LeishMANIAdb
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DAGKc domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DAGKc domain-containing protein
Gene product:
Diacylglycerol kinase catalytic domain containing protein, putative
Species:
Leishmania mexicana
UniProt:
E9AS58_LEIMU
TriTrypDb:
LmxM.19.1070
Length:
964

Annotations

LeishMANIAdb annotations

Could be a sphingosine kinase. Membrane-associated without any TM segments.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2
GO:0032991 protein-containing complex 1 1
GO:0042721 TIM22 mitochondrial import inner membrane insertion complex 4 1
GO:0098796 membrane protein complex 2 1
GO:0098798 mitochondrial protein-containing complex 2 1
GO:0098800 inner mitochondrial membrane protein complex 3 1

Expansion

Sequence features

E9AS58
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS58

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006839 mitochondrial transport 4 1
GO:0006886 intracellular protein transport 4 1
GO:0006996 organelle organization 4 1
GO:0007005 mitochondrion organization 5 1
GO:0007006 mitochondrial membrane organization 5 1
GO:0007007 inner mitochondrial membrane organization 6 1
GO:0008104 protein localization 4 1
GO:0009987 cellular process 1 2
GO:0015031 protein transport 4 1
GO:0016043 cellular component organization 3 1
GO:0033036 macromolecule localization 2 1
GO:0033365 protein localization to organelle 5 1
GO:0045039 protein insertion into mitochondrial inner membrane 6 1
GO:0045184 establishment of protein localization 3 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051204 protein insertion into mitochondrial membrane 5 1
GO:0051205 protein insertion into membrane 5 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0051668 localization within membrane 3 1
GO:0061024 membrane organization 4 1
GO:0070585 protein localization to mitochondrion 6 1
GO:0070727 cellular macromolecule localization 3 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0072594 establishment of protein localization to organelle 4 1
GO:0072655 establishment of protein localization to mitochondrion 5 1
GO:0072657 protein localization to membrane 4 1
GO:0090150 establishment of protein localization to membrane 4 1
GO:0090151 establishment of protein localization to mitochondrial membrane 4 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0008152 metabolic process 1 1
GO:0016310 phosphorylation 5 1
GO:0044237 cellular metabolic process 2 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 6
GO:0016301 kinase activity 4 6
GO:0016740 transferase activity 2 6
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 6
GO:0017050 D-erythro-sphingosine kinase activity 5 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 271 275 PF00656 0.400
