Cir_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AS54_LEIMU

TriTrypDb:

LmxM.19.1030

Length:

287

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AS54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS54

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.544
CLV_NRD_NRD_1	167	169	PF00675	0.643
CLV_NRD_NRD_1	196	198	PF00675	0.588
CLV_NRD_NRD_1	218	220	PF00675	0.518
CLV_NRD_NRD_1	255	257	PF00675	0.388
CLV_NRD_NRD_1	54	56	PF00675	0.452
CLV_PCSK_KEX2_1	169	171	PF00082	0.635
CLV_PCSK_KEX2_1	195	197	PF00082	0.713
CLV_PCSK_KEX2_1	54	56	PF00082	0.452
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.635
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.713
CLV_PCSK_SKI1_1	219	223	PF00082	0.425
CLV_PCSK_SKI1_1	278	282	PF00082	0.532
CLV_PCSK_SKI1_1	79	83	PF00082	0.468
CLV_PCSK_SKI1_1	91	95	PF00082	0.457
DEG_Nend_Nbox_1	1	3	PF02207	0.540
DOC_MAPK_gen_1	227	236	PF00069	0.602
DOC_MAPK_gen_1	276	283	PF00069	0.533
DOC_MAPK_gen_1	54	61	PF00069	0.411
DOC_MAPK_MEF2A_6	108	115	PF00069	0.467
DOC_USP7_MATH_1	104	108	PF00917	0.672
DOC_USP7_MATH_1	152	156	PF00917	0.763
DOC_USP7_MATH_1	157	161	PF00917	0.523
DOC_USP7_MATH_1	163	167	PF00917	0.642
DOC_USP7_MATH_1	183	187	PF00917	0.695
DOC_WW_Pin1_4	176	181	PF00397	0.584
DOC_WW_Pin1_4	97	102	PF00397	0.692
LIG_14-3-3_CanoR_1	11	16	PF00244	0.398
LIG_FHA_1	205	211	PF00498	0.514
LIG_FHA_1	258	264	PF00498	0.584
LIG_FHA_1	76	82	PF00498	0.546
LIG_FHA_2	209	215	PF00498	0.488
LIG_Integrin_RGD_1	197	199	PF01839	0.533
LIG_LIR_Gen_1	53	62	PF02991	0.531
LIG_LIR_Nem_3	14	18	PF02991	0.460
LIG_LIR_Nem_3	19	23	PF02991	0.450
LIG_LIR_Nem_3	53	59	PF02991	0.576
LIG_PCNA_yPIPBox_3	270	281	PF02747	0.552
LIG_Pex14_2	126	130	PF04695	0.592
LIG_SH2_CRK	20	24	PF00017	0.467
LIG_SH2_GRB2like	239	242	PF00017	0.524
LIG_SH2_SRC	239	242	PF00017	0.524
LIG_SH2_STAP1	56	60	PF00017	0.409
LIG_SH2_STAP1	86	90	PF00017	0.536
LIG_SH3_3	142	148	PF00018	0.595
LIG_SH3_3	95	101	PF00018	0.734
LIG_TRAF2_1	107	110	PF00917	0.611
LIG_TYR_ITIM	18	23	PF00017	0.469
LIG_UBA3_1	280	287	PF00899	0.443
MOD_CK1_1	100	106	PF00069	0.661
MOD_CK1_1	122	128	PF00069	0.615
MOD_CK1_1	179	185	PF00069	0.705
MOD_CK1_1	64	70	PF00069	0.420
MOD_CK2_1	104	110	PF00069	0.752
MOD_CK2_1	208	214	PF00069	0.554
MOD_GlcNHglycan	121	124	PF01048	0.480
MOD_GlcNHglycan	155	158	PF01048	0.734
MOD_GlcNHglycan	159	162	PF01048	0.538
MOD_GlcNHglycan	181	184	PF01048	0.705
MOD_GlcNHglycan	202	205	PF01048	0.492
MOD_GlcNHglycan	211	214	PF01048	0.447
MOD_GlcNHglycan	63	66	PF01048	0.434
MOD_GlcNHglycan	68	71	PF01048	0.432
MOD_GSK3_1	100	107	PF00069	0.650
MOD_GSK3_1	113	120	PF00069	0.553
MOD_GSK3_1	132	139	PF00069	0.688
MOD_GSK3_1	148	155	PF00069	0.633
MOD_GSK3_1	174	181	PF00069	0.729
MOD_GSK3_1	200	207	PF00069	0.546
MOD_LATS_1	255	261	PF00433	0.387
MOD_N-GLC_1	11	16	PF02516	0.433
MOD_N-GLC_2	187	189	PF02516	0.496
MOD_N-GLC_2	241	243	PF02516	0.511
MOD_NEK2_1	113	118	PF00069	0.619
MOD_NEK2_2	163	168	PF00069	0.544
MOD_PKA_2	75	81	PF00069	0.523
MOD_Plk_1	11	17	PF00069	0.476
MOD_Plk_1	132	138	PF00069	0.537
MOD_Plk_1	163	169	PF00069	0.544
MOD_Plk_4	122	128	PF00069	0.582
MOD_ProDKin_1	176	182	PF00069	0.584
MOD_ProDKin_1	97	103	PF00069	0.692
MOD_SUMO_for_1	130	133	PF00179	0.560
MOD_SUMO_for_1	143	146	PF00179	0.618
MOD_SUMO_for_1	29	32	PF00179	0.435
MOD_SUMO_rev_2	85	93	PF00179	0.479
TRG_ENDOCYTIC_2	20	23	PF00928	0.469
TRG_ENDOCYTIC_2	56	59	PF00928	0.466
TRG_ER_diArg_1	167	170	PF00400	0.702
TRG_ER_diArg_1	54	56	PF00400	0.446
TRG_ER_diLys_1	284	287	PF00400	0.551
TRG_NLS_MonoExtC_3	167	172	PF00514	0.643

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD46	Leptomonas seymouri	54%	100%
A0A3S7WVP3	Leishmania donovani	86%	97%
A0A422NC58	Trypanosoma rangeli	40%	100%
A4HA55	Leishmania braziliensis	75%	99%
A4HYC0	Leishmania infantum	86%	97%
D0A642	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4QDB2	Leishmania major	82%	99%
V5BKZ5	Trypanosoma cruzi	39%	100%