Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AS68_LEIMU

TriTrypDb:

LmxM.19.1170

Length:

998

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AS68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS68

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.680
CLV_C14_Caspase3-7	469	473	PF00656	0.502
CLV_C14_Caspase3-7	646	650	PF00656	0.700
CLV_C14_Caspase3-7	981	985	PF00656	0.609
CLV_NRD_NRD_1	206	208	PF00675	0.752
CLV_NRD_NRD_1	498	500	PF00675	0.685
CLV_NRD_NRD_1	526	528	PF00675	0.549
CLV_NRD_NRD_1	63	65	PF00675	0.656
CLV_NRD_NRD_1	680	682	PF00675	0.713
CLV_NRD_NRD_1	93	95	PF00675	0.650
CLV_PCSK_FUR_1	204	208	PF00082	0.571
CLV_PCSK_KEX2_1	144	146	PF00082	0.695
CLV_PCSK_KEX2_1	206	208	PF00082	0.752
CLV_PCSK_KEX2_1	498	500	PF00082	0.574
CLV_PCSK_KEX2_1	526	528	PF00082	0.563
CLV_PCSK_KEX2_1	63	65	PF00082	0.656
CLV_PCSK_KEX2_1	676	678	PF00082	0.633
CLV_PCSK_KEX2_1	680	682	PF00082	0.667
CLV_PCSK_KEX2_1	689	691	PF00082	0.708
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.673
CLV_PCSK_PC1ET2_1	676	678	PF00082	0.633
CLV_PCSK_PC1ET2_1	680	682	PF00082	0.667
CLV_PCSK_PC1ET2_1	689	691	PF00082	0.708
CLV_PCSK_SKI1_1	178	182	PF00082	0.720
CLV_PCSK_SKI1_1	327	331	PF00082	0.709
CLV_PCSK_SKI1_1	471	475	PF00082	0.518
CLV_PCSK_SKI1_1	477	481	PF00082	0.461
CLV_PCSK_SKI1_1	483	487	PF00082	0.422
CLV_PCSK_SKI1_1	537	541	PF00082	0.504
CLV_PCSK_SKI1_1	613	617	PF00082	0.586
CLV_PCSK_SKI1_1	891	895	PF00082	0.520
DEG_SPOP_SBC_1	12	16	PF00917	0.534
DEG_SPOP_SBC_1	160	164	PF00917	0.575
DEG_SPOP_SBC_1	224	228	PF00917	0.666
DEG_SPOP_SBC_1	276	280	PF00917	0.588
DEG_SPOP_SBC_1	284	288	PF00917	0.575
DEG_SPOP_SBC_1	32	36	PF00917	0.518
DEG_SPOP_SBC_1	346	350	PF00917	0.554
DEG_SPOP_SBC_1	38	42	PF00917	0.563
DEG_SPOP_SBC_1	449	453	PF00917	0.654
DEG_SPOP_SBC_1	650	654	PF00917	0.702
DEG_SPOP_SBC_1	978	982	PF00917	0.615
DOC_CKS1_1	266	271	PF01111	0.692
DOC_CYCLIN_RxL_1	477	490	PF00134	0.548
DOC_CYCLIN_yCln2_LP_2	266	272	PF00134	0.733
DOC_CYCLIN_yCln2_LP_2	382	388	PF00134	0.662
DOC_MAPK_FxFP_2	9	12	PF00069	0.536
DOC_MAPK_gen_1	63	69	PF00069	0.658
DOC_PP1_RVXF_1	142	149	PF00149	0.710
DOC_PP1_RVXF_1	176	182	PF00149	0.716
DOC_PP1_RVXF_1	950	956	PF00149	0.539
DOC_PP4_FxxP_1	705	708	PF00568	0.599
DOC_PP4_FxxP_1	729	732	PF00568	0.529
DOC_PP4_FxxP_1	9	12	PF00568	0.536
DOC_USP7_MATH_1	12	16	PF00917	0.534
DOC_USP7_MATH_1	187	191	PF00917	0.735
DOC_USP7_MATH_1	202	206	PF00917	0.588
DOC_USP7_MATH_1	234	238	PF00917	0.576
DOC_USP7_MATH_1	26	30	PF00917	0.524
DOC_USP7_MATH_1	277	281	PF00917	0.734
DOC_USP7_MATH_1	282	286	PF00917	0.686
DOC_USP7_MATH_1	316	320	PF00917	0.658
DOC_USP7_MATH_1	32	36	PF00917	0.522
DOC_USP7_MATH_1	371	375	PF00917	0.712
DOC_USP7_MATH_1	378	382	PF00917	0.651
DOC_USP7_MATH_1	38	42	PF00917	0.582
DOC_USP7_MATH_1	414	418	PF00917	0.613
DOC_USP7_MATH_1	433	437	PF00917	0.603
DOC_USP7_MATH_1	448	452	PF00917	0.596
DOC_USP7_MATH_1	454	458	PF00917	0.570
DOC_USP7_MATH_1	51	55	PF00917	0.606
DOC_USP7_MATH_1	553	557	PF00917	0.558
DOC_USP7_MATH_1	594	598	PF00917	0.715
DOC_USP7_MATH_1	638	642	PF00917	0.734
DOC_USP7_MATH_1	643	647	PF00917	0.688
DOC_USP7_MATH_1	651	655	PF00917	0.610
DOC_USP7_MATH_1	657	661	PF00917	0.543
DOC_USP7_MATH_1	709	713	PF00917	0.714
DOC_USP7_MATH_1	74	78	PF00917	0.599
DOC_USP7_MATH_1	764	768	PF00917	0.695
DOC_USP7_MATH_1	769	773	PF00917	0.644
DOC_USP7_MATH_1	775	779	PF00917	0.558
DOC_USP7_MATH_1	795	799	PF00917	0.661
DOC_USP7_MATH_1	82	86	PF00917	0.661
DOC_USP7_MATH_1	978	982	PF00917	0.708
DOC_USP7_MATH_1	983	987	PF00917	0.642
DOC_USP7_UBL2_3	676	680	PF12436	0.633
DOC_USP7_UBL2_3	689	693	PF12436	0.708
DOC_WW_Pin1_4	131	136	PF00397	0.587
DOC_WW_Pin1_4	225	230	PF00397	0.718
DOC_WW_Pin1_4	238	243	PF00397	0.604
DOC_WW_Pin1_4	265	270	PF00397	0.730
DOC_WW_Pin1_4	285	290	PF00397	0.530
DOC_WW_Pin1_4	336	341	PF00397	0.661
DOC_WW_Pin1_4	363	368	PF00397	0.703
DOC_WW_Pin1_4	39	44	PF00397	0.636
DOC_WW_Pin1_4	394	399	PF00397	0.692
DOC_WW_Pin1_4	407	412	PF00397	0.572
DOC_WW_Pin1_4	437	442	PF00397	0.638
DOC_WW_Pin1_4	45	50	PF00397	0.643
DOC_WW_Pin1_4	499	504	PF00397	0.717
DOC_WW_Pin1_4	505	510	PF00397	0.679
DOC_WW_Pin1_4	589	594	PF00397	0.735
DOC_WW_Pin1_4	655	660	PF00397	0.564
DOC_WW_Pin1_4	681	686	PF00397	0.699
DOC_WW_Pin1_4	749	754	PF00397	0.671
DOC_WW_Pin1_4	812	817	PF00397	0.799
DOC_WW_Pin1_4	822	827	PF00397	0.755
DOC_WW_Pin1_4	863	868	PF00397	0.641
DOC_WW_Pin1_4	906	911	PF00397	0.624
DOC_WW_Pin1_4	967	972	PF00397	0.716
DOC_WW_Pin1_4	979	984	PF00397	0.592
LIG_14-3-3_CanoR_1	127	136	PF00244	0.676
LIG_14-3-3_CanoR_1	139	148	PF00244	0.593
LIG_14-3-3_CanoR_1	191	198	PF00244	0.688
LIG_14-3-3_CanoR_1	206	212	PF00244	0.693
LIG_14-3-3_CanoR_1	216	224	PF00244	0.637
LIG_14-3-3_CanoR_1	327	335	PF00244	0.710
LIG_14-3-3_CanoR_1	498	503	PF00244	0.603
LIG_14-3-3_CanoR_1	537	546	PF00244	0.514
LIG_14-3-3_CanoR_1	554	561	PF00244	0.461
LIG_14-3-3_CanoR_1	690	699	PF00244	0.751
LIG_14-3-3_CanoR_1	901	910	PF00244	0.631
LIG_14-3-3_CanoR_1	94	99	PF00244	0.568
LIG_14-3-3_CanoR_1	952	956	PF00244	0.571
LIG_Actin_WH2_2	102	119	PF00022	0.578
LIG_Actin_WH2_2	456	473	PF00022	0.527
LIG_APCC_ABBA_1	908	913	PF00400	0.647
LIG_BIR_II_1	1	5	PF00653	0.526
LIG_BRCT_BRCA1_1	5	9	PF00533	0.518
LIG_BRCT_BRCA1_1	777	781	PF00533	0.562
LIG_FHA_1	16	22	PF00498	0.523
LIG_FHA_1	233	239	PF00498	0.735
LIG_FHA_1	250	256	PF00498	0.545
LIG_FHA_1	276	282	PF00498	0.559
LIG_FHA_1	310	316	PF00498	0.651
LIG_FHA_1	337	343	PF00498	0.676
LIG_FHA_1	34	40	PF00498	0.527
LIG_FHA_1	349	355	PF00498	0.580
LIG_FHA_1	463	469	PF00498	0.604
LIG_FHA_1	538	544	PF00498	0.498
LIG_FHA_2	116	122	PF00498	0.492
LIG_FHA_2	169	175	PF00498	0.684
LIG_GSK3_LRP6_1	826	831	PF00069	0.560
LIG_LIR_Apic_2	6	12	PF02991	0.524
LIG_LIR_Apic_2	866	872	PF02991	0.696
LIG_LIR_Apic_2	904	910	PF02991	0.563
LIG_LIR_LC3C_4	556	561	PF02991	0.537
LIG_LIR_Nem_3	778	784	PF02991	0.613
LIG_MYND_1	53	57	PF01753	0.576
LIG_MYND_1	732	736	PF01753	0.711
LIG_MYND_1	974	978	PF01753	0.650
LIG_Pex14_1	618	622	PF04695	0.588
LIG_PTAP_UEV_1	765	770	PF05743	0.662
LIG_SH2_CRK	747	751	PF00017	0.718
LIG_SH2_NCK_1	128	132	PF00017	0.485
LIG_SH2_PTP2	907	910	PF00017	0.554
LIG_SH2_STAP1	622	626	PF00017	0.626
LIG_SH2_STAT3	923	926	PF00017	0.596
LIG_SH2_STAT3	928	931	PF00017	0.520
LIG_SH2_STAT5	3	6	PF00017	0.522
LIG_SH2_STAT5	770	773	PF00017	0.633
LIG_SH2_STAT5	907	910	PF00017	0.637
LIG_SH2_STAT5	911	914	PF00017	0.625
LIG_SH2_STAT5	928	931	PF00017	0.395
LIG_SH2_STAT5	98	101	PF00017	0.608
LIG_SH3_1	590	596	PF00018	0.572
LIG_SH3_3	332	338	PF00018	0.637
LIG_SH3_3	340	346	PF00018	0.646
LIG_SH3_3	351	357	PF00018	0.555
LIG_SH3_3	382	388	PF00018	0.666
LIG_SH3_3	40	46	PF00018	0.603
LIG_SH3_3	401	407	PF00018	0.616
LIG_SH3_3	418	424	PF00018	0.555
LIG_SH3_3	517	523	PF00018	0.638
LIG_SH3_3	590	596	PF00018	0.572
LIG_SH3_3	705	711	PF00018	0.642
LIG_SH3_3	755	761	PF00018	0.714
LIG_SH3_3	763	769	PF00018	0.612
LIG_SH3_3	797	803	PF00018	0.612
LIG_SH3_3	813	819	PF00018	0.753
LIG_SH3_3	824	830	PF00018	0.634
LIG_SH3_3	968	974	PF00018	0.721
LIG_SUMO_SIM_anti_2	151	157	PF11976	0.680
LIG_SUMO_SIM_par_1	151	157	PF11976	0.680
LIG_SUMO_SIM_par_1	464	472	PF11976	0.504
LIG_SUMO_SIM_par_1	484	490	PF11976	0.559
LIG_TRAF2_1	603	606	PF00917	0.565
LIG_TRAF2_2	57	62	PF00917	0.518
LIG_WW_1	743	746	PF00397	0.555
LIG_WW_3	508	512	PF00397	0.693
MOD_CDC14_SPxK_1	502	505	PF00782	0.697
MOD_CDC14_SPxK_1	592	595	PF00782	0.573
MOD_CDC14_SPxK_1	658	661	PF00782	0.562
MOD_CDC14_SPxK_1	684	687	PF00782	0.643
MOD_CDK_SPxK_1	499	505	PF00069	0.692
MOD_CDK_SPxK_1	589	595	PF00069	0.601
MOD_CDK_SPxK_1	655	661	PF00069	0.566
MOD_CDK_SPxK_1	681	687	PF00069	0.643
MOD_CK1_1	13	19	PF00069	0.508
MOD_CK1_1	134	140	PF00069	0.636
MOD_CK1_1	164	170	PF00069	0.710
MOD_CK1_1	190	196	PF00069	0.600
MOD_CK1_1	2	8	PF00069	0.516
MOD_CK1_1	218	224	PF00069	0.727
MOD_CK1_1	25	31	PF00069	0.530
MOD_CK1_1	285	291	PF00069	0.710
MOD_CK1_1	319	325	PF00069	0.701
MOD_CK1_1	588	594	PF00069	0.663
MOD_CK1_1	597	603	PF00069	0.705
MOD_CK1_1	738	744	PF00069	0.682
MOD_CK1_1	749	755	PF00069	0.624
MOD_CK1_1	85	91	PF00069	0.694
MOD_CK1_1	874	880	PF00069	0.699
MOD_CK1_1	967	973	PF00069	0.685
MOD_CK2_1	115	121	PF00069	0.489
MOD_CMANNOS	618	621	PF00535	0.581
MOD_GlcNHglycan	129	132	PF01048	0.646
MOD_GlcNHglycan	163	166	PF01048	0.720
MOD_GlcNHglycan	185	188	PF01048	0.687
MOD_GlcNHglycan	192	195	PF01048	0.684
MOD_GlcNHglycan	217	220	PF01048	0.679
MOD_GlcNHglycan	24	27	PF01048	0.563
MOD_GlcNHglycan	28	31	PF01048	0.564
MOD_GlcNHglycan	316	319	PF01048	0.576
MOD_GlcNHglycan	332	335	PF01048	0.542
MOD_GlcNHglycan	354	357	PF01048	0.624
MOD_GlcNHglycan	389	392	PF01048	0.695
MOD_GlcNHglycan	407	410	PF01048	0.539
MOD_GlcNHglycan	416	419	PF01048	0.600
MOD_GlcNHglycan	435	438	PF01048	0.629
MOD_GlcNHglycan	444	447	PF01048	0.670
MOD_GlcNHglycan	452	455	PF01048	0.590
MOD_GlcNHglycan	456	459	PF01048	0.531
MOD_GlcNHglycan	493	496	PF01048	0.614
MOD_GlcNHglycan	600	603	PF01048	0.757
MOD_GlcNHglycan	645	648	PF01048	0.741
MOD_GlcNHglycan	715	719	PF01048	0.621
MOD_GlcNHglycan	72	75	PF01048	0.634
MOD_GlcNHglycan	721	724	PF01048	0.750
MOD_GlcNHglycan	737	740	PF01048	0.558
MOD_GlcNHglycan	753	756	PF01048	0.551
MOD_GlcNHglycan	766	769	PF01048	0.579
MOD_GlcNHglycan	771	774	PF01048	0.522
MOD_GlcNHglycan	795	798	PF01048	0.628
MOD_GlcNHglycan	84	87	PF01048	0.645
MOD_GlcNHglycan	873	876	PF01048	0.693
MOD_GlcNHglycan	965	969	PF01048	0.704
MOD_GlcNHglycan	987	990	PF01048	0.703
MOD_GSK3_1	11	18	PF00069	0.540
MOD_GSK3_1	127	134	PF00069	0.508
MOD_GSK3_1	159	166	PF00069	0.702
MOD_GSK3_1	183	190	PF00069	0.691
MOD_GSK3_1	214	221	PF00069	0.728
MOD_GSK3_1	22	29	PF00069	0.530
MOD_GSK3_1	230	237	PF00069	0.558
MOD_GSK3_1	271	278	PF00069	0.636
MOD_GSK3_1	290	297	PF00069	0.621
MOD_GSK3_1	325	332	PF00069	0.629
MOD_GSK3_1	33	40	PF00069	0.561
MOD_GSK3_1	348	355	PF00069	0.653
MOD_GSK3_1	359	366	PF00069	0.628
MOD_GSK3_1	387	394	PF00069	0.699
MOD_GSK3_1	431	438	PF00069	0.693
MOD_GSK3_1	450	457	PF00069	0.527
MOD_GSK3_1	462	469	PF00069	0.532
MOD_GSK3_1	548	555	PF00069	0.400
MOD_GSK3_1	585	592	PF00069	0.792
MOD_GSK3_1	594	601	PF00069	0.764
MOD_GSK3_1	634	641	PF00069	0.752
MOD_GSK3_1	651	658	PF00069	0.567
MOD_GSK3_1	70	77	PF00069	0.549
MOD_GSK3_1	822	829	PF00069	0.794
MOD_GSK3_1	839	846	PF00069	0.586
MOD_GSK3_1	960	967	PF00069	0.604
MOD_GSK3_1	979	986	PF00069	0.522
MOD_LATS_1	489	495	PF00433	0.583
MOD_N-GLC_1	238	243	PF02516	0.658
MOD_N-GLC_1	491	496	PF02516	0.599
MOD_N-GLC_1	833	838	PF02516	0.642
MOD_NEK2_1	1	6	PF00069	0.525
MOD_NEK2_1	115	120	PF00069	0.489
MOD_NEK2_1	329	334	PF00069	0.644
MOD_NEK2_1	33	38	PF00069	0.601
MOD_NEK2_1	69	74	PF00069	0.597