CLV_C14_Caspase3-7 831 835 PF00656 0.488
CLV_C14_Caspase3-7 925 929 PF00656 0.563
CLV_NRD_NRD_1 331 333 PF00675 0.269
CLV_NRD_NRD_1 552 554 PF00675 0.805
CLV_NRD_NRD_1 692 694 PF00675 0.740
CLV_NRD_NRD_1 951 953 PF00675 0.446
CLV_PCSK_FUR_1 550 554 PF00082 0.794
CLV_PCSK_KEX2_1 552 554 PF00082 0.805
CLV_PCSK_KEX2_1 692 694 PF00082 0.734
CLV_PCSK_KEX2_1 935 937 PF00082 0.455
CLV_PCSK_KEX2_1 950 952 PF00082 0.453
CLV_PCSK_PC1ET2_1 935 937 PF00082 0.345
CLV_PCSK_SKI1_1 395 399 PF00082 0.293
CLV_PCSK_SKI1_1 621 625 PF00082 0.558
CLV_PCSK_SKI1_1 868 872 PF00082 0.340
DEG_APCC_DBOX_1 620 628 PF00400 0.348
DEG_APCC_DBOX_1 926 934 PF00400 0.639
DEG_SPOP_SBC_1 186 190 PF00917 0.639
DEG_SPOP_SBC_1 336 340 PF00917 0.653
DEG_SPOP_SBC_1 510 514 PF00917 0.443
DEG_SPOP_SBC_1 519 523 PF00917 0.461
DEG_SPOP_SBC_1 650 654 PF00917 0.532
DEG_SPOP_SBC_1 677 681 PF00917 0.545
DOC_ANK_TNKS_1 559 566 PF00023 0.544
DOC_CDC14_PxL_1 790 798 PF14671 0.208
DOC_CKS1_1 125 130 PF01111 0.646
DOC_CKS1_1 616 621 PF01111 0.448
DOC_CKS1_1 916 921 PF01111 0.599
DOC_CYCLIN_yCln2_LP_2 294 300 PF00134 0.510
DOC_MAPK_DCC_7 204 214 PF00069 0.616
DOC_MAPK_gen_1 204 214 PF00069 0.661
DOC_MAPK_MEF2A_6 18 25 PF00069 0.563
DOC_MAPK_MEF2A_6 452 461 PF00069 0.421
DOC_PP1_RVXF_1 384 390 PF00149 0.488
DOC_PP1_RVXF_1 798 805 PF00149 0.205
DOC_PP1_RVXF_1 866 872 PF00149 0.497
DOC_PP2B_LxvP_1 582 585 PF13499 0.491
DOC_PP2B_LxvP_1 765 768 PF13499 0.310
DOC_PP4_FxxP_1 791 794 PF00568 0.208
DOC_PP4_FxxP_1 871 874 PF00568 0.488
DOC_SPAK_OSR1_1 814 818 PF12202 0.465
DOC_USP7_MATH_1 102 106 PF00917 0.640
DOC_USP7_MATH_1 108 112 PF00917 0.638
DOC_USP7_MATH_1 132 136 PF00917 0.780
DOC_USP7_MATH_1 186 190 PF00917 0.747
DOC_USP7_MATH_1 194 198 PF00917 0.775
DOC_USP7_MATH_1 224 228 PF00917 0.725
DOC_USP7_MATH_1 277 281 PF00917 0.564
DOC_USP7_MATH_1 336 340 PF00917 0.763
DOC_USP7_MATH_1 356 360 PF00917 0.596
DOC_USP7_MATH_1 364 368 PF00917 0.669
DOC_USP7_MATH_1 433 437 PF00917 0.383
DOC_USP7_MATH_1 650 654 PF00917 0.502
DOC_USP7_MATH_1 677 681 PF00917 0.517
DOC_USP7_MATH_1 94 98 PF00917 0.838
DOC_USP7_MATH_1 953 957 PF00917 0.693
DOC_WW_Pin1_4 124 129 PF00397 0.679
DOC_WW_Pin1_4 207 212 PF00397 0.672
DOC_WW_Pin1_4 315 320 PF00397 0.473
DOC_WW_Pin1_4 358 363 PF00397 0.721
DOC_WW_Pin1_4 441 446 PF00397 0.339
DOC_WW_Pin1_4 479 484 PF00397 0.506
DOC_WW_Pin1_4 511 516 PF00397 0.524
DOC_WW_Pin1_4 520 525 PF00397 0.457
DOC_WW_Pin1_4 599 604 PF00397 0.581
DOC_WW_Pin1_4 615 620 PF00397 0.397
DOC_WW_Pin1_4 627 632 PF00397 0.483
DOC_WW_Pin1_4 87 92 PF00397 0.698
DOC_WW_Pin1_4 915 920 PF00397 0.629
LIG_14-3-3_CanoR_1 192 200 PF00244 0.665
LIG_14-3-3_CanoR_1 216 222 PF00244 0.771
LIG_14-3-3_CanoR_1 223 232 PF00244 0.673
LIG_14-3-3_CanoR_1 365 371 PF00244 0.694
LIG_14-3-3_CanoR_1 421 426 PF00244 0.510
LIG_14-3-3_CanoR_1 456 462 PF00244 0.351
LIG_14-3-3_CanoR_1 550 559 PF00244 0.539
LIG_14-3-3_CanoR_1 613 617 PF00244 0.506
LIG_14-3-3_CanoR_1 66 71 PF00244 0.533
LIG_14-3-3_CanoR_1 805 810 PF00244 0.469
LIG_14-3-3_CanoR_1 906 916 PF00244 0.744
LIG_14-3-3_CanoR_1 921 927 PF00244 0.608
LIG_Actin_WH2_2 537 554 PF00022 0.459
LIG_APCC_ABBA_1 766 771 PF00400 0.199
LIG_BIR_III_2 728 732 PF00653 0.483
LIG_BRCT_BRCA1_1 371 375 PF00533 0.549
LIG_BRCT_BRCA1_1 47 51 PF00533 0.495
LIG_CaM_IQ_9 408 423 PF13499 0.546
LIG_DLG_GKlike_1 421 429 PF00625 0.510
LIG_EH1_1 234 242 PF00400 0.400
LIG_eIF4E_1 760 766 PF01652 0.310
LIG_FHA_1 11 17 PF00498 0.652
LIG_FHA_1 145 151 PF00498 0.556
LIG_FHA_1 232 238 PF00498 0.562
LIG_FHA_1 249 255 PF00498 0.513
LIG_FHA_1 465 471 PF00498 0.410
LIG_FHA_1 511 517 PF00498 0.574
LIG_FHA_1 520 526 PF00498 0.467
LIG_FHA_1 653 659 PF00498 0.417
LIG_FHA_1 771 777 PF00498 0.324
LIG_FHA_1 778 784 PF00498 0.275
LIG_FHA_1 828 834 PF00498 0.510
LIG_FHA_1 874 880 PF00498 0.579
LIG_FHA_2 125 131 PF00498 0.648
LIG_FHA_2 244 250 PF00498 0.491
LIG_FHA_2 303 309 PF00498 0.483
LIG_FHA_2 316 322 PF00498 0.482
LIG_FHA_2 470 476 PF00498 0.572
LIG_FHA_2 741 747 PF00498 0.318
LIG_FHA_2 822 828 PF00498 0.426
LIG_FHA_2 829 835 PF00498 0.440
LIG_FHA_2 886 892 PF00498 0.623
LIG_FHA_2 908 914 PF00498 0.603
LIG_Integrin_isoDGR_2 756 758 PF01839 0.465
LIG_IRF3_LxIS_1 623 630 PF10401 0.405
LIG_LIR_Gen_1 19 30 PF02991 0.556
LIG_LIR_Gen_1 307 314 PF02991 0.468
LIG_LIR_Gen_1 435 445 PF02991 0.362
LIG_LIR_Gen_1 741 752 PF02991 0.271
LIG_LIR_Nem_3 19 25 PF02991 0.552
LIG_LIR_Nem_3 307 312 PF02991 0.468
LIG_LIR_Nem_3 435 440 PF02991 0.362
LIG_NRBOX 929 935 PF00104 0.653
LIG_PDZ_Class_1 959 964 PF00595 0.606
LIG_Pex14_2 47 51 PF04695 0.579
LIG_SH2_PTP2 22 25 PF00017 0.497
LIG_SH2_SRC 718 721 PF00017 0.515
LIG_SH2_SRC 832 835 PF00017 0.400
LIG_SH2_STAP1 109 113 PF00017 0.619
LIG_SH2_STAP1 380 384 PF00017 0.537
LIG_SH2_STAP1 596 600 PF00017 0.497
LIG_SH2_STAP1 940 944 PF00017 0.555
LIG_SH2_STAT3 940 943 PF00017 0.686
LIG_SH2_STAT5 22 25 PF00017 0.497
LIG_SH2_STAT5 300 303 PF00017 0.440
LIG_SH2_STAT5 449 452 PF00017 0.305
LIG_SH2_STAT5 497 500 PF00017 0.402
LIG_SH2_STAT5 578 581 PF00017 0.487
LIG_SH2_STAT5 596 599 PF00017 0.506
LIG_SH2_STAT5 718 721 PF00017 0.515
LIG_SH2_STAT5 797 800 PF00017 0.299
LIG_SH2_STAT5 832 835 PF00017 0.400
LIG_SH2_STAT5 917 920 PF00017 0.598
LIG_SH3_1 452 458 PF00018 0.394
LIG_SH3_2 561 566 PF14604 0.438
LIG_SH3_3 1 7 PF00018 0.755
LIG_SH3_3 122 128 PF00018 0.685
LIG_SH3_3 179 185 PF00018 0.773
LIG_SH3_3 226 232 PF00018 0.709
LIG_SH3_3 23 29 PF00018 0.449
LIG_SH3_3 365 371 PF00018 0.582
LIG_SH3_3 452 458 PF00018 0.439
LIG_SH3_3 558 564 PF00018 0.481
LIG_SH3_3 600 606 PF00018 0.482
LIG_SH3_3 742 748 PF00018 0.380
