Miff domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AS60_LEIMU

TriTrypDb:

LmxM.19.1090

Length:

202

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AS60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS60

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.738
CLV_NRD_NRD_1	142	144	PF00675	0.417
CLV_PCSK_KEX2_1	142	144	PF00082	0.417
CLV_PCSK_SKI1_1	33	37	PF00082	0.389
DEG_APCC_DBOX_1	32	40	PF00400	0.589
DEG_APCC_DBOX_1	96	104	PF00400	0.556
DEG_MDM2_SWIB_1	172	179	PF02201	0.582
DEG_Nend_UBRbox_1	1	4	PF02207	0.617
DOC_CYCLIN_yClb5_NLxxxL_5	175	183	PF00134	0.453
DOC_PP2B_LxvP_1	79	82	PF13499	0.646
DOC_PP2B_LxvP_1	8	11	PF13499	0.613
DOC_USP7_MATH_1	111	115	PF00917	0.640
DOC_USP7_MATH_1	35	39	PF00917	0.699
DOC_USP7_MATH_1	84	88	PF00917	0.744
DOC_WW_Pin1_4	64	69	PF00397	0.636
DOC_WW_Pin1_4	80	85	PF00397	0.606
LIG_14-3-3_CanoR_1	126	136	PF00244	0.605
LIG_Actin_WH2_2	29	47	PF00022	0.595
LIG_deltaCOP1_diTrp_1	17	24	PF00928	0.596
LIG_eIF4E_1	99	105	PF01652	0.555
LIG_FHA_1	196	202	PF00498	0.456
LIG_FHA_1	58	64	PF00498	0.636
LIG_GBD_Chelix_1	187	195	PF00786	0.324
LIG_LIR_Gen_1	120	128	PF02991	0.617
LIG_LIR_Gen_1	174	184	PF02991	0.454
LIG_LIR_Gen_1	23	32	PF02991	0.579
LIG_LIR_Nem_3	120	125	PF02991	0.625
LIG_LIR_Nem_3	161	167	PF02991	0.641
LIG_LIR_Nem_3	174	179	PF02991	0.431
LIG_LIR_Nem_3	23	27	PF02991	0.580
LIG_NRBOX	132	138	PF00104	0.614
LIG_Pex14_2	172	176	PF04695	0.590
LIG_Pex14_2	192	196	PF04695	0.324
LIG_SH2_STAP1	167	171	PF00017	0.654
LIG_SH2_STAT3	99	102	PF00017	0.613
LIG_SH2_STAT5	164	167	PF00017	0.762
LIG_SH2_STAT5	193	196	PF00017	0.324
LIG_SH2_STAT5	99	102	PF00017	0.638
LIG_SH3_2	68	73	PF14604	0.634
LIG_SH3_3	53	59	PF00018	0.623
LIG_SH3_3	65	71	PF00018	0.632
MOD_CDK_SPxxK_3	66	73	PF00069	0.636
MOD_CK1_1	57	63	PF00069	0.705
MOD_CK1_1	80	86	PF00069	0.756
MOD_DYRK1A_RPxSP_1	66	70	PF00069	0.635
MOD_GlcNHglycan	113	116	PF01048	0.487
MOD_GlcNHglycan	156	159	PF01048	0.502
MOD_GSK3_1	137	144	PF00069	0.619
MOD_GSK3_1	154	161	PF00069	0.608
MOD_GSK3_1	80	87	PF00069	0.728
MOD_NEK2_1	137	142	PF00069	0.642
MOD_NEK2_2	35	40	PF00069	0.587
MOD_NEK2_2	86	91	PF00069	0.615
MOD_PKA_1	142	148	PF00069	0.625
MOD_PKA_2	141	147	PF00069	0.635
MOD_PKB_1	52	60	PF00069	0.612
MOD_Plk_1	22	28	PF00069	0.647
MOD_Plk_4	132	138	PF00069	0.614
MOD_Plk_4	4	10	PF00069	0.742
MOD_ProDKin_1	64	70	PF00069	0.635
MOD_ProDKin_1	80	86	PF00069	0.604
TRG_ENDOCYTIC_2	122	125	PF00928	0.621
TRG_ER_diArg_1	105	108	PF00400	0.680
TRG_ER_diArg_1	52	55	PF00400	0.610

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HYC6	Leishmania infantum	69%	84%
Q4QDA6	Leishmania major	58%	100%