MOD_PIKK_1	134	140	PF00454	0.530
MOD_PIKK_1	154	160	PF00454	0.679
MOD_PIKK_1	271	277	PF00454	0.661
MOD_PIKK_1	348	354	PF00454	0.603
MOD_PIKK_1	380	386	PF00454	0.593
MOD_PIKK_1	545	551	PF00454	0.560
MOD_PIKK_1	594	600	PF00454	0.791
MOD_PIKK_1	651	657	PF00454	0.563
MOD_PIKK_1	783	789	PF00454	0.666
MOD_PIKK_1	833	839	PF00454	0.624
MOD_PIKK_1	927	933	PF00454	0.494
MOD_PK_1	220	226	PF00069	0.700
MOD_PK_1	839	845	PF00069	0.559
MOD_PKA_1	498	504	PF00069	0.545
MOD_PKA_1	94	100	PF00069	0.564
MOD_PKA_2	138	144	PF00069	0.622
MOD_PKA_2	183	189	PF00069	0.715
MOD_PKA_2	190	196	PF00069	0.683
MOD_PKA_2	215	221	PF00069	0.719
MOD_PKA_2	22	28	PF00069	0.525
MOD_PKA_2	498	504	PF00069	0.610
MOD_PKA_2	512	518	PF00069	0.533
MOD_PKA_2	553	559	PF00069	0.656
MOD_PKA_2	594	600	PF00069	0.568
MOD_PKA_2	951	957	PF00069	0.569
MOD_Plk_1	319	325	PF00069	0.701
MOD_Plk_2-3	466	472	PF00069	0.501
MOD_Plk_4	149	155	PF00069	0.712
MOD_Plk_4	262	268	PF00069	0.727
MOD_Plk_4	290	296	PF00069	0.717
MOD_Plk_4	709	715	PF00069	0.653
MOD_Plk_4	775	781	PF00069	0.586
MOD_Plk_4	94	100	PF00069	0.451
MOD_Plk_4	951	957	PF00069	0.544
MOD_ProDKin_1	131	137	PF00069	0.589
MOD_ProDKin_1	225	231	PF00069	0.716
MOD_ProDKin_1	238	244	PF00069	0.603
MOD_ProDKin_1	265	271	PF00069	0.731
MOD_ProDKin_1	285	291	PF00069	0.528
MOD_ProDKin_1	336	342	PF00069	0.661
MOD_ProDKin_1	363	369	PF00069	0.706
MOD_ProDKin_1	39	45	PF00069	0.638
MOD_ProDKin_1	394	400	PF00069	0.687
MOD_ProDKin_1	407	413	PF00069	0.571
MOD_ProDKin_1	437	443	PF00069	0.639
MOD_ProDKin_1	499	505	PF00069	0.718
MOD_ProDKin_1	589	595	PF00069	0.736
MOD_ProDKin_1	655	661	PF00069	0.566
MOD_ProDKin_1	681	687	PF00069	0.701
MOD_ProDKin_1	749	755	PF00069	0.671
MOD_ProDKin_1	812	818	PF00069	0.795
MOD_ProDKin_1	822	828	PF00069	0.756
MOD_ProDKin_1	863	869	PF00069	0.641
MOD_ProDKin_1	906	912	PF00069	0.619
MOD_ProDKin_1	967	973	PF00069	0.714
MOD_ProDKin_1	979	985	PF00069	0.593
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.491
TRG_DiLeu_BaLyEn_6	534	539	PF01217	0.426
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.659
TRG_ENDOCYTIC_2	747	750	PF00928	0.719
TRG_ER_diArg_1	176	179	PF00400	0.715
TRG_ER_diArg_1	203	206	PF00400	0.689
TRG_ER_diArg_1	510	513	PF00400	0.749
TRG_NLS_MonoExtN_4	677	684	PF00514	0.558
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	483	487	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	537	541	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	939	943	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H766	Leishmania donovani	83%	100%
A4HA64	Leishmania braziliensis	61%	97%
A4HYD5	Leishmania infantum	82%	100%
Q4QD98	Leishmania major	81%	97%