LIG_SH3_3 88 94 PF00018 0.746
LIG_SUMO_SIM_anti_2 435 442 PF11976 0.362
LIG_SUMO_SIM_par_1 146 152 PF11976 0.512
LIG_SUMO_SIM_par_1 210 215 PF11976 0.617
LIG_SUMO_SIM_par_1 457 463 PF11976 0.368
LIG_SUMO_SIM_par_1 625 630 PF11976 0.409
LIG_SUMO_SIM_par_1 652 662 PF11976 0.418
LIG_SUMO_SIM_par_1 861 866 PF11976 0.400
LIG_UBA3_1 440 446 PF00899 0.312
LIG_WW_3 453 457 PF00397 0.469
MOD_CDK_SPK_2 441 446 PF00069 0.318
MOD_CDK_SPxK_1 615 621 PF00069 0.489
MOD_CDK_SPxK_1 915 921 PF00069 0.487
MOD_CDK_SPxxK_3 358 365 PF00069 0.642
MOD_CK1_1 11 17 PF00069 0.597
MOD_CK1_1 111 117 PF00069 0.521
MOD_CK1_1 135 141 PF00069 0.559
MOD_CK1_1 248 254 PF00069 0.376
MOD_CK1_1 268 274 PF00069 0.364
MOD_CK1_1 302 308 PF00069 0.278
MOD_CK1_1 369 375 PF00069 0.596
MOD_CK1_1 436 442 PF00069 0.481
MOD_CK1_1 460 466 PF00069 0.633
MOD_CK1_1 487 493 PF00069 0.768
MOD_CK1_1 503 509 PF00069 0.625
MOD_CK1_1 514 520 PF00069 0.569
MOD_CK1_1 530 536 PF00069 0.489
MOD_CK1_1 568 574 PF00069 0.627
MOD_CK1_1 667 673 PF00069 0.683
MOD_CK1_1 701 707 PF00069 0.505
MOD_CK1_1 75 81 PF00069 0.528
MOD_CK1_1 795 801 PF00069 0.294
MOD_CK1_1 875 881 PF00069 0.468
MOD_CK1_1 909 915 PF00069 0.646
MOD_CK2_1 224 230 PF00069 0.787
MOD_CK2_1 243 249 PF00069 0.299
MOD_CK2_1 469 475 PF00069 0.590
MOD_CK2_1 627 633 PF00069 0.474
MOD_CK2_1 701 707 PF00069 0.540
MOD_CK2_1 74 80 PF00069 0.664
MOD_CK2_1 740 746 PF00069 0.387
MOD_CK2_1 821 827 PF00069 0.432
MOD_CK2_1 885 891 PF00069 0.509
MOD_Cter_Amidation 948 951 PF01082 0.470
MOD_GlcNHglycan 104 107 PF01048 0.538
MOD_GlcNHglycan 110 113 PF01048 0.485
MOD_GlcNHglycan 140 143 PF01048 0.459
MOD_GlcNHglycan 192 195 PF01048 0.732
MOD_GlcNHglycan 196 199 PF01048 0.669
MOD_GlcNHglycan 217 220 PF01048 0.692
MOD_GlcNHglycan 267 270 PF01048 0.273
MOD_GlcNHglycan 30 33 PF01048 0.491
MOD_GlcNHglycan 301 304 PF01048 0.315
MOD_GlcNHglycan 368 371 PF01048 0.632
MOD_GlcNHglycan 462 465 PF01048 0.618
MOD_GlcNHglycan 553 556 PF01048 0.697
MOD_GlcNHglycan 590 593 PF01048 0.540
MOD_GlcNHglycan 680 683 PF01048 0.699
MOD_GlcNHglycan 713 716 PF01048 0.679
MOD_GlcNHglycan 720 723 PF01048 0.589
MOD_GlcNHglycan 74 77 PF01048 0.627
MOD_GlcNHglycan 864 868 PF01048 0.223
MOD_GlcNHglycan 882 885 PF01048 0.469
MOD_GlcNHglycan 94 97 PF01048 0.696
MOD_GlcNHglycan 956 959 PF01048 0.600
MOD_GSK3_1 107 114 PF00069 0.588
MOD_GSK3_1 131 138 PF00069 0.664
MOD_GSK3_1 159 166 PF00069 0.379
MOD_GSK3_1 186 193 PF00069 0.662
MOD_GSK3_1 400 407 PF00069 0.339
MOD_GSK3_1 432 439 PF00069 0.339
MOD_GSK3_1 460 467 PF00069 0.485
MOD_GSK3_1 487 494 PF00069 0.685
MOD_GSK3_1 510 517 PF00069 0.604
MOD_GSK3_1 52 59 PF00069 0.508
MOD_GSK3_1 568 575 PF00069 0.638
MOD_GSK3_1 652 659 PF00069 0.661
MOD_GSK3_1 664 671 PF00069 0.562
MOD_GSK3_1 7 14 PF00069 0.612
MOD_GSK3_1 72 79 PF00069 0.489
