Peroxin-12

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Peroxin-12

Gene product:

peroxisome assembly protein, putative

Species:

Leishmania mexicana

UniProt:

E9AS76_LEIMU

TriTrypDb:

LmxM.19.1250

Length:

461

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005777	peroxisome	6	1
GO:0005778	peroxisomal membrane	6	1
GO:0016020	membrane	2	1
GO:0020015	glycosome	7	1
GO:0031090	organelle membrane	3	1
GO:0031903	microbody membrane	5	1
GO:0032991	protein-containing complex	1	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0046860	glycosome membrane	7	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990351	transporter complex	2	1
GO:1990429	peroxisomal importomer complex	3	1

Expansion

Sequence features

E9AS76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS76

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	11
GO:0006625	protein targeting to peroxisome	5	11
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0006996	organelle organization	4	11
GO:0007031	peroxisome organization	5	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0015919	peroxisomal membrane transport	5	11
GO:0016043	cellular component organization	3	11
GO:0016558	protein import into peroxisome matrix	5	11
GO:0033036	macromolecule localization	2	11
GO:0033365	protein localization to organelle	5	11
GO:0043574	peroxisomal transport	4	11
GO:0044743	protein transmembrane import into intracellular organelle	4	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0055085	transmembrane transport	2	11
GO:0065002	intracellular protein transmembrane transport	4	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0071806	protein transmembrane transport	3	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0072594	establishment of protein localization to organelle	4	11
GO:0072662	protein localization to peroxisome	6	11
GO:0072663	establishment of protein localization to peroxisome	5	11
GO:0006513	protein monoubiquitination	8	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0008022	obsolete protein C-terminus binding	3	11
GO:0008270	zinc ion binding	6	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	258	262	PF00656	0.486
CLV_NRD_NRD_1	228	230	PF00675	0.321
CLV_NRD_NRD_1	245	247	PF00675	0.346
CLV_NRD_NRD_1	275	277	PF00675	0.212
CLV_NRD_NRD_1	326	328	PF00675	0.453
CLV_NRD_NRD_1	412	414	PF00675	0.563
CLV_NRD_NRD_1	456	458	PF00675	0.518
CLV_NRD_NRD_1	88	90	PF00675	0.271
CLV_PCSK_KEX2_1	228	230	PF00082	0.321
CLV_PCSK_KEX2_1	275	277	PF00082	0.195
CLV_PCSK_KEX2_1	326	328	PF00082	0.453
CLV_PCSK_KEX2_1	412	414	PF00082	0.545
CLV_PCSK_KEX2_1	456	458	PF00082	0.518
CLV_PCSK_KEX2_1	88	90	PF00082	0.271
CLV_PCSK_SKI1_1	127	131	PF00082	0.334
CLV_PCSK_SKI1_1	276	280	PF00082	0.274
CLV_PCSK_SKI1_1	342	346	PF00082	0.480
CLV_PCSK_SKI1_1	348	352	PF00082	0.465
CLV_PCSK_SKI1_1	413	417	PF00082	0.512
CLV_PCSK_SKI1_1	456	460	PF00082	0.648
CLV_PCSK_SKI1_1	70	74	PF00082	0.242
DEG_APCC_DBOX_1	347	355	PF00400	0.296
DEG_Nend_Nbox_1	1	3	PF02207	0.618
DEG_SCF_FBW7_1	308	315	PF00400	0.280
DEG_SPOP_SBC_1	101	105	PF00917	0.458
DOC_ANK_TNKS_1	88	95	PF00023	0.458
DOC_CDC14_PxL_1	96	104	PF14671	0.534
DOC_CKS1_1	136	141	PF01111	0.490
DOC_MAPK_gen_1	122	131	PF00069	0.534
DOC_MAPK_gen_1	228	237	PF00069	0.472
DOC_MAPK_gen_1	272	282	PF00069	0.390
DOC_MAPK_gen_1	374	383	PF00069	0.439
DOC_MAPK_gen_1	46	54	PF00069	0.458
DOC_MAPK_MEF2A_6	228	237	PF00069	0.472
DOC_MAPK_MEF2A_6	348	355	PF00069	0.253
DOC_MAPK_NFAT4_5	348	356	PF00069	0.296
DOC_PP1_RVXF_1	122	129	PF00149	0.442
DOC_PP1_RVXF_1	357	364	PF00149	0.315
DOC_PP2B_LxvP_1	131	134	PF13499	0.478
DOC_PP2B_LxvP_1	381	384	PF13499	0.441
DOC_USP7_MATH_1	101	105	PF00917	0.583
DOC_USP7_MATH_1	107	111	PF00917	0.535
DOC_USP7_MATH_1	44	48	PF00917	0.499
DOC_WW_Pin1_4	11	16	PF00397	0.539
DOC_WW_Pin1_4	110	115	PF00397	0.543
DOC_WW_Pin1_4	135	140	PF00397	0.469
DOC_WW_Pin1_4	169	174	PF00397	0.491
DOC_WW_Pin1_4	308	313	PF00397	0.237
DOC_WW_Pin1_4	369	374	PF00397	0.486
LIG_14-3-3_CanoR_1	156	162	PF00244	0.554
LIG_14-3-3_CanoR_1	254	260	PF00244	0.500
LIG_14-3-3_CanoR_1	326	331	PF00244	0.295
LIG_14-3-3_CanoR_1	399	403	PF00244	0.441
LIG_Actin_WH2_2	313	328	PF00022	0.321
LIG_APCC_ABBA_1	240	245	PF00400	0.534
LIG_eIF4E_1	125	131	PF01652	0.534
LIG_eIF4E_1	302	308	PF01652	0.271
LIG_EVH1_1	381	385	PF00568	0.502
LIG_FHA_1	23	29	PF00498	0.602
LIG_FHA_1	312	318	PF00498	0.250
LIG_FHA_1	421	427	PF00498	0.275
LIG_FHA_2	135	141	PF00498	0.537
LIG_FHA_2	16	22	PF00498	0.513
LIG_FHA_2	256	262	PF00498	0.521
LIG_FHA_2	327	333	PF00498	0.271
LIG_FHA_2	77	83	PF00498	0.464
LIG_LIR_Apic_2	311	316	PF02991	0.253
LIG_LIR_Gen_1	298	308	PF02991	0.389
LIG_LIR_Gen_1	58	68	PF02991	0.470
LIG_LIR_Gen_1	77	87	PF02991	0.472
LIG_LIR_Nem_3	298	303	PF02991	0.225
LIG_LIR_Nem_3	31	36	PF02991	0.565
LIG_LIR_Nem_3	58	64	PF02991	0.456
LIG_LYPXL_yS_3	430	433	PF13949	0.277
LIG_MYND_1	115	119	PF01753	0.416
LIG_NRBOX	125	131	PF00104	0.496
LIG_PDZ_Class_2	456	461	PF00595	0.345
LIG_SH2_CRK	218	222	PF00017	0.534
LIG_SH2_CRK	271	275	PF00017	0.491
LIG_SH2_CRK	313	317	PF00017	0.302
LIG_SH2_PTP2	286	289	PF00017	0.408
LIG_SH2_SRC	286	289	PF00017	0.408
LIG_SH2_STAP1	269	273	PF00017	0.526
LIG_SH2_STAT5	125	128	PF00017	0.534
LIG_SH2_STAT5	220	223	PF00017	0.475
LIG_SH2_STAT5	243	246	PF00017	0.499
LIG_SH2_STAT5	252	255	PF00017	0.544
LIG_SH2_STAT5	286	289	PF00017	0.359
LIG_SH2_STAT5	302	305	PF00017	0.233
LIG_SH2_STAT5	313	316	PF00017	0.243
LIG_SH2_STAT5	436	439	PF00017	0.408
LIG_SH2_STAT5	61	64	PF00017	0.576
LIG_SH3_3	109	115	PF00018	0.481
LIG_SH3_3	133	139	PF00018	0.482
LIG_SH3_3	379	385	PF00018	0.427
LIG_SH3_3	390	396	PF00018	0.397
LIG_SH3_3	49	55	PF00018	0.458
LIG_SH3_3	89	95	PF00018	0.467
LIG_SUMO_SIM_anti_2	207	212	PF11976	0.491
LIG_TRAF2_1	138	141	PF00917	0.453
LIG_UBA3_1	235	241	PF00899	0.471
LIG_UBA3_1	279	285	PF00899	0.458
MOD_CDK_SPK_2	369	374	PF00069	0.458
MOD_CDK_SPxxK_3	135	142	PF00069	0.534
MOD_CDK_SPxxK_3	312	319	PF00069	0.296
MOD_CK1_1	103	109	PF00069	0.555
MOD_CK1_1	110	116	PF00069	0.566
MOD_CK1_1	333	339	PF00069	0.344
MOD_CK2_1	134	140	PF00069	0.456
MOD_CK2_1	15	21	PF00069	0.518
MOD_CK2_1	325	331	PF00069	0.321
MOD_CK2_1	76	82	PF00069	0.470
MOD_GlcNHglycan	105	108	PF01048	0.376
MOD_GlcNHglycan	109	112	PF01048	0.359
MOD_GlcNHglycan	159	162	PF01048	0.384
MOD_GlcNHglycan	423	426	PF01048	0.488
MOD_GlcNHglycan	64	67	PF01048	0.334
MOD_GSK3_1	1	8	PF00069	0.619
MOD_GSK3_1	103	110	PF00069	0.569
MOD_GSK3_1	11	18	PF00069	0.543
MOD_GSK3_1	200	207	PF00069	0.597
MOD_GSK3_1	24	31	PF00069	0.496
MOD_GSK3_1	291	298	PF00069	0.259
MOD_GSK3_1	308	315	PF00069	0.305
MOD_GSK3_1	326	333	PF00069	0.371
MOD_N-GLC_1	10	15	PF02516	0.361
MOD_N-GLC_1	28	33	PF02516	0.258
MOD_NEK2_1	1	6	PF00069	0.630
MOD_NEK2_1	102	107	PF00069	0.489
MOD_NEK2_1	175	180	PF00069	0.563
MOD_NEK2_1	236	241	PF00069	0.446
MOD_NEK2_1	24	29	PF00069	0.507
MOD_NEK2_1	325	330	PF00069	0.323
MOD_NEK2_1	361	366	PF00069	0.258
MOD_NEK2_1	38	43	PF00069	0.499
MOD_NEK2_1	62	67	PF00069	0.541
MOD_PIKK_1	150	156	PF00454	0.534
MOD_PIKK_1	200	206	PF00454	0.562
MOD_PIKK_1	5	11	PF00454	0.631
MOD_PKA_1	326	332	PF00069	0.253
MOD_PKA_2	253	259	PF00069	0.496
MOD_PKA_2	325	331	PF00069	0.264
MOD_PKA_2	398	404	PF00069	0.422
MOD_Plk_1	256	262	PF00069	0.534
MOD_Plk_1	28	34	PF00069	0.432
MOD_Plk_1	330	336	PF00069	0.334
MOD_Plk_1	397	403	PF00069	0.529
MOD_Plk_1	76	82	PF00069	0.440
MOD_Plk_4	15	21	PF00069	0.512
MOD_Plk_4	231	237	PF00069	0.485
MOD_Plk_4	28	34	PF00069	0.468
MOD_Plk_4	38	44	PF00069	0.487
MOD_ProDKin_1	11	17	PF00069	0.532
MOD_ProDKin_1	110	116	PF00069	0.543
MOD_ProDKin_1	135	141	PF00069	0.469
MOD_ProDKin_1	169	175	PF00069	0.491
MOD_ProDKin_1	308	314	PF00069	0.237
MOD_ProDKin_1	369	375	PF00069	0.490
MOD_SUMO_for_1	211	214	PF00179	0.534
TRG_DiLeu_BaLyEn_6	356	361	PF01217	0.253
TRG_ENDOCYTIC_2	218	221	PF00928	0.441
TRG_ENDOCYTIC_2	33	36	PF00928	0.491
TRG_ENDOCYTIC_2	430	433	PF00928	0.307
TRG_ENDOCYTIC_2	61	64	PF00928	0.568
TRG_ER_diArg_1	122	125	PF00400	0.533
TRG_ER_diArg_1	274	276	PF00400	0.370
TRG_ER_diArg_1	325	327	PF00400	0.253
TRG_ER_diArg_1	455	457	PF00400	0.303
TRG_ER_diArg_1	87	89	PF00400	0.471
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1T8	Leptomonas seymouri	71%	100%
A0A1X0P610	Trypanosomatidae	45%	100%
A0A3S5H767	Leishmania donovani	94%	100%
A0A422NUP5	Trypanosoma rangeli	44%	100%
A4HA71	Leishmania braziliensis	87%	100%
A4HYE3	Leishmania infantum	94%	100%
D0A0S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
Q4QD90	Leishmania major	94%	100%
V5BED1	Trypanosoma cruzi	44%	100%