Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AS65_LEIMU

TriTrypDb:

LmxM.19.1140

Length:

778

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 0
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AS65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS65

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.496
CLV_C14_Caspase3-7	43	47	PF00656	0.661
CLV_NRD_NRD_1	159	161	PF00675	0.688
CLV_NRD_NRD_1	166	168	PF00675	0.772
CLV_NRD_NRD_1	231	233	PF00675	0.630
CLV_NRD_NRD_1	330	332	PF00675	0.515
CLV_NRD_NRD_1	645	647	PF00675	0.672
CLV_NRD_NRD_1	668	670	PF00675	0.467
CLV_NRD_NRD_1	709	711	PF00675	0.750
CLV_NRD_NRD_1	767	769	PF00675	0.629
CLV_PCSK_KEX2_1	158	160	PF00082	0.681
CLV_PCSK_KEX2_1	166	168	PF00082	0.611
CLV_PCSK_KEX2_1	231	233	PF00082	0.630
CLV_PCSK_KEX2_1	645	647	PF00082	0.670
CLV_PCSK_KEX2_1	668	670	PF00082	0.467
CLV_PCSK_KEX2_1	709	711	PF00082	0.749
CLV_PCSK_KEX2_1	767	769	PF00082	0.629
CLV_PCSK_SKI1_1	166	170	PF00082	0.524
CLV_PCSK_SKI1_1	331	335	PF00082	0.482
CLV_PCSK_SKI1_1	688	692	PF00082	0.487
DEG_Nend_UBRbox_2	1	3	PF02207	0.658
DEG_SCF_FBW7_1	227	233	PF00400	0.518
DEG_SCF_FBW7_1	249	256	PF00400	0.496
DEG_SPOP_SBC_1	117	121	PF00917	0.606
DEG_SPOP_SBC_1	143	147	PF00917	0.553
DOC_CKS1_1	227	232	PF01111	0.588
DOC_CYCLIN_yCln2_LP_2	337	343	PF00134	0.639
DOC_MAPK_gen_1	674	682	PF00069	0.509
DOC_MAPK_MEF2A_6	15	24	PF00069	0.397
DOC_PP2B_LxvP_1	689	692	PF13499	0.486
DOC_PP4_FxxP_1	599	602	PF00568	0.660
DOC_PP4_FxxP_1	694	697	PF00568	0.549
DOC_PP4_FxxP_1	9	12	PF00568	0.655
DOC_PP4_FxxP_1	94	97	PF00568	0.520
DOC_USP7_MATH_1	107	111	PF00917	0.665
DOC_USP7_MATH_1	117	121	PF00917	0.699
DOC_USP7_MATH_1	143	147	PF00917	0.575
DOC_USP7_MATH_1	182	186	PF00917	0.602
DOC_USP7_MATH_1	192	196	PF00917	0.620
DOC_USP7_MATH_1	230	234	PF00917	0.610
DOC_USP7_MATH_1	297	301	PF00917	0.548
DOC_USP7_MATH_1	400	404	PF00917	0.641
DOC_USP7_MATH_1	421	425	PF00917	0.588
DOC_USP7_MATH_1	558	562	PF00917	0.787
DOC_USP7_MATH_1	593	597	PF00917	0.726
DOC_USP7_MATH_1	712	716	PF00917	0.671
DOC_WW_Pin1_4	113	118	PF00397	0.657
DOC_WW_Pin1_4	132	137	PF00397	0.504
DOC_WW_Pin1_4	213	218	PF00397	0.538
DOC_WW_Pin1_4	226	231	PF00397	0.554
DOC_WW_Pin1_4	249	254	PF00397	0.693
DOC_WW_Pin1_4	266	271	PF00397	0.605
DOC_WW_Pin1_4	336	341	PF00397	0.620
DOC_WW_Pin1_4	416	421	PF00397	0.512
DOC_WW_Pin1_4	469	474	PF00397	0.626
DOC_WW_Pin1_4	553	558	PF00397	0.677
DOC_WW_Pin1_4	81	86	PF00397	0.746
LIG_14-3-3_CanoR_1	128	136	PF00244	0.521
LIG_14-3-3_CanoR_1	15	20	PF00244	0.439
LIG_14-3-3_CanoR_1	159	165	PF00244	0.680
LIG_14-3-3_CanoR_1	222	228	PF00244	0.604
LIG_14-3-3_CanoR_1	231	239	PF00244	0.628
LIG_14-3-3_CanoR_1	30	35	PF00244	0.362
LIG_14-3-3_CanoR_1	331	340	PF00244	0.506
LIG_14-3-3_CanoR_1	381	390	PF00244	0.532
LIG_14-3-3_CanoR_1	508	517	PF00244	0.603
LIG_BIR_III_2	504	508	PF00653	0.504
LIG_BRCT_BRCA1_1	595	599	PF00533	0.731
LIG_BRCT_BRCA1_1	62	66	PF00533	0.509
LIG_BRCT_BRCA1_1	694	698	PF00533	0.623
LIG_deltaCOP1_diTrp_1	684	694	PF00928	0.479
LIG_FHA_1	16	22	PF00498	0.478
LIG_FHA_1	170	176	PF00498	0.581
LIG_FHA_1	246	252	PF00498	0.642
LIG_FHA_1	300	306	PF00498	0.604
LIG_FHA_1	332	338	PF00498	0.505
LIG_FHA_1	357	363	PF00498	0.499
LIG_FHA_1	449	455	PF00498	0.537
LIG_FHA_1	457	463	PF00498	0.492
LIG_FHA_1	525	531	PF00498	0.518
LIG_FHA_1	554	560	PF00498	0.566
LIG_FHA_2	240	246	PF00498	0.662
LIG_FHA_2	250	256	PF00498	0.564
LIG_FHA_2	350	356	PF00498	0.556
LIG_FHA_2	537	543	PF00498	0.662
LIG_FHA_2	598	604	PF00498	0.656
LIG_Integrin_RGD_1	732	734	PF01839	0.546
LIG_LIR_Apic_2	218	224	PF02991	0.493
LIG_LIR_Apic_2	596	602	PF02991	0.683
LIG_LIR_Apic_2	693	697	PF02991	0.601
LIG_LIR_Gen_1	355	364	PF02991	0.497
LIG_LIR_Gen_1	675	685	PF02991	0.491
LIG_LIR_Nem_3	396	401	PF02991	0.539
LIG_LIR_Nem_3	527	531	PF02991	0.703
LIG_LIR_Nem_3	541	547	PF02991	0.562
LIG_LIR_Nem_3	63	69	PF02991	0.549
LIG_LIR_Nem_3	675	680	PF02991	0.570
LIG_LIR_Nem_3	684	690	PF02991	0.423
LIG_LIR_Nem_3	725	731	PF02991	0.600
LIG_NRBOX	300	306	PF00104	0.536
LIG_NRBOX	571	577	PF00104	0.562
LIG_PCNA_yPIPBox_3	751	762	PF02747	0.517
LIG_Pex14_2	694	698	PF04695	0.550
LIG_PTAP_UEV_1	704	709	PF05743	0.512
LIG_Rb_pABgroove_1	642	650	PF01858	0.491
LIG_RPA_C_Fungi	376	388	PF08784	0.479
LIG_SH2_CRK	17	21	PF00017	0.409
LIG_SH2_CRK	82	86	PF00017	0.527
LIG_SH2_NCK_1	34	38	PF00017	0.518
LIG_SH2_SRC	648	651	PF00017	0.566
LIG_SH2_STAP1	357	361	PF00017	0.496
LIG_SH2_STAP1	444	448	PF00017	0.428
LIG_SH2_STAT3	139	142	PF00017	0.721
LIG_SH2_STAT5	139	142	PF00017	0.651
LIG_SH2_STAT5	17	20	PF00017	0.507
LIG_SH2_STAT5	351	354	PF00017	0.578
LIG_SH2_STAT5	479	482	PF00017	0.654
LIG_SH2_STAT5	567	570	PF00017	0.470
LIG_SH3_1	8	14	PF00018	0.657
LIG_SH3_2	705	710	PF14604	0.514
LIG_SH3_3	119	125	PF00018	0.653
LIG_SH3_3	191	197	PF00018	0.503
LIG_SH3_3	224	230	PF00018	0.607
LIG_SH3_3	394	400	PF00018	0.738
LIG_SH3_3	414	420	PF00018	0.614
LIG_SH3_3	467	473	PF00018	0.621
LIG_SH3_3	520	526	PF00018	0.609
LIG_SH3_3	702	708	PF00018	0.588
LIG_SH3_3	8	14	PF00018	0.657
LIG_SUMO_SIM_par_1	245	252	PF11976	0.627
LIG_TRAF2_1	436	439	PF00917	0.493
LIG_TRAF2_1	563	566	PF00917	0.636
LIG_TRAF2_1	602	605	PF00917	0.655
LIG_Vh1_VBS_1	446	464	PF01044	0.410
LIG_WRC_WIRS_1	691	696	PF05994	0.590
LIG_WW_3	121	125	PF00397	0.599
LIG_WW_3	516	520	PF00397	0.579
MOD_CDK_SPK_2	226	231	PF00069	0.566
MOD_CDK_SPxK_1	118	124	PF00069	0.604
MOD_CDK_SPxK_1	226	232	PF00069	0.518
MOD_CDK_SPxxK_3	266	273	PF00069	0.490
MOD_CK1_1	110	116	PF00069	0.576
MOD_CK1_1	135	141	PF00069	0.553
MOD_CK1_1	162	168	PF00069	0.681
MOD_CK1_1	180	186	PF00069	0.510
MOD_CK1_1	238	244	PF00069	0.714
MOD_CK1_1	265	271	PF00069	0.639
MOD_CK1_1	379	385	PF00069	0.639
MOD_CK1_1	409	415	PF00069	0.491
MOD_CK1_1	509	515	PF00069	0.676
MOD_CK1_1	534	540	PF00069	0.556
MOD_CK1_1	548	554	PF00069	0.638
MOD_CK1_1	588	594	PF00069	0.579
MOD_CK1_1	653	659	PF00069	0.556
MOD_CK1_1	700	706	PF00069	0.752
MOD_CK1_1	715	721	PF00069	0.701
MOD_CK2_1	180	186	PF00069	0.668
MOD_CK2_1	239	245	PF00069	0.667
MOD_CK2_1	249	255	PF00069	0.567
MOD_CK2_1	349	355	PF00069	0.581
MOD_CK2_1	367	373	PF00069	0.656
MOD_CK2_1	405	411	PF00069	0.652
MOD_CK2_1	560	566	PF00069	0.661
MOD_CK2_1	678	684	PF00069	0.479
MOD_CK2_1	70	76	PF00069	0.610
MOD_CK2_1	769	775	PF00069	0.614
MOD_GlcNHglycan	109	112	PF01048	0.631
MOD_GlcNHglycan	182	185	PF01048	0.787
MOD_GlcNHglycan	190	193	PF01048	0.569
MOD_GlcNHglycan	264	267	PF01048	0.615
MOD_GlcNHglycan	384	387	PF01048	0.521
MOD_GlcNHglycan	423	426	PF01048	0.610
MOD_GlcNHglycan	508	511	PF01048	0.594
MOD_GlcNHglycan	547	550	PF01048	0.666
MOD_GlcNHglycan	56	59	PF01048	0.728
MOD_GlcNHglycan	562	565	PF01048	0.507
MOD_GlcNHglycan	590	594	PF01048	0.704
MOD_GlcNHglycan	694	697	PF01048	0.603
MOD_GlcNHglycan	705	708	PF01048	0.570
MOD_GSK3_1	109	116	PF00069	0.683
MOD_GSK3_1	127	134	PF00069	0.579
MOD_GSK3_1	138	145	PF00069	0.747
MOD_GSK3_1	162	169	PF00069	0.616
MOD_GSK3_1	188	195	PF00069	0.793
MOD_GSK3_1	222	229	PF00069	0.666
MOD_GSK3_1	230	237	PF00069	0.638
MOD_GSK3_1	239	246	PF00069	0.574
MOD_GSK3_1	249	256	PF00069	0.581
MOD_GSK3_1	262	269	PF00069	0.574
MOD_GSK3_1	283	290	PF00069	0.765
MOD_GSK3_1	295	302	PF00069	0.663
MOD_GSK3_1	331	338	PF00069	0.514
MOD_GSK3_1	377	384	PF00069	0.561
MOD_GSK3_1	405	412	PF00069	0.787
MOD_GSK3_1	448	455	PF00069	0.512
MOD_GSK3_1	48	55	PF00069	0.689
MOD_GSK3_1	534	541	PF00069	0.580
MOD_GSK3_1	543	550	PF00069	0.705
MOD_GSK3_1	567	574	PF00069	0.506
MOD_GSK3_1	585	592	PF00069	0.746
MOD_GSK3_1	593	600	PF00069	0.654
MOD_GSK3_1	648	655	PF00069	0.607
MOD_GSK3_1	712	719	PF00069	0.770
MOD_GSK3_1	98	105	PF00069	0.672
MOD_LATS_1	13	19	PF00433	0.460
