Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9AS78_LEIMU

TriTrypDb:

LmxM.19.1270

Length:

228

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	7
GO:0032991	protein-containing complex	1	7
GO:0140513	nuclear protein-containing complex	2	7
GO:1990904	ribonucleoprotein complex	2	7
GO:0005654	nucleoplasm	2	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0005686	U2 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0071004	U2-type prespliceosome	5	1
GO:0071010	prespliceosome	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0120114	Sm-like protein family complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

E9AS78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS78

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	7
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	7
GO:0000398	mRNA splicing, via spliceosome	8	7
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006396	RNA processing	6	8
GO:0006397	mRNA processing	7	7
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0008380	RNA splicing	7	7
GO:0009987	cellular process	1	8
GO:0016070	RNA metabolic process	5	8
GO:0016071	mRNA metabolic process	6	7
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0045292	mRNA cis splicing, via spliceosome	9	7
GO:0046483	heterocycle metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.707
CLV_NRD_NRD_1	224	226	PF00675	0.556
CLV_PCSK_KEX2_1	226	228	PF00082	0.590
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.641
DOC_USP7_MATH_1	102	106	PF00917	0.547
LIG_BIR_II_1	1	5	PF00653	0.711
LIG_IBAR_NPY_1	58	60	PF08397	0.607
LIG_LIR_Gen_1	210	217	PF02991	0.669
LIG_LIR_Nem_3	114	120	PF02991	0.645
LIG_LIR_Nem_3	210	216	PF02991	0.670
LIG_PCNA_yPIPBox_3	26	34	PF02747	0.378
LIG_PTB_Apo_2	55	62	PF02174	0.607
LIG_SH2_CRK	74	78	PF00017	0.517
LIG_SH2_NCK_1	4	8	PF00017	0.733
LIG_SH2_SRC	147	150	PF00017	0.706
LIG_SH2_SRC	182	185	PF00017	0.781
LIG_SH2_STAP1	213	217	PF00017	0.654
LIG_SH2_STAT3	124	127	PF00017	0.650
LIG_SH2_STAT5	147	150	PF00017	0.742
LIG_SH2_STAT5	33	36	PF00017	0.553
LIG_SH2_STAT5	37	40	PF00017	0.508
LIG_SH2_STAT5	60	63	PF00017	0.517
LIG_SH2_STAT5	76	79	PF00017	0.517
LIG_SH3_3	145	151	PF00018	0.488
MOD_CK1_1	167	173	PF00069	0.660
MOD_CK2_1	126	132	PF00069	0.749
MOD_GlcNHglycan	128	131	PF01048	0.698
MOD_GlcNHglycan	152	155	PF01048	0.782
MOD_GlcNHglycan	160	163	PF01048	0.665
MOD_GlcNHglycan	183	187	PF01048	0.779
MOD_GSK3_1	163	170	PF00069	0.731
MOD_GSK3_1	178	185	PF00069	0.623
MOD_N-GLC_1	157	162	PF02516	0.716
MOD_NEK2_1	77	82	PF00069	0.513
MOD_PIKK_1	102	108	PF00454	0.684
MOD_PKA_2	85	91	PF00069	0.691
MOD_Plk_2-3	143	149	PF00069	0.708
MOD_Plk_4	143	149	PF00069	0.724
TRG_ENDOCYTIC_2	213	216	PF00928	0.652
TRG_ENDOCYTIC_2	60	63	PF00928	0.516
TRG_ENDOCYTIC_2	74	77	PF00928	0.517
TRG_ER_diArg_1	225	228	PF00400	0.635
TRG_ER_diArg_1	51	54	PF00400	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PET4	Leptomonas seymouri	51%	100%
A0A3S7WVH7	Leishmania donovani	91%	100%
A4HA73	Leishmania braziliensis	78%	100%
A4HYE5	Leishmania infantum	91%	100%
D0A0T0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	95%
Q4QD88	Leishmania major	93%	100%