Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AS73_LEIMU

TriTrypDb:

LmxM.19.1220

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AS73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS73

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	234	238	PF00656	0.506
CLV_C14_Caspase3-7	65	69	PF00656	0.603
CLV_NRD_NRD_1	156	158	PF00675	0.543
CLV_NRD_NRD_1	179	181	PF00675	0.603
CLV_NRD_NRD_1	260	262	PF00675	0.592
CLV_NRD_NRD_1	72	74	PF00675	0.569
CLV_PCSK_FUR_1	260	264	PF00082	0.579
CLV_PCSK_KEX2_1	179	181	PF00082	0.557
CLV_PCSK_KEX2_1	260	262	PF00082	0.592
CLV_PCSK_KEX2_1	71	73	PF00082	0.590
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.572
CLV_PCSK_PC7_1	256	262	PF00082	0.666
CLV_PCSK_SKI1_1	180	184	PF00082	0.600
DEG_Nend_Nbox_1	1	3	PF02207	0.662
DEG_SCF_FBW7_1	168	173	PF00400	0.552
DOC_ANK_TNKS_1	208	215	PF00023	0.573
DOC_USP7_MATH_1	159	163	PF00917	0.439
DOC_USP7_MATH_1	170	174	PF00917	0.503
DOC_USP7_MATH_1	236	240	PF00917	0.788
DOC_USP7_MATH_1	279	283	PF00917	0.540
DOC_USP7_UBL2_3	270	274	PF12436	0.575
DOC_WW_Pin1_4	166	171	PF00397	0.576
DOC_WW_Pin1_4	277	282	PF00397	0.673
DOC_WW_Pin1_4	3	8	PF00397	0.709
LIG_14-3-3_CanoR_1	232	236	PF00244	0.719
LIG_14-3-3_CanoR_1	41	50	PF00244	0.551
LIG_14-3-3_CanoR_1	54	59	PF00244	0.443
LIG_BRCT_BRCA1_1	172	176	PF00533	0.470
LIG_BRCT_BRCA1_1	56	60	PF00533	0.452
LIG_FHA_1	31	37	PF00498	0.643
LIG_FHA_1	88	94	PF00498	0.543
LIG_FHA_2	185	191	PF00498	0.289
LIG_FHA_2	232	238	PF00498	0.741
LIG_Integrin_RGD_1	106	108	PF01839	0.494
LIG_LIR_Apic_2	286	292	PF02991	0.734
LIG_LIR_Gen_1	57	64	PF02991	0.530
LIG_LIR_Nem_3	190	195	PF02991	0.565
LIG_LIR_Nem_3	57	61	PF02991	0.425
LIG_NRBOX	92	98	PF00104	0.388
LIG_SH2_CRK	192	196	PF00017	0.458
LIG_SH2_SRC	92	95	PF00017	0.508
LIG_SH2_STAP1	151	155	PF00017	0.442
LIG_SH2_STAT3	118	121	PF00017	0.572
LIG_SH2_STAT3	273	276	PF00017	0.571
LIG_SH2_STAT5	118	121	PF00017	0.463
LIG_SH2_STAT5	134	137	PF00017	0.276
LIG_SH2_STAT5	92	95	PF00017	0.499
LIG_SH3_3	11	17	PF00018	0.636
MOD_CDK_SPxxK_3	277	284	PF00069	0.662
MOD_CK1_1	128	134	PF00069	0.521
MOD_CK1_1	162	168	PF00069	0.595
MOD_CK1_1	280	286	PF00069	0.749
MOD_CK1_1	30	36	PF00069	0.651
MOD_CK1_1	39	45	PF00069	0.696
MOD_CK2_1	184	190	PF00069	0.287
MOD_CK2_1	280	286	PF00069	0.703
MOD_GlcNHglycan	110	113	PF01048	0.502
MOD_GlcNHglycan	164	167	PF01048	0.587
MOD_GlcNHglycan	176	179	PF01048	0.411
MOD_GlcNHglycan	210	213	PF01048	0.704
MOD_GlcNHglycan	221	224	PF01048	0.655
MOD_GlcNHglycan	29	32	PF01048	0.681
MOD_GlcNHglycan	33	36	PF01048	0.668
MOD_GlcNHglycan	43	46	PF01048	0.474
MOD_GSK3_1	162	169	PF00069	0.542
MOD_GSK3_1	170	177	PF00069	0.470
MOD_GSK3_1	219	226	PF00069	0.673
MOD_GSK3_1	26	33	PF00069	0.615
MOD_GSK3_1	280	287	PF00069	0.699
MOD_GSK3_1	36	43	PF00069	0.588
MOD_GSK3_1	44	51	PF00069	0.514
MOD_N-GLC_1	237	242	PF02516	0.667
MOD_NEK2_1	135	140	PF00069	0.380
MOD_NEK2_1	40	45	PF00069	0.625
MOD_NEK2_1	99	104	PF00069	0.403
MOD_PKA_1	86	92	PF00069	0.567
MOD_PKA_2	208	214	PF00069	0.701
MOD_PKA_2	219	225	PF00069	0.708
MOD_PKA_2	228	234	PF00069	0.611
MOD_PKA_2	40	46	PF00069	0.585
MOD_Plk_1	159	165	PF00069	0.646
MOD_Plk_1	87	93	PF00069	0.543
MOD_Plk_4	128	134	PF00069	0.423
MOD_Plk_4	170	176	PF00069	0.479
MOD_Plk_4	92	98	PF00069	0.432
MOD_ProDKin_1	166	172	PF00069	0.567
MOD_ProDKin_1	277	283	PF00069	0.677
MOD_ProDKin_1	3	9	PF00069	0.707
MOD_SUMO_rev_2	79	89	PF00179	0.541
TRG_ENDOCYTIC_2	192	195	PF00928	0.444
TRG_ENDOCYTIC_2	58	61	PF00928	0.415
TRG_ER_diArg_1	260	263	PF00400	0.587
TRG_ER_diArg_1	71	73	PF00400	0.566
TRG_NLS_MonoExtC_3	182	188	PF00514	0.580
TRG_NLS_MonoExtN_4	180	187	PF00514	0.590
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDU4	Leptomonas seymouri	60%	100%
A0A1X0P732	Trypanosomatidae	49%	99%
A0A3R7K6K4	Trypanosoma rangeli	46%	100%
A0A3S7WVI0	Leishmania donovani	95%	100%
A4HA59	Leishmania braziliensis	80%	100%
A4HYE0	Leishmania infantum	95%	100%
D0A0S5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
Q4QD93	Leishmania major	93%	100%
V5BNH1	Trypanosoma cruzi	43%	100%