LeishMANIAdb
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Transmembrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
membrane-bound O-acyltransferase, putative
Species:
Leishmania mexicana
UniProt:
E9AS86_LEIMU
TriTrypDb:
LmxM.19.1347
Length:
754

Annotations

LeishMANIAdb annotations

Membrane-bound O-acyltransferase involved in the remodeling of glycosylphosphatidylinositol (GPI) anchors. Related to fungal GUP1 proteins.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 33
NetGPI no yes: 0, no: 33
Cellular components
Term Name Level Count
GO:0016020 membrane 2 34
GO:0110165 cellular anatomical entity 1 34
GO:0005737 cytoplasm 2 5
GO:0005783 endoplasmic reticulum 5 5
GO:0043226 organelle 2 5
GO:0043227 membrane-bounded organelle 3 5
GO:0043229 intracellular organelle 3 5
GO:0043231 intracellular membrane-bounded organelle 4 5

Expansion

Sequence features

E9AS86
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS86

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0016740 transferase activity 2 7
GO:0016746 acyltransferase activity 3 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 287 291 PF00656 0.325
CLV_C14_Caspase3-7 56 60 PF00656 0.517
CLV_C14_Caspase3-7 697 701 PF00656 0.277
CLV_NRD_NRD_1 147 149 PF00675 0.349
CLV_NRD_NRD_1 150 152 PF00675 0.345
CLV_NRD_NRD_1 205 207 PF00675 0.363
CLV_NRD_NRD_1 327 329 PF00675 0.581
CLV_NRD_NRD_1 724 726 PF00675 0.376
CLV_PCSK_FUR_1 148 152 PF00082 0.367
CLV_PCSK_FUR_1 629 633 PF00082 0.227
CLV_PCSK_KEX2_1 147 149 PF00082 0.374
CLV_PCSK_KEX2_1 150 152 PF00082 0.363
CLV_PCSK_KEX2_1 251 253 PF00082 0.309
CLV_PCSK_KEX2_1 327 329 PF00082 0.541
CLV_PCSK_KEX2_1 631 633 PF00082 0.331
CLV_PCSK_KEX2_1 724 726 PF00082 0.424
CLV_PCSK_PC1ET2_1 251 253 PF00082 0.309
CLV_PCSK_PC1ET2_1 631 633 PF00082 0.299
CLV_PCSK_PC7_1 720 726 PF00082 0.354
CLV_PCSK_SKI1_1 598 602 PF00082 0.455
CLV_Separin_Metazoa 721 725 PF03568 0.623
DEG_APCC_DBOX_1 63 71 PF00400 0.602
DEG_APCC_KENBOX_2 99 103 PF00400 0.290
DEG_MDM2_SWIB_1 588 595 PF02201 0.235
DEG_Nend_UBRbox_1 1 4 PF02207 0.612
DEG_ODPH_VHL_1 246 259 PF01847 0.325
DEG_SCF_FBW7_1 445 452 PF00400 0.227
DEG_SPOP_SBC_1 459 463 PF00917 0.200
DEG_SPOP_SBC_1 475 479 PF00917 0.198
DEG_SPOP_SBC_1 7 11 PF00917 0.622
DOC_CDC14_PxL_1 608 616 PF14671 0.193
DOC_CKS1_1 292 297 PF01111 0.252
DOC_CKS1_1 446 451 PF01111 0.227
DOC_CKS1_1 746 751 PF01111 0.604
DOC_CYCLIN_yCln2_LP_2 103 109 PF00134 0.305
DOC_CYCLIN_yCln2_LP_2 732 738 PF00134 0.538
DOC_MAPK_DCC_7 578 587 PF00069 0.343
DOC_MAPK_gen_1 206 214 PF00069 0.557
DOC_MAPK_gen_1 724 734 PF00069 0.556
DOC_MAPK_MEF2A_6 727 736 PF00069 0.550
DOC_MAPK_RevD_3 134 148 PF00069 0.244
DOC_PP1_RVXF_1 307 314 PF00149 0.318
DOC_PP1_RVXF_1 596 603 PF00149 0.259
DOC_PP2B_LxvP_1 103 106 PF13499 0.381
DOC_PP2B_LxvP_1 245 248 PF13499 0.315
DOC_PP2B_LxvP_1 732 735 PF13499 0.547
DOC_PP2B_LxvP_1 736 739 PF13499 0.531
DOC_PP4_FxxP_1 387 390 PF00568 0.289
DOC_USP7_MATH_1 178 182 PF00917 0.644
DOC_USP7_MATH_1 194 198 PF00917 0.612
DOC_USP7_MATH_1 352 356 PF00917 0.429
DOC_USP7_MATH_1 396 400 PF00917 0.345
DOC_USP7_MATH_1 402 406 PF00917 0.499
DOC_USP7_MATH_1 410 414 PF00917 0.499
DOC_USP7_MATH_1 449 453 PF00917 0.261
DOC_USP7_MATH_1 53 57 PF00917 0.637
DOC_USP7_MATH_1 6 10 PF00917 0.626
DOC_USP7_MATH_2 357 363 PF00917 0.270
DOC_USP7_UBL2_3 100 104 PF12436 0.298
DOC_USP7_UBL2_3 330 334 PF12436 0.303
DOC_WW_Pin1_4 291 296 PF00397 0.293
DOC_WW_Pin1_4 445 450 PF00397 0.227
DOC_WW_Pin1_4 462 467 PF00397 0.212
DOC_WW_Pin1_4 630 635 PF00397 0.646
DOC_WW_Pin1_4 738 743 PF00397 0.724
DOC_WW_Pin1_4 745 750 PF00397 0.597
LIG_14-3-3_CanoR_1 150 158 PF00244 0.664
LIG_14-3-3_CanoR_1 252 256 PF00244 0.537
LIG_14-3-3_CanoR_1 309 314 PF00244 0.370
LIG_14-3-3_CanoR_1 327 333 PF00244 0.376
LIG_14-3-3_CanoR_1 64 68 PF00244 0.619
LIG_Actin_RPEL_3 414 433 PF02755 0.411
LIG_Actin_WH2_2 582 600 PF00022 0.345
LIG_BRCT_BRCA1_1 503 507 PF00533 0.215
LIG_BRCT_BRCA1_1 71 75 PF00533 0.312
LIG_CSL_BTD_1 292 295 PF09270 0.291
LIG_deltaCOP1_diTrp_1 290 299 PF00928 0.364
LIG_deltaCOP1_diTrp_1 518 527 PF00928 0.244
LIG_deltaCOP1_diTrp_1 555 563 PF00928 0.504
LIG_EH1_1 233 241 PF00400 0.325
LIG_eIF4E_1 138 144 PF01652 0.244
LIG_FHA_1 292 298 PF00498 0.292
LIG_FHA_1 336 342 PF00498 0.408
LIG_FHA_1 37 43 PF00498 0.742
LIG_FHA_1 488 494 PF00498 0.222
LIG_FHA_1 575 581 PF00498 0.427
LIG_FHA_1 679 685 PF00498 0.395
LIG_FHA_1 693 699 PF00498 0.383
LIG_FHA_1 727 733 PF00498 0.566
LIG_FHA_2 63 69 PF00498 0.633
LIG_LIR_Apic_2 531 536 PF02991 0.499
LIG_LIR_Gen_1 504 515 PF02991 0.250
LIG_LIR_Gen_1 577 587 PF02991 0.220
LIG_LIR_Gen_1 683 694 PF02991 0.226
LIG_LIR_Gen_1 72 82 PF02991 0.291
LIG_LIR_LC3C_4 613 616 PF02991 0.193
LIG_LIR_Nem_3 290 296 PF02991 0.405
LIG_LIR_Nem_3 380 385 PF02991 0.315
LIG_LIR_Nem_3 398 403 PF02991 0.378
LIG_LIR_Nem_3 405 409 PF02991 0.488
LIG_LIR_Nem_3 504 510 PF02991 0.286
LIG_LIR_Nem_3 518 524 PF02991 0.425
LIG_LIR_Nem_3 577 582 PF02991 0.304
LIG_LIR_Nem_3 683 689 PF02991 0.261
LIG_LIR_Nem_3 72 78 PF02991 0.280
LIG_MLH1_MIPbox_1 503 507 PF16413 0.193
LIG_MYND_2 201 205 PF01753 0.517
LIG_Pex14_1 299 303 PF04695 0.336
LIG_Pex14_1 420 424 PF04695 0.411
LIG_Pex14_1 556 560 PF04695 0.498
LIG_Pex14_1 563 567 PF04695 0.498
LIG_Pex14_2 284 288 PF04695 0.285
LIG_Pex14_2 517 521 PF04695 0.361
LIG_Pex14_2 523 527 PF04695 0.520
LIG_Pex14_2 552 556 PF04695 0.499
LIG_Pex14_2 579 583 PF04695 0.327
LIG_Pex14_2 588 592 PF04695 0.355
LIG_REV1ctd_RIR_1 521 529 PF16727 0.459
LIG_SH2_CRK 567 571 PF00017 0.498
LIG_SH2_CRK 82 86 PF00017 0.248
LIG_SH2_NCK_1 533 537 PF00017 0.391
LIG_SH2_PTP2 439 442 PF00017 0.283
LIG_SH2_SRC 244 247 PF00017 0.397
LIG_SH2_SRC 439 442 PF00017 0.293
LIG_SH2_SRC 533 536 PF00017 0.391
LIG_SH2_STAP1 706 710 PF00017 0.484
LIG_SH2_STAP1 82 86 PF00017 0.279
LIG_SH2_STAT3 469 472 PF00017 0.191
LIG_SH2_STAT3 706 709 PF00017 0.496
LIG_SH2_STAT3 715 718 PF00017 0.480
LIG_SH2_STAT5 127 130 PF00017 0.287
LIG_SH2_STAT5 244 247 PF00017 0.439
LIG_SH2_STAT5 382 385 PF00017 0.340
LIG_SH2_STAT5 388 391 PF00017 0.352
LIG_SH2_STAT5 403 406 PF00017 0.441
LIG_SH2_STAT5 439 442 PF00017 0.354
LIG_SH2_STAT5 569 572 PF00017 0.498
LIG_SH2_STAT5 61 64 PF00017 0.602
LIG_SH2_STAT5 69 72 PF00017 0.319
LIG_SH2_STAT5 690 693 PF00017 0.315
LIG_SH3_3 127 133 PF00018 0.313
LIG_SH3_3 196 202 PF00018 0.579
LIG_SH3_3 736 742 PF00018 0.583
LIG_SUMO_SIM_anti_2 208 213 PF11976 0.433
LIG_SUMO_SIM_anti_2 490 495 PF11976 0.227
LIG_SUMO_SIM_anti_2 645 651 PF11976 0.360
LIG_SUMO_SIM_anti_2 681 686 PF11976 0.214
LIG_SUMO_SIM_par_1 430 435 PF11976 0.227
LIG_SUMO_SIM_par_1 489 495 PF11976 0.225
LIG_SUMO_SIM_par_1 648 653 PF11976 0.217
LIG_SUMO_SIM_par_1 694 702 PF11976 0.405
LIG_TYR_ITIM 108 113 PF00017 0.258
LIG_TYR_ITIM 386 391 PF00017 0.255
LIG_TYR_ITIM 437 442 PF00017 0.205
LIG_TYR_ITIM 565 570 PF00017 0.496
LIG_TYR_ITIM 80 85 PF00017 0.320
LIG_UBA3_1 245 251 PF00899 0.325
LIG_UBA3_1 710 714 PF00899 0.619
LIG_WRC_WIRS_1 310 315 PF05994 0.277
LIG_WRC_WIRS_1 397 402 PF05994 0.365
LIG_WRC_WIRS_1 549 554 PF05994 0.470
LIG_WRC_WIRS_1 81 86 PF05994 0.303
LIG_WW_3 749 753 PF00397 0.618
MOD_CDK_SPxxK_3 745 752 PF00069 0.606
MOD_CK1_1 18 24 PF00069 0.656
MOD_CK1_1 193 199 PF00069 0.597
MOD_CK1_1 312 318 PF00069 0.243
MOD_CK1_1 464 470 PF00069 0.205
MOD_CK1_1 63 69 PF00069 0.682
MOD_CK1_1 661 667 PF00069 0.372
MOD_CK1_1 9 15 PF00069 0.689
MOD_CK2_1 319 325 PF00069 0.376
MOD_CK2_1 62 68 PF00069 0.611
MOD_CMANNOS 553 556 PF00535 0.299
MOD_GlcNHglycan 163 166 PF01048 0.531
MOD_GlcNHglycan 191 195 PF01048 0.460
MOD_GlcNHglycan 196 199 PF01048 0.471
MOD_GlcNHglycan 22 25 PF01048 0.467
MOD_GlcNHglycan 319 322 PF01048 0.481
MOD_GlcNHglycan 379 382 PF01048 0.427
MOD_GlcNHglycan 451 454 PF01048 0.425
MOD_GSK3_1 150 157 PF00069 0.678
MOD_GSK3_1 189 196 PF00069 0.695
MOD_GSK3_1 2 9 PF00069 0.610
MOD_GSK3_1 251 258 PF00069 0.560
MOD_GSK3_1 445 452 PF00069 0.333
MOD_GSK3_1 458 465 PF00069 0.329
MOD_GSK3_1 474 481 PF00069 0.211
MOD_GSK3_1 497 504 PF00069 0.227
MOD_GSK3_1 574 581 PF00069 0.425
MOD_GSK3_1 614 621 PF00069 0.232
MOD_GSK3_1 658 665 PF00069 0.495
MOD_GSK3_1 676 683 PF00069 0.381
MOD_GSK3_1 694 701 PF00069 0.284
MOD_N-GLC_1 303 308 PF02516 0.451
MOD_N-GLC_1 475 480 PF02516 0.391
MOD_N-GLC_1 497 502 PF02516 0.391
MOD_NEK2_1 143 148 PF00069 0.417
MOD_NEK2_1 189 194 PF00069 0.587
MOD_NEK2_1 255 260 PF00069 0.340
MOD_NEK2_1 284 289 PF00069 0.413
MOD_NEK2_1 317 322 PF00069 0.309
MOD_NEK2_1 377 382 PF00069 0.227
MOD_NEK2_1 432 437 PF00069 0.248
MOD_NEK2_1 474 479 PF00069 0.198
MOD_NEK2_1 543 548 PF00069 0.495
MOD_NEK2_1 572 577 PF00069 0.535
MOD_NEK2_1 614 619 PF00069 0.230
MOD_NEK2_1 62 67 PF00069 0.569
MOD_NEK2_1 678 683 PF00069 0.334
MOD_PIKK_1 298 304 PF00454 0.363
MOD_PIKK_1 642 648 PF00454 0.432
MOD_PK_1 207 213 PF00069 0.435
MOD_PK_1 578 584 PF00069 0.345
MOD_PKA_1 150 156 PF00069 0.505
MOD_PKA_1 251 257 PF00069 0.501
MOD_PKA_2 150 156 PF00069 0.552
MOD_PKA_2 251 257 PF00069 0.501
MOD_PKA_2 63 69 PF00069 0.550
MOD_PKA_2 726 732 PF00069 0.640
MOD_PKB_1 148 156 PF00069 0.509
MOD_Plk_1 207 213 PF00069 0.472
MOD_Plk_1 303 309 PF00069 0.250
MOD_Plk_1 375 381 PF00069 0.227
MOD_Plk_1 53 59 PF00069 0.538
MOD_Plk_1 650 656 PF00069 0.244
MOD_Plk_1 676 682 PF00069 0.356
MOD_Plk_4 184 190 PF00069 0.581
MOD_Plk_4 207 213 PF00069 0.656
MOD_Plk_4 257 263 PF00069 0.357
MOD_Plk_4 284 290 PF00069 0.374
MOD_Plk_4 303 309 PF00069 0.258
MOD_Plk_4 38 44 PF00069 0.747
MOD_Plk_4 432 438 PF00069 0.449
MOD_Plk_4 489 495 PF00069 0.319
MOD_Plk_4 501 507 PF00069 0.293
MOD_Plk_4 548 554 PF00069 0.470
MOD_Plk_4 578 584 PF00069 0.420
MOD_Plk_4 614 620 PF00069 0.226
MOD_Plk_4 680 686 PF00069 0.354
MOD_Plk_4 69 75 PF00069 0.339
MOD_Plk_4 80 86 PF00069 0.399
MOD_ProDKin_1 291 297 PF00069 0.291
MOD_ProDKin_1 445 451 PF00069 0.227
MOD_ProDKin_1 462 468 PF00069 0.212
MOD_ProDKin_1 630 636 PF00069 0.646
MOD_ProDKin_1 738 744 PF00069 0.727
MOD_ProDKin_1 745 751 PF00069 0.600
MOD_SUMO_rev_2 413 419 PF00179 0.422
MOD_SUMO_rev_2 697 705 PF00179 0.386
TRG_DiLeu_BaLyEn_6 199 204 PF01217 0.536
TRG_DiLeu_BaLyEn_6 292 297 PF01217 0.340
TRG_DiLeu_BaLyEn_6 422 427 PF01217 0.427
TRG_DiLeu_BaLyEn_6 595 600 PF01217 0.299
TRG_ENDOCYTIC_2 110 113 PF00928 0.461
TRG_ENDOCYTIC_2 126 129 PF00928 0.323
TRG_ENDOCYTIC_2 388 391 PF00928 0.345
TRG_ENDOCYTIC_2 439 442 PF00928 0.351
TRG_ENDOCYTIC_2 567 570 PF00928 0.498
TRG_ENDOCYTIC_2 82 85 PF00928 0.378
TRG_ER_diArg_1 147 150 PF00400 0.489
TRG_ER_diArg_1 723 725 PF00400 0.567
TRG_NES_CRM1_1 518 531 PF08389 0.422
TRG_NES_CRM1_1 537 550 PF08389 0.439
TRG_Pf-PMV_PEXEL_1 641 646 PF00026 0.244

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4IRP6 Bodo saltans 33% 100%
A0A1X0P614 Trypanosomatidae 40% 100%
A0A1X0P616 Trypanosomatidae 36% 100%
A0A1X0P718 Trypanosomatidae 34% 100%
A0A3Q8IAC1 Leishmania donovani 31% 97%
A0A3Q8IBC3 Leishmania donovani 32% 100%
A0A3Q8IBE0 Leishmania donovani 32% 90%
A0A3Q8IDD7 Leishmania donovani 31% 97%
A0A3S5H769 Leishmania donovani 31% 100%
A0A3S5IRW9 Trypanosoma rangeli 40% 100%
A0A3S7WVJ2 Leishmania donovani 32% 90%
A0A3S7WVK4 Leishmania donovani 31% 97%
A0A3S7WVM5 Leishmania donovani 83% 100%
A4HA75 Leishmania braziliensis 29% 97%
A4HA76 Leishmania braziliensis 31% 100%
A4HA77 Leishmania braziliensis 28% 100%
A4HA80 Leishmania braziliensis 28% 100%
A4HA81 Leishmania braziliensis 30% 100%
A4HA82 Leishmania braziliensis 28% 100%
A4HYG3 Leishmania infantum 83% 100%
E8NHJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9AGT0 Leishmania infantum 32% 90%
E9AGT1 Leishmania infantum 32% 100%
E9AGT2 Leishmania infantum 32% 100%
E9AGT3 Leishmania infantum 31% 97%
E9AGT4 Leishmania infantum 31% 97%
E9AS85 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
Q4QD77 Leishmania major 81% 100%
Q4QD78 Leishmania major 30% 100%
Q4QD79 Leishmania major 30% 100%
Q4QD80 Leishmania major 30% 100%
Q4QD81 Leishmania major 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS