Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania mexicana

UniProt:

E9AS52_LEIMU

TriTrypDb:

LmxM.19.1010

Length:

869

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0031931	TORC1 complex	4	8
GO:0031932	TORC2 complex	4	8
GO:0032991	protein-containing complex	1	8
GO:0038201	TOR complex	3	8
GO:0140535	intracellular protein-containing complex	2	8
GO:0005737	cytoplasm	2	1
GO:0005840	ribosome	5	5
GO:0043226	organelle	2	5
GO:0043228	non-membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043232	intracellular non-membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5
GO:1990904	ribonucleoprotein complex	2	5

Expansion

Sequence features

E9AS52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AS52

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	8
GO:0009987	cellular process	1	8
GO:0031929	TOR signaling	4	8
GO:0035556	intracellular signal transduction	3	8
GO:0050789	regulation of biological process	2	8
GO:0050794	regulation of cellular process	3	8
GO:0065007	biological regulation	1	8
GO:0032956	regulation of actin cytoskeleton organization	5	1
GO:0032970	regulation of actin filament-based process	4	1
GO:0033043	regulation of organelle organization	5	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051493	regulation of cytoskeleton organization	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	314	318	PF00656	0.518
CLV_C14_Caspase3-7	736	740	PF00656	0.816
CLV_C14_Caspase3-7	760	764	PF00656	0.591
CLV_NRD_NRD_1	265	267	PF00675	0.541
CLV_NRD_NRD_1	864	866	PF00675	0.641
CLV_PCSK_KEX2_1	265	267	PF00082	0.609
CLV_PCSK_KEX2_1	863	865	PF00082	0.566
CLV_PCSK_PC1ET2_1	863	865	PF00082	0.620
CLV_PCSK_SKI1_1	184	188	PF00082	0.697
CLV_PCSK_SKI1_1	245	249	PF00082	0.520
CLV_PCSK_SKI1_1	266	270	PF00082	0.509
CLV_PCSK_SKI1_1	42	46	PF00082	0.517
CLV_PCSK_SKI1_1	493	497	PF00082	0.657
CLV_PCSK_SKI1_1	600	604	PF00082	0.435
CLV_PCSK_SKI1_1	76	80	PF00082	0.525
CLV_PCSK_SKI1_1	801	805	PF00082	0.311
DEG_APCC_DBOX_1	346	354	PF00400	0.540
DEG_Nend_UBRbox_2	1	3	PF02207	0.476
DEG_SPOP_SBC_1	35	39	PF00917	0.503
DEG_SPOP_SBC_1	638	642	PF00917	0.749
DOC_CKS1_1	422	427	PF01111	0.685
DOC_MAPK_MEF2A_6	600	607	PF00069	0.437
DOC_MAPK_MEF2A_6	852	859	PF00069	0.473
DOC_PP1_RVXF_1	380	386	PF00149	0.408
DOC_PP4_FxxP_1	626	629	PF00568	0.433
DOC_PP4_FxxP_1	92	95	PF00568	0.533
DOC_SPAK_OSR1_1	625	629	PF12202	0.429
DOC_USP7_MATH_1	17	21	PF00917	0.474
DOC_USP7_MATH_1	302	306	PF00917	0.694
DOC_USP7_MATH_1	361	365	PF00917	0.426
DOC_USP7_MATH_1	575	579	PF00917	0.758
DOC_USP7_MATH_1	638	642	PF00917	0.620
DOC_USP7_MATH_1	689	693	PF00917	0.653
DOC_USP7_MATH_1	694	698	PF00917	0.563
DOC_USP7_MATH_1	764	768	PF00917	0.649
DOC_USP7_UBL2_3	446	450	PF12436	0.748
DOC_WW_Pin1_4	259	264	PF00397	0.452
DOC_WW_Pin1_4	421	426	PF00397	0.705
DOC_WW_Pin1_4	440	445	PF00397	0.816
DOC_WW_Pin1_4	523	528	PF00397	0.754
DOC_WW_Pin1_4	605	610	PF00397	0.427
DOC_WW_Pin1_4	641	646	PF00397	0.528
DOC_WW_Pin1_4	690	695	PF00397	0.603
DOC_WW_Pin1_4	739	744	PF00397	0.747
DOC_WW_Pin1_4	776	781	PF00397	0.744
DOC_WW_Pin1_4	787	792	PF00397	0.670
LIG_14-3-3_CanoR_1	22	28	PF00244	0.557
LIG_14-3-3_CanoR_1	464	468	PF00244	0.633
LIG_14-3-3_CanoR_1	507	513	PF00244	0.573
LIG_14-3-3_CanoR_1	52	57	PF00244	0.381
LIG_14-3-3_CanoR_1	690	694	PF00244	0.548
LIG_14-3-3_CanoR_1	76	82	PF00244	0.470
LIG_14-3-3_CanoR_1	841	846	PF00244	0.498
LIG_Actin_WH2_2	620	635	PF00022	0.493
LIG_APCC_ABBAyCdc20_2	79	85	PF00400	0.583
LIG_BRCT_BRCA1_1	154	158	PF00533	0.514
LIG_BRCT_BRCA1_1	79	83	PF00533	0.496
LIG_BRCT_BRCA1_1	843	847	PF00533	0.536
LIG_eIF4E_1	601	607	PF01652	0.483
LIG_FHA_1	206	212	PF00498	0.595
LIG_FHA_1	466	472	PF00498	0.684
LIG_FHA_1	699	705	PF00498	0.801
LIG_FHA_1	849	855	PF00498	0.457
LIG_FHA_1	95	101	PF00498	0.507
LIG_FHA_2	225	231	PF00498	0.426
LIG_FHA_2	312	318	PF00498	0.612
LIG_FHA_2	334	340	PF00498	0.548
LIG_FHA_2	41	47	PF00498	0.514
LIG_FHA_2	415	421	PF00498	0.758
LIG_FHA_2	758	764	PF00498	0.632
LIG_IRF3_LxIS_1	628	635	PF10401	0.449
LIG_LIR_Apic_2	278	283	PF02991	0.440
LIG_LIR_Apic_2	443	448	PF02991	0.733
LIG_LIR_Apic_2	483	487	PF02991	0.751
LIG_LIR_Apic_2	90	95	PF02991	0.523
LIG_LIR_Gen_1	155	166	PF02991	0.497
LIG_LIR_Gen_1	219	226	PF02991	0.597
LIG_LIR_Gen_1	358	367	PF02991	0.432
LIG_LIR_Gen_1	590	599	PF02991	0.481
LIG_LIR_Gen_1	8	17	PF02991	0.491
LIG_LIR_Gen_1	844	853	PF02991	0.299
LIG_LIR_Gen_1	96	107	PF02991	0.436
LIG_LIR_LC3C_4	494	498	PF02991	0.665
LIG_LIR_Nem_3	155	161	PF02991	0.461
LIG_LIR_Nem_3	219	225	PF02991	0.605
LIG_LIR_Nem_3	358	362	PF02991	0.459
LIG_LIR_Nem_3	590	595	PF02991	0.485
LIG_LIR_Nem_3	796	800	PF02991	0.430
LIG_LIR_Nem_3	844	848	PF02991	0.313
LIG_LIR_Nem_3	96	102	PF02991	0.445
LIG_Pex14_1	811	815	PF04695	0.517
LIG_SH2_CRK	359	363	PF00017	0.464
LIG_SH2_CRK	445	449	PF00017	0.812
LIG_SH2_CRK	484	488	PF00017	0.743
LIG_SH2_CRK	599	603	PF00017	0.449
LIG_SH2_PTP2	32	35	PF00017	0.499
LIG_SH2_SRC	32	35	PF00017	0.499
LIG_SH2_STAP1	63	67	PF00017	0.440
LIG_SH2_STAT3	63	66	PF00017	0.446
LIG_SH2_STAT5	170	173	PF00017	0.647
LIG_SH2_STAT5	267	270	PF00017	0.436
LIG_SH2_STAT5	32	35	PF00017	0.499
LIG_SH2_STAT5	601	604	PF00017	0.443
LIG_SH2_STAT5	99	102	PF00017	0.410
LIG_SH3_3	419	425	PF00018	0.763
LIG_SH3_3	44	50	PF00018	0.503
LIG_SH3_3	657	663	PF00018	0.754
LIG_SH3_3	796	802	PF00018	0.385
LIG_SUMO_SIM_anti_2	55	60	PF11976	0.571
LIG_SUMO_SIM_par_1	55	60	PF11976	0.509
LIG_TRAF2_1	336	339	PF00917	0.647
LIG_TYR_ITSM	95	102	PF00017	0.500
LIG_WRC_WIRS_1	113	118	PF05994	0.620
LIG_WRC_WIRS_1	147	152	PF05994	0.537
LIG_WRC_WIRS_1	695	700	PF05994	0.532
LIG_WRC_WIRS_1	78	83	PF05994	0.504
LIG_WW_1	144	147	PF00397	0.565
MOD_CDC14_SPxK_1	262	265	PF00782	0.474
