Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AS81_LEIMU

TriTrypDb:

LmxM.19.1300

Length:

854

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AS81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS81

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	5
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016310	phosphorylation	5	5
GO:0019538	protein metabolic process	3	5
GO:0036211	protein modification process	4	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043412	macromolecule modification	4	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0071704	organic substance metabolic process	2	5
GO:1901564	organonitrogen compound metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003824	catalytic activity	1	5
GO:0004672	protein kinase activity	3	5
GO:0005488	binding	1	5
GO:0005524	ATP binding	5	5
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	5
GO:0017076	purine nucleotide binding	4	5
GO:0030554	adenyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032559	adenyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:0097367	carbohydrate derivative binding	2	5
GO:0140096	catalytic activity, acting on a protein	2	5
GO:1901265	nucleoside phosphate binding	3	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.670
CLV_C14_Caspase3-7	569	573	PF00656	0.674
CLV_C14_Caspase3-7	602	606	PF00656	0.517
CLV_NRD_NRD_1	12	14	PF00675	0.475
CLV_NRD_NRD_1	135	137	PF00675	0.674
CLV_NRD_NRD_1	225	227	PF00675	0.645
CLV_NRD_NRD_1	451	453	PF00675	0.620
CLV_NRD_NRD_1	566	568	PF00675	0.626
CLV_NRD_NRD_1	774	776	PF00675	0.416
CLV_PCSK_KEX2_1	12	14	PF00082	0.475
CLV_PCSK_KEX2_1	135	137	PF00082	0.674
CLV_PCSK_KEX2_1	225	227	PF00082	0.645
CLV_PCSK_KEX2_1	451	453	PF00082	0.620
CLV_PCSK_KEX2_1	566	568	PF00082	0.626
CLV_PCSK_KEX2_1	774	776	PF00082	0.416
CLV_PCSK_SKI1_1	135	139	PF00082	0.667
CLV_PCSK_SKI1_1	210	214	PF00082	0.584
CLV_PCSK_SKI1_1	225	229	PF00082	0.530
CLV_PCSK_SKI1_1	286	290	PF00082	0.514
CLV_PCSK_SKI1_1	307	311	PF00082	0.499
CLV_PCSK_SKI1_1	370	374	PF00082	0.554
CLV_PCSK_SKI1_1	598	602	PF00082	0.507
CLV_PCSK_SKI1_1	774	778	PF00082	0.415
CLV_PCSK_SKI1_1	838	842	PF00082	0.475
CLV_Separin_Metazoa	759	763	PF03568	0.609
DEG_APCC_DBOX_1	597	605	PF00400	0.501
DEG_APCC_DBOX_1	710	718	PF00400	0.581
DEG_APCC_DBOX_1	773	781	PF00400	0.414
DEG_SPOP_SBC_1	116	120	PF00917	0.689
DOC_CKS1_1	308	313	PF01111	0.477
DOC_CYCLIN_RxL_1	367	374	PF00134	0.562
DOC_CYCLIN_RxL_1	684	695	PF00134	0.627
DOC_CYCLIN_RxL_1	700	709	PF00134	0.464
DOC_CYCLIN_RxL_1	710	718	PF00134	0.493
DOC_CYCLIN_yClb5_NLxxxL_5	338	347	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	24	27	PF00134	0.629
DOC_CYCLIN_yCln2_LP_2	721	727	PF00134	0.564
DOC_MAPK_gen_1	12	20	PF00069	0.478
DOC_MAPK_gen_1	523	532	PF00069	0.617
DOC_MAPK_gen_1	774	782	PF00069	0.451
DOC_MAPK_MEF2A_6	762	769	PF00069	0.565
DOC_PP1_RVXF_1	588	594	PF00149	0.579
DOC_PP2B_LxvP_1	127	130	PF13499	0.622
DOC_PP2B_LxvP_1	155	158	PF13499	0.607
DOC_PP2B_LxvP_1	176	179	PF13499	0.526
DOC_PP2B_LxvP_1	23	26	PF13499	0.634
DOC_PP4_FxxP_1	28	31	PF00568	0.628
DOC_PP4_FxxP_1	308	311	PF00568	0.486
DOC_USP7_MATH_1	160	164	PF00917	0.629
DOC_USP7_MATH_1	169	173	PF00917	0.632
DOC_USP7_MATH_1	278	282	PF00917	0.595
DOC_USP7_MATH_1	388	392	PF00917	0.621
DOC_USP7_MATH_1	393	397	PF00917	0.528
DOC_USP7_MATH_1	419	423	PF00917	0.534
DOC_USP7_MATH_1	540	544	PF00917	0.778
DOC_USP7_MATH_1	732	736	PF00917	0.580
DOC_USP7_MATH_1	831	835	PF00917	0.576
DOC_WW_Pin1_4	117	122	PF00397	0.683
DOC_WW_Pin1_4	178	183	PF00397	0.647
DOC_WW_Pin1_4	186	191	PF00397	0.582
DOC_WW_Pin1_4	211	216	PF00397	0.646
DOC_WW_Pin1_4	307	312	PF00397	0.495
DOC_WW_Pin1_4	336	341	PF00397	0.508
DOC_WW_Pin1_4	509	514	PF00397	0.639
DOC_WW_Pin1_4	557	562	PF00397	0.521
DOC_WW_Pin1_4	630	635	PF00397	0.529
LIG_14-3-3_CanoR_1	210	215	PF00244	0.584
LIG_14-3-3_CanoR_1	346	352	PF00244	0.565
LIG_14-3-3_CanoR_1	420	424	PF00244	0.463
LIG_14-3-3_CanoR_1	45	51	PF00244	0.602
LIG_14-3-3_CanoR_1	451	455	PF00244	0.685
LIG_14-3-3_CanoR_1	526	531	PF00244	0.553
LIG_14-3-3_CanoR_1	590	600	PF00244	0.535
LIG_Actin_WH2_2	196	212	PF00022	0.592
LIG_AP2alpha_1	798	802	PF02296	0.548
LIG_BIR_II_1	1	5	PF00653	0.487
LIG_BIR_III_4	464	468	PF00653	0.542
LIG_BIR_III_4	572	576	PF00653	0.679
LIG_BRCT_BRCA1_1	141	145	PF00533	0.646
LIG_BRCT_BRCA1_1	329	333	PF00533	0.358
LIG_BRCT_BRCA1_1	528	532	PF00533	0.562
LIG_BRCT_BRCA1_1	663	667	PF00533	0.630
LIG_BRCT_BRCA1_1	794	798	PF00533	0.499
LIG_CaM_IQ_9	738	754	PF13499	0.571
LIG_Clathr_ClatBox_1	714	718	PF01394	0.575
LIG_deltaCOP1_diTrp_1	474	482	PF00928	0.470
LIG_deltaCOP1_diTrp_1	661	667	PF00928	0.628
LIG_FHA_1	621	627	PF00498	0.527
LIG_FHA_1	684	690	PF00498	0.622
LIG_FHA_1	710	716	PF00498	0.446
LIG_FHA_1	827	833	PF00498	0.411
LIG_FHA_2	240	246	PF00498	0.562
LIG_FHA_2	33	39	PF00498	0.642
LIG_FHA_2	346	352	PF00498	0.417
LIG_FHA_2	59	65	PF00498	0.570
LIG_FHA_2	617	623	PF00498	0.547
LIG_Integrin_RGD_1	66	68	PF01839	0.572
LIG_LIR_Gen_1	281	290	PF02991	0.394
LIG_LIR_Gen_1	599	608	PF02991	0.509
LIG_LIR_Gen_1	61	70	PF02991	0.567
LIG_LIR_Gen_1	729	739	PF02991	0.574
LIG_LIR_Nem_3	185	191	PF02991	0.673
LIG_LIR_Nem_3	281	285	PF02991	0.422
LIG_LIR_Nem_3	29	33	PF02991	0.629
LIG_LIR_Nem_3	304	308	PF02991	0.512
LIG_LIR_Nem_3	599	603	PF02991	0.495
LIG_LIR_Nem_3	61	65	PF02991	0.569
LIG_LIR_Nem_3	729	734	PF02991	0.567
LIG_LIR_Nem_3	800	805	PF02991	0.546
LIG_MYND_1	130	134	PF01753	0.609
LIG_NRBOX	716	722	PF00104	0.576
LIG_PCNA_yPIPBox_3	395	405	PF02747	0.531
LIG_PCNA_yPIPBox_3	682	692	PF02747	0.476
LIG_Pex14_1	476	480	PF04695	0.477
LIG_Pex14_1	663	667	PF04695	0.630
LIG_Pex14_2	798	802	PF04695	0.548
LIG_PTB_Apo_2	474	481	PF02174	0.473
LIG_SH2_CRK	366	370	PF00017	0.576
LIG_SH2_NCK_1	558	562	PF00017	0.517
LIG_SH2_SRC	62	65	PF00017	0.532
LIG_SH2_STAP1	784	788	PF00017	0.455
LIG_SH2_STAT5	191	194	PF00017	0.668
LIG_SH2_STAT5	483	486	PF00017	0.481
LIG_SH2_STAT5	640	643	PF00017	0.470
LIG_SH2_STAT5	658	661	PF00017	0.720
LIG_SH2_STAT5	851	854	PF00017	0.638
LIG_SH3_1	187	193	PF00018	0.673
LIG_SH3_1	812	818	PF00018	0.467
LIG_SH3_2	130	135	PF14604	0.610
LIG_SH3_3	127	133	PF00018	0.616
LIG_SH3_3	176	182	PF00018	0.660
LIG_SH3_3	187	193	PF00018	0.564
LIG_SH3_3	534	540	PF00018	0.518
LIG_SH3_3	642	648	PF00018	0.591
LIG_SH3_3	66	72	PF00018	0.652
LIG_SH3_3	665	671	PF00018	0.640
LIG_SH3_3	694	700	PF00018	0.480
LIG_SH3_3	812	818	PF00018	0.615
LIG_SUMO_SIM_anti_2	35	44	PF11976	0.653
LIG_SUMO_SIM_anti_2	599	605	PF11976	0.499
LIG_SUMO_SIM_anti_2	764	770	PF11976	0.591
LIG_SUMO_SIM_par_1	125	131	PF11976	0.605
LIG_SUMO_SIM_par_1	29	35	PF11976	0.631
LIG_SUMO_SIM_par_1	712	718	PF11976	0.570
LIG_TRAF2_1	193	196	PF00917	0.655
LIG_TRAF2_1	242	245	PF00917	0.559
LIG_TRAF2_1	783	786	PF00917	0.596
LIG_WW_3	132	136	PF00397	0.634
MOD_CDK_SPK_2	211	216	PF00069	0.646
MOD_CDK_SPxK_1	117	123	PF00069	0.686
MOD_CK1_1	128	134	PF00069	0.532
MOD_CK1_1	171	177	PF00069	0.676
MOD_CK1_1	453	459	PF00069	0.678
MOD_CK1_1	709	715	PF00069	0.433
MOD_CK1_1	791	797	PF00069	0.600
MOD_CK2_1	239	245	PF00069	0.611
MOD_CK2_1	556	562	PF00069	0.693
MOD_CK2_1	616	622	PF00069	0.620
MOD_CK2_1	659	665	PF00069	0.473
MOD_Cter_Amidation	223	226	PF01082	0.664
MOD_Cter_Amidation	449	452	PF01082	0.609
MOD_GlcNHglycan	171	174	PF01048	0.672
MOD_GlcNHglycan	175	179	PF01048	0.641
MOD_GlcNHglycan	293	296	PF01048	0.499
MOD_GlcNHglycan	378	381	PF01048	0.689
MOD_GlcNHglycan	389	393	PF01048	0.628
MOD_GlcNHglycan	401	404	PF01048	0.444
MOD_GlcNHglycan	412	415	PF01048	0.384
MOD_GlcNHglycan	444	447	PF01048	0.658
MOD_GlcNHglycan	46	49	PF01048	0.608
MOD_GlcNHglycan	469	472	PF01048	0.393
MOD_GlcNHglycan	497	500	PF01048	0.436
MOD_GlcNHglycan	572	576	PF01048	0.622
MOD_GlcNHglycan	694	697	PF01048	0.629
MOD_GSK3_1	115	122	PF00069	0.684
MOD_GSK3_1	140	147	PF00069	0.492
MOD_GSK3_1	174	181	PF00069	0.652
MOD_GSK3_1	182	189	PF00069	0.580
MOD_GSK3_1	259	266	PF00069	0.620
MOD_GSK3_1	40	47	PF00069	0.668
MOD_GSK3_1	495	502	PF00069	0.445
MOD_GSK3_1	562	569	PF00069	0.519
MOD_GSK3_1	612	619	PF00069	0.609
MOD_GSK3_1	659	666	PF00069	0.621
MOD_GSK3_1	788	795	PF00069	0.616
MOD_LATS_1	10	16	PF00433	0.472
MOD_N-GLC_1	291	296	PF02516	0.505
MOD_N-GLC_1	336	341	PF02516	0.508
MOD_NEK2_1	301	306	PF00069	0.520
MOD_NEK2_1	32	37	PF00069	0.490
MOD_NEK2_1	40	45	PF00069	0.596
MOD_NEK2_1	405	410	PF00069	0.433
MOD_NEK2_1	519	524	PF00069	0.737
MOD_NEK2_1	591	596	PF00069	0.546
MOD_NEK2_1	659	664	PF00069	0.616
MOD_NEK2_1	740	745	PF00069	0.553
MOD_NEK2_1	769	774	PF00069	0.571
MOD_NEK2_1	788	793	PF00069	0.453
MOD_NEK2_1	826	831	PF00069	0.412
MOD_NEK2_2	450	455	PF00069	0.684
MOD_PIKK_1	182	188	PF00454	0.674
MOD_PIKK_1	405	411	PF00454	0.474
MOD_PIKK_1	545	551	PF00454	0.642
MOD_PIKK_1	746	752	PF00454	0.576
MOD_PIKK_1	831	837	PF00454	0.436
MOD_PKA_1	12	18	PF00069	0.475
MOD_PKA_1	566	572	PF00069	0.525
MOD_PKA_2	12	18	PF00069	0.623
MOD_PKA_2	345	351	PF00069	0.695
MOD_PKA_2	419	425	PF00069	0.547
MOD_PKA_2	44	50	PF00069	0.604
MOD_PKA_2	450	456	PF00069	0.618
MOD_PKA_2	566	572	PF00069	0.614
MOD_PKA_2	616	622	PF00069	0.642
MOD_Plk_1	405	411	PF00069	0.474
MOD_Plk_1	778	784	PF00069	0.471
MOD_Plk_1	788	794	PF00069	0.495
MOD_Plk_4	233	239	PF00069	0.498
MOD_Plk_4	663	669	PF00069	0.633
MOD_ProDKin_1	117	123	PF00069	0.686
MOD_ProDKin_1	178	184	PF00069	0.648
MOD_ProDKin_1	186	192	PF00069	0.581
MOD_ProDKin_1	211	217	PF00069	0.648
MOD_ProDKin_1	307	313	PF00069	0.488
MOD_ProDKin_1	336	342	PF00069	0.506
MOD_ProDKin_1	509	515	PF00069	0.640
MOD_ProDKin_1	557	563	PF00069	0.521
MOD_ProDKin_1	630	636	PF00069	0.526
MOD_SUMO_rev_2	68	75	PF00179	0.512
TRG_DiLeu_BaEn_1	202	207	PF01217	0.564
TRG_DiLeu_BaEn_1	622	627	PF01217	0.522
TRG_DiLeu_BaEn_1	716	721	PF01217	0.573
TRG_DiLeu_BaLyEn_6	368	373	PF01217	0.489
TRG_DiLeu_BaLyEn_6	587	592	PF01217	0.581
TRG_DiLeu_BaLyEn_6	710	715	PF01217	0.584
TRG_DiLeu_BaLyEn_6	816	821	PF01217	0.606
TRG_ENDOCYTIC_2	191	194	PF00928	0.668
TRG_ENDOCYTIC_2	305	308	PF00928	0.506
TRG_ENDOCYTIC_2	366	369	PF00928	0.578
TRG_ENDOCYTIC_2	483	486	PF00928	0.481
TRG_ENDOCYTIC_2	62	65	PF00928	0.532
TRG_ER_diArg_1	11	13	PF00400	0.475
TRG_ER_diArg_1	134	136	PF00400	0.672
TRG_ER_diArg_1	225	227	PF00400	0.632
TRG_ER_diArg_1	710	713	PF00400	0.587
TRG_ER_diArg_1	773	775	PF00400	0.415
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.649
TRG_Pf-PMV_PEXEL_1	370	374	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	452	457	PF00026	0.691
TRG_Pf-PMV_PEXEL_1	713	718	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	775	779	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WVK3	Leishmania donovani	86%	100%
A4HYE8	Leishmania infantum	86%	100%
Q4QD85	Leishmania major	84%	100%