CHCH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CHCH domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AS70_LEIMU

TriTrypDb:

LmxM.19.1190

Length:

130

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005758	mitochondrial intermembrane space	6	1
GO:0031970	organelle envelope lumen	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AS70

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS70

Function

Biological processes
Term	Name	Level	Count
GO:0008535	respiratory chain complex IV assembly	7	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0017004	cytochrome complex assembly	6	1
GO:0022607	cellular component assembly	4	1
GO:0033108	mitochondrial respiratory chain complex assembly	6	1
GO:0033617	mitochondrial cytochrome c oxidase assembly	7	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.639
DEG_APCC_KENBOX_2	41	45	PF00400	0.447
DOC_CKS1_1	118	123	PF01111	0.685
DOC_CKS1_1	46	51	PF01111	0.378
DOC_MAPK_gen_1	99	107	PF00069	0.640
DOC_PP4_FxxP_1	76	79	PF00568	0.498
DOC_USP7_UBL2_3	70	74	PF12436	0.664
DOC_WW_Pin1_4	117	122	PF00397	0.684
DOC_WW_Pin1_4	45	50	PF00397	0.355
LIG_14-3-3_CanoR_1	11	19	PF00244	0.595
LIG_BIR_II_1	1	5	PF00653	0.600
LIG_CtBP_PxDLS_1	16	20	PF00389	0.673
LIG_FHA_1	79	85	PF00498	0.544
LIG_LIR_Apic_2	43	49	PF02991	0.339
LIG_LIR_Apic_2	75	79	PF02991	0.525
LIG_LIR_Gen_1	35	46	PF02991	0.355
LIG_LIR_Nem_3	35	41	PF02991	0.355
LIG_SH2_CRK	46	50	PF00017	0.348
LIG_SH2_PTP2	38	41	PF00017	0.217
LIG_SH2_STAT5	113	116	PF00017	0.725
LIG_SH2_STAT5	38	41	PF00017	0.194
LIG_SH2_STAT5	58	61	PF00017	0.473
LIG_WRC_WIRS_1	73	78	PF05994	0.632
MOD_CDK_SPxxK_3	45	52	PF00069	0.378
MOD_CK2_1	29	35	PF00069	0.326
MOD_GSK3_1	6	13	PF00069	0.607
MOD_GSK3_1	68	75	PF00069	0.628
MOD_NEK2_1	10	15	PF00069	0.599
MOD_PKA_2	10	16	PF00069	0.600
MOD_Plk_2-3	29	35	PF00069	0.356
MOD_ProDKin_1	117	123	PF00069	0.685
MOD_ProDKin_1	45	51	PF00069	0.355
MOD_SUMO_rev_2	25	32	PF00179	0.498
TRG_ENDOCYTIC_2	38	41	PF00928	0.335
TRG_ER_diLys_1	126	130	PF00400	0.719
TRG_NES_CRM1_1	100	111	PF08389	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P869	Leptomonas seymouri	85%	100%
A0A0S4JMW5	Bodo saltans	63%	100%
A0A1X0P636	Trypanosomatidae	76%	90%
A0A3R7MHI5	Trypanosoma rangeli	74%	86%
A0A3S7WVM9	Leishmania donovani	98%	100%
A4HA62	Leishmania braziliensis	93%	100%
A4HYD7	Leishmania infantum	98%	100%
D0A0R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	90%
Q4QD96	Leishmania major	98%	100%