MOD_LATS_1	374	380	PF00433	0.493
MOD_LATS_1	543	549	PF00433	0.664
MOD_N-GLC_1	132	137	PF02516	0.773
MOD_N-GLC_1	243	248	PF02516	0.657
MOD_N-GLC_1	409	414	PF02516	0.640
MOD_N-GLC_1	87	92	PF02516	0.662
MOD_NEK2_1	239	244	PF00069	0.655
MOD_NEK2_1	283	288	PF00069	0.672
MOD_NEK2_1	415	420	PF00069	0.581
MOD_NEK2_1	448	453	PF00069	0.515
MOD_NEK2_1	48	53	PF00069	0.684
MOD_NEK2_1	547	552	PF00069	0.663
MOD_NEK2_1	589	594	PF00069	0.677
MOD_NEK2_1	658	663	PF00069	0.664
MOD_NEK2_1	698	703	PF00069	0.644
MOD_NEK2_1	721	726	PF00069	0.490
MOD_NEK2_2	393	398	PF00069	0.470
MOD_PIKK_1	138	144	PF00454	0.580
MOD_PIKK_1	2	8	PF00454	0.675
MOD_PIKK_1	230	236	PF00454	0.526
MOD_PIKK_1	400	406	PF00454	0.486
MOD_PIKK_1	409	415	PF00454	0.645
MOD_PIKK_1	87	93	PF00454	0.651
MOD_PK_1	160	166	PF00069	0.681
MOD_PK_1	676	682	PF00069	0.561
MOD_PKA_1	159	165	PF00069	0.680
MOD_PKA_1	166	172	PF00069	0.611
MOD_PKA_1	331	337	PF00069	0.491
MOD_PKA_2	127	133	PF00069	0.687
MOD_PKA_2	159	165	PF00069	0.667
MOD_PKA_2	166	172	PF00069	0.642
MOD_PKA_2	230	236	PF00069	0.526
MOD_PKA_2	524	530	PF00069	0.783
MOD_PKB_1	158	166	PF00069	0.689
MOD_Plk_1	244	250	PF00069	0.657
MOD_Plk_1	48	54	PF00069	0.657
MOD_Plk_1	565	571	PF00069	0.560
MOD_Plk_1	649	655	PF00069	0.538
MOD_Plk_4	135	141	PF00069	0.647
MOD_Plk_4	393	399	PF00069	0.470
MOD_Plk_4	439	445	PF00069	0.502
MOD_Plk_4	456	462	PF00069	0.516
MOD_Plk_4	571	577	PF00069	0.569
MOD_Plk_4	593	599	PF00069	0.754
MOD_Plk_4	653	659	PF00069	0.476
MOD_Plk_4	717	723	PF00069	0.496
MOD_ProDKin_1	113	119	PF00069	0.659
MOD_ProDKin_1	132	138	PF00069	0.500
MOD_ProDKin_1	213	219	PF00069	0.541
MOD_ProDKin_1	226	232	PF00069	0.557
MOD_ProDKin_1	249	255	PF00069	0.693
MOD_ProDKin_1	266	272	PF00069	0.606
MOD_ProDKin_1	336	342	PF00069	0.625
MOD_ProDKin_1	416	422	PF00069	0.514
MOD_ProDKin_1	469	475	PF00069	0.628
MOD_ProDKin_1	553	559	PF00069	0.680
MOD_ProDKin_1	81	87	PF00069	0.744
TRG_DiLeu_BaLyEn_6	449	454	PF01217	0.549
TRG_ENDOCYTIC_2	357	360	PF00928	0.493
TRG_ENDOCYTIC_2	398	401	PF00928	0.769
TRG_ENDOCYTIC_2	728	731	PF00928	0.570
TRG_ER_diArg_1	158	160	PF00400	0.681
TRG_ER_diArg_1	166	168	PF00400	0.611
TRG_ER_diArg_1	230	232	PF00400	0.545
TRG_ER_diArg_1	644	646	PF00400	0.671
TRG_ER_diArg_1	668	671	PF00400	0.465
TRG_ER_diArg_1	708	710	PF00400	0.748
TRG_ER_diArg_1	766	768	PF00400	0.559
TRG_Pf-PMV_PEXEL_1	645	649	PF00026	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEQ0	Leptomonas seymouri	29%	100%
A0A3S7WVJ5	Leishmania donovani	75%	96%
A4HYD2	Leishmania infantum	75%	96%
Q4QDA1	Leishmania major	74%	100%