MOD_CDC14_SPxK_1	443	446	PF00782	0.739
MOD_CDC14_SPxK_1	447	450	PF00782	0.752
MOD_CDK_SPxK_1	259	265	PF00069	0.454
MOD_CDK_SPxK_1	440	446	PF00069	0.741
MOD_CDK_SPxxK_3	259	266	PF00069	0.518
MOD_CDK_SPxxK_3	787	794	PF00069	0.603
MOD_CK1_1	133	139	PF00069	0.791
MOD_CK1_1	149	155	PF00069	0.402
MOD_CK1_1	177	183	PF00069	0.713
MOD_CK1_1	189	195	PF00069	0.522
MOD_CK1_1	240	246	PF00069	0.561
MOD_CK1_1	259	265	PF00069	0.291
MOD_CK1_1	305	311	PF00069	0.777
MOD_CK1_1	397	403	PF00069	0.735
MOD_CK1_1	470	476	PF00069	0.662
MOD_CK1_1	509	515	PF00069	0.706
MOD_CK1_1	525	531	PF00069	0.744
MOD_CK1_1	551	557	PF00069	0.766
MOD_CK1_1	637	643	PF00069	0.754
MOD_CK1_1	74	80	PF00069	0.465
MOD_CK1_1	787	793	PF00069	0.717
MOD_CK1_1	816	822	PF00069	0.548
MOD_CK1_1	827	833	PF00069	0.556
MOD_CK1_1	9	15	PF00069	0.498
MOD_CK2_1	145	151	PF00069	0.501
MOD_CK2_1	333	339	PF00069	0.603
MOD_CK2_1	40	46	PF00069	0.515
MOD_CK2_1	449	455	PF00069	0.828
MOD_CK2_1	470	476	PF00069	0.811
MOD_CK2_1	739	745	PF00069	0.817
MOD_GlcNHglycan	118	121	PF01048	0.716
MOD_GlcNHglycan	126	129	PF01048	0.667
MOD_GlcNHglycan	179	182	PF01048	0.730
MOD_GlcNHglycan	188	191	PF01048	0.689
MOD_GlcNHglycan	213	216	PF01048	0.607
MOD_GlcNHglycan	239	242	PF01048	0.591
MOD_GlcNHglycan	258	261	PF01048	0.255
MOD_GlcNHglycan	300	303	PF01048	0.502
MOD_GlcNHglycan	358	362	PF01048	0.530
MOD_GlcNHglycan	402	405	PF01048	0.685
MOD_GlcNHglycan	436	439	PF01048	0.832
MOD_GlcNHglycan	451	454	PF01048	0.719
MOD_GlcNHglycan	457	460	PF01048	0.692
MOD_GlcNHglycan	493	496	PF01048	0.579
MOD_GlcNHglycan	527	530	PF01048	0.695
MOD_GlcNHglycan	577	580	PF01048	0.601
MOD_GlcNHglycan	59	62	PF01048	0.419
MOD_GlcNHglycan	617	620	PF01048	0.479
MOD_GlcNHglycan	636	639	PF01048	0.713
MOD_GlcNHglycan	650	653	PF01048	0.574
MOD_GlcNHglycan	713	716	PF01048	0.737
MOD_GlcNHglycan	73	76	PF01048	0.525
MOD_GlcNHglycan	766	769	PF01048	0.742
MOD_GSK3_1	112	119	PF00069	0.621
MOD_GSK3_1	124	131	PF00069	0.603
MOD_GSK3_1	132	139	PF00069	0.721
MOD_GSK3_1	145	152	PF00069	0.392
MOD_GSK3_1	173	180	PF00069	0.704
MOD_GSK3_1	186	193	PF00069	0.602
MOD_GSK3_1	281	288	PF00069	0.503
MOD_GSK3_1	298	305	PF00069	0.432
MOD_GSK3_1	357	364	PF00069	0.450
MOD_GSK3_1	36	43	PF00069	0.573
MOD_GSK3_1	390	397	PF00069	0.659
MOD_GSK3_1	432	439	PF00069	0.822
MOD_GSK3_1	440	447	PF00069	0.742
MOD_GSK3_1	451	458	PF00069	0.696
MOD_GSK3_1	463	470	PF00069	0.636
MOD_GSK3_1	48	55	PF00069	0.556
MOD_GSK3_1	487	494	PF00069	0.557
MOD_GSK3_1	505	512	PF00069	0.483
MOD_GSK3_1	518	525	PF00069	0.511
MOD_GSK3_1	529	536	PF00069	0.692
MOD_GSK3_1	615	622	PF00069	0.481
MOD_GSK3_1	633	640	PF00069	0.730
MOD_GSK3_1	690	697	PF00069	0.647
MOD_GSK3_1	70	77	PF00069	0.464
MOD_GSK3_1	705	712	PF00069	0.718
MOD_GSK3_1	731	738	PF00069	0.702
MOD_GSK3_1	753	760	PF00069	0.609
MOD_GSK3_1	823	830	PF00069	0.556
MOD_GSK3_1	83	90	PF00069	0.359
MOD_N-GLC_1	156	161	PF02516	0.446
MOD_N-GLC_1	455	460	PF02516	0.604
MOD_N-GLC_1	480	485	PF02516	0.751
MOD_N-GLC_1	551	556	PF02516	0.756
MOD_N-GLC_1	690	695	PF02516	0.560
MOD_N-GLC_1	757	762	PF02516	0.675
MOD_N-GLC_2	169	171	PF02516	0.440
MOD_NEK2_1	116	121	PF00069	0.620
MOD_NEK2_1	156	161	PF00069	0.435
MOD_NEK2_1	186	191	PF00069	0.710
MOD_NEK2_1	199	204	PF00069	0.449
MOD_NEK2_1	205	210	PF00069	0.528
MOD_NEK2_1	211	216	PF00069	0.560
MOD_NEK2_1	235	240	PF00069	0.475
MOD_NEK2_1	434	439	PF00069	0.772
MOD_NEK2_1	463	468	PF00069	0.800
MOD_NEK2_1	520	525	PF00069	0.720
MOD_NEK2_1	6	11	PF00069	0.492
MOD_NEK2_1	613	618	PF00069	0.415
MOD_NEK2_1	632	637	PF00069	0.598
MOD_NEK2_1	821	826	PF00069	0.517
MOD_NEK2_1	83	88	PF00069	0.510
MOD_NEK2_2	487	492	PF00069	0.660
MOD_PIKK_1	149	155	PF00454	0.510
MOD_PIKK_1	235	241	PF00454	0.495
MOD_PIKK_1	308	314	PF00454	0.564
MOD_PIKK_1	698	704	PF00454	0.835
MOD_PIKK_1	83	89	PF00454	0.456
MOD_PK_1	390	396	PF00069	0.652
MOD_PK_1	52	58	PF00069	0.363
MOD_PKA_2	463	469	PF00069	0.632
MOD_PKA_2	487	493	PF00069	0.640
MOD_PKA_2	506	512	PF00069	0.739
MOD_PKA_2	632	638	PF00069	0.613
MOD_PKA_2	689	695	PF00069	0.545
MOD_Plk_1	156	162	PF00069	0.446
MOD_Plk_1	357	363	PF00069	0.503
MOD_Plk_1	390	396	PF00069	0.652
MOD_Plk_1	480	486	PF00069	0.684
MOD_Plk_1	509	515	PF00069	0.613
MOD_Plk_1	619	625	PF00069	0.392
MOD_Plk_1	827	833	PF00069	0.556
MOD_Plk_2-3	784	790	PF00069	0.744
MOD_Plk_4	112	118	PF00069	0.531
MOD_Plk_4	190	196	PF00069	0.628
MOD_Plk_4	275	281	PF00069	0.422
MOD_Plk_4	408	414	PF00069	0.745
MOD_Plk_4	487	493	PF00069	0.559
MOD_Plk_4	52	58	PF00069	0.363
MOD_Plk_4	6	12	PF00069	0.493
MOD_Plk_4	77	83	PF00069	0.535
MOD_Plk_4	87	93	PF00069	0.394
MOD_ProDKin_1	259	265	PF00069	0.454
MOD_ProDKin_1	421	427	PF00069	0.705
MOD_ProDKin_1	440	446	PF00069	0.819
MOD_ProDKin_1	523	529	PF00069	0.755
MOD_ProDKin_1	605	611	PF00069	0.427
MOD_ProDKin_1	641	647	PF00069	0.527
MOD_ProDKin_1	690	696	PF00069	0.600
MOD_ProDKin_1	739	745	PF00069	0.750
MOD_ProDKin_1	776	782	PF00069	0.747
MOD_ProDKin_1	787	793	PF00069	0.664
MOD_SUMO_rev_2	288	296	PF00179	0.609
TRG_DiLeu_BaEn_1	207	212	PF01217	0.622
TRG_DiLeu_BaEn_1	219	224	PF01217	0.536
TRG_DiLeu_BaLyEn_6	766	771	PF01217	0.720
TRG_ENDOCYTIC_2	147	150	PF00928	0.489
TRG_ENDOCYTIC_2	359	362	PF00928	0.508
TRG_ENDOCYTIC_2	599	602	PF00928	0.458
TRG_ENDOCYTIC_2	99	102	PF00928	0.410
TRG_ER_diArg_1	265	267	PF00400	0.609
TRG_ER_diArg_1	29	32	PF00400	0.500
TRG_ER_diArg_1	864	866	PF00400	0.644
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.683
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7T2	Leptomonas seymouri	55%	100%
A0A1X0P678	Trypanosomatidae	34%	100%
A0A3S7WVI8	Leishmania donovani	87%	100%
A4HA53	Leishmania braziliensis	71%	98%
A4HYB8	Leishmania infantum	87%	100%
Q4QDB4	Leishmania major	86%	100%