Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AS74_LEIMU

TriTrypDb:

LmxM.19.1230

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AS74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS74

PDB structure(s): 7aih_Aq , 7ane_Aq

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	67	71	PF00656	0.787
CLV_NRD_NRD_1	167	169	PF00675	0.565
CLV_NRD_NRD_1	178	180	PF00675	0.664
CLV_NRD_NRD_1	321	323	PF00675	0.587
CLV_PCSK_FUR_1	176	180	PF00082	0.501
CLV_PCSK_KEX2_1	167	169	PF00082	0.565
CLV_PCSK_KEX2_1	178	180	PF00082	0.664
CLV_PCSK_KEX2_1	321	323	PF00082	0.587
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.589
DEG_Nend_Nbox_1	1	3	PF02207	0.581
DEG_SPOP_SBC_1	64	68	PF00917	0.613
DOC_CYCLIN_yCln2_LP_2	159	165	PF00134	0.511
DOC_MAPK_gen_1	129	137	PF00069	0.439
DOC_MAPK_MEF2A_6	120	128	PF00069	0.459
DOC_MAPK_MEF2A_6	35	42	PF00069	0.519
DOC_MAPK_NFAT4_5	35	43	PF00069	0.517
DOC_PP2B_LxvP_1	26	29	PF13499	0.536
DOC_PP4_FxxP_1	183	186	PF00568	0.729
DOC_USP7_MATH_1	190	194	PF00917	0.613
DOC_USP7_MATH_1	257	261	PF00917	0.706
DOC_USP7_MATH_1	295	299	PF00917	0.587
DOC_USP7_MATH_1	64	68	PF00917	0.752
DOC_WW_Pin1_4	65	70	PF00397	0.498
LIG_14-3-3_CanoR_1	100	108	PF00244	0.716
LIG_14-3-3_CanoR_1	129	137	PF00244	0.474
LIG_14-3-3_CanoR_1	167	174	PF00244	0.520
LIG_14-3-3_CanoR_1	273	282	PF00244	0.644
LIG_14-3-3_CanoR_1	322	328	PF00244	0.595
LIG_FHA_1	111	117	PF00498	0.578
LIG_FHA_1	130	136	PF00498	0.510
LIG_FHA_1	152	158	PF00498	0.283
LIG_FHA_1	202	208	PF00498	0.684
LIG_FHA_1	221	227	PF00498	0.323
LIG_LIR_Apic_2	160	164	PF02991	0.479
LIG_LIR_Apic_2	180	186	PF02991	0.504
LIG_LIR_Gen_1	169	177	PF02991	0.637
LIG_LIR_Nem_3	105	111	PF02991	0.706
LIG_LIR_Nem_3	169	174	PF02991	0.629
LIG_LIR_Nem_3	276	282	PF02991	0.619
LIG_RPA_C_Fungi	262	274	PF08784	0.439
LIG_SH2_CRK	171	175	PF00017	0.624
LIG_SH2_CRK	51	55	PF00017	0.675
LIG_SH2_NCK_1	51	55	PF00017	0.662
LIG_SH2_STAT3	10	13	PF00017	0.617
LIG_SH2_STAT5	10	13	PF00017	0.617
LIG_SH2_STAT5	108	111	PF00017	0.739
LIG_SH3_3	246	252	PF00018	0.662
LIG_SH3_3	298	304	PF00018	0.515
LIG_SH3_3	9	15	PF00018	0.523
LIG_SUMO_SIM_anti_2	217	223	PF11976	0.565
MOD_CK1_1	166	172	PF00069	0.519
MOD_CK1_1	217	223	PF00069	0.506
MOD_CK1_1	233	239	PF00069	0.588
MOD_CK1_1	265	271	PF00069	0.720
MOD_GlcNHglycan	192	195	PF01048	0.555
MOD_GlcNHglycan	232	235	PF01048	0.737
MOD_GlcNHglycan	264	267	PF01048	0.690
MOD_GlcNHglycan	269	272	PF01048	0.568
MOD_GlcNHglycan	292	295	PF01048	0.536
MOD_GlcNHglycan	298	301	PF01048	0.467
MOD_GSK3_1	102	109	PF00069	0.652
MOD_GSK3_1	230	237	PF00069	0.706
MOD_GSK3_1	258	265	PF00069	0.696
MOD_N-GLC_1	102	107	PF02516	0.684
MOD_N-GLC_1	234	239	PF02516	0.477
MOD_N-GLC_1	290	295	PF02516	0.530
MOD_NEK2_1	151	156	PF00069	0.410
MOD_NEK2_2	281	286	PF00069	0.536
MOD_PIKK_1	166	172	PF00454	0.618
MOD_PIKK_1	273	279	PF00454	0.683
MOD_PKA_1	321	327	PF00069	0.581
MOD_PKA_2	166	172	PF00069	0.563
MOD_PKA_2	296	302	PF00069	0.497
MOD_PKA_2	321	327	PF00069	0.581
MOD_Plk_1	102	108	PF00069	0.718
MOD_Plk_1	217	223	PF00069	0.621
MOD_Plk_4	217	223	PF00069	0.484
MOD_Plk_4	27	33	PF00069	0.608
MOD_ProDKin_1	65	71	PF00069	0.496
MOD_SUMO_rev_2	311	318	PF00179	0.562
TRG_ENDOCYTIC_2	171	174	PF00928	0.622
TRG_ENDOCYTIC_2	51	54	PF00928	0.634
TRG_ER_diArg_1	128	131	PF00400	0.454
TRG_ER_diArg_1	135	138	PF00400	0.433
TRG_ER_diArg_1	176	179	PF00400	0.496
TRG_NLS_MonoExtC_3	320	325	PF00514	0.589
TRG_NLS_MonoExtN_4	321	326	PF00514	0.583
TRG_Pf-PMV_PEXEL_1	278	283	PF00026	0.632
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM80	Leptomonas seymouri	64%	96%
A0A1X0P627	Trypanosomatidae	36%	100%
A0A3Q8IDC8	Leishmania donovani	92%	100%
A0A3R7NH36	Trypanosoma rangeli	44%	100%
A4HA69	Leishmania braziliensis	84%	100%
A4HYE1	Leishmania infantum	91%	100%
D0A0S6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
Q4QD92	Leishmania major	88%	99%
V5AZ17	Trypanosoma cruzi	43%	100%