MOD_GSK3_1 822 829 PF00069 0.294
MOD_LATS_1 157 163 PF00433 0.378
MOD_LATS_1 419 425 PF00433 0.362
MOD_LATS_1 709 715 PF00433 0.583
MOD_LATS_1 803 809 PF00433 0.346
MOD_N-GLC_1 117 122 PF02516 0.581
MOD_N-GLC_1 954 959 PF02516 0.500
MOD_N-GLC_2 153 155 PF02516 0.547
MOD_N-GLC_2 400 402 PF02516 0.388
MOD_NEK2_1 187 192 PF00069 0.646
MOD_NEK2_1 265 270 PF00069 0.278
MOD_NEK2_1 299 304 PF00069 0.208
MOD_NEK2_1 357 362 PF00069 0.729
MOD_NEK2_1 389 394 PF00069 0.397
MOD_NEK2_1 432 437 PF00069 0.486
MOD_NEK2_1 47 52 PF00069 0.482
MOD_NEK2_1 551 556 PF00069 0.761
MOD_NEK2_1 740 745 PF00069 0.423
MOD_NEK2_1 777 782 PF00069 0.299
MOD_NEK2_1 815 820 PF00069 0.388
MOD_NEK2_2 52 57 PF00069 0.493
MOD_NEK2_2 594 599 PF00069 0.602
MOD_OFUCOSY 402 408 PF10250 0.406
MOD_PIKK_1 163 169 PF00454 0.418
MOD_PIKK_1 187 193 PF00454 0.529
MOD_PIKK_1 260 266 PF00454 0.208
MOD_PK_1 805 811 PF00069 0.362
MOD_PKA_2 215 221 PF00069 0.668
MOD_PKA_2 224 230 PF00069 0.583
MOD_PKA_2 364 370 PF00069 0.625
MOD_PKA_2 52 58 PF00069 0.499
MOD_PKA_2 551 557 PF00069 0.768
MOD_PKA_2 565 571 PF00069 0.642
MOD_PKA_2 612 618 PF00069 0.746
MOD_PKA_2 643 649 PF00069 0.653
MOD_PKA_2 667 673 PF00069 0.529
MOD_PKA_2 804 810 PF00069 0.328
MOD_PKB_1 346 354 PF00069 0.485
MOD_Plk_1 701 707 PF00069 0.540
MOD_Plk_2-3 469 475 PF00069 0.518
MOD_Plk_4 42 48 PF00069 0.346
MOD_Plk_4 433 439 PF00069 0.499
MOD_Plk_4 740 746 PF00069 0.417
MOD_Plk_4 747 753 PF00069 0.314
MOD_Plk_4 782 788 PF00069 0.264
MOD_Plk_4 792 798 PF00069 0.311
MOD_Plk_4 805 811 PF00069 0.380
MOD_Plk_4 828 834 PF00069 0.208
MOD_Plk_4 929 935 PF00069 0.526
MOD_ProDKin_1 124 130 PF00069 0.601
MOD_ProDKin_1 207 213 PF00069 0.591
MOD_ProDKin_1 315 321 PF00069 0.310
MOD_ProDKin_1 358 364 PF00069 0.656
MOD_ProDKin_1 441 447 PF00069 0.339
MOD_ProDKin_1 479 485 PF00069 0.637
MOD_ProDKin_1 511 517 PF00069 0.654
MOD_ProDKin_1 520 526 PF00069 0.568
MOD_ProDKin_1 599 605 PF00069 0.738
MOD_ProDKin_1 615 621 PF00069 0.487
MOD_ProDKin_1 627 633 PF00069 0.607
MOD_ProDKin_1 87 93 PF00069 0.624
MOD_ProDKin_1 915 921 PF00069 0.527
TRG_DiLeu_BaLyEn_6 903 908 PF01217 0.691
TRG_ENDOCYTIC_2 22 25 PF00928 0.344
TRG_ER_diArg_1 346 349 PF00400 0.485
TRG_ER_diArg_1 550 553 PF00400 0.800
TRG_ER_diArg_1 691 693 PF00400 0.624
TRG_ER_diArg_1 950 952 PF00400 0.486
TRG_Pf-PMV_PEXEL_1 332 337 PF00026 0.364
TRG_Pf-PMV_PEXEL_1 621 625 PF00026 0.429
TRG_Pf-PMV_PEXEL_1 693 698 PF00026 0.530
TRG_Pf-PMV_PEXEL_1 906 911 PF00026 0.703
TRG_Pf-PMV_PEXEL_1 924 928 PF00026 0.445
TRG_PTS1 961 964 PF00515 0.494

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IM78 Leptomonas seymouri 38% 100%
A0A3S7WVF1 Leishmania donovani 82% 100%
A4HYC4 Leishmania infantum 83% 100%
Q4QDA8 Leishmania major 81% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS