Cir_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AS54_LEIMU

TriTrypDb:

LmxM.19.1030

Length:

287

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9AS54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS54

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.544
CLV_NRD_NRD_1	167	169	PF00675	0.643
CLV_NRD_NRD_1	196	198	PF00675	0.588
CLV_NRD_NRD_1	218	220	PF00675	0.518
CLV_NRD_NRD_1	255	257	PF00675	0.388
CLV_NRD_NRD_1	54	56	PF00675	0.452
CLV_PCSK_KEX2_1	169	171	PF00082	0.635
CLV_PCSK_KEX2_1	195	197	PF00082	0.713
CLV_PCSK_KEX2_1	54	56	PF00082	0.452
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.635

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD46	Leptomonas seymouri	54%	100%
A0A3S7WVP3	Leishmania donovani	86%	97%
A0A422NC58	Trypanosoma rangeli	40%	100%
A4HA55	Leishmania braziliensis	75%	99%
A4HYC0	Leishmania infantum	86%	97%
D0A642	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4QDB2	Leishmania major	82%	99%
V5BKZ5	Trypanosoma cruzi	39%	100%

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