298 PF02991 0.462
LIG_LIR_Nem_3 312 318 PF02991 0.384
LIG_LIR_Nem_3 58 63 PF02991 0.320
LIG_LIR_Nem_3 72 78 PF02991 0.270
LIG_LIR_Nem_3 96 100 PF02991 0.607
LIG_LYPXL_S_1 138 142 PF13949 0.384
LIG_LYPXL_yS_3 139 142 PF13949 0.581
LIG_MLH1_MIPbox_1 228 232 PF16413 0.190
LIG_PDZ_Wminus1_1 397 399 PF00595 0.543
LIG_Pex14_2 291 295 PF04695 0.338
LIG_Pex14_2 71 75 PF04695 0.381
LIG_Pex14_2 8 12 PF04695 0.601
LIG_PTB_Apo_2 189 196 PF02174 0.454
LIG_PTB_Phospho_1 189 195 PF10480 0.454
LIG_SH2_CRK 196 200 PF00017 0.483
LIG_SH2_CRK 315 319 PF00017 0.428
LIG_SH2_NCK_1 114 118 PF00017 0.698
LIG_SH2_SRC 114 117 PF00017 0.727
LIG_SH2_STAP1 179 183 PF00017 0.537
LIG_SH2_STAP1 63 67 PF00017 0.392
LIG_SH2_STAT5 170 173 PF00017 0.482
LIG_SH2_STAT5 179 182 PF00017 0.483
LIG_SH2_STAT5 196 199 PF00017 0.474
LIG_SH2_STAT5 305 308 PF00017 0.408
LIG_SH2_STAT5 40 43 PF00017 0.198
LIG_SH2_STAT5 76 79 PF00017 0.308
LIG_SH2_STAT5 82 85 PF00017 0.410
LIG_SH3_3 375 381 PF00018 0.452
LIG_SUMO_SIM_anti_2 256 261 PF11976 0.439
LIG_SUMO_SIM_anti_2 64 69 PF11976 0.310
LIG_SUMO_SIM_par_1 24 31 PF11976 0.331
LIG_SUMO_SIM_par_1 253 258 PF11976 0.373
LIG_SUMO_SIM_par_1 368 377 PF11976 0.489
LIG_TRAF2_1 86 89 PF00917 0.469
LIG_TYR_ITIM 137 142 PF00017 0.607
LIG_TYR_ITIM 313 318 PF00017 0.471
LIG_WRC_WIRS_1 288 293 PF05994 0.382
MOD_CDK_SPxxK_3 359 366 PF00069 0.557
MOD_CK1_1 153 159 PF00069 0.430
MOD_CK1_1 181 187 PF00069 0.518
MOD_CK1_1 212 218 PF00069 0.430
MOD_CK1_1 327 333 PF00069 0.511
MOD_CK2_1 104 110 PF00069 0.711
MOD_DYRK1A_RPxSP_1 359 363 PF00069 0.413
MOD_GlcNHglycan 107 110 PF01048 0.522
MOD_GlcNHglycan 214 217 PF01048 0.231
MOD_GlcNHglycan 285 288 PF01048 0.365
MOD_GlcNHglycan 330 333 PF01048 0.671
MOD_GlcNHglycan 359 362 PF01048 0.757
MOD_GSK3_1 105 112 PF00069 0.645
MOD_GSK3_1 177 184 PF00069 0.501
MOD_GSK3_1 212 219 PF00069 0.445
MOD_GSK3_1 27 34 PF00069 0.382
MOD_GSK3_1 283 290 PF00069 0.362
MOD_GSK3_1 320 327 PF00069 0.441
MOD_GSK3_1 335 342 PF00069 0.537
MOD_GSK3_1 370 377 PF00069 0.556
MOD_GSK3_1 42 49 PF00069 0.275
MOD_GSK3_1 52 59 PF00069 0.331
MOD_N-GLC_1 374 379 PF02516 0.643
MOD_N-GLC_1 46 51 PF02516 0.410
MOD_NEK2_1 28 33 PF00069 0.289
MOD_NEK2_1 291 296 PF00069 0.342
MOD_NEK2_1 306 311 PF00069 0.390
MOD_NEK2_2 287 292 PF00069 0.371
MOD_PKA_1 379 385 PF00069 0.449
MOD_PKA_2 209 215 PF00069 0.430
MOD_PKA_2 365 371 PF00069 0.534
MOD_PKA_2 379 385 PF00069 0.421
MOD_Plk_1 374 380 PF00069 0.444
MOD_Plk_1 42 48 PF00069 0.290
MOD_Plk_1 61 67 PF00069 0.236
MOD_Plk_4 223 229 PF00069 0.277
MOD_Plk_4 255 261 PF00069 0.358
MOD_Plk_4 277 283 PF00069 0.292
MOD_Plk_4 28 34 PF00069 0.281
MOD_ProDKin_1 320 326 PF00069 0.445
MOD_ProDKin_1 335 341 PF00069 0.422
MOD_ProDKin_1 359 365 PF00069 0.542
MOD_SUMO_rev_2 314 324 PF00179 0.433
TRG_DiLeu_BaLyEn_6 244 249 PF01217 0.336
TRG_ENDOCYTIC_2 114 117 PF00928 0.702
TRG_ENDOCYTIC_2 139 142 PF00928 0.522
TRG_ENDOCYTIC_2 15 18 PF00928 0.326
TRG_ENDOCYTIC_2 196 199 PF00928 0.484
TRG_ENDOCYTIC_2 315 318 PF00928 0.463
TRG_ENDOCYTIC_2 76 79 PF00928 0.273
TRG_ER_diArg_1 126 129 PF00400 0.673
TRG_ER_diArg_1 165 168 PF00400 0.434
TRG_ER_diArg_1 356 359 PF00400 0.539
TRG_ER_diArg_1 378 380 PF00400 0.580
TRG_ER_diArg_1 387 389 PF00400 0.502
TRG_Pf-PMV_PEXEL_1 387 391 PF00026 0.751
TRG_Pf-PMV_PEXEL_1 85 89 PF00026 0.305

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P344 Leptomonas seymouri 57% 100%
A0A0N1I1J3 Leptomonas seymouri 31% 100%
A0A0S4IVL2 Bodo saltans 37% 100%
A0A0S4JH63 Bodo saltans 34% 100%
A0A1X0P677 Trypanosomatidae 38% 100%
A0A1X0P6S8 Trypanosomatidae 34% 100%
A0A1X0P729 Trypanosomatidae 32% 100%
A0A3Q8ID01 Leishmania donovani 30% 100%
A0A3Q8IK66 Leishmania donovani 88% 100%
A0A3S5IRX0 Trypanosoma rangeli 39% 100%
A0A422MQK2 Trypanosoma rangeli 34% 100%
A4H9I2 Leishmania braziliensis 30% 100%
A4HA84 Leishmania braziliensis 71% 100%
A4HXR8 Leishmania infantum 30% 100%
A4HYG7 Leishmania infantum 87% 100%
C9ZUG5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
C9ZZW0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
D0A051 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9AS88 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
O08564 Rattus norvegicus 25% 100%
O88956 Cavia porcellus 26% 100%
P60588 Sus scrofa 25% 100%
Q05521 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 100%
Q2HJ61 Bos taurus 24% 100%
Q4QD76 Leishmania major 84% 100%
Q61469 Mus musculus 27% 100%
Q8K593 Rattus norvegicus 24% 100%
Q8LFD1 Arabidopsis thaliana 26% 100%
Q9UUA6 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 100%
Q9V576 Drosophila melanogaster 26% 100%
V5B5J9 Trypanosoma cruzi 38% 100%
V5BM01 Trypanosoma cruzi 35% 100%
V5BWA7 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS