Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AS82_LEIMU

TriTrypDb:

LmxM.19.1310

Length:

978

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AS82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS82

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	188	192	PF00656	0.514
CLV_C14_Caspase3-7	224	228	PF00656	0.768
CLV_C14_Caspase3-7	236	240	PF00656	0.737
CLV_C14_Caspase3-7	246	250	PF00656	0.672
CLV_C14_Caspase3-7	324	328	PF00656	0.628
CLV_C14_Caspase3-7	442	446	PF00656	0.656
CLV_C14_Caspase3-7	611	615	PF00656	0.627
CLV_C14_Caspase3-7	757	761	PF00656	0.683
CLV_C14_Caspase3-7	891	895	PF00656	0.662
CLV_NRD_NRD_1	133	135	PF00675	0.568
CLV_NRD_NRD_1	155	157	PF00675	0.710
CLV_NRD_NRD_1	161	163	PF00675	0.672
CLV_NRD_NRD_1	215	217	PF00675	0.539
CLV_NRD_NRD_1	289	291	PF00675	0.626
CLV_NRD_NRD_1	366	368	PF00675	0.741
CLV_NRD_NRD_1	420	422	PF00675	0.735
CLV_NRD_NRD_1	579	581	PF00675	0.712
CLV_NRD_NRD_1	64	66	PF00675	0.705
CLV_NRD_NRD_1	649	651	PF00675	0.542
CLV_NRD_NRD_1	870	872	PF00675	0.663
CLV_PCSK_FUR_1	131	135	PF00082	0.540
CLV_PCSK_KEX2_1	107	109	PF00082	0.642
CLV_PCSK_KEX2_1	133	135	PF00082	0.568
CLV_PCSK_KEX2_1	215	217	PF00082	0.539
CLV_PCSK_KEX2_1	289	291	PF00082	0.626
CLV_PCSK_KEX2_1	366	368	PF00082	0.741
CLV_PCSK_KEX2_1	420	422	PF00082	0.735
CLV_PCSK_KEX2_1	579	581	PF00082	0.712
CLV_PCSK_KEX2_1	64	66	PF00082	0.705
CLV_PCSK_KEX2_1	649	651	PF00082	0.545
CLV_PCSK_KEX2_1	749	751	PF00082	0.667
CLV_PCSK_KEX2_1	870	872	PF00082	0.663
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.630
CLV_PCSK_PC1ET2_1	749	751	PF00082	0.667
CLV_PCSK_SKI1_1	145	149	PF00082	0.553
CLV_PCSK_SKI1_1	367	371	PF00082	0.743
CLV_PCSK_SKI1_1	382	386	PF00082	0.567
CLV_PCSK_SKI1_1	579	583	PF00082	0.670
CLV_PCSK_SKI1_1	772	776	PF00082	0.613
DEG_APCC_DBOX_1	668	676	PF00400	0.633
DEG_COP1_1	43	52	PF00400	0.620
DEG_Nend_UBRbox_2	1	3	PF02207	0.740
DEG_SPOP_SBC_1	176	180	PF00917	0.536
DOC_ANK_TNKS_1	310	317	PF00023	0.561
DOC_ANK_TNKS_1	63	70	PF00023	0.697
DOC_CKS1_1	915	920	PF01111	0.590
DOC_CYCLIN_RxL_1	576	585	PF00134	0.669
DOC_CYCLIN_RxL_1	769	778	PF00134	0.668
DOC_CYCLIN_yCln2_LP_2	920	926	PF00134	0.709
DOC_PP1_RVXF_1	956	963	PF00149	0.637
DOC_PP2B_LxvP_1	619	622	PF13499	0.557
DOC_PP2B_LxvP_1	637	640	PF13499	0.502
DOC_PP2B_LxvP_1	728	731	PF13499	0.615
DOC_PP2B_LxvP_1	736	739	PF13499	0.647
DOC_USP7_MATH_1	151	155	PF00917	0.715
