PINc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Fcf1, putative

Species:

Leishmania mexicana

UniProt:

E9AS72_LEIMU

TriTrypDb:

LmxM.19.1210

Length:

209

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0030684	preribosome	3	11
GO:0032040	small-subunit processome	4	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

E9AS72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS72

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.289
CLV_NRD_NRD_1	54	56	PF00675	0.569
CLV_PCSK_FUR_1	139	143	PF00082	0.289
CLV_PCSK_KEX2_1	141	143	PF00082	0.284
CLV_PCSK_KEX2_1	177	179	PF00082	0.289
CLV_PCSK_KEX2_1	27	29	PF00082	0.501
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.289
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.289
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.501
CLV_PCSK_SKI1_1	13	17	PF00082	0.472
CLV_PCSK_SKI1_1	132	136	PF00082	0.287
CLV_PCSK_SKI1_1	159	163	PF00082	0.329
CLV_PCSK_SKI1_1	43	47	PF00082	0.587
CLV_PCSK_SKI1_1	55	59	PF00082	0.598
DOC_CYCLIN_yCln2_LP_2	77	83	PF00134	0.368
DOC_MAPK_DCC_7	178	188	PF00069	0.289
DOC_MAPK_gen_1	126	135	PF00069	0.289
DOC_MAPK_gen_1	177	188	PF00069	0.282
DOC_MAPK_HePTP_8	176	188	PF00069	0.289
DOC_MAPK_MEF2A_6	129	137	PF00069	0.289
DOC_MAPK_MEF2A_6	179	188	PF00069	0.289
DOC_MAPK_NFAT4_5	130	138	PF00069	0.289
DOC_PP2B_LxvP_1	77	80	PF13499	0.396
DOC_USP7_UBL2_3	126	130	PF12436	0.289
DOC_USP7_UBL2_3	14	18	PF12436	0.579
DOC_USP7_UBL2_3	43	47	PF12436	0.595
DOC_WW_Pin1_4	33	38	PF00397	0.647
LIG_14-3-3_CanoR_1	145	152	PF00244	0.289
LIG_14-3-3_CanoR_1	159	168	PF00244	0.308
LIG_Actin_WH2_2	120	138	PF00022	0.289
LIG_EH1_1	9	17	PF00400	0.509
LIG_FHA_1	85	91	PF00498	0.319
LIG_GBD_Chelix_1	100	108	PF00786	0.341
LIG_LIR_Apic_2	203	208	PF02991	0.488
LIG_LIR_Gen_1	118	127	PF02991	0.391
LIG_LIR_Gen_1	140	149	PF02991	0.372
LIG_LIR_Gen_1	46	57	PF02991	0.569
LIG_LIR_Gen_1	86	94	PF02991	0.320
LIG_LIR_Nem_3	118	124	PF02991	0.391
LIG_LIR_Nem_3	140	146	PF02991	0.277
LIG_LIR_Nem_3	46	52	PF02991	0.572
LIG_LIR_Nem_3	67	73	PF02991	0.474
LIG_LIR_Nem_3	86	92	PF02991	0.322
LIG_PCNA_yPIPBox_3	97	109	PF02747	0.465
LIG_SH2_CRK	49	53	PF00017	0.553
LIG_SH2_STAP1	49	53	PF00017	0.586
LIG_SH2_STAT5	167	170	PF00017	0.289
LIG_SH2_STAT5	190	193	PF00017	0.289
LIG_SH2_STAT5	196	199	PF00017	0.289
LIG_SH3_1	181	187	PF00018	0.289
LIG_SH3_3	181	187	PF00018	0.272
LIG_UBA3_1	104	111	PF00899	0.289
LIG_UBA3_1	188	193	PF00899	0.289
MOD_CK1_1	21	27	PF00069	0.494
MOD_CK1_1	39	45	PF00069	0.595
MOD_CK1_1	72	78	PF00069	0.542
MOD_CK2_1	29	35	PF00069	0.583
MOD_Cter_Amidation	127	130	PF01082	0.289
MOD_GSK3_1	29	36	PF00069	0.582
MOD_GSK3_1	39	46	PF00069	0.538
MOD_N-GLC_1	39	44	PF02516	0.650
MOD_N-GLC_1	90	95	PF02516	0.348
MOD_PIKK_1	159	165	PF00454	0.361
MOD_PIKK_1	57	63	PF00454	0.552
MOD_PKA_2	144	150	PF00069	0.289
MOD_PKA_2	194	200	PF00069	0.289
MOD_Plk_1	18	24	PF00069	0.537
MOD_Plk_1	90	96	PF00069	0.349
MOD_Plk_2-3	29	35	PF00069	0.581
MOD_ProDKin_1	33	39	PF00069	0.646
MOD_SUMO_rev_2	144	153	PF00179	0.366
TRG_ENDOCYTIC_2	49	52	PF00928	0.556
TRG_ER_diArg_1	178	181	PF00400	0.289
TRG_NES_CRM1_1	125	140	PF08389	0.289
TRG_NLS_MonoExtC_3	176	181	PF00514	0.289
TRG_NLS_MonoExtN_4	126	133	PF00514	0.289

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7T8	Leptomonas seymouri	91%	100%
A0A0S4JGW7	Bodo saltans	74%	100%
A0A1X0P7I3	Trypanosomatidae	78%	100%
A0A3Q8IAB0	Leishmania donovani	97%	100%
A0A3R7LSN9	Trypanosoma rangeli	76%	100%
A4HA60	Leishmania braziliensis	94%	100%
A4HYD9	Leishmania infantum	97%	100%
D0A0S4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	100%
O13610	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	54%	100%
Q05498	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	100%
Q32PD0	Bos taurus	67%	100%
Q4QD94	Leishmania major	97%	100%
Q55GM5	Dictyostelium discoideum	51%	100%
Q5RFQ0	Pongo abelii	67%	100%
Q9CTH6	Mus musculus	66%	100%
Q9Y324	Homo sapiens	67%	100%