DOC_USP7_MATH_1	177	181	PF00917	0.587
DOC_USP7_MATH_1	42	46	PF00917	0.737
DOC_USP7_MATH_1	436	440	PF00917	0.626
DOC_USP7_MATH_1	48	52	PF00917	0.681
DOC_USP7_MATH_1	551	555	PF00917	0.713
DOC_USP7_MATH_1	711	715	PF00917	0.707
DOC_USP7_MATH_1	731	735	PF00917	0.514
DOC_USP7_MATH_1	787	791	PF00917	0.599
DOC_USP7_MATH_1	852	856	PF00917	0.644
DOC_USP7_MATH_1	954	958	PF00917	0.482
DOC_USP7_MATH_1	969	973	PF00917	0.456
DOC_WW_Pin1_4	106	111	PF00397	0.659
DOC_WW_Pin1_4	161	166	PF00397	0.766
DOC_WW_Pin1_4	237	242	PF00397	0.837
DOC_WW_Pin1_4	270	275	PF00397	0.679
DOC_WW_Pin1_4	314	319	PF00397	0.640
DOC_WW_Pin1_4	330	335	PF00397	0.649
DOC_WW_Pin1_4	342	347	PF00397	0.625
DOC_WW_Pin1_4	351	356	PF00397	0.698
DOC_WW_Pin1_4	358	363	PF00397	0.664
DOC_WW_Pin1_4	383	388	PF00397	0.700
DOC_WW_Pin1_4	392	397	PF00397	0.607
DOC_WW_Pin1_4	444	449	PF00397	0.707
DOC_WW_Pin1_4	451	456	PF00397	0.699
DOC_WW_Pin1_4	51	56	PF00397	0.741
DOC_WW_Pin1_4	567	572	PF00397	0.528
DOC_WW_Pin1_4	715	720	PF00397	0.591
DOC_WW_Pin1_4	848	853	PF00397	0.566
DOC_WW_Pin1_4	877	882	PF00397	0.573
DOC_WW_Pin1_4	897	902	PF00397	0.618
DOC_WW_Pin1_4	908	913	PF00397	0.762
DOC_WW_Pin1_4	914	919	PF00397	0.722
DOC_WW_Pin1_4	936	941	PF00397	0.659
DOC_WW_Pin1_4	948	953	PF00397	0.585
DOC_WW_Pin1_4	97	102	PF00397	0.689
DOC_WW_Pin1_4	973	978	PF00397	0.649
LIG_14-3-3_CanoR_1	156	166	PF00244	0.720
LIG_14-3-3_CanoR_1	478	482	PF00244	0.647
LIG_14-3-3_CanoR_1	649	659	PF00244	0.749
LIG_14-3-3_CanoR_1	70	78	PF00244	0.643
LIG_14-3-3_CanoR_1	725	731	PF00244	0.714
LIG_14-3-3_CanoR_1	735	739	PF00244	0.663
LIG_APCC_ABBAyCdc20_2	772	778	PF00400	0.477
LIG_BIR_III_2	445	449	PF00653	0.659
LIG_BRCT_BRCA1_1	971	975	PF00533	0.582
LIG_CSL_BTD_1	937	940	PF09270	0.529
LIG_eIF4E_1	272	278	PF01652	0.627
LIG_FHA_1	196	202	PF00498	0.624
LIG_FHA_1	212	218	PF00498	0.589
LIG_FHA_1	411	417	PF00498	0.737
LIG_FHA_1	430	436	PF00498	0.511
LIG_FHA_1	716	722	PF00498	0.581
LIG_FHA_1	843	849	PF00498	0.664
LIG_FHA_1	90	96	PF00498	0.681
LIG_FHA_1	915	921	PF00498	0.591
LIG_FHA_2	141	147	PF00498	0.553
LIG_FHA_2	19	25	PF00498	0.582
LIG_FHA_2	219	225	PF00498	0.608
LIG_FHA_2	271	277	PF00498	0.635
LIG_FHA_2	297	303	PF00498	0.594
LIG_FHA_2	440	446	PF00498	0.654
LIG_FHA_2	478	484	PF00498	0.686
LIG_FHA_2	545	551	PF00498	0.553
LIG_FHA_2	593	599	PF00498	0.548
LIG_FHA_2	609	615	PF00498	0.603
LIG_FHA_2	659	665	PF00498	0.681
LIG_FHA_2	669	675	PF00498	0.555
LIG_FHA_2	757	763	PF00498	0.753
LIG_FHA_2	839	845	PF00498	0.595
LIG_FHA_2	963	969	PF00498	0.613
LIG_GSK3_LRP6_1	908	913	PF00069	0.547
LIG_LIR_Gen_1	24	33	PF02991	0.568
LIG_LIR_Gen_1	439	449	PF02991	0.594
LIG_LIR_Gen_1	968	978	PF02991	0.629
LIG_LIR_LC3C_4	275	279	PF02991	0.624
LIG_LIR_Nem_3	21	25	PF02991	0.609
LIG_LIR_Nem_3	463	468	PF02991	0.719
LIG_LIR_Nem_3	575	581	PF02991	0.668
LIG_LIR_Nem_3	594	599	PF02991	0.520
LIG_LIR_Nem_3	968	973	PF02991	0.609
LIG_PDZ_Class_1	973	978	PF00595	0.649
LIG_SH2_CRK	578	582	PF00017	0.672
LIG_SH2_STAP1	22	26	PF00017	0.622
LIG_SH2_STAP1	793	797	PF00017	0.633
LIG_SH2_STAP1	970	974	PF00017	0.615
LIG_SH2_STAT5	186	189	PF00017	0.526
LIG_SH2_STAT5	272	275	PF00017	0.632
LIG_SH2_STAT5	353	356	PF00017	0.679
LIG_SH3_2	335	340	PF14604	0.563
LIG_SH3_2	59	64	PF14604	0.692
LIG_SH3_3	235	241	PF00018	0.726
LIG_SH3_3	332	338	PF00018	0.556
LIG_SH3_3	454	460	PF00018	0.584
LIG_SH3_3	482	488	PF00018	0.623
LIG_SH3_3	54	60	PF00018	0.739
LIG_SH3_3	875	881	PF00018	0.581
LIG_SH3_3	906	912	PF00018	0.640
LIG_SH3_3	915	921	PF00018	0.793
LIG_SH3_3	924	930	PF00018	0.662
LIG_SUMO_SIM_par_1	432	439	PF11976	0.518
LIG_SUMO_SIM_par_1	670	678	PF11976	0.687
LIG_TRAF2_2	930	935	PF00917	0.517
LIG_TYR_ITIM	576	581	PF00017	0.487
LIG_ULM_U2AF65_1	870	875	PF00076	0.563
LIG_WRC_WIRS_1	555	560	PF05994	0.533
LIG_WW_2	918	921	PF00397	0.661
MOD_CDK_SPK_2	237	242	PF00069	0.680
MOD_CDK_SPxK_1	392	398	PF00069	0.666
MOD_CDK_SPxxK_3	444	451	PF00069	0.701
MOD_CDK_SPxxK_3	877	884	PF00069	0.526
MOD_CK1_1	180	186	PF00069	0.587
MOD_CK1_1	229	235	PF00069	0.618
MOD_CK1_1	296	302	PF00069	0.682
MOD_CK1_1	356	362	PF00069	0.703
MOD_CK1_1	408	414	PF00069	0.687
MOD_CK1_1	429	435	PF00069	0.707
MOD_CK1_1	439	445	PF00069	0.598
MOD_CK1_1	447	453	PF00069	0.535
MOD_CK1_1	51	57	PF00069	0.626
MOD_CK1_1	554	560	PF00069	0.713
MOD_CK1_1	620	626	PF00069	0.609
MOD_CK1_1	677	683	PF00069	0.651
MOD_CK1_1	712	718	PF00069	0.708
MOD_CK1_1	726	732	PF00069	0.587
MOD_CK1_1	734	740	PF00069	0.605
MOD_CK1_1	838	844	PF00069	0.721
MOD_CK1_1	85	91	PF00069	0.677
MOD_CK1_1	888	894	PF00069	0.707
MOD_CK2_1	140	146	PF00069	0.554
MOD_CK2_1	18	24	PF00069	0.589
MOD_CK2_1	303	309	PF00069	0.715
MOD_CK2_1	528	534	PF00069	0.629
MOD_CK2_1	544	550	PF00069	0.571
MOD_CK2_1	556	562	PF00069	0.657
MOD_CK2_1	621	627	PF00069	0.725
MOD_CK2_1	658	664	PF00069	0.689
MOD_CK2_1	668	674	PF00069	0.650
MOD_CK2_1	677	683	PF00069	0.573
MOD_CK2_1	692	698	PF00069	0.612
MOD_CK2_1	756	762	PF00069	0.773
MOD_CK2_1	838	844	PF00069	0.597
MOD_Cter_Amidation	418	421	PF01082	0.737
MOD_GlcNHglycan	12	15	PF01048	0.699
MOD_GlcNHglycan	227	231	PF01048	0.701
MOD_GlcNHglycan	245	248	PF01048	0.674
MOD_GlcNHglycan	251	254	PF01048	0.640
MOD_GlcNHglycan	312	315	PF01048	0.726
MOD_GlcNHglycan	355	358	PF01048	0.728
MOD_GlcNHglycan	417	420	PF01048	0.645
MOD_GlcNHglycan	549	554	PF01048	0.618
MOD_GlcNHglycan	619	622	PF01048	0.688
MOD_GlcNHglycan	623	626	PF01048	0.684
MOD_GlcNHglycan	693	697	PF01048	0.613
MOD_GlcNHglycan	721	724	PF01048	0.643
MOD_GlcNHglycan	887	890	PF01048	0.705
MOD_GlcNHglycan	905	908	PF01048	0.658
MOD_GlcNHglycan	952	955	PF01048	0.652
MOD_GSK3_1	10	17	PF00069	0.662
MOD_GSK3_1	118	125	PF00069	0.692
MOD_GSK3_1	157	164	PF00069	0.776
MOD_GSK3_1	176	183	PF00069	0.533
MOD_GSK3_1	225	232	PF00069	0.678
MOD_GSK3_1	25	32	PF00069	0.461
MOD_GSK3_1	310	317	PF00069	0.742
MOD_GSK3_1	356	363	PF00069	0.710
MOD_GSK3_1	383	390	PF00069	0.572
MOD_GSK3_1	399	406	PF00069	0.619
MOD_GSK3_1	410	417	PF00069	0.619
MOD_GSK3_1	447	454	PF00069	0.574
MOD_GSK3_1	460	467	PF00069	0.632
MOD_GSK3_1	51	58	PF00069	0.673
MOD_GSK3_1	556	563	PF00069	0.668
MOD_GSK3_1	617	624	PF00069	0.573
MOD_GSK3_1	673	680	PF00069	0.702
MOD_GSK3_1	70	77	PF00069	0.594
MOD_GSK3_1	711	718	PF00069	0.613
MOD_GSK3_1	719	726	PF00069	0.629
MOD_GSK3_1	734	741	PF00069	0.684
MOD_GSK3_1	832	839	PF00069	0.722
MOD_GSK3_1	848	855	PF00069	0.527
MOD_GSK3_1	85	92	PF00069	0.725
MOD_GSK3_1	903	910	PF00069	0.730
MOD_GSK3_1	946	953	PF00069	0.647
MOD_GSK3_1	969	976	PF00069	0.623
MOD_N-GLC_1	249	254	PF02516	0.649
MOD_N-GLC_1	657	662	PF02516	0.652
MOD_N-GLC_1	712	717	PF02516	0.677
MOD_N-GLC_1	726	731	PF02516	0.552
MOD_NEK2_1	118	123	PF00069	0.748
MOD_NEK2_1	257	262	PF00069	0.716
MOD_NEK2_1	617	622	PF00069	0.558
MOD_NEK2_1	675	680	PF00069	0.616
MOD_NEK2_1	721	726	PF00069	0.743
MOD_NEK2_1	792	797	PF00069	0.664
MOD_NEK2_2	151	156	PF00069	0.692
MOD_NEK2_2	436	441	PF00069	0.579
MOD_PIKK_1	399	405	PF00454	0.695
MOD_PIKK_1	496	502	PF00454	0.748
MOD_PIKK_1	819	825	PF00454	0.469
MOD_PKA_1	156	162	PF00069	0.691
MOD_PKA_1	649	655	PF00069	0.537
MOD_PKA_2	195	201	PF00069	0.678
MOD_PKA_2	225	231	PF00069	0.544
MOD_PKA_2	310	316	PF00069	0.622
MOD_PKA_2	477	483	PF00069	0.671
MOD_PKA_2	496	502	PF00069	0.694
MOD_PKA_2	528	534	PF00069	0.583
MOD_PKA_2	649	655	PF00069	0.626
MOD_PKA_2	668	674	PF00069	0.606
MOD_PKA_2	731	737	PF00069	0.604
MOD_PKA_2	819	825	PF00069	0.638
MOD_PKA_2	883	889	PF00069	0.609
MOD_Plk_1	427	433	PF00069	0.640
MOD_Plk_1	657	663	PF00069	0.631
MOD_Plk_1	726	732	PF00069	0.598
MOD_Plk_1	946	952	PF00069	0.645
MOD_Plk_2-3	185	191	PF00069	0.524
MOD_Plk_2-3	477	483	PF00069	0.683
MOD_Plk_2-3	544	550	PF00069	0.605
MOD_Plk_4	119	125	PF00069	0.613
MOD_Plk_4	206	212	PF00069	0.658
MOD_Plk_4	25	31	PF00069	0.515
MOD_Plk_4	436	442	PF00069	0.698
MOD_Plk_4	460	466	PF00069	0.722
MOD_Plk_4	572	578	PF00069	0.665
MOD_Plk_4	668	674	PF00069	0.677
MOD_Plk_4	738	744	PF00069	0.534
MOD_Plk_4	787	793	PF00069	0.690
MOD_Plk_4	838	844	PF00069	0.718
MOD_Plk_4	969	975	PF00069	0.617
MOD_ProDKin_1	106	112	PF00069	0.657
MOD_ProDKin_1	161	167	PF00069	0.763
MOD_ProDKin_1	237	243	PF00069	0.838
MOD_ProDKin_1	270	276	PF00069	0.676
MOD_ProDKin_1	314	320	PF00069	0.640
MOD_ProDKin_1	330	336	PF00069	0.652
MOD_ProDKin_1	342	348	PF00069	0.625
MOD_ProDKin_1	351	357	PF00069	0.699
MOD_ProDKin_1	358	364	PF00069	0.664
MOD_ProDKin_1	383	389	PF00069	0.699
MOD_ProDKin_1	392	398	PF00069	0.612
MOD_ProDKin_1	444	450	PF00069	0.709
MOD_ProDKin_1	451	457	PF00069	0.700
MOD_ProDKin_1	51	57	PF00069	0.740
MOD_ProDKin_1	567	573	PF00069	0.525
MOD_ProDKin_1	715	721	PF00069	0.593
MOD_ProDKin_1	848	854	PF00069	0.562
MOD_ProDKin_1	877	883	PF00069	0.575
MOD_ProDKin_1	897	903	PF00069	0.616
MOD_ProDKin_1	908	914	PF00069	0.760
MOD_ProDKin_1	936	942	PF00069	0.658
MOD_ProDKin_1	948	954	PF00069	0.577
MOD_ProDKin_1	97	103	PF00069	0.687
MOD_SUMO_rev_2	467	476	PF00179	0.656
TRG_DiLeu_BaEn_2	805	811	PF01217	0.596
TRG_DiLeu_BaLyEn_6	505	510	PF01217	0.679
TRG_DiLeu_BaLyEn_6	770	775	PF01217	0.675
TRG_DiLeu_BaLyEn_6	793	798	PF01217	0.625
TRG_ENDOCYTIC_2	578	581	PF00928	0.673
TRG_ENDOCYTIC_2	970	973	PF00928	0.614
TRG_ER_diArg_1	215	217	PF00400	0.569
TRG_ER_diArg_1	288	290	PF00400	0.614
TRG_ER_diArg_1	578	580	PF00400	0.676
TRG_ER_diArg_1	64	66	PF00400	0.705
TRG_ER_diArg_1	649	651	PF00400	0.600
TRG_Pf-PMV_PEXEL_1	469	473	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	579	584	PF00026	0.750
TRG_Pf-PMV_PEXEL_1	796	801	PF00026	0.708

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H768	Leishmania donovani	81%	100%
A4HA78	Leishmania braziliensis	58%	97%
A4HYE9	Leishmania infantum	81%	100%
Q4QD84	Leishmania major	81%	99%